Karim Majzoub

Karim Majzoub

@karimaj.bsky.social

Group leader @igmm-montpel.bsky.social studying viruses - Amateur athlete and musician- Husband and father- Europtimist @biolum-montpellier.bsky.social https://www.igmm.cnrs.fr/en/team/rna-viruses-and-host-factors/

2.4K followers7.3K following243 posts

Karim Majzoub
@karimaj.bsky.social

Switching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activation

cell.comSwitching of transcriptional control from interferon regulatory factor 2 to interferon regulatory factor 1 drives innate immune cell activationToll-like receptor signaling activates proinflammatory interferon-stimulated genes (ISGs) even in the absence of interferon by triggering a shift from IRF2 to IRF1 occupancy at ISG promoters and enhan...
Karim Majzoub
@karimaj.bsky.social

@jeremydufloo.bsky.social had a brief and productive visit to our lab one summer ago and he came up with this discovery : Glycosphingolipids are essential entry factors for non-influenza orthomyxoviruses

microbiologyresearch.orgGlycosphingolipids are essential entry factors for non-influenza orthomyxovirusesThogotoviruses and quaranjaviruses are arthropod-borne orthomyxoviruses that circulate widely in wildlife and domestic animals and include several zoonotic members. Despite their close phylogenetic re...

Karim Majzoub reposted

Kranzusch Lab
@kranzuschlab.bsky.social

The shared principles of human and bacterial antiviral immunity An honor to highlight remarkable discoveries from many labs over the past 12 years that unite previously disparate fields of how animal cells and prokaryotes defend against viruses. www.nature.com/articles/s41... rdcu.be/fzwyB

nature.comShared principles of human and bacterial antiviral immunity - NatureThe Review describes shared ancient, conserved mechanisms between human antiviral immunity and bacterial anti-phage systems, outlining universal principles of pathogen sensing, signalling and effector...

Karim Majzoub reposted

Sam Díaz-Muñoz (they / ella)
@sociovirology.bsky.social

Replying to @sociovirology.bsky.social

@karimaj.bsky.social Now talking about work led by Joe McKellar out this year www.cell.com/cell/fulltex... #SocialViruses26

cell.comDeltaviruses spread through a viral Trojan HorseMcKellar et al. have discovered that some satellite viruses act as the ultimate hitchhikers. They physically become a virus inside a virus, hiding within helper virus particles by hitching a ride as a...
Karim Majzoub
@karimaj.bsky.social

Very honored and proud to present our work at the French Academy of Science (Académie des sciences) with Joe McKellar who was amongst 6 Laureats this year , getting a prestigious price " Les Grandes Avancées Françaises en Biologie". Bravo @viroscope.bsky.social ! @academiesciences.bsky.social

IGMM-Montpellier@igmm-montpel.bsky.social

Bravo à Joe McKellar et à Karim Majzoub @karimaj.bsky.social ! 🏆 Joe McKellar est l’un des 6 lauréats du prix « Grandes Avancées Françaises en Biologie 2026 » de l’Académie des sciences @academiesciences.bsky.social 🔬 #IGMM #CNRS #Biologie #Recherche #Science

Karim Majzoub reposted

Elisa Franco
@francolab.bsky.social

RNA is more than genetic information: it can be a tool for cellular architects. In our new paper, we engineer RNA motifs to physically reorganize intracellular space in living mammalian cells. www.nature.com/articles/s41...

nature.comProgrammable artificial RNA condensates in mammalian cells - Nature NanotechnologyModular RNA nanostar motifs spontaneously assemble into programmable synthetic condensates in the nucleus and cytoplasm, with RNA design controlling localization, sequence-specific target recruitment ...
Karim Majzoub
@karimaj.bsky.social

Kudos to @nadinelaguette.bsky.social team and all co-authors on this nice paper where our lab had a modest contribution! @viroscope.bsky.social 🔥

Journal of Experimental Medicine@jem.org

Vila, Messaoud-Nacer, Taffoni, @nadinelaguette.bsky.social et al show that DNA-PKcs, a major DNA damage response actor, interacts w/ cyclic dinucleotides through its kinase domain, ensuring CDN-associated signal termination, while CDNs inhibit DNA-PKcs catalytic activity rupress.org/jem/article/...

Karim Majzoub reposted

Viroscope
@viroscope.bsky.social

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

sciencedirect.comDeltaviruses spread through a viral Trojan HorseHepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
Karim Majzoub
@karimaj.bsky.social

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

sciencedirect.comDeltaviruses spread through a viral Trojan HorseHepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
View full thread
Karim Majzoub
@karimaj.bsky.social

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

sciencedirect.comDeltaviruses spread through a viral Trojan HorseHepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
View full thread
Karim Majzoub
@karimaj.bsky.social

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

sciencedirect.comDeltaviruses spread through a viral Trojan HorseHepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
Karim Majzoub
@karimaj.bsky.social

My thoughts with my home country Lebanon 🇱🇧. May it be protected from this human craze ! Mes pensées avec mon pays , le Liban 🇱🇧 , qu’il soit protégé de la folie des hommes! #Lebanon #Liban

Karim Majzoub reposted

Stèf Blanc
@steffffff.bsky.social

⚡️ Permanent Researcher position opening in Stephane Blanc group at PHIM, INRAE, Montpellier France  “Traffic of viral macromolecules within host plants and role in the biology of multi-component viral systems  🦠 More info 👉 jobs.inrae.fr/concours/con... ❗️Deadline March 4th 2025

jobs.inrae.frChargé-e de recherche sur le trafic des macromolécules de virus de planteCR-2025-SPE-6 - Le Plant Health Institute of Montpellier (PHIM) développe des recherches sur la santé des plantes, et plus particulièrement sur les interactions plantes-microorganismes et bioagresseur...
Karim Majzoub
@karimaj.bsky.social

Kudos to @eriani-martinlab.bsky.social and team for this important discovery !

CNRS@cnrs.fr

#PressRelease🗞️ A specific molecular mechanism has been identified as the cause of the most frequent genetic forms of amyotrophic lateral sclerosis (ALS, also known as Charcot’s disease) and frontotemporal dementia (FTD). 👉 www.cnrs.fr/en/press/discov...

Karim Majzoub reposted

Alex Crits-Christoph
@acritschristoph.bsky.social

All you want for christmas is.... transposon mutagenesis! Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team. Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)

bioRxiv Synthetic Biology@biorxiv-synthbio.bsky.social

A scalable transposon mutagenesis system for non-model bacteria https://www.biorxiv.org/content/10.64898/2025.12.22.696024v1