Mo Khalil

Thrilled to receive an NIH Director's New Innovator Award! Our project will engineer proteins to help us understand and rewire signaling at immune synapses, which represent tools for discovery and potential immunotherapies. @mitdeptofbe.bsky.social @mitcheme.bsky.social @mitkochinstitute.bsky.social

Initial set of our new T1 T-DNA vectors now available on @addgene.bsky.social: pT1 (no selection marker): lnkd.in/dcnTN8Rj pT1-B (BASTA selection marker): lnkd.in/dgTZmuCx pT1-K (kan selection marker): lnkd.in/dqgv4QRc pT1-H (hygro selection marker): lnkd.in/dhrs5Tsg

And here is another direct link to the preprint. Enjoy! www.biorxiv.org/content/10.6...

🌱 NEW PREPRINT & SPECIAL day! We unveil an advance for plant science, engineering, and synbio in first (of many) Khalil <> Gehring collabs, led by the one-and-only @willshaw.bsky.social. Thread below on principles + design of a new, single-integrating T-DNA vector for precision plant xformation! 👇

5 days left now to apply for the postdoc opportunity in my lab at Imperial in London 🇬🇧 - there’s a chance that we can hire 2 people into the team on this synthetic biology and materials theme. Application link is here - www.imperial.ac.uk/jobs/search-...

🚨 An exciting frontier is bringing synthetic biology to MULTIcellular systems. To effectively engineer them, we need design principles. What are the benefits of group formation? What are the costs? See our new preprint led by @heidiklumpe.bsky.social to learn more!👇 www.biorxiv.org/content/10.6...

Calling all Scientists! Research Administrators! Deans! Fans of Science! No one is coming to save us. Here is your assignment. I have written a step by step, easy to understand "how-to" document to help you comment on the proposed OMB rule. elizabethginexi.substack.com/p/what-we-ne...

What an honor to receive the Kuwait Prize! A testament to the remarkable achievements and hard work of #Khalil-Lab members past and present. It’s always an honor to be recognized as a scientist, and especially meaningful to celebrate my background as a Palestinian-Jordanian 🙏 tinyurl.com/2jvrjszb

Busy week for the Khalil lab getting ready of our big move next week! P.s. Graveyard of Oligos 🧬 from our prolific former postdoc @willshaw.bsky.social

Interrupting the regular (science) broadcast to brag about my wife and Hisel Flynn Architects on having their beautiful work featured in the @bostonglobe.com! 🏠😍 www.bostonglobe.com/2026/03/26/m...

Startups are providing tantalizing glimpses of AI-assisted antibody discovery and claiming game-changing potential, even as new models remain hidden and industry awaits full disclosure and benchmarking www.nature.com/articles/s41... [🔓read free with login]

Unstructured transcription factor interactions enable emergent specificity | @science.org www.science.org/doi/10.1126/...

🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...

This is a beautiful paper examining the molecular genetics of facultative multicellularity in a marine black yeast. I also love that they figure out the ecological context for the behavior (MC form when in sponges, where there are nutrients, & uni when starving!). www.nature.com/articles/s41...

Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ? doi.org/10.1093/nar/...

🚨 AIMBE calls on the scientific community to urge Congress to ensure timely passage of the FY2026 budget 👇 Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath. takeaction.io/aimbe/protec...

In today's issue of Cell-->if you are looking for a good distraction from the news (who isn't), check it out! www.cell.com/cell/fulltex...

We traveled to DC to talk to Congressional Staffers about the impact of NIH and NIBIB funding. It enables us to develop synthetic biology tools to advance cell & genetic medicines for patients in need. REPOST to deliver the message that SCIENCE saves lives & makes America GREAT!

7 years old! 🎂🎉🎈Happy birthday to our adventurous twins!

I hailed a Tesla Model 3, according to Uber-equivalent in Cairo, Egypt 😂😂

Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...

So cool, a novel archaeon with a super small genome and no metabolic genes! "An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses." www.biorxiv.org/content/10.1...