David Hofer

Some news: Last April, I left Ginkgo Bioworks after 8+ years as a software engineer there. Since then, I’ve been working on starting a new company called GenHub with a couple other ex-Ginkgo people, Bob Van Hove and Chris Mitchell. (1/5)

Was at the world cycling championship women’s elite race in Montreal today. Demi Vollering won; I got a picture of her and the top three finishers on the last lap. One thing they don’t show on TV is the sweep car

[guy who can’t fully remember that Gramsci quote] it’s Monster Time

Toledo is enjoying a nap

Turkeys (the bird) are named in most languages after the place they are believed to have come from. In England they were imported from the Ottoman Empire. In Turkey, they are called “Indias”. In India, they are called “Perus”.

Went hiking in the Adirondacks this weekend, then hung out by a river

My solar + electric system just crossed over to being a net exporter for the year to date. It’ll probably go back to being a net importer in November or December, but I’m enjoying it for now

If you missed the solar eclipse, this is what it looked like:

Messi goes super saiyan in the last 20 of every match and every opposing coach is like, what if he didn’t and we could just defend a narrow lead until the whistle

Just read this morning there’s an effort to get rideshare drivers in Massachusetts to use EVs because they drive far more miles on average than anyone else, and I like how pragmatic my state is, overall

Stage 2 Tarragone to Barcelone - After you, youngster #letourdepoupees #couchpeloton #sbscycling #TDF2026

Stage 1 Barcelone to Barcelone - Stocking up for a hot TTT #letourdepoupees #couchpeloton #sbscycling #TDF2026

“Comparing 1 acre of growing corn for ethanol, to 1 acre of solar panels to charge EVs”

absolute height of comedy is when they cut to the goal and you see how many kid keepers they've got

The bell: Buttercup Festival 3-386

Relatable.

The New PJs (1/4)

Toledo is enjoying the weather today on the back porch

A network of research centers that was well-positioned to respond to the current Ebola outbreak in the Democratic Republic of Congo had its funding canceled last year by the Trump administration. My latest for @wired.com: www.wired.com/story/us-res...

YOU’RE LISTENING TO SISYPHUS FM, THE HOME OF NON-STOP ROCK

@jtkantor.bsky.social I’m at the game tonight with a Belgian friend. Could you play Papaoutai by Stromae for him?

Quite a flex to turn up at the presidential palace, get him to confirm you as prime minister, call him unfit to serve with no moral authority, tell him to resign, and then pose for a picture

Cat timeline cleanser: My cat sitter recently got both an action shot of Hamburg and a closeup of Toledo

New GenHub post: Cloning a combinatorial library into a plasmid, and viewing the result as a sequence graph: www.genhub.bio/blog/2026/3/...

Oh, they’re having trouble getting spice off Arrakis? The emperor better go there himself to take charge of things

The most relaxed cat in the world, currently. I can’t move. Don’t send help

My cat Hamburg has a pretty excellent diamond pattern by his shoulder blades

For non-bioinformaticians, here’s Toledo on the lookout for birdies, and warmer weather

Everybody knows that Pupper just won Downhill Gold

We've known for a while that Waymo has remote people in the loop (they were overwhelmed with "no green light" exec decisions during the Dec 20 SF power failure), but we did not know that many of them are in the Philippines--suggests a large scale contingent. futurism.com/advanced-tra...

Saw some lovely offshore wind farms flying out of Amsterdam today

DOCTOR: I told him he needed to get out to a show, that was how he would cure his depression. CHOTINER: So you learned this technique in school? DR: No, not— listen it was good advice. Pagliacci was in town. C: Right. Is it standard to give advice before learning a patient’s name? DR: Now look