Jo Carpenter

The Moser Group is presenting our work on Wednesday afternoon at #FENS2026! •Mechanism for L-R sweeps •Attention modulation of sweeps •Grid/place remapping rules & dynamics •”Mega torus” as a hi-capacity memory space •Moving the grid bump •Development of tori & rings •RSC/HC pops. in a spatial task

Toroidal manifolds abruptly emerge at P10 in rat pups! 🤪🍩 Several days later, space is *gradually* anchored to these tori when the puppachino actively navigates Congrats to the big boss @matteoguardamagna.bsky.social 🤠

🚀 New preprint from the lab! Our first foray into the subiculum uses in vivo whole-cell recordings to show that dendritic plateaus are a prominent, learning-dependent signaling mode of subicular neurons. Feedback is welcome! www.biorxiv.org/content/10.6...

Excited to share our study in Neuron led by @travisgoode.bsky.social, a K99 PDF (interviewing for Faculty) and Sahay lab team with collaborators at BROAD, Hopkins, and UW Seattle, defining a neural circuit that links prior experience with feeding behavior. Open Access: sahaylab.com/publications

Do you love quantifying animal behavior as much as we do? We have just the tool for you! Presenting #OCTRON - a pipeline that helps you create rich annotation data and enables training of custom segmentation models. Have a look, particularly if you work with non-model / invertebrate organisms!

*First preprint from our lab* !!!!! How does the brain learn to anchor its internal sense of direction to the outside world? 🧭 led by Mark Plitt @markplitt.bsky.social & Dan Turner-Evans, w/ Vivek Jayaraman: “Octopamine instructs head direction plasticity” www.biorxiv.org/content/10.6... Thread ⬇️

Your stomach called – your striatum picked up! But does this actually happen in humans? Using simultaneous dopamine PET/fMRI, we show that the gut hormone ghrelin helps the brain adjust motivation to current metabolic need. Here’s what we found👇 Preprint: shorturl.at/pq4A3 #neuroskyence #🩺

🧠📢 New preprint alert Large-scale ephys is exploding but spike sorting remains the computational bottleneck. A 2-hr, 6-probe Neuropixels 2.0 Quad Base session can take over a week to sort on a single machine. Here's a better solution. 🧵 #neuroskyence #compneurosky

Still at SfN on the last day? During the morning session on the 19th, 8:00AM - 12:00PM, come check out our posters from the Moser, Zong, and Gonzalo Cogno groups in row QQ ('Grid cells and spatially modulated cells'). Ephys, imaging, remapping, development, sweeps and more! 🧠 Detailed thread below 👇

SFN 2025 let’s gooo!! Moser group posters are held Wednesday morning (QQ), so if you’re leaving early feel free to come find us to chat :)

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

“If everything is everywhere, why have distinct areas? Here we show that the function of a brain area is more related to how different types of information are combined (formatted) in neural representations than merely whether that information is present.”

Our collaboration - from PhD work - examining input-specific (EC L3) contributions to rate and temporal coding in CA1 place cells is now out in @natcomms.nature.com 🔬🧠 rdcu.be/evWtz

Amazing study: @tamir-eliav.bsky.social from the Ulanovsky lab describes replay events in a large scale environment (200 m tunnel). 🦇 www.cell.com/cell/abstrac...

(1/6) Thrilled to share our triple-N dataset (Non-human Primate Neural Responses to Natural Scenes)! It captures thousands of high-level visual neuron responses in macaques to natural scenes using #Neuropixels.

Check out my preprint on hippocampal ripple diversity, with @vitorlds.bsky.social and David Dupret at the MRC BNDU, where we reveal that distinct CA1 laminar profiles of ripples are associated with different reactivation dynamics: www.biorxiv.org/content/10.1...

1/ Our paper appeared in @Nature today! www.nature.com/articles/s41... w/ Fiete Lab and @khonamikail.bsky.social . Explains emergence of multiple grid cell modules, w/ excellent match to data! Novel mechanism for applying across vast systems from development to ecosystems. 🧵👇

Every scientist, long before they were a scientist, was a little kid who stood in front of a fish tank or stared up at the stars or turned over a rock to look at the bugs underneath and said “wow”. On the best days, working in science still feels like that.

Congratulations Abe and Rich!!

We are still taking applications!

It’s an incredible feeling to see something you’ve poured your heart into come to life. This work was born from my curiosity about hippocampal “cognitive tuning.” Our interpretation of the environment depends on our actions, constantly evolving as we pursue our goals www.nature.com/articles/s41...

Our paper on ketamine’s effect on astrocytes and behavior is out in Neuron by Marc Duque, Alex Chen, Eric Hsu, and colleagues @marcduque.bsky.social @alexbchen.bsky.social @ehsu6.bsky.social, with the Engert, Fishman, & Bergles labs, www.sciencedirect.com/science/arti...

celebrating another year of excellent science, happy animals, and *happy people* at the kavli ❤️✨ @kavlintnu.bsky.social

Do octopuses dream? In any case, can't get enough of watching them sleep 😴🐙 Look at this symphony of patterns and movements! Incredible. youtu.be/006DjAixu9E?...

In those animals we didn't observe a correlation between ripples and glucose fluctuations. To me, this strongly suggested pancreatic insulin release is a mechanistic intermediate

Wow, thanks so much Adrien! It was such an exciting project to work on, and many directions to follow up. Another *really hidden gem (it didn't end up in the paper), we (@jocarpenter and I) treated three rats with streptozotocin which effectively kills beta cells in the pancreas...

Awesome pub looking at the unique role of AD- and M2-projecting RSC circuits from Xiaoxiao Lin et al. #neuroskyence www.nature.com/articles/s41...

Thankful for a loving family, all of my super funny friends, a happy and collaborative lab environment, and my rat Rafael for giving me some beautiful data tonight 🤩🥰🍗

While this result is really exciting, the paper also contains some hidden gems. Ext Data Fig. 3, for instance, show the power spectrum of ripple occurrence. It reveals that ripple rates fluctuate not only on a 24-hour circadian cycle but also on a 4-hour ultradian cycle. 5/

Very timely piece. With 3-4 probes per rat and ultra long recordings, I’ve already generated 95TB of data for a single project. Thinking lots these days about how to store and publish all of this… 😬😬 Raw files vs. spike times x behavior or something in between?? Or both?

go.bsky.app/LdtUYZS I created a starter pack for the growing community of hippocampus physiologists that have joined the great migration. Also included the physiology-adjacent. Tell me who I haven’t found yet

Now out in Neuron! We benchmark place cell models using a massive CA1 dataset—nearly 70,000 rate maps—collected as mice explore environments with different geometries BVC models perform remarkably well, but we hope this dataset/approach becomes a resource for testing/refining place cell models

This paper adds to a nice list of papers recently that (broadly) merge brain and body biology: The others one are www.biorxiv.org/content/10.1... And www.nature.com/articles/s41...

Super-psyched to share this preprint from my student Yicong (Alan) Zheng: "Recurrent Inhibitory Dynamics in the Entorhinal Cortex Support Pattern Separation" www.biorxiv.org/content/10.1... It's a new biologicaly-based computational model of the entorhinal-hippocampal system. Thread (1/?)

It’s always a fun lab meeting when the prodigal child @Erik_Hermansen1 returns! (booking conference rooms is not our strong suit)

When you’re unexpectedly in town and all your friends are neuroscientists

SfN 2024 😍

At @FENSorg this year? Poster #PS01-26AM-004 (WED) Presenting my work on remapping of neural populations across the HPC-EC circuit using data from 3 simultaneously-recorded Neuropixels 2.0 probes (CA1-MEC/PaS-Sub) in freely moving rats exploring 5 different rooms over 12 hours!

@MartinBjerke_ presenting his PhD work (with @adric_dunn) using some classic @Drake memes at @kavliYROCK ‘s annual NeuroSys symposium !! 🧠

pre-presentation sun exposure ☀️ come see our recent work from the Moser group at SFN YY1-YY5 at 1pm today Unpictured: new group leader @soledad_gcogno

At SFN 2018 in San Diego, I met my future PhD advisors @MayBrittMoser @EdvardMoser and future partner @davidwtingley 🥰 I’m super stoked to be back in my old college town this year to present Part 1 of my PhD work, catch up with old friends, and see some new science !! 🧠

congratulations @davidwtingley on an awesome PhD defense! you are a brilliant scientist and the best partner.

did I just watch a presidential debate or an episode of the real housewives?

So far, my first year of grad school has consisted of: - moving to a new continent - being in a *very* long distance relationship - being emotionally tested by various physics and math classes - recording some place cells - a global pandemic