Lucas Anger

Lucas Anger

@luanger.bsky.social

PhD student in the Ladoux-Mège lab at Institute Jacques Monod in Paris. I enjoy mechanobiology, biophysics, when things are nematic, and doing little silly drawings.

99 followers183 following10 posts

Lucas Anger reposted

🔬 We're hiring a Laboratory Manager! Join our growing international team at the Max Planck Center for Physics and Medicine in Erlangen! 🧬 Cell & molecular biology 🧪 Lab coordination & experimental research 📩 Apply now: [https://www.fau-jobs.de/jobposting/8173a98034c48d53d57bce14503883cbdbf6f3b80]

Lucas Anger reposted

New 📄 🚨! #CellBio is teeming with simulations comprising an extraordinarily high number of components. We argue that model complexity will not automatically lead to a better understanding of biological systems & discuss how modeling practices could be repurposed: arxiv.org/abs/2608.06998 #philsci

arxiv.orgSimulating is not always understanding: When model complexity obscures biologyIn cell biology, computational models of biological systems range from minimal representations with a handful of parameters to whole-cell simulations tracking thousands of molecular species across a c...

This principal stress rule reveals a mechanical feedback loop: anisotropy sets division orientation and scales with cell-cycle duration. After cytokinesis, anisotropic stress is relieved. Importantly, the rule depends on anisotropy, not pressure: it holds for both tension and compression.

Thus, the coupling between anisotropic stress and proliferation resembles a mechanostat: proliferating tissues can reach lower stress anisotropy through the feedback control of cell division, providing a mechanical "path" toward tissue mechanical homeostasis.

That is a lot of questions, but we found a surprisingly simple answer: across multiple cell lines and even intestinal organoids, cells tend to divide along the principal direction of intercellular stress.

This result integrates previous observations on the mechanical regulation of division orientation, including seemingly conflicting ones. By measuring the intercellular stress tensor, we identify anisotropic stress as a unifying mechanical cue within a common anisotropic framework.

Cells both sense and reshape their mechanical environment. During division, geometry guides division orientation (✨Hertwig's rule✨), while isotropic stresses regulate proliferation, with tension generally promoting and compression inhibiting cell-cycle progression.

But these mechanical cues can sometimes compete. This led us to ask: is there a unifying mechanism underlying these apparent discrepancies? What happens in hexagonal cells without a well-defined long axis? How does this fit into a homeostatic perspective?

Lucas Anger reposted

Replying to @levayerr.bsky.social

Reviewing process has always been painfull, but it will just become useless and impossible to publish if we start accepting this (we are not helping science...and better refusing to review if you have no time rather than using these tools without filter)

Lucas Anger reposted

Lucas Anger reposted

Truly honoured and grateful to have received alongside other young researchers the prize "Grandes avancées françaises en biologie" from the @academiesciences.bsky.social for our paper on mechanical cell competition together with @luanger.bsky.social and S. Monfared www.nature.com/articles/s41...

Institut Jacques Monod@ijmonod.bsky.social

📣 Andreas Schoenit, ( @andreasschoenit.bsky.social ) doctorant en biophysique dans le laboratoire "Adhésion cellulaire et mécanique" est lauréat des Grandes avancées françaises en biologie de la Fondation Mergier Bourdeix ! Plus d'informations 🔗 www.ijm.fr/prix-des-gra...

Lucas Anger reposted

Lucas Anger reposted

Lucas Anger reposted

Lucas Anger reposted

Lucas Anger reposted