Anuj

For decades, how methanogenic archaea activate the MCR complex to produce methane remained a mystery. Today in Nature, we report the high-resolution cryo-EM structure of the MCR activation complex! www.nature.com/articles/s41...

We wrote a short Spotlight article in @cp-trendsmicrobiol.bsky.social to highlight the wonderful work from @rhyswg.bsky.social and @ashleighkropp.bsky.social www.cell.com/trends/micro...

Congratulations to the winners of best PhD talk @ #MAdLand2026 from right to left: @caeciliafkunz.bsky.social from @jandevries.bsky.social lab, who won @theplantjournal.bsky.social award 🌱 @thanahartmann.bsky.social from Schuller lab and @hannahlepper.bsky.social from @franzificht.bsky.social lab

So happy to see this paper finally out 🥳 it took only seven years after the first purification of archaeal peptidoglycan 🤣 Congrats to all the people involved 🥂🍾 And here is the story behind the paper: communities.springernature.com/posts/cracki...

A sad day. Ada's pioneering work on the ribosome changed how we understand one of the central machines of life. She is a remarkable example of curiosity and boldness in pursuing questions that seemed impossible. Her scientific courage and persistence has been an inspiration.

Powering methanogenesis from fatty acids by a twin-heme-mediated reverse redox-loop https://www.biorxiv.org/content/10.64898/2026.08.18.745454v1

One month left to apply!! 🧪 @biozentrum.unibas.ch seeks a group👩‍🔬 exploring molecular questions relevant to climate 🌍, including biogeochemical cycles (e.g., carbon, nitrogen) ♻️, bioenergetic energy conversion (e.g., photosynthesis, chemosynthesis) ☀️⚗️, and the adaptation to environmental change 🌊🌡️🦠🌾

PLEASE SHARE! New job openings in my lab @zmbp-tuebingen.bsky.social. We have a broad interest into the mechanistic basis of how molecular complexes are rewired during cellular development in plants and during invasion by pathogens. 🌱🍄🔬 See details below 👇 #PlantSciJobs

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

Who's interested in time-resolved serial crystallography on [FeFe]-hydrogenase?? Check out Moritz' new preprint: www.biorxiv.org/content/10.6...

The title says it all. Check out our preprint 👇👇👇👇

Nature research paper: Architecture of the 8 MDa Hdr–Vhu–Fwd super-assembly in class I methanogens go.nature.com/4h34dRD

Awesome work to determine the structure of a freakin 8MDa enzyme complex with over 600 FeS clusters! Sophia won the poster prize at the recent GRC C1 👏 www.nature.com/articles/s41...

Mother of all electron-bifurcating complexes is here! Congratulations to Sophia @sophia-pa.bsky.social for discovering and determining the structure of this mega assembly! You put in so much effort to get this paper published. I am so happy and proud of you and your achievement!

1/ Happy to share our preprint! The Mtr complex catalyses the second-to-last step of the methanogenesis and is an essential bioenergetic machine in most methanogenic archaea. Anaerobic cryo-EM of Mtr reveals a nitrogenase-like metallocluster bound at its active site! www.biorxiv.org/content/10.6...

Check out this latest work from @gyanaprakash.bsky.social on the structure of an electron bifurcating/confurcating hydrogenase from cyanobacteria!

1/7 New preprint: we found that Chlamydomonas carries a giant and unexpectedly elaborate chloroplast RNA polymerase with 12 previously unknown subunits, overturning the idea that the complexity of this organellar enzyme emerged during plant terrestrialization! www.biorxiv.org/content/10.6...

I’m extremely grateful for the ERC Advanced Grant – with the awarded 2.5 Mio EUR, we will tackle how electrodynamics effects control the energy currents of life. 🎉 🎉 🎉 www.su.se/english/news...

Excited to share our new preprint! 🧬❄️ by brilliant @mdreimann.bsky.social and great collaborators! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition #ArchaeaSky www.biorxiv.org/content/10.6...

Do you enjoy the thrill of discovery? Does this photo give you good vibes? Then you might be the right person to join our lab! Current projects range from chloroplast transcription to thylakoid membrane remodeling & we would be happy to welcome bright and motivated people at all career stages!

Very happy to share my first preprint from my PhD 🎉 doi.org/10.64898/202... We develop an αHL-based framework to engineer and quantify selective diffusion across synthetic membranes using controlled nanopore chemistry. 1/7

Cool to see our recent paper among the "Editors' Highlights" in @natcomms.nature.com that "aim to showcase the 50 best papers recently published" 🥰 www.nature.com/collections/...

Check out our latest paper – today out in JACS - on proton gates in the antiporter modules of Complex I! So proud of my amazing lab – Sofia Badolato, Sarah Rossmann & Hyunho Kim – and thank you @kawresearch.bsky.social for long-term support of our work. pubs.acs.org/doi/10.1021/...

Endlich wieder Massephase! 🙏🏻 Hier der Presseartikel für unsere neue Publikation: www.uni-potsdam.de/de/nachricht... @unipotsdam.bsky.social @unimarburg.bsky.social @schullerjm.bsky.social @natcomms.nature.com

Now online with @natcomms.nature.com 🤩 doi.org/10.1038/s414...

We just received funding for a 2yr postdoc position on cryoEM of fungal gpcrs. Official call will open soon. Contact me if you‘re interested!

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

Thanks for the fun collaboration into this fascinating “oil eating” biomachine. I learned a lot! 🧪 #TeamTomo

1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...

New preprint alert 🚨: Who actually drives methane production in anoxic sediments 🧬🔥? We point to a transcriptionally dominant 🦠 clade: VadinHA17. shorturl.at/Rijc0 @bledinadede.bsky.social @taylorpriest.bsky.social

Breathing both ways: simultaneous aerobic–anaerobic respiration in microbes

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

Highly recommended! Very cool science and great projects!

Check out the latest work on PSI:Cytc6 complex from Chlamy! many congratulations @gyanaprakash.bsky.social and @schullerjm.bsky.social #cryoem

I am truly honoured and delighted to receive the GBM #PhDAward from @gbmev.bsky.social Grateful to @schullerjm.bsky.social and Prof. Volker Müller for their continuous support and guidance! www.uni-marburg.de/en/prfolder-...

Carbonic anhydrase catalyses the interconversion of CO2 and HCO3- and helps increasing the net-CO2 concentration inside cells. Why? CO2-reducing enzymes like RuBisCO are notoriously slow and ineffective. However, import of HCO3- is typically coupled to ATP consumption...

This is a proud and exciting moment for me. Manon continues to redefine our understanding of pyrenoid biology, as she pushes the frontiers of #TeamTomo straight into the natural world around us 🌍🌊🌾🔬 Her new group at @gmivienna.bsky.social will explore fresh and impactful questions. Check it out! 🧪👩‍🔬

Stunning video installation by Isabell Bullerschen featuring our T. kivui #CryoET data 🧡 On view until April 19th at the HEK in #Basel! hek.ch/en/program/e...

A childhood dream has come true – I was appointed Full Professor for Sustainable Biotechnology at the University of Düsseldorf @hhu.de : tinyurl.com/f43s74hp and as Director of the Institute for Molecular Enzyme Technology (IMET, www.iet.uni-duesseldorf.de/en/) at FZ Jülich @fz-juelich.de .

Happy to share our new paper on proton transfer in metalloenzymes, out now in @pccp.rsc.org! Exploiting crystallography, electrochemistry, FTIR spectroscopy, and QM calculations we identified a Zundel ion in the catalytic proton tranfer pathway of [FeFe]-hydrogenase. doi.org/10.1039/D5CP...

New preprint by @alok-bharadwaj.bsky.social explaining the workings of SURFER, a simple tool to segment membrane, micelle or nanodisc densities in cryoEM maps. Try it via the @chimerax.ucsf.edu ToolShed: cxtoolshed.rbvi.ucsf.edu/apps/chimera... Despite LocScale in the name, it works on any map.

At long last, the Chlamy chloroplast ribosome hat 🎩 (now renamed the arm 💪) is here to say hello👋! We first spotted this extended structure in green algae a decade ago, and @florentwaltz.bsky.social did beautiful work bringing it into focus! #CryoEM ❄️ #TeamTomo 🔬 #PlantScience 🌾 #ProtistsOnSky 🧪

This is what I call a booster 🚀: Milton and colleagues use a novel, bipyridium-type redox mediator to increase the electrochemical H2 evolution activity of [FeFe]-hydrogenase by a factor of 10 compared to previous protocols. pubs.acs.org/doi/full/10....

An incredibly challenging single particle cryo-EM structure. Capturing both the N and C termini was difficult enough, but the project required a major effort to resolve the full length protein structure to capture the overall architecture of the KICSTOR-GATOR1 complex. Well worth it in the end!

I am very excited to share our new preprint - "A Zundel Ion in the Catalytic Proton Transfer Pathway of [FeFe]-Hydrogenase" - for which we revisited an older theory of ours, and came to surprising conclusions... 🧵 doi.org/10.26434/che...

Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...

Our latest work on the nitrogenase-like methylthio-alkane reductase, which specifically reduces reduces carbon-sulfide bonds is now out @natcatal.nature.com: doi.org/10.1038/s419.... We find for the first time large #nitrogenase metalloclusters (P- and L-cluster) outside nitrogenases.

Great work from the lab of @rebeleinlab.bsky.social ! Now out in @natcatal.nature.com