Pinned
As seen on @biorxivpreprint.bsky.social: our story on how the dreaded late blight pathogen hijacks a helper NLR pathway is now out in its final form! 🎉 Meet AVRcap1b: the two-faced effector 🧵👇 www.science.org/doi/10.1126/...
Mauricio Contreras
@mpcontreras.bsky.social
Group Leader at @zmbp-tuebingen.bsky.social NLR and effector biology Board Member @ISMPMI.bsky.social 🇦🇷🇮🇹🇨🇺
1K followers375 following82 posts
Pinned
As seen on @biorxivpreprint.bsky.social: our story on how the dreaded late blight pathogen hijacks a helper NLR pathway is now out in its final form! 🎉 Meet AVRcap1b: the two-faced effector 🧵👇 www.science.org/doi/10.1126/...
Mauricio Contreras reposted
Professorship Experimental Plant Biochemistry. Tübingen, Germany. #plantscijob #plantscijobs #plantsciencejob www.academics.de/jobs/w3-prof...
Mauricio Contreras reposted
Agrobacterium-mediated transient expression has revolutionized plant research, but is largely confined to solanaceous species. This study shows that an engineered strain allows efficient transient expression across diverse dicot crop species. 🧪 #AcademicSky #plants plos.io/3W0hqlP
Mauricio Contreras reposted
Haven't used this is in a while, but a new paper from the group is a good excuse. This is monster of a paper from Sebastian Kaiser about the evolution of non-ribosomal peptides. www.nature.com/articles/s41...
Mauricio Contreras reposted
Kicking off day 2 of #ICBPI in Nanjing, the legendary @parkergroup.bsky.social talking about plant TIR domain signaling!
Now @dianagdlc.bsky.social presenting her beautiful story on effector recognition via molecular mimicry in a barley NLR. Their findings enabled engineering of multiple pathogen recognition in one receptor! www.science.org/doi/10.1126/...
Mauricio Contreras reposted
Less than 5% chance!!! Come on @erc.europa.eu We need to find a solution. Otherwise, we will lose a generation of young researchers.
Mauricio Contreras reposted
New research. Conveniently, Marchantia has relatively few transcription factors. Yet, we need to leverage on that at the family scale to have a more comprehensive picture. In this paper, we focused on ERFs, the second largest TF family. #PlantScience www.biorxiv.org/content/10.6...
Mauricio Contreras reposted
Excited to share this bioRxiv where we identify another host target for a Magnaporthe effector. Here we characterise the interaction between the zinc finger fold effector (Tie1) to a conserved family of transcription factors called the Tubby-like F-box proteins (TLPs) www.biorxiv.org/content/10.6...
Mauricio Contreras reposted
🌱 How do plants read chitin length? The receptor CHIP13 works like a molecular measuring tape. What began 13 years ago with a recalcitrant protein is now in @science.org. Thanks to all my co-authors and colleagues! doi.org/10.1126/scie...
Mauricio Contreras reposted
LoL-align is out in @natmethods.nature.com! It aligns protein structures without superposition. More sensitive than TM-align and DALI, producing better alignments 5–20× faster. Now available in Foldseek! 📄 www.nature.com/articles/s41... 💾 github.com/steineggerlab/foldseek 🌐 search.foldseek.com
Mauricio Contreras reposted
Anyone brave enough for an adventure in the uncharted waters of plant immunity and cell biology? We have a PhD studentship available as part of the NRP DTP - join us! biodtp.norwichresearchpark.ac.uk/projects/how...
Mauricio Contreras reposted
🚨 TOMORROW! Rising Stars of IS-MPMI self-nominations close 14 Oct. Early-career? Put yourself forward: a speaking slot in our 18 Nov webinar, and a shot at a plenary talk + funded travel to Jeju 2027. Apply with the link! 👇 docs.google.com/forms/d/e/1F...
Mauricio Contreras reposted
📣 Applications are now OPEN for the John Innes Foundation Rotation PhD Programme This 4-year #PhD programme trains graduate students in Plant & Microbial Sciences @earlhaminst.bsky.social @johninnescentre.bsky.social @thesainsburylab.bsky.social ➡️https://okt.to/qjy60T 🗓️ Apply before 12 Nov '26
Mauricio Contreras reposted
A helper NLR monitors catalytic perturbation of a vesicle trafficking regulator targeted by pathogen effectors https://www.biorxiv.org/content/10.64898/2026.10.06.757045v1
Mauricio Contreras reposted
Convergent recognition of tobamovirus movement proteins by phylogenetically distinct NLR immune receptors https://www.biorxiv.org/content/10.64898/2026.10.05.756766v1
Mauricio Contreras reposted
This Is What 20 Years of Science Looks Like | Kamoun Lab Tribute Twenty years. More than a hundred people. One long-running obsession: how plants and their pathogens fight it out. #KamounLab #PlantPathology #PlantScience #OpenScience #TSL #Norwich #LabLife youtu.be/ZJtN6OBqA6Y?...
Mauricio Contreras reposted
Plant Microbe Enthusiasts! Register for our next FREE Road to Jeju Legends in IS-MPMI Webinar featuring Eva Kondorosi, happening October 28, 2026: uchicago.zoom.us/webinar/regi...
Mauricio Contreras reposted
🌱New preprint 🎉 I am happy to share this last work of my PhD research! We uncover a novel role of cysteine protease RD19 in immunity. RD19 regulates RBOHD-generated ROS and is required for induced resistance responses. www.biorxiv.org/content/10.6... More details in the thread below! 🧵
Mauricio Contreras reposted
Effector-host networks in the barley powdery mildew pathosystem reveal significant targeting of ubiquitin-associated proteins and transcriptional regulators https://www.biorxiv.org/content/10.64898/2026.10.01.756047v1
Mauricio Contreras reposted
#plantsci Assistant Professor position in Canada🇨🇦 www.academicwork.ca/jobs/tenure-... Heard from a colleague that it is a very supportive department!
Mauricio Contreras reposted
Great to present a major update to our manuscript: www.biorxiv.org/content/10.6... In collaboration with @grandpahiro.bsky.social, @sara-stolze.bsky.social, Matthieu Platre & the teams of Götz Hensel & Gunther Döhlemann we demonstrate that….. (1/x)
Mauricio Contreras reposted
Our story with @hobbslabutah.bsky.social discovering CBASS sensing of phage proteases out now in @science.org New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo www.science.org/doi/10.1126/...
After >10 years of our lab studying bacterial cGAS-like enzymes, @hobbslabutah.bsky.social finally reconstitutes viral sensing in vitro and discovers how these ancient receptors sense phage protease enzymes to detect virion assembly and activate antiviral immunity www.biorxiv.org/content/10.6...
Mauricio Contreras reposted
Rice blast fungus hijacks a rice RALF peptide to initiate infection https://www.biorxiv.org/content/10.64898/2026.09.30.754903v1
Mauricio Contreras reposted
5 years ago, @hacquardst.bsky.social and I became very interested in 𝑃𝑙𝑒𝑐𝑡𝑜𝑠𝑝ℎ𝑎𝑒𝑟𝑒𝑙𝑙𝑎 𝑐𝑢𝑐𝑢𝑚𝑒𝑟𝑖𝑛𝑎, an emerging fungal pathogen that colonizes the roots of many plants 🌱 🍅 🌾 🆕📝 Final result of a huge team effort to uncover the bases of its multi-host compatibility👇 www.nature.com/articles/s41...
Mauricio Contreras reposted
Very excited to share the first preprint from my PhD with the community! This is also the first paper from the Plant Immunogenomics group with @galofir.bsky.social, so stay tuned for more! www.biorxiv.org/content/10.6... 1/n 🧵
Mauricio Contreras reposted
Exciting News! Sophien Kamoun to give the Opening Keynote Lecture at the 2027 IS-MPMI Congress in Jeju Korea (18-22 July 2027). ismpmi.org/events/2027-...
Mauricio Contreras reposted
Did you miss yesterday's fantastic Legends of IS-MPMI webinar with @jonathandgjones.bsky.social? You can watch the whole thing on our YouTube channel! 👇 youtu.be/yynU5Bu8BRM?...
Mauricio Contreras reposted
Now out! Together with Kenneth Berendzen, Yu Zhou et al., in a commendable team effort, set up a FANS-FAPS protocol for the isolation of plant Cajal bodies @zmbp-tuebingen.bsky.social — revealing kingdom-specific protein composition: academic.oup.com/nar/article/...
Mauricio Contreras reposted
Pathway to Independence – an interview with Josep Mercadal In this interview, @josepmercadal.bsky.social talks about the importance of interdisciplinary diversity for developmental biology, as well as his hopes and plans for his future lab. doi.org/10.1242/dev....
Mauricio Contreras reposted
🚨 Please share! 🚨 I'm recruiting a fully funded 4-year Gatsby Sainsbury PhD studentship at Durham! 🌱🤖 Designing plant immune receptors from scratch, combining AI protein design with structural biology and plant immunity. If you're interested please get in touch! benthamlab.org shorturl.at/U2PdV
Mauricio Contreras reposted
9 researchers from Latin America and the Caribbean (LAC), including 4 Colombians awarded #ERCStg2026. euraxess.ec.europa.eu/worldwide/la... and if I get this right, 97 LAC in total have been awarded ERC grants: euraxess.ec.europa.eu/worldwide/la...
Mauricio Contreras reposted
🚨Reminder: Our next Legends of IS-MPMI webinar with @jonathandgjones.bsky.social is TOMORROW! The webinar is completely free and open to the public. Register using the link below👇, don't miss out!
Plant-Microbe enthusiasts! The next Road to Jeju Legends of ISMPMI series speaker is Jonathan Jones. The webinar is free to attend, but you must register: uchicago.zoom.us/webinar/regi... Attend live on September 30, 2026 3pm UTC or watch it later on the ismpmi.org.
Mauricio Contreras reposted
Nominations are open for IS-MPMI’s 2027 Early Career Achievement Award and the Outstanding Achievement Award. These awards recognize the outstanding science, teaching, mentoring, outreach, and service to the community of our members. Nominate by 1 Dec, 2026. ismpmi.org/events/congr....
Mauricio Contreras reposted
We are crowdfunding for a bench in a peaceful spot at Winterbourne Botanic Garden in Birmingham in memory of Philippa Borrill. Please share widely. Please email me or @drelunadiez.bsky.social for more details. 💚🌾🌿🌳 If you would like to contribute, the link is below ⬇️.
Mauricio Contreras reposted
Our story on DELLA in Marchantia paleacea is now published (including few updates): doi.org/10.1111/nph.... Thanks again to all co-authors!! #PlantScience
1/ ✨ New preprint alert ✨ It is my pleasure to share: "Stepwise evolution of the developmental and symbiotic functions of DELLA in land plants" Here we investigated the role of the single GRAS transcription factor DELLA in #MyMarchantia doi.org/10.64898/202... #PlantScience A thread...
Mauricio Contreras reposted
Our interdisciplinary collaboration with Stephanie Kath-Schorr group characterizes Thio-pRib-AMP, an enhanced derivative of a natural plant nucleotide immune second messenger. Thio-pRib-AMP leaf spray increases plant disease resistance. Check it out: doi.org/10.21203/rs....
Mauricio Contreras reposted
Synthetic FLS2 receptor oligomer boosts plant innate immunity | Science Advances www.science.org/doi/10.1126/...
Mauricio Contreras reposted
Check out our new preprint: a very cool fluorescence tool developed by @samwalds.bsky.social www.biorxiv.org/content/10.6...
Mauricio Contreras reposted
Two seemingly unrelated sides of our lab collided today in the AWESOME new Angiosperm Phylogeny Group system poster: flowers 🌸 and phylogenomics 🧬 Need a new genome? Just pick up the phone and “dial-a-genome” 📞🧬 @getgenome.bsky.social www.tudelft.nl/en/hortus-bo...
Mauricio Contreras reposted
Replying to @davidjhoey.bsky.social
For actually constructing phylogenetic trees, I have compiled this separate repository which I have written over several years with advice and best practices for constructing phylogenetic trees. Any feedback on this is also welcome! github.com/davidjhoey/p...
Mauricio Contreras reposted
The Department of Plant and Microbial Biology at UC Berkeley currently has two open Assistant Professor positions (aprecruit.berkeley.edu/JPF05382 & aprecruit.berkeley.edu/JPF05522). Interested individuals are welcome to apply to one or both searches.
Mauricio Contreras reposted
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...
Mauricio Contreras reposted
Think the proteasome & its regulation is highly conserved? Think again🔄 Our new preprint (🧵 by lead author @glangin.bsky.social 👇) reveals how gene expansion, regulatory diversification & stress-responsive specialization shaped the evolution of the proteasome in 🌱 www.biorxiv.org/content/10.6...
Preprint Alert! 🚨 Have you ever wondered how highly conserved molecular complexes adapted to ever changing cellular environments? Thrilled to show our work on 26S proteasome evolution in the green lineage. 🌱🧬👇 www.biorxiv.org/content/10.6... A thread🧵
Mauricio Contreras reposted
The PhD and Postdoc application links are now live! Come join me at UNIL to work on deep learning for protein structure, interactions & design. pickybinders.org#open-positions
Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!
Mauricio Contreras reposted
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
Mauricio Contreras reposted
6 years later, he has an ERC... @delaconcepcionjc.bsky.social uni-tuebingen.de/universitaet...