Brendan Harley

Brendan Harley

@profharley.bsky.social

#blacklivesmatter | #translivesmatter | 🍉 Harvard & MIT trained bioengineer Professor @ U. Illinois & Cancer Center at Illinois health | society | Imagination & discovery Partner @kateclancy.bsky.social | runner | dad | nerd

3.2K followers2.8K following659 posts

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George Floyd. Breonna Taylor. Ahmaud Arbery. Deeply ingrained, systemic racism is responsible for an incalculable loss & horrific suffering in our communities. I must do better. Listening, amplifying, celebrating, supporting, fighting. #BlackLivesMatter

Brendan Harley reposted

Your monthly reminder that if you're using ChatGPT to do your science, you're failing your colleagues, community, and all of us. Here, ChatGPT makes up data and presents it as the real thing — then apologizes when confronted.

Curious about strategies to study how glioblastoma cohorts interact with the vasculature in the brain? Come check out Dr. Payan's poster. Z4. Right now! #harleylab #bmes2026

Brendan Harley@profharley.bsky.social

Come check out some #HarleyLab work at #BMES2026 on Friday! Ali Nunes, superstar Research Scientist (who is applying to grad school this cycle): tissue models of craniofacial bone regeneration. Dr. Btirrany Payan, postdoc extraordinaire: granular hydrogel models of glioblastoma progression.

See you in Magnolia 78 at 9:15. Ali Nunes will share some really exciting work on developing an in vitro wound model to study graft integration #harleylab #bmes2026

Brendan Harley@profharley.bsky.social

Come check out some #HarleyLab work at #BMES2026 on Friday! Ali Nunes, superstar Research Scientist (who is applying to grad school this cycle): tissue models of craniofacial bone regeneration. Dr. Btirrany Payan, postdoc extraordinaire: granular hydrogel models of glioblastoma progression.

Brendan Harley reposted

As the person in my union who gets to handle grievances, can I just say that administrators should really stop trying to fuck with humanists. THEY ARE ARCHIVISTS. THEY ALWAYS HAVE RECEIPTS.

Come check out some #HarleyLab work at #BMES2026 on Friday! Ali Nunes, superstar Research Scientist (who is applying to grad school this cycle): tissue models of craniofacial bone regeneration. Dr. Btirrany Payan, postdoc extraordinaire: granular hydrogel models of glioblastoma progression.

Brendan Harley reposted

NEW: A ProPublica data analysis shows that delays resulting from USPS’ cost-cutting measures have endangered the validity of ballots mailed in rural areas. Counties that voted for Trump in 2024 have been most affected.

propublica.orgBallot Rejections Soared in Rural Counties After USPS Reduced Mail ServiceA ProPublica data analysis shows that delays resulting from the agency’s cost-cutting measures have endangered the validity of ballots mailed in rural areas. Counties that voted for Trump in 2024 have...

Brendan Harley reposted

Using single-cell distributions & multicellular spheroids, we report the impact of heterogeneous cell populations and metronomic TMZ dosing on drug response and migration. We show that the combination therapy of TMZ with an MGMT inhibitor, lomeguatrib, can modulate TMZ resistance in vitro.

This hydrogel model enables systematic investigation of GBM heterogeneity, phenotypic plasticity, & therapeutic resistance in an ECM microenvironment, offering a valuable platform for translational research. Appreciative of support from NIH (R01 CA256481, R01CA279195, R35 CA283859, T32 EB019944).

Dr. Victoria Kriuchkovskaia led this work to describe a tissue engineering approach to address cell heterogeneity. Glioblastoma (GBM) is the most common & aggressive primary brain tumor in adults. Temozolomide (TMZ) is the standard-of-care, but its efficacy is compromised by drug resistance.

To investigate the interplay between tumor heterogeneity, drug resistance, and the extracellular matrix (ECM) microenvironment, we adapted a 3D methacrylamide-functionalized gelatin (GelMA) hydrogel model to study the behavior of mixed populations of TMZ-sensitive and TMZ-resistant GBM cells.

Brendan Harley reposted

Together with other scientists I’m suing the 🇺🇸 US National Institutes of Health for violating our 1st Amendment rights & censoring our health science. I’m ready to shine a light on the darkest days. Buckle up, read on. This gets pretty wild… THREAD

ACLU@aclu.org

By terminating research grants like Kelton's to censor views it doesn’t like, the NIH is blocking scientists from work that would advance public health for all of us. We're pushing back. Tell Congress to demand the NIH restore the grants and stop its censorship campaign at aclu.org/nih_censorship_

Brendan Harley reposted

SCOOP: 'Tommy' from the now-viral exchange with Abdul El-Sayed is Thomas Teepell, a former staffer for Republican Senator Josh Hawley with close ties to Christian Nationalist Sean Feucht. He's the son of a former Bobby Jindal staffer whose consultant work was instrumental in getting Hawley elected.

thehandbasket.co'Tommy' from viral El-Sayed video is former Sen. Hawley staffer with Christian nationalist tiesThomas Teepell is the son of a former long-time Bobby Jindal staffer who's close to Sean Feucht.

Brendan Harley reposted

Replying to @kevinmkruse.bsky.social

I've spent nearly a decade researching and writing this book, so I'm going to be excited to show it off. I guess I could've fed my research into AI and had it quickly shit out something that sort of resembles a book. But it's not as good as the real thing and I don't get to take pride in the work.

Brendan Harley reposted

The people pushing this garbage are just untalented and lazy losers who assume the rest of us must be untalented and lazy losers too.

This post is unavailable.

Brendan Harley reposted

Replying to @kevinmkruse.bsky.social

Never thought I'd have to say this but there's an inherent joy in working hard at something, slowly getting better at it and taking pride in the results. And you'll find that other people will be impressed by the results of your dedication too, in a way they will not be impressed by your AI shit

Brendan Harley reposted

I swear to god so much of this is literally just people confusing measles and chicken pox

Aaron Rupar@atrupar.com

Minnesota Republican state Sen. Bill Lieske: "Back in the day when the measles vaccine didn't exist, measles was a joke! ... yes, there are increases cases. How many of those are actually resulting in deaths? Are they just going home with the sniffles? Back in the day, people had measles parties."

Brendan Harley reposted

Replying to @donmoyn.bsky.social

3. DOGE made false claims about employee performance in order to fire them, but did not want to put their names to these emails. So they would coerce civil servants into doing so. If the civil servants refused, they were fired. (Not just DOGE, other Trump appointees like Kash Patel did this).

Endometriotic lesions are often found on pelvic tissues and organs, especially the ovaries. We investigated the role of tissue tropism on endometrioma initiation. Cell origin (endometriotic vs non-endometriotic), substrate stiffness, & epithelial-stromal interactions shape attachment patterns.

We identify ovarian-specific motifs that significantly increase endometriotic (vs non-endometriotic) cell cohort attachment that may be implicated in early disease etiology. Appreciative of the support from NIH (R01 HD118600, T32 HD108075, R01 DK099528, R01 DK125471, R01 CA256481, & T32EB019944).

Trophoblast invasion into the decidualized endometrium is an important aspect of blastocyst implantation necessary for pregnancy. There are many processes involving the early implantation and invasion of trophoblast cells into the maternal decidua that are not well described. 2/3

We describe a microfluidic model of the trophoblast–endometrial interface used to quantify metrics of trophoblast cell invasion, endothelial cell motility, and the influence of decidualization hormones on these processes. Appreciative of the support from NIH (R01 HD118600 and T32 HD108075). 3/3

Brendan Harley reposted

Looking forward to the same scrutiny being impartially applied to Elon Musk and Melania Trump, whose immigration documents are much much worse than anything alleged about Omar's father

Dante Atkins@danteatkins.bsky.social

When Dems talk about the Ilhan Omar situation, they need to stop using language that implies that Omar might have done anything wrong. Trump is not "investigating" Omar. They are trying to denaturalize and deport a sitting Congressmember by scrutinizing decades old paperwork from when she was a kid

💯

Itai Yanai@itaiyanai.bsky.social

1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research!

Brendan Harley reposted

This quote exactly describes our current USA science policy right now. I was stopped in my tracks while listening this morning. Please educate yourself about what is happening. The destruction of USA science is horrific under this administration.

Jeremy Berg@jeremymberg.bsky.social

@noamross.net on NPR this morning. www.npr.org/2026/10/09/n... "I am always enthusiastic about more investment into science, but you could think of this as someone planting a tree somewhere where THEY just burned down a forest. We've lost so much scientific investment under this administration."

Brendan Harley reposted

Replying to @lmesseri.bsky.social

strong statement from the Association for Human Mathematicians. "Releasing over 700 files at once is not a demonstration of scholarship, but a demonstration of power. We urge mathematicians to discontinue their work with OpenAI and to return to a vision of science that centers human understanding."

ahmath.orgStatements — AHM

This guy went to Yale.

Action News 5@actionnews5.com

Florida Governor Ron DeSantis called the name of Hurricane Isaias "weird," and said he plans on calling it Isaiah. Preparations for Hurricane Isaias are underway across parts of the Gulf Coast as the storm is expected to bring strong winds and life-threatening storm surge.