JAMA Network Open

Higher baseline anxiety and potentially cancer diagnostic tests were associated with increased anxiety after immediate #LaboratoryTesting result release, supporting more individualized patient support. ja.ma/4iaTiEE

Among females in Japan, #ADHD showed a childhood peak and a second young adult peak, indicating changing recognition of diagnoses across the life course. ja.ma/4slGO1G

Systematic review: Trials of therapeutic #Psilocybin focused mainly on depression, but media reports often extended potential benefits to anxiety and posttraumatic stress disorder despite limited or no trial evidence. ja.ma/3UDapaf

For cisplatin-ineligible muscle-invasive #BladderCancer, perioperative #EnfortumabVedotin plus pembrolizumab with radical cystectomy was associated with improved survival and was cost-effective vs radical cystectomy alone over 10 years. ja.ma/4i9RHyG

After emergency department discharge for acute pain, many patients had unused #Opioids at 2 weeks and 3 months, supporting more tailored prescribing and safer disposal strategies. ja.ma/4BgDCYV

Among pregnant women, all identified social vulnerability profiles were associated with inadequate #CervicalCancer screening, with the greatest disadvantage in those with migrant or linguistic barriers. ja.ma/4eL8bfJ

In advanced #UrothelialCarcinoma, treatment-emergent skin toxic effects during first-line enfortumab vedotin plus pembrolizumab were associated with longer overall survival. ja.ma/4hVgwj9

For metastatic hormone-sensitive #ProstateCancer, next-generation androgen receptor inhibitors were associated with longer overall survival than an androgen synthesis inhibitor in US clinical practice. ja.ma/3W0W6ww

Patients with #IntracerebralHemorrhage arrived faster than those with #AcuteIschemicStroke, but after adjustment were less likely to meet emergency department care targets. ja.ma/4saDndQ

For opioid-naive adults with Medicaid coverage and #AcuteLowBackPain, #Chiropractic care and physical therapy were associated with lower risk of subsequent #OpioidUseDisorder or overdose than pharmacologic treatment. ja.ma/4Bwwhoz

During a severe #Chemotherapy shortage, more than 1 in 4 carboplatin allocation decisions at a multisite health system were not aligned with policy intent, chiefly because of incomplete documentation. ja.ma/4s9ETNo

This systematic review and meta-analysis of 19 studies found #ADHD was associated with increased mortality from all causes, suicide, accidents/injuries and natural causes; ADHD medication use was associated with lower mortality. ja.ma/47tEs7b

In this RCT of adults with #depression, a home-based intervention combining transcranial direct current stimulation (#tDCS) with gamified cognitive control training was feasible and safe, but did not show greater efficacy than sham control. ja.ma/4yZZeHI

Among adults with #OCD, the Bergen 4-Day Treatment was more effective than internet-based cognitive behavioral therapy (#CBT) in reducing severity of OCD and improving secondary outcomes, with benefits maintained at 3-month follow-up. ja.ma/4yphYPB

In this cluster RCT of patients with type 2 #diabetes, an agenda-setting kit did not improve illness intrusiveness, treatment burden, diabetes distress, or HbA1c at 6 months compared with usual care alone; however, patient medication adherence increased. ja.ma/4yxHeDf

⚕️Despite preliminary evidence of cancer specific benefits AND higher rates of both cardiovascular & kidney disease, #cancerSurvivors with #diabetes were 30% LESS LIKELY to be on GLP-1 receptor agonist than those with #DM but no #cancer hx. @jamanetworkopen.com @huntsmancancer.bsky.social @jama.com

New study by @pennpsc.bsky.social & @pennaging.bsky.social researchers Kevin Volpp & @scotthalpernmd.bsky.social & colleagues on recruiting minority patients for heart disease clinical trials with small cash incentives. FIND IT in @jamanetworkopen.com: https://bit.ly/3V9H6vJ

Congratulations to our DPhil student Ronald Chow, who has led an international team to develop a pioneering tool to measure 'time toxicity' in cancer care! 👏 An exciting contribution to patient-centred cancer research, published in @jamanetworkopen.com. 🔗 jamanetwork.com/journals/jam...

congrats to @jamanetworkopen.com founding associate editor & colleague @royperlis.bsky.social named as inagural JAMA AI editor in chief!

📊 Among more than 1 million children in US families with mixed citizenship status, noncitizen children were more often uninsured than citizen children, indicating unequal insurance access within the same household. ja.ma/4hRfyo5

In children born preterm, the association between epigenetic aging and #Neurodevelopment was context dependent, with severe brain injury modifying the association between epigenetic age acceleration and motor outcomes. ja.ma/4iotWUO

📊 Among adolescents and young adults with #Depression, misuse of prescription psychotherapeutic drugs and prescription drug use disorder were more common than among peers without depression. ja.ma/4ssEMNj

Among older primary care patients, an electronic health record-integrated #FallPrevention tool with tailored #Exercise recommendations was associated with a modest but significant reduction in falls and fall-related injuries vs usual care. ja.ma/4Ba5e21

#CervicalCancer screening rates increased across all groups from 2019-2024. However, disparities persisted, particularly among American Indian, Alaska Native, Native Hawaiian, and Pacific Islander patients, along with those in the Western and Southern US. ja.ma/4dJtDBu

National #Homicide mortality among women of reproductive age declined after the COVID-19 surge, but post-Dobbs trends diverged, with less favorable trajectories in states with sustained abortion bans vs states without such bans. ja.ma/4ymo17t

A national study of Icelandic women found technology-facilitated sexual violence and other coercive sexual acts highly prevalent, particularly among younger women, indicating that action is needed to respond to the evolving landscape of sexual violence. ja.ma/4i057gx

🩸 Among adults with acute nontraumatic coma undergoing prehospital rapid sequence induction, point-of-care #GFAP testing showed high diagnostic accuracy for intracranial hemorrhage and may help guide triage to specialist care. ja.ma/4hY3IqW

In Veterans with #COPD and/or asthma, #AATD testing and augmentation therapy were low. Further disparities were associated with older adults, those actively using tobacco, patients from minoritized racial and ethnic groups, and those farther from care. ja.ma/4youLlk

In metastatic androgen pathway modulator-resistant #ProstateCancer, outcomes with Lu-177 prostate-specific membrane antigen were broadly consistent across treatment lines and taxane sequencing groups. ja.ma/3TXQ9Qq

📊 Higher #UltraprocessedFoods intake in middle-aged adults was associated with greater body fat, greater visceral adipose tissue, and higher odds of vascular brain injury on #MRI, but not with differences in cognitive performance. ja.ma/4s4WIwW

🫀 In Danish adults aged 30 years or older, socioeconomic inequality in major adverse cardiovascular events persisted over 4 decades. Rates fell across all income groups, but lower income remained associated with higher #CardiovascularDisease burden. ja.ma/4yQW8We

📊 Among patients with #RectalCancer treated with total neoadjuvant treatment, watch-and-wait was associated with better long-term bowel function, social and physical functioning, role functioning, and global health status vs total mesorectal excision. ja.ma/3TBUPLK

📊 Among #BreastCancer survivors receiving aromatase inhibitors, carbon dioxide laser therapy did not improve sexual function, dyspareunia, or vaginal health more than sham treatment at 12 months when both groups received nonhormonal first-line therapy. ja.ma/4yXRp5q

Among adults eligible for hereditary cancer #GeneticTesting, a digital intervention increased testing uptake by 6 months and telephone health coaching increased uptake by 12 months vs usual care. ja.ma/4B8Vqp2

For adults initiating #Buprenorphine during hospitalization, a patient navigation and #mHealth incentive intervention was feasible to deliver and highly rated, with similar outpatient linkage as usual care in this pilot trial. ja.ma/4yNGKKr

Among adults receiving recommended care for #Diabetes, #Hypertension, or both, out-of-pocket costs were higher in high-deductible health plans than in non–high-deductible health plans. ja.ma/4yO00aE

Among patients with acute #Stroke due to medium vessel occlusion, perfusion mismatch profiles were not associated with 90-day functional outcomes and did not modify the effect of endovascular thrombectomy. ja.ma/4evo2im

After a federal immigration enforcement deployment in Washington, DC, pediatric #EmergencyDepartment visits declined immediately, with larger decreases among patients who preferred Spanish and among Hispanic patients. ja.ma/4B3DlIW

In Australia, police-recorded #SexualAssault and family and domestic violence-related assault against children increased from 2014 to 2024, while assault hospitalizations and overall child maltreatment substantiations remained generally stable. ja.ma/4yd8C9z

Patient-reported #DisrespectfulOrJudgmentalLanguage was associated with lower trust in clinicians’ documentation and was more commonly reported by adults with low income or chronic pain. ja.ma/4i04m7q

Point-of-sale prices in #Medicare Part D fell in 2024 after retroactive pharmacy fees were eliminated, with larger declines for multisource drugs than for single-source drugs. ja.ma/4rY1agZ

Among veterans with #IschemicHeartDisease, #CardiacRehabilitation participation was higher at facilities offering home-based cardiac rehabilitation than at facilities offering center-based programs or community care referral alone. ja.ma/4yFoClP

Among African women with #BreastCancer, standard #Immunohistochemistry markers identified basal-like tumors well but often misclassified PAM50 luminal B tumors as luminal A. ja.ma/4s9auif

For patients with acute #MyocardialInfarction, new #PercutaneousCoronaryIntervention facilities were associated with lower mortality only in communities without baseline percutaneous coronary intervention access. ja.ma/4hCctIk

Adults aged 60 years and older in Beijing who had never received #Influenza vaccination were more likely to opt out and were less responsive to vaccine effectiveness than previously vaccinated adults. ja.ma/4zxDbbj

Among US youths, #Epilepsy-related mortality increased from 1999 to 2023, with increases observed overall and among adolescents aged 11 to 19 years. ja.ma/4yjRf7g

California youths woke later and slept longer than peers in other states, consistent with later school start times under California Senate Bill 328 for improving #Sleep among adolescents. ja.ma/4hKAPOI

In #ProjectViva, maternal diets with better #MediterraneanDiet Scores, lower dietary inflammation, and more seafood, were associated with lower odds of infant #colic and #eczema; prenatal peanut, nut or egg intake were not linked to colic and eczema risk. ja.ma/4jSxakF

There is a lot of talk off #IDSky about the @jamanetworkopen.com article about increased mortality in Cefepime. I highly recommend the editorial: -Difference is small (<1%) -Most studies before 2010 -Dosing/Breakpoints changes since trials -ACORN shows real 🌎safety jamanetwork.com/journals/jam...

In NOHARM, an NIH Collaboratory Trial newly published in @jamanetworkopen.com, a strategy to promote nondrug pain care after surgery reduced exposure to opioids without worsening pain interference, physical function, and other patient-reported outcomes. Learn more ➡️ duke.is/pctnews20260...