Michael Kearse

On Mon 10/26 Lainie Boyle (Bass lab @bbass.bsky.social) will defend her thesis entitled "Defining RDE-4 dsRNA binding motif functions in antiviral Dicer activity." 3pm in HSEB 1700!

Don't miss today's defense by Lainie Boyle at 3pm!

⚠️ Another problematic NIH policy needs your attention ⚠️ NOT-OD-26-112: grants.nih.gov/grants/guide... Redefines transient expression as "genetic modification". If adopted, mRNA medicines could be forbidden. Comments close October 19! Please go comment on this! osp.od.nih.gov/comment-form...

New preprint from the lab! Riboswitches toggle by rearranging base pairs. Can you get the same toggling without changing the secondary structure? Turns out yes. We designed a minimal modular RNA that forms or breaks a tertiary contact in response to ligand binding. www.biorxiv.org/content/10.6...

📣NAR is recruiting a new Executive Editor!📣Seeking an established researcher with expertise in RNA biology and translation mechanisms to help shape the journal's scientific direction, oversee peer review, and support its growth. Apply by 30 Sept 2026: academic.oup.com/nar/pages/ex...

New preprint from Kaley Simcox in the Koutmou lab! She developed a HILIC-MS/MS approach for total tRNA sequencing, achieving 75–100% coverage for most isoacceptors - without ion-pairing reagents. This enabled the discovery of new modified positions on E. coli tRNAs. doi.org/10.64898/202...

Hot off the press from the RTI: The Pseudomonas aeruginosa ribonuclease Ribocin cleaves eukaryotic ribosomes at helix 69 to inhibit host translation pubmed.ncbi.nlm.nih.gov/42160310/?ut... #RNA #RNATherapeutics

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

Check out our new preprint on IRES studies (www.biorxiv.org/content/10.6...). We show a recently proposed IRES “toolbox” results in mRNA annotation errors and false-positive IRES activities. We provide an alternative set of robust approaches. (1/4)

So, so, honored by this award—it is daunting to know that my heroes have won this award! Thanks to my heroes and mentors, and my trainees, who are everything!!!!

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine. faculty-einstein.icims.com/jobs/17847/a...

🧪 My lab has an opening for a postdoc position soon! Please share/get in touch!

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)

Some things I’m very proud of from my group in no particular order: three selected talks! We work so hard on communicating our science clearly and effectively that I am especially proud of this

New work led by Madison Bandini out in @pnas.org using live cell imaging to show how HIV targets the cell cycle to double viral genomes and increase transcription. Awesome collaboration with cell cycle heroes in Suzuki lab @mcardlelab.bsky.social @uwmadison.bsky.social. www.pnas.org/doi/10.1073/...

My talk from the latest RNA Collaborative Seminar Series is now available on YouTube. The second talk in the session was given by Rachel Braun (Sara Cherry’s lab) on TTP and its role in regulating antiviral immunity. youtu.be/2Aj-xbi3dPI #RNAsky #RNAbiology

Please RT‼️ #TenureTrack position @zmbh.uni-heidelberg.de one of the best #proteostasis research centres in the world. www.nature.com/naturecareer...

Announcing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!

Anyone at Harvard need a super well-trained undergrad next semester? Cell culture, molecular bio, microscopy and data analysis. Very careful and rigorous. Good lab citizen. Ready to jump in and learn/get some data! Has light course load, so plenty of time for research! Let me know of any leads!

📢 We are pleased to announce the Molecular Mechanisms of RNA in Disease – The NCCR RNA & Disease Final Symposium Jan 26-29, 2026, in St. Moritz! 🔗 Details & updates: finalsymposium.nccr-rna-and-disease.ch @snf-fns-ch.bsky.social @unibe.ch @ethzurich.bsky.social

#RNAsky #RNAbiology

From @kylecottrell.bsky.social lab rnajournal.cshlp.org/content/31/1...

Registration is open for "The complex life of #RNA" 2026 @embl.org in Heidelberg! Excellent invited speakers and 30 short talks and even more flash talks selected from the abstracts!

Thank you to our sponsors for the GA RNA Salon @rnasociety.bsky.social and Lexogen- we hosted Dr. Francesca Storici for our annual symposium yesterday @dunhamlab.bsky.social @ghaleilab.bsky.social

Dang, hard disagree. The best papers to write and read are works of art, not merely a list of data and statements. Don’t let LLMs take this away too, for gods sake.

Latest from the lab! Analysis of everyone’s favorite regulatory mechanism in bacteria — the RF2 programmed frameshift! Likely present in the ancestor of bacteria, use of this mechanism is influenced by stop codon usage! Big congrats to @cassidyprints.bsky.social journals.asm.org/doi/10.1128/...

Great lab, great mentor and I love UNC Biology!

The Johri Lab has an open postdoc position. Please send me an email, if interested. Start date is flexible. Please do share! Thank you in advance.

We have a new preprint for you. Naked mole rats are very long-lived rodents and have increased translational fidelity. Interestingly, 28S ribosomal RNA is split. Here we investigated the structure of the ribosome by single particle cryo-EM. Take a look. www.biorxiv.org/content/10.1...

Want to do a PhD in biology? Our projects for 2026 are now live! If you're considering a PhD, or know someone who is, we have projects that span the biosciences to serve as inspiration. Reach out to our academics to discuss these or more options if you have an idea of your own 👇 bit.ly/dphilbio25

From MBoC: Timothy J. Stasevich, Colorado State University, developed All Probes Plasmids (APPs) to simplify single-mRNA translation imaging—just 2 plasmids for multicolor, long-term tracking. www.molbiolcell.org/doi/10.1091/... #CellBiology

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

www.biorxiv.org/content/10.1...

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested! embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!

Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404

🎉 Congratulations to Needhi Bhalla, UC Santa Cruz (www.bhallalab.com ), named a 2025 #ASCB Fellow! This honor celebrates her outstanding contributions to cell biology, leadership, & service. Fellows will be recognized at #CellBio2025 in Philadelphia this December. #CellBiology

@joachimgoedhart.bsky.social and Flurescent protein colleagues--help! With advice from imaging freinds, we tagged a protein of interest with "tagRFP", which we now know from its protein sequence and digging is a derivative of eqFP578 from Entacmaea quadricolor. We want an antibody to it but 1/n

This preprint was accepted @rnajournal.bsky.social! It is now online ahead of print! @cancer-inst-purdue.bsky.social @purduernaclub.bsky.social rnajournal.cshlp.org/content/earl...

I’m excited to share that I’ve started a new chapter as Assistant Professor & Clinical Microbiology Section Director at @dukemedschool.bsky.social 🏥🔬. This is a dream opportunity, and I’m so grateful 🙏. Looking forward to growing, learning, and advancing clinical microbiology & patient care 🚀💙.