Michael Fischbach

Michael Fischbach

@mfgrp.bsky.social

Liu (Liao) Family Professor of Bioengineering, ChEM-H @Stanford.

1.2K followers27 following55 posts

Michael Fischbach reposted

Tami Lieberman
@contaminatedsci.bsky.social

Replying to @petrovadmitri.bsky.social

This pair of papers demonstrating strong and systemic immune responses to skin commensals applied topically to unbroken skin, including induction of B cells for vaccination. www.nature.com/articles/s41... www.nature.com/articles/s41...

nature.comSkin autonomous antibody production regulates host-microbiota interactions - NatureNature - Skin autonomous antibody production regulates host-microbiota interactions

Michael Fischbach reposted

Christopher Barnes
@cobarnes27.bsky.social

What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed πŸ€―πŸ‘‡πŸΎ

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

ᐯIα‘•TOα–‡ α‘ŽIα˜”ET, α—°α—ͺ
@nizet.bsky.social

Insanely creative and original immunology and bioengineering work from the Fischbach Lab at Stanford with high translational potential Full article in NATURE: www.nature.com/articles/s41... Follow the scientists: @mfgrp.bsky.social @djenetbousbaine.bsky.social @katebauman.bsky.social

goodnewsnetwork.orgStanford Scientists Transform Ubiquitous Skin Bacterium into a Topical Vaccine Against TetanusEven better, it’s cheap, entirely pain-free, no need to stand in a line, and not followed by fever, swelling, redness, or a sore arm.

Michael Fischbach reposted

Taia Wang Laboratory
@wanglaboratory.bsky.social

Beautiful work with exciting implications for topical vaccination by @mfgrp.bsky.social ✨ Give this a read πŸ‘‡

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Stanford Department of Bioengineering
@bioe-stanford.bsky.social

Vaccines, but make it skincare!🧴🧬 Congratulations to Stanford BioE Professor Michael Fischbach @mfgrp.bsky.social & @djenetbousbaine.bsky.social for engineering a skin bacterium that could lead to needle-free vaccines.

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Djenet Bousbaine
@djenetbousbaine.bsky.social

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Marshall Burke
@marshallburke.bsky.social

Your hand lotion is now also a vaccine. Hot damn

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Christina (Chris) Tobin Kahrstrom
@microchris.bsky.social

Replying to @microchris.bsky.social

Illuminating thread by author β€ͺ@mfgrp.bsky.social bsky.app/profile/mfgr...

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Andreas Peschel
@andreaspeschel.bsky.social

Brilliant work congrats to the authors!

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Tim Stearns
@stearnslab.bsky.social

Awesome thread from @mfgrp.bsky.social about what might be the most amazing result you'll hear about in 2024: antigens stuck on the surface of the skin bacterium S. epidermidis generate a strong immune response in mouse.

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Scott_Boyd_Lab_Stanford
@scottboydlab.bsky.social

A remarkable story from @mfgrp.bsky.social and colleagues: immunization via skin S. epidermidis generates systemic and mucosal antibody responses.

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Zamin Iqbal
@zaminiqbal.bsky.social

This is the most amazing thread since they did a similar thing to cure a cancer

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Leyla Asadi, MD PhD
@leylaaa.bsky.social

Wonder. Awe. Excitement. Very cool thread on a very cool finding. #IDSky

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Shai Bel (The Mucus Man)
@mucusman.bsky.social

Holy shit this is amazing!!! 🀯

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Conor McClune
@cmcclune.bsky.social

discovery that a skin microbe can, without inflammation, induce a systemic B-cell response... and then engineering that microbe into a potent vaccine platform that can be applied as a topical cream. amazing work from @djenetbousbaine.bsky.social and @mfgrp.bsky.social! www.nature.com/articles/s41...

nature.comDiscovery and engineering of the antibody response to a prominent skin commensal - NatureNature - Discovery and engineering of the antibody response to a prominent skin commensal
Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Sorek Lab
@soreklab.bsky.social

An amazing discovery, and a very informative and engaging thread. Could develop into a transformative new mode for efficient vaccination

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Carolyn King
@immunologyking.bsky.social

one to savor over the holidays. also so cool to see how the directions of the work between @mfgrp.bsky.social and Belkaid labs diverged.

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Leif Erik Sander πŸ‡ͺπŸ‡ΊπŸ‡ΊπŸ‡¦
@sanderlab.bsky.social

Brilliant 🧡on a fascinating study demonstrating potent systemic and mucosal antibody responses to the common skin commensal Staph. epidermidis. Engineered S. epi expressing or displaying unrelated antigens elicited protective immunity,suggesting it could serve as topical vaccines. πŸ’‰

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55

Michael Fischbach reposted

Damian Maseda
@dmaseda.bsky.social

Co-opting a skin commensal to design new vaccines! An amazingly creative and thoughtful new approach that integrates our knowledge of immune system responses. #ImmunoSky

Michael Fischbach@mfgrp.bsky.social

Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55