Mauricio Contreras

Mauricio Contreras

@mpcontreras.bsky.social

Group Leader at @zmbp-tuebingen.bsky.social NLR and effector biology Board Member @ISMPMI.bsky.social 🇦🇷🇮🇹🇨🇺

1K followers375 following82 posts

Pinned

Mauricio Contreras reposted

Agrobacterium-mediated transient expression has revolutionized plant research, but is largely confined to solanaceous species. This study shows that an engineered strain allows efficient transient expression across diverse dicot crop species. 🧪 #AcademicSky #plants plos.io/3W0hqlP

Mauricio Contreras reposted

Mauricio Contreras reposted

New research. Conveniently, Marchantia has relatively few transcription factors. Yet, we need to leverage on that at the family scale to have a more comprehensive picture. In this paper, we focused on ERFs, the second largest TF family. #PlantScience www.biorxiv.org/content/10.6...

biorxiv.orgFunctional diversification of ERF transcription factors in land plantsThe ERF family is one of the largest families of plant-specific transcription factors, controlling diverse developmental processes and stress responses. Extensive gene duplication and redundancy in fl...

Mauricio Contreras reposted

Excited to share this bioRxiv where we identify another host target for a Magnaporthe effector. Here we characterise the interaction between the zinc finger fold effector (Tie1) to a conserved family of transcription factors called the Tubby-like F-box proteins (TLPs) www.biorxiv.org/content/10.6...

biorxiv.orgA Blast Fungus Effector Targets a Tubby-like F-box Protein to Suppress Plant ImmunityThe blast fungus Magnaporthe oryzae is one of the most destructive pathogens of rice, secreting effector proteins that reprogram host cells to enable infection. Identifying plant targets of these fung...

Mauricio Contreras reposted

Mauricio Contreras reposted

🚨 TOMORROW! Rising Stars of IS-MPMI self-nominations close 14 Oct. Early-career? Put yourself forward: a speaking slot in our 18 Nov webinar, and a shot at a plenary talk + funded travel to Jeju 2027. Apply with the link! 👇 docs.google.com/forms/d/e/1F...

docs.google.comSelf nomination form for Rising Stars of IS-MPMI Early Career Webinar Series November 18th 2026Sponsored by GetGenome

Mauricio Contreras reposted

🌱New preprint 🎉 I am happy to share this last work of my PhD research! We uncover a novel role of cysteine protease RD19 in immunity. RD19 regulates RBOHD-generated ROS and is required for induced resistance responses. www.biorxiv.org/content/10.6... More details in the thread below! 🧵

biorxiv.orgArabidopsis cysteine protease RD19 limits RBOHD-generated ROS production in pattern triggered immunityPlants perceive pathogenic threats through receptors localized at the plasma membrane and inside cells to initiate pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), respectively....

Mauricio Contreras reposted

Our story with @hobbslabutah.bsky.social discovering CBASS sensing of phage proteases out now in @science.org New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo www.science.org/doi/10.1126/...

science.orgPhage proteases activate CBASS antiphage immunityCyclic oligonucleotide–based antiphage signaling systems (CBASS) are bacterial immune pathways evolutionarily related to cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) in humans. ...
Kranzusch Lab@kranzuschlab.bsky.social

After >10 years of our lab studying bacterial cGAS-like enzymes, @hobbslabutah.bsky.social finally reconstitutes viral sensing in vitro and discovers how these ancient receptors sense phage protease enzymes to detect virion assembly and activate antiviral immunity www.biorxiv.org/content/10.6...

Mauricio Contreras reposted

5 years ago, @hacquardst.bsky.social and I became very interested in 𝑃𝑙𝑒𝑐𝑡𝑜𝑠𝑝ℎ𝑎𝑒𝑟𝑒𝑙𝑙𝑎 𝑐𝑢𝑐𝑢𝑚𝑒𝑟𝑖𝑛𝑎, an emerging fungal pathogen that colonizes the roots of many plants 🌱 🍅 🌾 🆕📝 Final result of a huge team effort to uncover the bases of its multi-host compatibility👇 www.nature.com/articles/s41...

nature.comCarbohydrate-active enzymes from a core root mycobiota member enable infection of multiple plant hosts - Nature MicrobiologyHost-induced fungal CAZymes act as disease determinants and drive multihost compatibility.

Mauricio Contreras reposted

Mauricio Contreras reposted

Mauricio Contreras reposted

Mauricio Contreras reposted

🚨 Please share! 🚨 I'm recruiting a fully funded 4-year Gatsby Sainsbury PhD studentship at Durham! 🌱🤖 Designing plant immune receptors from scratch, combining AI protein design with structural biology and plant immunity. If you're interested please get in touch! benthamlab.org shorturl.at/U2PdV

benthamlab.orgBentham Lab — Durham UniversityBentham Lab, Centre for Programmable Biological Matter, Durham University. Structural biology and de novo protein design applied to host-pathogen interactions, plant immunity, and neglected tropical d...

Mauricio Contreras reposted

Mauricio Contreras reposted

🚨Reminder: Our next Legends of IS-MPMI webinar with @jonathandgjones.bsky.social is TOMORROW! The webinar is completely free and open to the public. Register using the link below👇, don't miss out!

Plant-Microbe enthusiasts! The next Road to Jeju Legends of ISMPMI series speaker is Jonathan Jones. The webinar is free to attend, but you must register: uchicago.zoom.us/webinar/regi... Attend live on September 30, 2026 3pm UTC or watch it later on the ismpmi.org.

Mauricio Contreras reposted

Nominations are open for IS-MPMI’s 2027 Early Career Achievement Award​​ and the Outstanding Achievement Award. These awards recognize the outstanding science, teaching, mentoring, outreach, and service to the community of our members​. Nominate by 1 Dec, 2026. ismpmi.org/events/congr....

ismpmi.orgAwards - IS-MPMINominations for the 2027 Awards are Open! IS-MPMI’s 2027 awards recognized the outstanding service, scientific innovations, and significant accomplishments of our members​ with the Early Career Achiev...

Mauricio Contreras reposted

We are crowdfunding for a bench in a peaceful spot at Winterbourne Botanic Garden in Birmingham in memory of Philippa Borrill. Please share widely. Please email me or @drelunadiez.bsky.social for more details. 💚🌾🌿🌳 If you would like to contribute, the link is below ⬇️.

Mauricio Contreras reposted

Our story on DELLA in Marchantia paleacea is now published (including few updates): doi.org/10.1111/nph.... Thanks again to all co-authors!! #PlantScience

doi.orgStepwise evolution of the developmental and symbiotic functions of <fc>DELLA</fc> in land plantsProposed model for the stepwise evolution of DELLA functions in the green lineage.
Katharina Melkonian@katharinamel1.bsky.social

1/ ✨ New preprint alert ✨ It is my pleasure to share: "Stepwise evolution of the developmental and symbiotic functions of DELLA in land plants" Here we investigated the role of the single GRAS transcription factor DELLA in #MyMarchantia doi.org/10.64898/202... #PlantScience A thread...

Mauricio Contreras reposted

Mauricio Contreras reposted

Mauricio Contreras reposted

Mauricio Contreras reposted

ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...

Mauricio Contreras reposted

Think the proteasome & its regulation is highly conserved? Think again🔄 Our new preprint (🧵 by lead author @glangin.bsky.social 👇) reveals how gene expansion, regulatory diversification & stress-responsive specialization shaped the evolution of the proteasome in 🌱 www.biorxiv.org/content/10.6...

biorxiv.orgGene repertoire expansion and cis-regulatory diversification shaped 26S proteasome evolution within a proteostasis-centered networkThe 26S proteasome is essential for proteostasis and constitutes one of the most conserved molecular machineries in eukaryotes. Its homeostasis is maintained by a mechanistically conserved feedback lo...
Gautier Langin@glangin.bsky.social

Preprint Alert! 🚨 Have you ever wondered how highly conserved molecular complexes adapted to ever changing cellular environments? Thrilled to show our work on 26S proteasome evolution in the green lineage. 🌱🧬👇 www.biorxiv.org/content/10.6... A thread🧵

Mauricio Contreras reposted

The PhD and Postdoc application links are now live! Come join me at UNIL to work on deep learning for protein structure, interactions & design. pickybinders.org#open-positions

career5.successfactors.euCareer Opportunities: PhD student position in deep learning for enzyme structure & catalysis (22980)
Janani Durairaj (Jay)@ninjani.bsky.social

Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!