Andreas Schoenit

Excited to share a new preprint! We address a longstanding question related to stratifying tissues: What are the physical mechanisms that drive epidermal cell delamination? Find out why this👇 traction force pattern emerges and how it is linked to upward cell motion: www.biorxiv.org/content/10.6...

🔬 We're hiring a Laboratory Manager! Join our growing international team at the Max Planck Center for Physics and Medicine in Erlangen! 🧬 Cell & molecular biology 🧪 Lab coordination & experimental research 📩 Apply now: [https://www.fau-jobs.de/jobposting/8173a98034c48d53d57bce14503883cbdbf6f3b80]

Awesome new paper led by @luanger.bsky.social uncovering a feedback between anisotropy of the internal tissue stress, cell division orientation and cell cycle duration in dense epithelia! Glad to have contributed a tiny bit to this nice story. Take a look 👇

Not every cell react the same way to caspase activation. In our recent study (led by @tomcumming.bsky.social and initiated by @avillars.bsky.social ), we tried to better understand what explains this difference and outlined a role of past caspase exposure 👇 www.nature.com/articles/s41...

📢 PhD Thesis defense 📅 September 29th 📍 Institut Jacques Monod Lucas Anger ( @luanger.bsky.social) ( @bladoux.bsky.social @rmmege.bsky.social Lab ) will defend his PhD thesis “Intercellular stress invariants and fluctuations in epithelial mechanical homeostasis" ➡️ buff.ly/F6PVKtX

From cell signaling to collective tissue dynamics, our community is sharing incredible research! 🔬 Thanks to everyone! Want to become an @epimechfc.bsky.social delegate and share your passion for science with us? Reach out and let us host your next thread.🧵 👉 epithelialmechanics.github.io/threads/

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

E-cadherin-mediated neighborhood surveillance dictates pre-malignant outcomes https://www.biorxiv.org/content/10.64898/2026.09.02.748765v1

Happy to share our new preprint! We uncover how local force imbalances drive keratinocyte delamination and upward motion, while neighboring cells close the basal layer below. Amazing work from @andreasschoenit.bsky.social! www.biorxiv.org/content/10.6...

Happy to share our new study @ijmonod.bsky.social on how surface curvature shapes multicellular organization and function. How curvature controls tissue chirality, patterns distinct architectures, and influences myogenic differentiation? www.biorxiv.org/content/10.6...

Excited to share our lab's new preprint led by @huanting-ong.bsky.social on paired-surface spatial mechanomics! We link nanoindentation maps with #SpatialTranscriptomics to connect local tissue mechanics with molecular state. 🔗https://www.biorxiv.org/content/10.64898/2026.08.29.748050v1 🧵1/7

Local mechanical heterogeneity drives epidermal cell delamination https://www.biorxiv.org/content/10.64898/2026.08.30.747990v1

Curvature-guided chiral collective organization of myoblast tissues https://www.biorxiv.org/content/10.64898/2026.08.25.747076v1

Anger, L., Schoenit, A., Wodrascka, F., Rossé, C., Mège, R.-M., Ladoux, B., & Marcq, P. (2026). Tissue stress measurements with Bayesian inversion stress microscopy. The European Physical Journal E, 49(1-2), 2. #EpithelialMechanicsReview buff.ly/ELaOtv9

Happy to share our new paper @natcomms.nature.com on the role of active nematics on myoblast fusion and myotube growth! www.nature.com/articles/s41... Amazinf work from @dubey837.bsky.social, @yoannletoquin.bsky.social and Aleksandra Ardaševa!

🦠 How do phages interact with their bacterial hosts... across infection phases and across diverse phage-host combinations? You can address such questions with the PhageExpressionAtlas now published. Please spread the word and provide your feedback as a user: academic.oup.com/nargab/artic...

How do tissues safely remove cells? Join me, @marija-matejcic.bsky.social in this perspective on the past, present and future of epithelial cell extrusion 🧵 0/16

Thrilled to share our new work on the coupling between cell proliferation and intercellular stress organization! Cool collaboration between @bladoux.bsky.social / @rmmege.bsky.social lab and Doostmohammadi lab, combining experiments + simulations. Main points below : www.biorxiv.org/content/10.6...

What determines how epithelial cells divide when shape cues disappear? Our new work shows that division follows the axis of maximal stress anisotropy. This “principal-stress rule” links mechanics, proliferation, and homeostasis. Amazing work from @luanger.bsky.social. www.biorxiv.org/content/10.6...

Take a look at this new preprint led by @fanny-wodrascka.bsky.social on tension-driven cell extrusion! Using optogenetics, she studied how tensile stresses can influence fate (alive or dead) and direction (apical or basal) of extruded cells. Happy to have contributed a bit to this nice story!

Every 3D tissue is a map waiting to be drawn. Flatten a curved tissue, follow how it deforms, find its hidden axis, or measure its shape to explain how it moves: it's all cartography!

New paper in Advanced Materials! We present DNA hydrogel microparticles for 3D tissue engineering, showing programmable material properties and cell-material interactions! Special thanks to Eleni Dalaka @gflaesch.bsky.social @kgoepfrich.bsky.social @xaviertrepat.bsky.social doi.org/10.1002/adma...

Spectacular Developmental Biology Jacques Monod Conference in Roscoff. Thanks to @bardinlab.bsky.social and @lionlchristiaen.bsky.social for putting together such an exciting scientific program. And the setting was incredible too, with a beautiful sunset to end the meeting.

Biophysical principles of cell competition and elimination

Happy to share our new review on biophysical principles of cell competition and elimination: www.cell.com/trends/cell-... With @bladoux.bsky.social and @rmmege.bsky.social, we discuss mechanical fitness, how loser cells are removed through various strategies and how forces can effect their fate

Really happy to share my PhD story about the regulation of developmental speed in the Drosophila eye 🪰😃👀, which is now published @embojournal.org: link.springer.com/article/10.1... Grateful to everyone who make this possible, particularly F. Schweisguth @pasteur.fr @devstempasteur.bsky.social

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

Happy to share our new paper on collective cell dynamics. Great work from Yuan Shen @ijmonod.bsky.social ! Dynamic heterogeneity and hidden fluidity in dense epithelial tissues | Science Advances www.science.org/doi/10.1126/...

We are happy to share our new bioRxiv pre-print on A-P axis patterning. A great collaboration with Felix Zhou (UT Southwestern) & the Yeomans group (Physics, Oxford) www.biorxiv.org/content/10.6...

Hello epithelia enthusiasts! I’m @inesfournon.bsky.social and I study epithelial mechanics in sea anemones 🪼 Did you know epithelial cell extrusion had never been described outside bilaterian animals before? Well… not anymore 👀 Read ⬇️🧵1/9

Our new review on epithelial barrier homeostasis has been published in Trends in Cell Biology(www.cell.com/trends/cell-...)! Please use the following link for free access until May 1: authors.elsevier.com/a/1mlnq3QxxT...

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)

Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development! @karengrace12.bsky.social @nicolettapetridou.bsky.social 🔗 doi.org/10.1242/dev....

New paper alert!🤩Super proud that our story led by superstar postdocs @liujinghui.bsky.social and @nerlielisa.bsky.social is finally out! We found how electrical signals are key for promoting organ regenerative growth!!! A thread 🧵https://www.science.org/doi/10.1126/sciadv.aec0687

Latest work from the lab by Aude Nommick et al., in which we propose a "size-scaling" model for microtubule force exertion that regulates centrosome centration vs decentration during embryo development! @ijmonod.bsky.social www.biorxiv.org/content/10.6...

Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon. Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity. Plus: a clever way to measure cell volume. www.pnas.org/doi/10.1073/...

My PhD work showed that vimentin is not only a passive marker of EMT, but plays an active role in collective migration, controlling the mechanics of epithelial leader cells. I am grateful to my supervisors, Rene-Marc & Benoit Ladoux, as well as to all the co-authors. www.biorxiv.org/content/10.6...

Our paper on tissue stress measurements is now out in Eur. Phys. J. E. rdcu.be/eX59E. Great work from @luanger.bsky.social and @andreasschoenit.bsky.social and collaboration with P. Marcq @pmmh-lab.bsky.social Code: github.com/pmarcq/BISM/ and Examples on github.com/ASmushyCell/...

Anger, L., Schoenit, A., Wodrascka, F., Rossé, C., Mège, R. M., Ladoux, B., & Marcq, P. (2025). Tissue stress measurements with Bayesian Inversion Stress Microscopy. arXiv preprint arXiv:2512.00550. arxiv.org/abs/2512.00550 #EpithelialMechanics

So proud to share this beautiful work developed in collaboration with @lorealfrance.bsky.social Using 3D imaging at an outstanding level of resolution, we have uncovered the intricate cellular dynamics of human hair follicles - and the movies are stunning! More details here: tinyurl.com/4vrywf3z

Are you investigating cell tissues and interested in stress patterns? TFM + BISM reveals them! 👇 With @luanger.bsky.social and P. Marcq, we summarise the applicability across different exp. conditions regularly used in the @bladoux.bsky.social @rmmege.bsky.social lab. Full pipeline on Lucas GitHub!

The latest story from my group. Working toward build regionally distinct skin and amnion piece by piece.

Exciting News! 🥳 Our Epithelial Mechanics Fan Club website is now live! 🎉 👉 epithelialmechanics.github.io Discover our #EpithelialMechanics threads and get to know our amazing delegates behind them. Would you like to share your story? Please DM us!

1/ 🎉Excited to share our new preprint @vignjeviclab.bsky.social @davidbrueckner.bsky.social : "Self-organization of tumor heterogeneity and plasticity" biorxiv.org/content/10.1... Tumor heterogeneity and plasticity drive metastasis and relapse. How is tumor patterning coordinated? A thread👇

Happy to share the last version of our story @currentbiology.bsky.social on the role of interfacial tension in mechanical cell competition led by @leovalon.bsky.social and Alexis Matamoro Vidal www.sciencedirect.com/science/arti...