LinderLab

Congratulations to our lab member Konstantin Sopelniak for a superior disputation of his work on phagocytosis of Borrelia and Candida by human macrophages👨‍🎓

Next stop: Meeting of the German Society for Hygiene and Microbiology dghm-kongress.de

My latest @newscientist.com cartoon. many more here: www.newscientist.com/author/tom-gauld/

The lab visiting the Monet exhibition at Port de Lumières in Hamburg 🎨

The LinderLab reflecting on itself 🪞

Our lab member Fan Yang giving a super nice talk about Borrelia outer membrane vesicles (OMVs) at the Extracellular Vesicles Workshop in Hamburg 🦠

Our lab member Canberk Yesilada giving an excellent talk on Borrelia phagocytosis by human macrophages at the Nordinfect Symposium 🎤

Proudly presenting posters at the Nordinfect Symposium in Hamburg 👍

Happy to report that the collaborative publication with the Windhorst and Marlovits groups has been selected as Paper of the Month (PoM) at the University Medical Center Hamburg-Eppendorf 👍

How do hundreds of proteins grip the cell’s actin skeleton? After 4 years of work, we discovered a tiny, 9-amino-acid conserved motif that acts as a universal molecular anchor—defining a whole new class of actin-binding proteins! Read it here: www.nature.com/articles/s41...

An evolutionarily conserved, short linear actin filament-binding motif (SFM), present in >100 proteins. Great collaboration with the Windhorst and Marlovits labs. Happy to have contributed, by using macrophage podosomes as a readout. Publication in Nat Cell Biol: www.nature.com/articles/s41...

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

Nothing better for procrastination than going through some live cell imaging of Endosomes... Today we have the fusion of two equally sized PI(3)P positive endosomes. This is at 5s framerate, wish I had taken it at higher temporal resolution but still super cool to see

onlinelibrary.wiley.com/doi/10.1002/... "Dr. Pollard reflects on key discoveries that shaped the actin field and on the role of quantitative thinking in biology."

That’s a wrap for #JCSimaging, organised by @franbottanelli.bsky.social, @guijacquemet.bsky.social, @drmichaelway.bsky.social & Giulia Zanetti. Thanks to everyone who joined us and made the conference such a wonderful community event. journals.biologists.com/jcs

Beautiful location here at #JCSimaging

@jcellsci.bsky.social @biologists.bsky.social team ready to welcome everybody and the sun is shining! #JCSimaging

Target cell adhesion limits macrophage #phagocytosis and promotes #trogocytosis, say @kirstin-rollins.bsky.social, @mmorrissey.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of JCB Immune Cell Biology collection 👉 rupress.org/jcb/collecti... #AAI2026

Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages

Podosomes in phagocytosis! 😋 + Candida auris Our new paper "Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages" has now been published in Cell Reports: pubmed.ncbi.nlm.nih.gov/41863801/

Podosomes in endocytosis! 🔬 Check out our new preprint "Drebrin forms a cortical hub that connects actin, microtubules, and clathrin for endocytic transport of β2 integrin" www.biorxiv.org/content/10.6...

New publication: Live Biological Imaging Across Scales 10 chapters on live imaging from molecules to organisms, written by leading experts and edited by Claire Wells and yours truly Can now be pre-ordered by your online or brick-and-mortar vendor of choice 🔬

Ho ho ho 🎄🎅

A warm welcome to our new PhD student Emma Lautenbach, who will work on the intricacies of the podosome cap 🧢

A warm welcome to our new lab member Canberk Yesilada, who will be/is already working on his PhD thesis on Borrelia phagocytosis by macrophages 🤗

Macrophages are super! SoRA (superresolution after optical reassignment) microscopy video of a primary human macrophage transfected with Lifeact-GFP to visualize actin-rich podosomes. Star-like appearance is due to connecting cables linking individual podosomes into a cell-wide superstructure ✨

On our way to Heidelberg to the meeting of the German Society for Cell Biology 🧫

New preprint: Phagocytic podosomes enable efficient uptake of Candida auris by primary human macrophages 🦠👄 www.biorxiv.org/content/10.1...

Our paper on podosome regulation by myosins 1e/f is now online. We introduce the concept of the podosome base, a region of plasma membrane-associated components 🔬 Cool collaboration with @renaudpoincloux.bsky.social‬ and Krendel labs www.sciencedirect.com/science/arti...

Congratulations to our lab member Bryan Barcelona to a super fancy defense on software-based analysis of cell and podosome parameters 👨‍🎓

Cellular fireworks (in a primary human macrophage): Microtubule +tips, labeled by CLIP170-GFP, move from the microtubule organizing center (MTOC) to the cell periphery ✨

This is why we love #cellmigration #Leukocytes: #Neutrophils (cyan) #Macrophages (orange) chemotaxis. I couldn't share it before the retirement of @zebrafishrock.bsky.social, but cool #microscopy in #zebrafish continue to rock ! #scicomm #scisky @cellcommlab.bsky.social @focalplane.bsky.social 🧪🔬

A warm welcome to our new master student Mahmood Tarmom, who will work on podosome proteins of (yet) unknown function 🔬

Coming up: "Live Biological Imaging Across Scales", part of the Royal Microscopic Society line of Wiley books. Featuring 10 chapters from international experts on live imaging from molecules to organisms. Edited by Claire M. Wells and yours truly 📘🧬🐭

Our preprint on podosome regulation by unconventional myosins in now on BioRxiv. Great collaboration with the @renaudpoincloux.bsky.social and Krendel labs. www.biorxiv.org/content/10.1... We introduce the concept of the "podosome base", a region of plasma membrane-associated podosome components.

My latest @newscientist.com cartoon

Interesting preprint from the Windhorst, Marlovits and Linder (@linderlab.bsky.social) groups: They investigate the spectrum of actin binding motives that may exist in many proteins. www.biorxiv.org/content/10.1...

Interested in cutting edge Microscopy Techniques? Check out the latest special issue of Journal of Microscopy, edited by yours truly 🔬 onlinelibrary.wiley.com/toc/13652818...

🧑‍🎓👩‍🎓We are hiring: PhD student positions in Molecular Infection Biology in DFG Research Training Group Humans and Microbes @cssbhamburg.bsky.social @leibnizliv.bsky.social @bosse-lab.bsky.social @linderlab.bsky.social @itzenlab.bsky.social #UKE #UHH #BNITM 📬Apply until June 20, 2025. grk2771.de

Upcoming meeting: 11th Trippenhuis meeting of the Dutch Society for Cell Biology (Amsterdam, May 8-9) 🏠

We are hiring! The DFG-funded RTG2771 training group is offering PhD positions in molecular infection biology for 3-4 years For more information, see grk2771.de (our lab is project 4) 👨‍🎓

Farewell sushi dinner for our longtime assistant Andrea who is now retiring 🥲🍣

Congratulations to our lab member Rawan Batlouni for an excellent MD thesis on phagocytic podosomes 👨‍🎓

A warm welcome to our new MD student Fan Yang, who will work on Borrelia-macrophage interaction 🤗

Video of a FIB-SEM analysed macrophage phagosome containing a single Borrelia cell being compacted by membrane tubulation, leading to reduction of the phagosome volume. Phagosome membrane in blue, Borrelia in turquoise. Watch for start of transparency mid-video 🪱 pubmed.ncbi.nlm.nih.gov/33380490/

Registration and abstract submission for our International Symposium Cell and Structural Biology of Host Pathogen Interaction from 10 – 12 Sept 2025 @cssbhamburg.bsky.social in Hamburg, Germany are now open. ✅ Register here: express.converia.de/frontend/ind... 💡More info: humansandmicrobes2025.de

🚨 Save the date! 🚨 We're thrilled to announce our International Symposium on Cell & Structural Biology of Host-Pathogen Interaction 📅 Sept 10-12, 2025 📍 @cssbhamburg.bsky.social Hamburg Registration starts soon For more info: humansandmicrobes2025.de

New account, new publication: Our video article on building your own tumor spheroid-macrophage coinvasion assay is now online 🎤 review.jove.com/de/t/67374/a...