John Lindner

John Lindner

@johnmlindner.bsky.social

Molecular Immunologist TCRs, BCRs, and their ligands Head of Immunology Discovery at BioMed X Heidelberg, Germany and New Haven, CT

1K followers224 following23 posts

John Lindner reposted

In the face of pushback against workplace inclusion and diversity practices by some in power, it is incumbent on responsible leaders everywhere to ensure true fairness, recognize talent, and support the careers particularly of those given an inherent societal disadvantage! #InternationalWomensDay

John Lindner reposted

I’m biased of course but this is a detailed new mechanism for the direct action of IL-2 on antigen-experiencing B cells, driving early/extrafollicular antibody responses! Congrats to @katyely.bsky.social and all co-authors on a job diligently and well done! Glad I could help #immunosky #bcells

Katia Faliti @katyely.bsky.social

✨ Ever wondered why B cells are so fond of IL-2? Wonder no more! Our study is now published in Immunity @cellpress.bsky.social 🔍📑 A truly perfect Thanksgiving gift! 🧑‍🔬💉🔬https://authors.elsevier.com/c/1kAq43qNrUxuTR

🙋‍♂️ Is IL6R D358A also protective against fibrotic progression?

Gabriele Pollara@gpollara.bsky.social

🚨 Delighted to share our paper defining a new role for IL-6 in TB. 🚨 We used genetic variation to show *reduced* IL-6 signalling is causally associated with *lower* risk of TB. Lead author @gushamilton.bsky.social #TBSky #IDSky #ImmunoSky www.thelancet.com/journals/lan... Thread 👇 (1/8)

Indeed a fascinating new look at intratumoral T cell subsets! Would be great to learn about TCR clonality of “Subset 3” and whether these cells are (pre-)enriched for tumor specificities! #immunosky

Roham Parsa@rohamparsa.bsky.social

I’m very fascinated about this study showing stem cell-like effector CD4 T cells that can become the classic T helper subsets. In tumors, Tregs suppress these cells, blocking Th1 seeding and anti-tumor effects! Jenkins lab also recently described a similar CD4 phenotype with different implications.

Agree 💯 and will add that the only substantial way to make those models better at this point is to increase the quality and quantity of training data, which for us only happens in the wet lab

Calin Plesa@calin.bsky.social

Every day a new foundation model drops, and as an experimentalist, I just skim the preprint and go back to my pipettes. Foundation model fatigue. The bar for adoption is high and requires experimental validation.

John Lindner reposted

A little more than a week left to apply, for more information feel free to get in touch! And please forward to any friends and colleagues looking for a New England position in a unique academia/industry hybrid research center

John Lindner reposted

John Lindner reposted

This worked for me!

Anna Obenauf@obenaufa.bsky.social

🐦➡️🦋 Looking to rebuild your network on Bluesky by reconnecting with your existing X/Twitter contacts? The Skylink browser extension makes it easy! chromewebstore.google.com/detail/sky-f... Thanks @jmschreiber91.bsky.social! #scicomm #cancer #tumorimmunology

Happy to have played a (small) role in this study, thanks @katyely.bsky.social for the opportunity to collaborate! Great read on the effects of #autoimmunity on #covid #vaccination!

Katia Faliti @katyely.bsky.social

Our study just out! "Disease-associated B cells and immune endotypes shape adaptive immune responses to SARS-CoV-2 mRNA vaccination in human SLE". 🔗 * rdcu.be/dZWI9 * lnkd.in/desv-ZrV #SLE | #Autoimmunity | #mRNAvaccines | Disease-associated #Bcells shape anti-vaccine immunity in SLE. 👩‍🔬 💉💉💉 🦠

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