Marco Grillo

Online teaching can be puzzling sometimes: it's difficult to read the room without being in the room. For me, it helps a lot if students keep their camera on during the lessons. That smile appearing on students' faces when they understand a hard concept is the best feedback I can get, even via Zoom.

#Mastodon paper was published in @dev-journal.bsky.social. A great home for this outstanding piece of software, long in the making. @preibischs.bsky.social ambitious plan for SPIM data processing and analysis from 2007 is finally finished 😀 journals.biologists.com/dev/article/...

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

Nice example of how AI predictions are limited by the training set. AlphaFold has not learned the rules of protein folding, it's just great at predicting structures based on what it has already seen. Added constraints (e.g. alignment revealing conservation patterns) can help make a good prediction.

Interested in using #Drosophila genetics & advanced imaging combined with modeling to study inter-organ transport and epithelial dynamics? We’re hiring a #PhD student @uni-muenster.de, based at the Multiscale Imaging Center and @sfb1348.bsky.social Graduate School. Apply here tinyurl.com/ypx74a5d

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

🎙️ Yesterday, Hower was invited to present our in situ technology at the VIB Spatial Omics 26 conference. It was a great opportunity to show the spatial omics field what we have been brewing!🔬 Thank you to the organizers and everyone who joined the session!✨ Catch Hower at poster #63 today💬

Journal impact factors were released yesterday. In our latest @dev-journal.bsky.social Editorial, @jamesbriscoe.bsky.social and I discuss how we are all architects of impact, highlighting that measuring the influence and support journals provide goes beyond a single number. doi.org/10.1242/dev....

What is the evolutionary origin of the organizer? New work from @kremnyovs.bsky.social, @tclebedeva.bsky.social & Hejnol Lab @uni-jena.de reports the blastopore lip of the #ctenophore Mnemiopsis leidyi, a member of the evolutionary sister group to all other metazoans, exhibits organizer activity.

Janelia is built for this moment. Starting today, we're taking on 2 big bets: cracking how a vertebrate brain generates behavior, & building AI-in-the-Loop Discovery — a new way of doing biology. Tiny transparent fish + one of neuroscience’s biggest questions? Let's go: hhmi.news/2BigBets

Our latest: Minimal essential requirements for neural tube self-organisation How does a single cell give rise to a tissue with the right cell types in the right proportions? We deconstruct and rebuild a self-organising tissue from first principles A thread🧵 www.biorxiv.org/content/10.6...

Mechanisms of magnetosensing in pigeons - a surprise appearance of macrophages! Getting home in the dark | Science www.science.org/doi/10.1126/...

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

Is the purpose of science and 🧪 training to churn out papers or to create a healthy knowledge community? In a @nature.com comment, @mjcrockett.bsky.social and I check in on how AI helps with the former while jeopardizing the latter 1/

A gentle reminder that if your customers are scientists, your products and claims will be extensively (and rightfully) scrutinized.

of many projects Craig Venter led, of personal significance was the fly genome, a unique and i think unexpected collaboration of his company Celera Genomics and the BDGP, led by my pd advisor Gerry Rubin. the power of a shotgun sequenced metazoan, benchmarked to a physical map, transformed genomics.

Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...

At @szndohrn.bsky.social, the floor tiles have stitching and segmentation artifacts :) Just finished teaching the marvels of spatial omics to the great group of PhD students of @zoocell.biologists.social.ap.brid.gy, together with @alvarocrevenna.bsky.social. What a week! 🔬🍕🍝🍷🧪

New Pre-Print Alert! Evolving initial conditions: an alternative developmental route to morphological diversity with Shannon Taylor and @jamesehammond.bsky.social www.biorxiv.org/content/10.6...

As mentioned elsewhere, I've been dreaming of solving this problem for a looooooooong time. Nice to see that my dreams were also the dreams of a very talented team! Slightly different approach, same problem, similar logic. Loving this!