Olov Andersson

Olov Andersson

@o-andersson-lab.bsky.social

organogenesis, islet biology, regeneration, zebrafish, diabetes and associated diseases https://www.uu.se/en/department/medical-cell-biology/research/research-groups/olov-andersson

276 followers255 following21 posts

Olov Andersson
@o-andersson-lab.bsky.social

In case you are interested in (re)generation of insulin-producing cells, check out this preprint and our perspective @jiaruimi.bsky.social @zebrafishrock.bsky.social @uu.se

Development@dev-journal.bsky.social

In preprints – ‘slow & steady’ versus ‘fast & ready’ (re)generation of insulin-expressing cells in #zebrafish @o-andersson-lab.bsky.social & co discuss a preprint by Gräßlin & co that extends knowledge of cellular conversions in the pancreas, based on single-cell transcriptomics & epigenetics.

journals.biologists.comIn preprints – ‘slow and steady’ versus ‘fast and ready’ (re)generation of insulin-expressing cells in zebrafish | Development | The Company of Biologists

Olov Andersson reposted

Spagnoli_Lab.
@labspagnoli.bsky.social

🚨We are #hiring! Excited to welcome a talented #postdoc to join the lab. and be part of an interdisciplinary research program #Type1DiabetesGrandChallenge -- harnessing #pancreas #development for #stem cell therapy of #diabetes. 🧫🧪🔬 Join us! Apply before 23 July. ⤵️ my.corehr.com/pls/coreport...

Olov Andersson reposted

Christian Mosimann
@chrmosimann.bsky.social

*** GRC Developmental Biology 2027 - Jan 17-22 @ Renaissance Tuscany Il Ciocco Resort *** Join us for a fabulous 2027 Gordon Conference on all things #devbio & the trainee-led GRS! More info on registration, abstract submission, et al., here: www.grc.org/developmenta... #GRCDevBio2027 🧬🐭🐟🪰🌱❤️

Olov Andersson reposted

John F. Rawls
@jfrawls.bsky.social

Two new articles from our lab!! Davis et al identified epithelial transcription factor ELF3 as a key mediator of host-microbiota interaction in zebrafish tinyurl.com/pkavnxdp Morash et al revealed enteroendocrine cell subtypes in zebrafish & catalogued their peptide hormones tinyurl.com/bdzbm2xm

tinyurl.comIdentification of intestinal enteroendocrine cell subtypes and their associated hormones in zebrafishEnteroendocrine cells (EECs) in the gut epithelium secrete diverse hormones that regulate digestion, energy use, and behavior. This study identifies EEC subtypes and their hormone profiles in zebrafis...

Olov Andersson reposted

Diabetologia
@diabetologiajnl.bsky.social

Bri2 BRICHOS domain inhibits cytotoxic IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress. #T1D #SC-islets #CellTherapy link.springer.com/article/10.1... 🔓

link.springer.comBri2 BRICHOS domain inhibits IAPP amyloid formation and improves beta cell function in stem cell-derived islets under metabolic stress - DiabetologiaAims/hypothesis Accumulation of islet amyloid polypeptide (IAPP) and amyloid formation is associated with beta cell dysfunction and cell death in human islets and may also contribute to graft failure ...

Olov Andersson reposted

Daniel Drucker
@danieljdrucker.bsky.social

Deadlines are approaching (some next week!) for @keystoneSymposia.bsky.social #IsletBiology & #Diabetes : #BetaCell Compensation, Failure & Recovery, this March in Breckenridge! See scholarship, abstract and discount reg dates: keysym.us/KSDiabetes26 #KSDiabetes26

keysym.usIslet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery | Keystone SymposiaJoin us at the Keystone Symposia on Islet Biology and Diabetes: Beta Cell Compensation, Failure and Recovery, March 2026, in Breckenridge, with field leaders!

Olov Andersson reposted

Christos Karampelias
@ckarampelias.bsky.social

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

embopress.orgBenchmarking porcine pancreatic ductal organoids for drug screening applications | EMBO Molecular MedicineimageimageState-of-the-art single-cell RNA sequencing and proteomics approaches were employed to benchmark porcine and human pancreatic ductal organoid systems for use as a drug screening and testing ...

Olov Andersson reposted

SinghLab@SNIoE
@singhlab.bsky.social

🚨 Just out in Nature Communications: Cholangiocytes contribute to hepatocyte regeneration after partial #liver #injury during growth in #zebrafish We challenge old assumptions on liver regeneration! 🔗 nature.com/articles/s41... 🧵(1/8)

nature.comCholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish - Nature CommunicationsDuring partial liver injury in growing zebrafish, cholangiocytes regenerate hepatocytes through transdifferentiation, revealing a stage-specific regeneration mechanism regulated by mTORC1 signaling.

Olov Andersson reposted

Dimitris Petroutsos
@petroutsoslab.bsky.social

Replying to @petroutsoslab.bsky.social

Bring your favourite model system and help advance our understanding of how living organisms interact with and adapt to their environment. Apply here: uu.varbi.com/en/what:job/...

uu.varbi.comAssistant Professor in Environmental PhysiologyUppsala University’s tenure track system grants assistant professors the possibility to be assessed for promotion to the position as associate professor. The university provides support in various a

Olov Andersson reposted

Eduardo Villablanca
@ejvillablanca.bsky.social

We’re excited to share our recently published story “A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as modulators of mucosal healing” in @mucosalimmunol.bsky.social Fantastic work led by @ramoralescastro.bsky.social ! www.mucosalimmunology.org/article/S193...

mucosalimmunology.orgA zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healingThe intestine is a semipermeable tissue responsible for the absorption of essential nutrients while limiting exposure to harmful environmental factors. To maintain these functions, the intestinal epit...

Olov Andersson reposted

Bagnat Lab
@bagnatlab.bsky.social

What an elegant study showing that the mode and shape of cell division is defined by interphase morphology! This work suggests how cell fate and morphological asymmetries can be propagated via cell division in tissues. www.science.org/doi/10.1126/... #academiasky

science.orgInterphase cell morphology defines the mode, symmetry, and outcome of mitosisDuring tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...
Olov Andersson
@o-andersson-lab.bsky.social

Great opportunity & startup for someone that wants to start their lab studying inflammation/immune system (perhaps in metabolism, diabetes or the islet...) external/international candidates are wanted: uu.varbi.com/en/what:job/...

uu.varbi.comAssociate Senior Lecturer (SciLifeLab Fellow) in inflammation researchThe Science for Life Laboratory (SciLifeLab) is a national center for leading edge technological infrastructures that supports large-scale data and hypothesis-driven research in the field of molecular
Olov Andersson
@o-andersson-lab.bsky.social

Amazing work on a DRiP neoantigen in beta-cells, where a protective SNP creating an IRE1 digestion motif and reducing the level of ER stress, DRiP, and type 1 diabetes... www.cell.com/cell/fulltex...

cell.comGenetic protection from type 1 diabetes resulting from accelerated insulin mRNA decayInsulin gene variation predisposes individuals to type 1 diabetes (T1D). We report a new mechanism of genetic protection from T1D in which insulin mRNA with a protective SNP is broken down by IRE1α, t...

Olov Andersson reposted

Anna Krook
@annakrook.bsky.social

Deadline extended to March 23!!👇

Anna Krook@annakrook.bsky.social

Don’t miss this unique meeting bringing together leading Swedish researchers and practitioners in diabetes to share the latest advancements in diabetes research 👉 lnkd.in/dbbh6vcd Hope to see you in Umeå!

Olov Andersson reposted

Christos Karampelias
@ckarampelias.bsky.social

Happy to share our work on pancreatic ductal organoids from the human-relevant pig model across developmental stages ranging from embryonic to adult animals and using them for drug screening applications from the @heikolickert.bsky.social lab. #PancSky #devbio 🧪🧬 www.biorxiv.org/content/10.1... /1

biorxiv.orgBenchmarking porcine pancreatic ductal organoids for drug screening applicationsPrimary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and disease. Yet, donor material availability, and a lack of extensive benchmarking limits the range ...

Olov Andersson reposted

KatajistoLab
@katajistolab.bsky.social

1/6 Proudly presenting Sharif’s @sharifiqbal.bsky.social paper on the role of Asporin in intestinal regeneration through TGF-B-dependent fetal-like reversion www.sciencedirect.com/science/arti... out in @cp-cellstemcell.bsky.social @pekka-katajisto.bsky.social @helsinki.fi @metastem.bsky.social 🧵

sciencedirect.comFetal-like reversion in the regenerating intestine is regulated by mesenchymal asporinMesenchymal cells and the extracellular matrix (ECM) support epithelium during homeostasis and regeneration. However, the role of the mesenchyme in ep…

Olov Andersson reposted

Di Jiang
@dijiang319.bsky.social

A new #evolution #EvoDevo #devbio #amphioxus #invertebrate paper this week @ScienceAdvances | Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates www.science.org/doi/full/10....

science.orgSingle-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordatesSingle-cell profiling of the amphioxus digestive tract reveals scattered distribution of three endocrine-like cell clusters.

Olov Andersson reposted

Zebrafish Rock! 🎃
@zebrafishrock.bsky.social

Notable inclusions include latests works of the Martik Lab, @sgraingerphd.bsky.social, @singhlab.bsky.social, @ditalialab.bsky.social, @o-andersson-lab.bsky.social, @blmartin.bsky.social, @tillymommersteeg.bsky.social, Megason Lab, Yelon Lab, Maves Lab, @thelovelylab.bsky.social among others!

the Node@the-node.bsky.social

📃January in preprints First preprint list of 2025 is out! Check out the #preprints in #DevBio, #StemCell biology (and related fields) that came out in January. Congrats to everyone involved 🎉 And as usual, let us know if we've missed anything 👀 thenode.biologists.com/january-in-p...

thenode.biologists.comJanuary in preprints - the NodeWelcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv – use these
Olov Andersson
@o-andersson-lab.bsky.social

Check out our review on beta-cell regeneration - special thanks to the great coauthors @ckarampelias.bsky.social et al #UppsalaUniversity #HelmholtzMunich www.nature.com/articles/s41...

nature.comMechanistic insights and approaches for beta cell regeneration - Nature Chemical BiologyThis Review highlights recent advances in the identification of small-molecule mediators of beta cell regeneration, discussing the diverse pathways and cellular processes altered by these compounds.

Olov Andersson reposted

SinghLab@SNIoE
@singhlab.bsky.social

Excited to share our latest work on #liver #regeneration in @biorxiv-devbio.bsky.social ! We uncover how cholangiocytes contribute to hepatocyte regeneration, even in the presence of spared hepatocytes, using our novel CellCousin model in #zebrafish: www.biorxiv.org/content/10.1... 🐟✨ A 🧵👇 (1/12)

biorxiv.orgCholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafishThe liver's regenerative ability depends on injury extent. Minor injuries are repaired by hepatocyte self-duplication, while severe damage triggers cholangiocyte involvement in hepatocyte recovery. Th...

Olov Andersson reposted

Richard Sever
@richardsever.bsky.social

2024 saw another record for bioRxiv postings. Thanks to all the CSHL staff, affiliates, authors, funders, and everyone who advocates for the project. Happy New Year and #letsmakethisthenorm ! 🧪

Olov Andersson reposted

Diabetologia
@diabetologiajnl.bsky.social

Up front & free to read in our Jan issue #editorspicks: Molecular mechanisms underlying glucose‑dependent insulinotropic polypeptide secretion in human duodenal organoids tinyurl.com/muc8sata

tinyurl.comMolecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoids - DiabetologiaAims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by enteroendocrine K cells in the proximal small intestine. This study aimed to explore the function ...

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