CAP-IT

CAP-IT

@ncicapit.org

Official Account of the National Cancer Institute Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) Network. www.ncicapit.org

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CAP-IT
@ncicapit.org

Launched by the National Cancer Institute in 2021, Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) aims to develop a network for collaborative research in precision cancer prevention and interception. More info: t.ly/wlcI_ or ncicapit.org.

t.lyCancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT)The Cancer Prevention-Interception Targeted Agent Discovery Program (CAP-IT) is a collaborative research network with the goal of discovering targeted agents to
CAP-IT
@ncicapit.org

At today’s hashtag#CAPITSCMeeting, Dr. Shizuko Sei thanked outgoing SC Chair Dr. Yong Li for his contributions to the network and welcomed incoming Chair Dr. Margie Clapper, who shared brief remarks.

CAP-IT
@ncicapit.org

Dr. Sei provided NCI updates, while WG Chairs Drs. Alan Hutson and Clapper highlighted recent activities and upcoming plans.

CAP-IT
@ncicapit.org

Dr. Warren Casey, Director of the NIH Office of Research Innovation, Validation, and Application (ORIVA), presented NIH efforts to advance human-based science, an important and timely topic for many investigators and helped clarify common questions and misconceptions.

CAP-IT
@ncicapit.org

New #CAPITPublication! Congratulations to Dr. Margie Clapper and Dr. Erica Golemis and colleagues on their new review, “Recent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD),” published in Cancer and Metastasis Reviews. pmc.ncbi.nlm.nih.gov/articles/PMC...

pmc.ncbi.nlm.nih.govRecent advances in etiology and treatment of von Hippel-Lindau Disease (VHLD)Von Hippel-Lindau disease (VHLD) is a rare autosomal dominant disease, occuring in ~ 1 in 35,000 individuals. Overall, individuals with inherited mutations in the VHL tumor suppressor gene are predisp...
CAP-IT
@ncicapit.org

Take a listen to the first episode of #CAPITPodcast! 🔗https://capit.riverside.com Dr. Margie Clapper of talks with Erica Kirschner of in a candid, touching, and inspiring conversation about living with hereditary cancer risk, and the promise of cancer prevention and interception.

CAP-IT
@ncicapit.org

Worth revisiting: “NCI Resources for Cancer Immunoprevention Research,” published in Cancer Immunology Research, highlights NCI-supported resources available to advance cancer immunoprevention research. aacrjournals.org/cancerimmuno...

aacrjournals.orgNCI Resources for Cancer Immunoprevention ResearchAbstractCancer prevention and early detection, the first two of the eight primary goals of the National Cancer Plan released in April 2023, are at the forefront of the nation's strategic efforts to re...

CAP-IT reposted

Cancer Cell
@cp-cancercell.bsky.social

Subclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapy

dlvr.itSubclinical cholestasis is a hallmark of gut dysbiosis causing resistance to cancer immunotherapyMallard de La Varende et al. demonstrate that gut dysbiosis impairs tumor immunosurveillance through the gut-liver axis, causing subclinical cholestasis and immunotherapy resistance in tumors distant from gastrointestinal and hepatic tissues. Gut dysbiosis triggers plasma elevation of γ-glutamyl transferase, increase in TCDCA in humans (TMCA in mice), and drop in sMAdCAM-1 levels.
CAP-IT
@ncicapit.org

At today's #ARTNetSCMeeting, co-chair Dr. Alan Hutson of @roswellpark.bsky.social provided updates on ARTNet's recent activities and upcoming initiatives. Associate member Dr. Jennifer Wargo shared advances on how the microbiome shapes cancer development, immune responses, & immunotherapy outcomes.

CAP-IT
@ncicapit.org

Congratulations to Dr. Yong Li on his appointment as the inaugural Director of Molecular Oncology & Cellular Therapeutics and the inaugural holder of the Paul and Linda DeBruce Endowed Chair in Cancer Immunotherapy at @childrensmercy.org! 🎉 news.childrensmercy.org/childrens-me...

news.childrensmercy.orgChildren’s Mercy Names Yong Li, Ph.D. To Lead New Program Expanding Hope and Treatment Options for Children Facing Cancer and Other Serious DiseasesFamilies facing childhood cancer and other life-threatening illnesses need more than today’s treatments—they need hope for what’s next. To help bring new possibilities to children and their families, ...
CAP-IT
@ncicapit.org

At today’s #CAPITSCMeeting, Dr. Alan Hutson provided updates on the DRCC and the Bioinformatics WG. Dr. Margie Clapper shared progress from the Resource Sharing WG. Dr. Fenghuang Zhan of UAMS presented “Advances in CAR-T Immune Therapy: Targeting Tumor Cells and Environmental Cells in Myeloma.”

CAP-IT
@ncicapit.org

The June 2026 CAP-IT Newsletter is now live, featuring: 🔹 CAP-IT Summit highlights 🔹 Patient advocate panel discussion 🔹 U54 Center and DRCC progress updates 🔹 Recent network achievements and activities Read the full newsletter: indd.adobe.com/view/f35dd5b...

CAP-IT
@ncicapit.org

We have built an AI for Cancer Webinar Catalog — a curated collection of artificial intelligence webinars gathered from publicly available sources across a wide range of academic, industry, and professional organizations. Explore the catalog here: ncicapit.org/en/resources...

CAP-IT
@ncicapit.org

At today’s Bioinformatics & Computational Biology #CAPITWGMeeting, WG Chair Dr. Alan Hutson of @roswellpark.bsky.social k provided working group updates, and Dr. Li Zhang of Fox Chase Cancer Center presented on “Bayesian Compositional Models for Analyzing Microbiome Data.”

CAP-IT
@ncicapit.org

Save the date! The #CAPITSummit is happening on March 30, 2026. A full day of science, strategy, and community—bringing together researchers, clinicians, and advocates to advance cancer prevention and interception. Register now and join us: tinyurl.com/5c6snwyz

tinyurl.comRegistration for the NCI CAP-IT Annual Summit: March 30, 2026The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...
CAP-IT
@ncicapit.org

Save the date! The hashtag#CAPITSummit is happening on March 30, 2026. A full day of science, strategy, and community - bringing together researchers, clinicians, and advocates to advance cancer prevention and interception. Register now and join us: tinyurl.com/5c6snwyz

tinyurl.comRegistration for the NCI CAP-IT Annual Summit: March 30, 2026The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

CAP-IT reposted

Cancer Cell
@cp-cancercell.bsky.social

Rewiring natural killer cells for next-generation cancer therapies

dlvr.itRewiring natural killer cells for next-generation cancer therapiesHarnessing the cytotoxic potential of natural killer (NK) cells for cancer immunotherapy has proven challenging. In this issue of Cancer Cell, Biederstädt et al. and Nikolic et al. utilize genome-wide CRISPR screening to uncover novel regulators of NK cell function, paving the way for developing next-generation NK cell therapies.
CAP-IT
@ncicapit.org

At today’s #CAPIT Bioinformatics & Computational Biology WG meeting, Dr. Chi Zhang of University of Nebraska - Lincoln presented his work on AI-powered image feature extraction and data synthesis in pancreatic cancer.

CAP-IT
@ncicapit.org

A personalized neoantigen vaccine + Montanide/poly-ICLC/ipilimumab reshapes the T cell landscape in melanoma patients: - Strong CD8+ responses - TCR repertoires expanded beyond anti–PD-1 - Vaccine-specific TILs identified post-treatment www.cell.com/cell/abstrac...? #Neoantigen #Melanoma #Tcells

cell.comA multi-adjuvant personal neoantigen vaccine generates potent immunity in melanomaA personalized neoantigen peptide vaccine formulated with Montanide plus poly-ICLC and administered with local ipilimumab plus systemic nivolumab induces robust neoepitope-specific T cell responses an...
CAP-IT
@ncicapit.org

New in @cellcellpress.bsky.social : Exercise boosts immune checkpoint inhibitor (ICI) efficacy in #Melanoma via microbiota-derived formate, which enhances CD8⁺ T cell immunity through Nrf2 activation. cell.com/cell/abstrac... #Immunotherapy #Microbiome #CancerResearch

cell.comExercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacyExercise enhances antitumor immunity and immunotherapy effectiveness by increasing microbiota-derived formate, which boosts CD8 T cell function and may serve as a biomarker of melanoma suppression.

CAP-IT reposted

Nature Reviews Clinical Oncology
@natrevclinonc.nature.com

Now online!

nature.comEHA–EMN Evidence-Based Guidelines for diagnosis, treatment and follow-up of patients with multiple myelomaNature Reviews Clinical Oncology, Published online: 07 July 2025; doi:10.1038/s41571-025-01041-xIn these Evidence-Based Guidelines, a multidisciplinary panel of experts from the European Hematology Association and the European Myeloma Network provide key treatment recommendations for patients with smouldering multiple myeloma, and newly diagnosed or relapsed and/or refractory multiple myeloma, addressing the use of established drugs and novel immunotherapies as well as the management of disease-specific and treatment-related complications and adverse events.
CAP-IT
@ncicapit.org

New study in Cell: HIF upregulates endogenous retroviruses in clear cell kidney cancer, generating tumor-specific antigens. ERV-targeting T cells show promise for immunotherapy and HIF stabilizers may unlock similar responses in other tumors. #CAPITPublication pubmed.ncbi.nlm.nih.gov/40023154/

pubmed.ncbi.nlm.nih.govHIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy - PubMedClear cell renal cell carcinoma (ccRCC), despite having a low mutational burden, is considered immunogenic because it occasionally undergoes spontaneous regressions and often responds to immunotherapi...
CAP-IT
@ncicapit.org

We’re excited to announce that the CAP-IT Virtual Annual Summit will be held on July 24, 2025! Register here: docs.google.com/forms/d/e/1F... For more information, visit : ncicapit.org or email: CAP-IT@nih.gov #CancerPrevention #NCICAPIT

docs.google.comRegistration for the NCI CAP-IT Annual Summit: July 24, 2025The upcoming NCI CAP-IT Summit is set to convene a diverse mix of participants, including senior leaders, experts, and emerging talents such as junior investigators and trainees, all dedicated to the ...

CAP-IT reposted

Nature Reviews Cancer
@natrevcancer.nature.com

REVIEW 🚨 Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development + clinical translation continue to face challenges. Here, Zaidi, Jaffee & Yarchoan summarize this & highlight advances in the field. 📖 👇

bit.lyRecent advances in therapeutic cancer vaccines - Nature Reviews CancerCancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development and clinical translation continues to face challenges. Here, Zaidi, Jaffee and Yarchoan summarize the failures of cancer vaccines of the past, to highlight recent advancements in the field.