Jackson Hoffman

Starting in 1 hour!

🧬🧬🧬 Join us on Wednesday next week for the next #FNucleosome seminar. We've got two exciting transcription/chromatin talks from @nellykanata.bsky.social and Yukun Wang! You can register here to receive the zoom invite: us06web.zoom.us/webinar/regi...

Please share! I am recruiting up to 2 postdoctoral fellows. Application: apply.interfolio.com/191385

Are you interested doing a Postdoc in my lab? One thing I can promise: We’ll have fun. liu.se/en/work-at-l...

In 2 hours...

Happy Pluripotency Day! #Oct4

📢🧬Join us on Wednesday, Oct 7th for the next #FragileNucleosome seminar to hear exciting chromatin stories from Moonmoon and Paul! If you still haven't registered for our series: us06web.zoom.us/webinar/regi...

I will hire a Postdoc to study the genomic determinants of tumor heterogeneity Please, get in touch if interested, or help me spread the voice @scilifelab.se @kawresearch.bsky.social @liu.se liu.se/en/research/...

CUT&ID does Genomics+Proteomics in one shot via the fusion protein Lazarus Out @narjournal.bsky.social Unstoppable @annanordin.bsky.social is thinker+executor Get in touch if you wish to try it—plasmid soon @addgene.bsky.social 🙏 @liu.se @scilifelab.se @kawresearch.bsky.social @cancerfonden

We are recruiting! Wet&Dry either combined or separate. If you are excited about gene regulation, new methods in genomics and AI-based interpretation! Talk to us!

📢🧬join us on Wednesday, Sept 23rd for the next #FNucleosome seminar to hear exciting chromatin/transcription stories from Oscar Campos and @giacomodonatijd.bsky.social! Register here: us06web.zoom.us/webinar/regi...

Hello World ! Reminder about our open postdoc position 🧪🧬 Reviewing applications until October - get in touch to know more about what's hot in the lab these days ! Application details in the post below 👇👇 #EvoEpi #MolaroLab #watwat #ERC

I'm super excited for our new season of #FragileNucleosome seminars, which kicks off tomorrow with @mpalamin.bsky.social and @robertovn.bsky.social!

🎤 #FragileNucleosome is back next Wednesday! Hope you enjoyed the summer!Join us next 📅Wednesday to hear about 🧬fascinating research from @mpalamin.bsky.social from Krebs lab and @robertovn.bsky.social from Vos lab. To register if you haven't before: us06web.zoom.us/webinar/regi...

📣 Preprint alert! We developed a method to analyze concurrent interactions between multiple chromatin regions at single alleles at sub-nucleosome resolution (multi-way Micro-Capture-C, mwMCC) & used this to study structural synergy within super-enhancers. 1/14 www.biorxiv.org/content/10.6...

The Nano Lab is opening in the Dept. of BioSciences, Rice University, Oct 2026! 🧠🦉 We’ll be profiling and perturbing the molecular cues that shape the human brain using single-cell functional genomics and cortical organoids.

Our PBAF paper is finally out in Science Advances! We’ve been working on this project for upwards of 10 years (depending on who you ask), with Alisha heading the effort (and doing most of the work) to understand the role of PBRM1 in breast cancer metastasis. www.science.org/doi/full/10..... (1/11)

Join the lab to study mechanisms of transcription factors, transcription, and/or chromatin! jobrxiv.org/job/uconn-he...

📄 That's a wrap 📄 we're excited to share that the latest from @arnaudkr.bsky.social 's lab and Judith Zaugg's lab is at last online at doi.org/10.1038/s415.... Many thanks to my co-first @valentinabaderna.bsky.social and to @embl.org for the wonderful research environment.

Next summer's Epigenetics GRC (I'm co-chairing with Deborah Bouch'is) is shaping up nicely with an all-star lineup of speakers working on a broad range of organisms and systems and everything from molecular mechanisms to new phenomena. Apply and put it on your calendar! www.grc.org/epigenetics-...

Preprint alert! 🚨 We are very excited to share our new manuscript on Bohring-Opitz syndrome, a devastating rare monogenic disorder driven by truncating variants in ASXL1. This project was led by PhD student Emma Doyle, one of the OG Conway lab members 💪. 1/6 www.biorxiv.org/content/10.6...

I am very excited to share the work of my PhD with @eddaschulz.bsky.social, now on BioRxiv! 🎉 🧵⬇️ (1/9) How does the transcription↔️chromatin crosstalk ensure monoallelic expression?

RNA-seq tells us how much RNA is present in the cell. But to understand gene regulation, we need to easily measure the synthesis and decay rates driving this abundance. We introduce AIR-seq: analog intrinsic recoding sequencing. (1/6) www.biorxiv.org/content/10.6...

Congrats to the Beamish #UMichMed and Watts #NIEHS labs on the new paper investigating the requirement for Sox8 in transcription, histone modification, and cell identity/function in proximal tubule cells!: www.sciencedirect.com/science/arti...

40 individuals with the clinical picture of FOXG1 syndrome and a completely intact FOXG1 gene. So what’s going wrong then? Our new paper in @natcomms.nature.com traces the answer to a stretch of non-coding DNA 665 kb away from the gene. (1/7)

Congrats to @charlyguardia.bsky.social and @asmitasingh.bsky.social on the new paper! Awesome work out of RDBL here at NIEHS!

Learn to say no early on. It is not your problem that there are not enough women around to fill quotas.

Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:

Excited to share the first preprint from my lab! Transcription has been implicated in regulating SMC complex function, but how this works has been unclear. Here, we use a yeast quiescence model to examine how transcription targets condensin.

📢 Attention Recent Graduates 📢 I’m hiring a Postgraduate Research Associate to join my growing team at Yale! If you’re passionate about RNA biology/Gene Regulation and are looking to gain hand-on research experience before graduate school, please consider applying! postdocs.yale.edu/posts/2026-0...

Still very impressed by the work of the @andersshansen.bsky.social team. Excited to see how these findings extend to endogenous enhancers in future studies!

This is brilliant! www.nature.com/articles/s41...

The Kaplan Lab at the University of Pittsburgh has received funds to recruit a postdoctoral fellow to establish a multiplexed assay of variant effect for a disease gene. This relates to our studies on RNA Polymerase II. This project requires experience with human cell lines and genomics 1/

Apply to be part of our fall seminar series!

FASTEN YOUR SEATBELTS: Tamina Weiss, inspired by previous data from @ppagella86.bsky.social found that beta-catenin is more than an adaptor protein downstream of #WNT It is an orchestrator that scouts and opens enhancers for transcriptional activation @biorxivpreprint.bsky.social

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

Very excited to present some of my PhD work from the @claudiocantu81.bsky.social Cantù lab tomorrow!

Join us on Wednesday for some great science before the world cup matches!!

Excited to share the first pre-print from our lab!! Check it out here! www.biorxiv.org/content/10.6... We found that many RNA-binding proteins canonically understood to regulate RNA processing can also function like transcription factors and cofactors to directly regulate transcription.

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Exciting breakthrough technology from the lab, now live in @cellcellpress.bsky.social ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

We’ve recently been awarded a MIRA R35 and an R01 to study non-canonical roles and missense mutations of the Polycomb system in health, cancer, and neurodevelopmental disorders. We are seeking an animal tech with lab manager duties. Please share!

See our handy graphical abstract and article for free here: bit.ly/4vsl845

🎉Save the date! Black In Neuro Week 2026 is July 27–Aug 2. We're celebrating our 6th annual BIN Week with returning favorites like #NeuroRacism, #NeuroAcrossTheDiaspora, and #BINRollCall plus a brand new theme: #BlackInTime. ✨ 🧠 #BINW26 #AReimaginedFuture

I am very grateful and excited about this opportunity! Big thank you to our fantastic team who have made this possible and to many supportive mentors 🙏

Reminder that the Local Organic Intelligence Model located in your skull runs quite inexpensively on snacks and caffeine arstechnica.com/ai/2026/06/a...

We're starting in 45 minutes, register and join us to hear about the outstanding work Mark, Jake, and Sid are doing!

My Fragile Nucleosome seminar is now on YouTube www.youtube.com/watch?v=ksXp... I discuss our recent work showing that linker histone H1 behaves as a liquid-like glue for chromatin organization in living human cells 🧬 Paper: www.science.org/doi/full/10.... Huge thanks to @fnucleosome.bsky.social!

Don’t miss Jake’s talk this Wednesday! @jcornwallscoones.bsky.social

At this time tomorrow, you could be watching a couple of great chromatin talks from the future! While much of our audience will be watching these talks on Apr 22nd, Shabih Shakeel and @kazu-maeshima.bsky.social will be presenting on Apr 23rd!