Lars Dietrich

Lars Dietrich

@laahrs.bsky.social

I love bacteria. Biofilm metabolism & antibiotic tolerance dietrichlab.com Biological Sciences, Columbia University (a yawn is a silent scream for coffee)

1.9K followers993 following28 posts

Lars Dietrich reposted

FACULTY POSITION: We are seeking an Assistant Professor to join our growing and vibrant Department of Microbiology at Cornell! FOCUS: Using bacteria to address 21st century challenges. (part of a cohort hire in SynBio). *please repost* academicjobsonline.org/ajo/jobs/33098 #MicroSky

academicjobsonline.orgCornell University, Microbiology/CALS Job #AJO33098, WDR-00061962 Assistant Professor - Harnessing the Power of Synthetic Biology, Microbiology/CALS, Cornell University, Ithaca, New York, US

Lars Dietrich reposted

𝗖𝘆𝗮𝗻𝗼𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗙𝗮𝗿-𝗥𝗲𝗱 𝗟𝗶𝗴𝗵𝘁 𝗗𝗶𝘀𝘁𝗿𝗶𝗰𝘁 please read Sofie van Dorst's 10-part 🧵here on bluesky – or on Nov 02 in our blog: smallthingsconsidered.blog #MicroSky #ProtistsOnSky #teamtomo #CryoEM #CryoET

sofie.rec@sofie-dot-rec.bsky.social

I’m very excited to share the first big project from my PhD (my first proper-first, yay!) where we use cryoET and a fun new flavour of CLEM to study the re-organisation of photosynthetic machinery of cyanobacteria growing beyond the red limit of light. doi.org/10.64898/202...

Incredibly excited about our latest work on R-bodies, 5+ years in the making! These coiled protein ribbons extend into ~10 µm needles in a pH-dependent manner & we caught them springing open inside amoebae after P. aeruginosa gets eaten. (animation: Jegg Yoon)🧵1/2 www.biorxiv.org/content/10.6...

Meet DeaR: a long-sought toxin that assembles into a gorgeous ~1 MDa dodecamer and deaminates ADP, rewiring host purine metabolism. We propose different R-bodies deliver different toxins—cytotoxic effectors delivered by R-bodies (CEDRs). Great work by Devin, Kiavash, @ttoac.bsky.social et al. 2/2

Lars Dietrich reposted

Lars Dietrich reposted

Lars Dietrich reposted

Watching Flagella (or Cilia) in Motion by Christoph — Still images do not tell whether cells rotate their flagella like a propeller or flap them like a whip. To find out, one has to film living cells...

smallthingsconsidered.blogWatching Flagella (or Cilia) in Motionby Christoph — Still images do not tell whether cells rotate their flagella like a propeller or flap them like a whip. To find out, one has to film living cells...

Lars Dietrich reposted

Lars Dietrich reposted

Ten years ago Tami, Roy, and I released a movie we made of antibiotic resistance evolving in real time. I thought maybe a couple thousand people tops would see it. I couldn't have imagined it would be seen millions of times, and be taught from middle school through the graduate level worldwide

Lars Dietrich reposted

Lars Dietrich reposted

Lars Dietrich reposted

Excited to share our paper with @savitski-lab.bsky.social, led by @tarabartolec.bsky.social, Karin Mitosch & Clément Potel, out now in @nature.com. We show that T7 phage broadly disables bacterial defenses using a unique ‘loose cannon’ protein kinase. www.nature.com/articles/s41...

nature.comPervasive phosphorylation by phage T7 kinase disarms bacterial defences - NatureThe T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.
Typas Lab@typaslab.bsky.social

Excited to share our preprint with @savitski_lab led by @tarabartolec.bsky.social, @KMitosch & Clément Potel! We uncovered a mechanism by which the T7 phage broadly counteracts DNA-targeting bacterial defenses by deploying a loose cannon kinase in its genome @embl.org www.biorxiv.org/content/10.1...

Lars Dietrich reposted

Hey friends of microbial evolution and science education! I posted the talk about EvolvingSTEM for anyone unable to attend #ISME20 in New Zealand. youtu.be/xzHI05eH104

youtu.beEvolvingSTEM at ISME2026: building science identity in students from grades 6-12YouTube video by Vaughn Cooper
Vaughn Cooper@vscooper.micropopbio.org

So sad to be missing out on #ISME20 in Auckland! The invitation to attend and present about EvolvingSTEM by the inimitable @siouxsiew.bsky.social was incredible. Having been unwell (another story) I had to be take care. But: glad that my recorded talk and live Q&A are happening NOW! Will post later.

Lars Dietrich reposted

Biofilm formation in #Bacillus subtilis is thought to precede sporulation, but T. Updegrove says that a subpopulation of sporulating cells triggers other cells to become biofilm formers via an intracellular metabolite (glycerol) repurposed as a signaling molecule (!) www.science.org/doi/10.1126/...

science.orgA metabolite morphogen coordinates multicellular development in Bacillus subtilisCell-cell signaling using a core metabolite repurposed as a developmental cue coordinates bacterial multicellular development.

Lars Dietrich reposted

Lars Dietrich reposted

Lars Dietrich reposted

Time for a new edition of Canadian biochemist and medical researcher extraordinaire Maud Menten (1878-1960), 🐡🧪👩🏼‍🔬 #histsci coauthor of the Michalis-Menten equation, inventor of the azo-dye coupling which was the first example of enzyme histochemistry for imaging tissues and the first 🧵

Lars Dietrich reposted

Lars Dietrich reposted

#MicrobiologyMonday: Gliding motility allows cells to move smoothly along surfaces without flagella. Although this strategy has evolved independently across many microbial lineages, common mechanical principles emerge. Learn more in #JBacteriology: asm.social/2SJ

Lars Dietrich reposted

Lars Dietrich reposted

Replying to @baym.lol

By all means, if you're deciding, take the time you need. But if you're deciding between two places, and there are three others you've ruled out, let those three know as soon as possible, not once you've picked a school You could make a huge difference to someone else's life

Lars Dietrich reposted

Annual reminder: if you’ve been accepted to multiple graduate programs and are still deciding, please let the ones you’re definitely not going to know as soon as possible! -Someone who got into his PhD off the waitlist the day after the deadline

Lars Dietrich reposted

(bacterial) cell divisionists take note 👇 the schwille lab did it again! now adding FtsN*) to the party, with FtsA, FtsZ and the Min gang already on board... *) cytoplasm.domain thx séamus for pointing this out🙏 #MicroSky

smallthingsconsidered.blogHow FtsZ-rings get shov­eled to mid­cell in vitroPictures Considered #61 by Christoph — The last thirty years have been an "eye-open­ing" jour­ney for mi­cro­bial cell bio­logists, quite li­ter­al­ly. I am, of course, talk­ing about fluores­cent…
Séamus Holden 🔬🦠🧫@seamusholden.bsky.social

Neat paper from Schwille lab. They demonstrate constriction of synthetic vesicles using important components of the bacterial cell division machinery, FtsZ and FtsN. They induce strong constriction of Z-rings in vesicles just by adding the cytoplasmic domain of FtsN www.nature.com/articles/s41...

Lars Dietrich reposted

Happy #InternationalWomensDay to the brilliant women in our Hypothesis Fund community who are taking the intellectual risks to pursue bold ideas, supporting one another, and transforming science together. You inspire us every day. 💫 #IWD2026

Lars Dietrich reposted

#OnThisDay in 1938, American evolutionary biologist Lynn Margulis was born. Margulis is most known for developing and popularising the endosymbiotic theory, which explains how eukaryotic cells evolved organelles from simpler prokaryotic organisms that resided within another and became incorporated.

Lars Dietrich reposted

Lars Dietrich reposted

One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22

Lars Dietrich reposted

a daring approach: looking at LUCA's ancestors, i.e. pre-darwinian evolution. but not surprising it's coming from @kacarlab.bsky.social 👏 glad to see Iwabe et al. (1989) among the references (blew my mind when it came out >30 y ago)

Kaçar Lab at UW-Madison@kacarlab.bsky.social

What happened before the last universal common ancestor? Pre-LUCA evolution is hard to study. In our new Cell Genomics Perspective we spotlight how paralogous proteins open a window onto the deepest chapters of evolution. 🧬🌍 Out today! --> www.cell.com/cell-genomic... @cellpress.bsky.social

Lars Dietrich reposted

Seema Mattoo on Bordetella pertussis and whooping cough! Matters Microbial, @mattoolab.bsky.social @markowenmartin.bsky.social #MicroSky

Microbetv@microbetv.bsky.social

New from Matters Microbial— episode 123: What Whooping Cough Can Teach Us Dr. Seema Mattoo joins @markowenmartin.bsky.social to discuss the fascinating molecular genetics of the bacterium Bordetella pertussis, which can cause the human disease whooping cough. 🔗⬇️

Lars Dietrich reposted

@poojag96.bsky.social work on the bioenergetics of spore germination is now published- Pooja had a really nice summary that I've put below but essentially we think the role of bioenergetics in spore germination has been completely overlooked! www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...