Harald Ringbauer

Harald Ringbauer

@hringbauer.bsky.social

Population Geneticist | Ancient DNA Research Group Leader at MPI-EVA Leipzig www.hringbauer.com

990 followers594 following73 posts

Harald Ringbauer reposted

🚨 Ancient DNA Alert 🚨 Do you depend on BWA aln, and worry that the world’s HPC clusters are pivoting towards GPUs? Fear no more! We here present G-ALN, a GPU implementation that is >6 times faster and produces byte-identical outputs to BWA aln! www.biorxiv.org/content/10.6...

Harald Ringbauer reposted

Harald Ringbauer reposted

Quite the saga I found myself involved in! Was a stimulating way to spend my evenings. Highly impressed by the folks at I4R and the important work they're doing.

Institute for Replication@i4replication.bsky.social

Our chair and a few replicators investigated a paper about elite footballers. And missed the bigger story. An independent researcher showed us what we had failed to see. This is I4R’s CRAVE–football investigation. It starts with a PNAS paper. #CRAVEFiles

This group is really useful to keep up to date with new papers in #PopGen and adjacent fields. ⏬️

Shai Carmi@shaicarmi.bsky.social

Given the recent decline of social media for high quality science discussions, I have recently moved most of my activity into this Slack group, dedicated to population genetics and genetic genealogy. Everyone is welcome to join: join.slack.com/t/geneticgen...

Harald Ringbauer reposted

Given the recent decline of social media for high quality science discussions, I have recently moved most of my activity into this Slack group, dedicated to population genetics and genetic genealogy. Everyone is welcome to join: join.slack.com/t/geneticgen...

join.slack.comJoin Genetic genealogy science on SlackSlack is a new way to communicate with your team. It’s faster, better organized, and more secure than email.
Shai Carmi@shaicarmi.bsky.social

Given several new followers here, I'm posting the link to our Slack group "genetic genealogy science". We post and discuss manuscripts on phasing/imputation, IBD, recombination, demographic inference, ancient DNA, ancestry/admixture, etc. All are welcome. join.slack.com/t/geneticgen...

Great to see @annikafreudiger.bsky.social paper published! 🎉 We analyzed how genetic markers are used to estimate relatedness in wild animals - a big field with 2861 relevant publications. 📈🧬 Even in 2026 mainly STRs are used - and we argue for low coverage WGS data and a simple aDNA estimator.

Molecular Ecology@molecology.bsky.social

New in MEC! @annikafreudiger.bsky.social et al. assess genetic relatedness on rhesus macaques and find that low-coverage whole-genome sequencing offers an accurate, cost-effective alternative to widely used methods. @wileyecology.bsky.social 📷 Caribbean Primate Research Center 🔗 buff.ly/pPOONsu 1/3

Link to published paper: doi.org/10.1111/mec.... And link to prior BlueSky thread on our preprint summarizing our work: bsky.app/profile/hrin...

doi.orgGenetic Estimates of Relatedness: Established Practices and New Opportunities Through Low Coverage Whole‐Genome SequencingIdentifying close relatives in wild animal populations is fundamental across many research fields. Genetic estimates of relatedness have expanded rapidly in recent decades, drawing on a range of gene....
Harald Ringbauer@hringbauer.bsky.social

(1/2) The preprint of our perspective on genetic estimates of relatedness in animal populations is out! Big Congratulations to Annika! doi.org/10.32942/X28... A systematic review of 2,861 articles shows that, even in 2025, 75% of such studies use microsatellites. And most use only a few! #PopGen

It is great to now have a proper way to cite pileupCaller! The code to generate pseudohaploid genotypes from BAMs is one of the most quoted github code chunks in human ancient DNA research.

Stephan Schiffels@stschiff.bsky.social

Finally an official publication of Pileupcaller. Please cite. Thanks to @joss-openjournals.bsky.social for the review process and publishing!

Harald Ringbauer reposted

We just published a brief preprint on aDNA from two Medieval Ottonic emperors. 🧬👑 We confirm via IBD segments that remains attributed to Otto "the Great" and "Saint" Heinrich are third-degree relatives. As historically attested - suggesting that they are authentic. ✅️ doi.org/10.64898/202... (1/3)

Their two Ys are a perfect match too - as in the historic relationship. ✅️ They both are in a R1b haplogroup that is very rare today. The whole male lineage of emperors (which died out with Saint Henry) did not leave a big legacy! Shoutout to FamilyTreeDNA for a productive collaboration. 🙌 (2/3)

Sequencing the emperors is not mere celebrity genomics. Authentic remains from Medieval people with known life histories build a ressource for improving bioarchaelogical methods (like mapping C14 reservoir effects). And the genomes will also help identifying other Medieval elites. (3/3)

The HAAM summer school is always a fantastic online workshop on popgen analysis via aDNA. Check out the 2026 version! ⬇️💡🧬

HAAM-community@haam-community.bsky.social

🆕 HAAM Summer School 2026 📅 June 1-5, 2026 📍 Online 💰 Free 🧑‍🔬🧑‍💻 For Students & ECR 🔓 Applications open until April 13, 2026! 🔗 Apply here: forms.gle/ckqTgQxnEENJ...

Harald Ringbauer reposted

Harald Ringbauer reposted

Harald Ringbauer reposted

Harald Ringbauer reposted

We hope this little guide and review of the recent literature on SVs will be useful for the community in #ecology #evolution #genomics #PopGen. Great lead by Kat!!

Katarina Stuart@katarinastuart.bsky.social

New review! Theory & a practical guide to structural variants in popgen🧬 Many thanks to my co-authors: @rebekahoomen.bsky.social @annatigano.bsky.social @marenwellenreuther.bsky.social @janawold.bsky.social @dlfield.bsky.social @clairemerot.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

(1/2) The preprint of our perspective on genetic estimates of relatedness in animal populations is out! Big Congratulations to Annika! doi.org/10.32942/X28... A systematic review of 2,861 articles shows that, even in 2025, 75% of such studies use microsatellites. And most use only a few! #PopGen

(2/2) Using whole-genome sequencing (WGS) and STR data from a Rhesus macaque population, we show that low-coverage WGS data, even at 0.05x, have better accuracy than STR data for relatedness estimates. We therefore advocate for WGS data!

Harald Ringbauer reposted

We developed/optimised the protocol to enrich low aDNA content libraries using Twist panels. 🎣🧬👩‍🔬 #aDNA #Labwork

bioRxivpreprint@biorxivpreprint.bsky.social

Lets Tweap again: Economic and SNP retrieval optimisation for target enrichment of ancient DNA https://www.biorxiv.org/content/10.64898/2026.01.15.699081v1

Harald Ringbauer reposted

SciLifeLab has opened a call for #postdoc fellows in Data-Driven Life Science. We would be happy to host such fellows! Get in touch if you are interested in applying with a project on the evolution of humans and domestic animals using ancient and/or modern DNA 🧪🏺 www.scilifelab.se/data-driven/...

scilifelab.seDDLS Research School Postdoc call 2026Call for Academic and Industrial Postdoctoral Fellowships in Data-Driven Life Science 2026 Generic Description of the DDLS Postdoc Program The SciLifeLab and Wallenberg National Program for Data-Drive...

Harald Ringbauer reposted

#AI may indeed exacerbate our bad academic habits: #LLM science summaries were nearly five times more likely than human-authored science summaries to contain broad generalizations (95% CI [3.06, 7.70], p < 0.001). And newer models over-generalized more; not less! doi.org/10.1098/rsos... #philSci

doi.orgGeneralization bias in large language model summarization of scientific researchAbstract. Artificial intelligence chatbots driven by large language models (LLMs) have the potential to increase public science literacy and support scient
Matt Grossmann@mattgrossmann.bsky.social

Because AI models are trained on current research practices, they may exacerbate our tendencies like overselling results from limited data, overinterpreting statistical significance, & quickly claiming causality, especially because they are even better at generating interpretations of any results

Harald Ringbauer reposted

This smells distinctly like collider bias and/or selection bias and/or regression to the mean... You simply can't select teen prodigies, and world class athletes rom databases, and go run regressions without serious consideration of the selection process!

Mike Inouye@mikeinouye.bsky.social

"Most top achievers (Nobel laureates and world-class musicians, athletes, chess players) demonstrated lower performance than many peers during their early years. Across the highest adult performance, peak performance is negatively correlated with early performance" www.science.org/doi/10.1126/...

Harald Ringbauer reposted

Harald Ringbauer reposted

Happy to share my work with my advisor Zachary Szpiech! Why are associations between ROH & complex traits inconsistent across studies? We use realistic simulations to show how demographic history and genetic architecture interact to shape the phenotypic impact of ROH. www.biorxiv.org/content/10.6...

biorxiv.orgThe Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of HomozygosityRuns of homozygosity (ROH) are contiguous genomic regions where all sites are homozygous, inherited from identical haplotypes due to shared ancestry. The number and length of ROH in individuals varies...

Harald Ringbauer reposted

More Italians 😂 #aDNA #PopGen

bioRxiv Genetics@biorxiv-genetic.bsky.social

Ancient genomes from the siege and destruction of Middle Bronze Age Roca Vecchia (Apulia, Italy) shed light on Aegean contacts and conflicts https://www.biorxiv.org/content/10.64898/2025.12.15.694319v1

Harald Ringbauer reposted

A new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers. buff.ly/K7CGFLV

Harald Ringbauer reposted

SKULL OF THOMAS AQUINAS: TAKE A LEFT NOW PRIEST: No, the GPS says we have to keep going— SKULL: I KNOW A SHORTCUT PRIEST: Do you remember the last ti— SKULL: FOR THOSE WITH FAITH, NO EVIDENCE IS NECESSARY; FOR THOSE WITHOUT IT, NO EVIDENCE WILL SUFFICE

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Harald Ringbauer reposted

Harald Ringbauer reposted

As I told the CNN, without details and data it is not possible to assess the claims. More importantly, the scientific value of this media campaign, balanced against the possible stigmatization of individuals with these real conditions today, is highly questionable. edition.cnn.com/2025/11/13/s...

edition.cnn.comResearchers say they have verified and sequenced Hitler’s DNA – and found a genetic disorder | CNNAnalysis of Adolf Hitler’s DNA reveals he may have had a rare genetic disorder that can delay puberty.

Harald Ringbauer reposted

Putting aside the deeper issues of why this analysis was done and how it has been promoted, the choice to broadcast a tv show before releasing a preprint should make people skeptical of the results. How can one be sure of their scientific claims?

Pontus Skoglund@pontus-skoglund.bsky.social

As I told the CNN, without details and data it is not possible to assess the claims. More importantly, the scientific value of this media campaign, balanced against the possible stigmatization of individuals with these real conditions today, is highly questionable. edition.cnn.com/2025/11/13/s...

Harald Ringbauer reposted

✨Thrilled to share that the first chapter of my Ph.D. thesis is NOW OUT in Science Advances! ✨🥳🎉 🧬. This couldn't have been possible without the support of everyone involved @genscapelab.bsky.social, @nirajrai.bsky.social, ‪@cdelafc.bsky.social‬, @jaurban2204.bsky.social, @mootspoints.bsky.social

GenSCAPE (aka Raghavan) Lab 🧬@genscapelab.bsky.social

1/n Delighted to share our newly published work in Science Advances, investigating human genetic histories at the northern frontier of the Himalayas 🧬🏔️: www.science.org/doi/10.1126/...

Iseult@iseultjackson.bsky.social

🦠💀🦠 Happy to share our (with @gunnar-u-neumann.bsky.social) new preprint on ancient Salmonella enterica genomes! We analysed 53 new genomes along with published ancient and modern datasets to learn about lineage replacements and host adaptation in prehistory: www.biorxiv.org/content/10.1...

Harald Ringbauer reposted

Excited to share that I’ve started as Associate Professor at the Technical University of Denmark! 🧑‍🎓 I also received an a NNF Emerging Investigator grant to use genomics + machine learning to study extinction. 👉 PhD & Postdoc positions coming soon — follow for updates! Reposts appreciated 🙏

Harald Ringbauer reposted