Andrew Ellisdon

Andrew Ellisdon

@drellisdon.bsky.social

Structural biology and protein engineering at Monash University. Cryo-EM and AI/ML-guided structural biology of cancer and immune complexes. https://www.ellisdonlab.com/

768 followers518 following24 posts

Andrew Ellisdon reposted

Andrii Bugai
@abugai.bsky.social

Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...

nature.comMolecular basis of polyadenylated RNA fate determination in the nucleus - NatureBiochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

Andrew Ellisdon reposted

Alex Noble
@alexjamesnoble.bsky.social

I'm excited to announce the launch of CryoArcana, our cryoEM/ET firm! We have extensive experience to offer biotechs and academics. Our overall aim is to improve human well-being. Feel free to contact us for help with any #cryoEM problem.

cryoarcana.bsky.social@cryoarcana.bsky.social

We are pleased to launch CryoArcana, a cryoEM/ET consulting and advisory firm, to bring our 24+ years of expertise to industry & academia. We offer consulting in optimizing workflows and advisory across the entire pipeline. We plan to expand our services. cryoarcana.com

Andrew Ellisdon reposted

Brett Collins
@brettcollins.bsky.social

Nice paper by Ji Sun and Dario Alessi labs describing multiple distinct Rab GTPase binding sites in the LRRK2 kinase involved in Parkinson Disease.

bioRxiv Biochemistry@biorxiv-biochem.bsky.social

Elucidating the molecular interplay between LRRK2 and Rab GTPases https://www.biorxiv.org/content/10.64898/2026.04.30.722110v1

Andrew Ellisdon reposted

GBM (Gesellschaft für Biochemie und Molekularbiologie)
@gbmev.bsky.social

Cytokine receptors do not get old, my friends!

Nature Reviews Immunology@natrevimmunol.nature.com

Cytokine multimerization: when more is more and sometimes less

dlvr.itCytokine multimerization: when more is more and sometimes lessNature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01290-6This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

Andrew Ellisdon reposted

Nature Reviews Immunology
@natrevimmunol.nature.com

ICYMI: Cytokine multimerization: when more is more and sometimes less

dlvr.itCytokine multimerization: when more is more and sometimes lessNature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01290-6This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

Andrew Ellisdon reposted

Nature Metabolism
@natmetabolism.nature.com
dlvr.itLysosomal phosphoinositide turnover acts upstream of RagGTPase–mTORC1 and controls muscle growthNature Metabolism, Published online: 18 March 2026; doi:10.1038/s42255-026-01484-1The accumulation of phosphoinositides at the lysosomal surface is shown to enhance RagGTPase–mTORC1 activity, which affects skeletal muscle cell differentiation. Inhibition of this signalling pathway improves muscle physiology in a mouse myopathy model.

Andrew Ellisdon reposted

Biohub
@biohub.org

🧵Antibiotic resistance is a public health crisis. But viruses called phages have been solving this problem for millennia. New research in @nature.com reveals how 3 different phages attack the same weak spot—a protein called MurJt—potentially leading to a new class of antibiotics.

Andrew Ellisdon reposted

Patrick Pausch
@patrick-pausch.bsky.social

1/6) Hot off the press @natsmb.nature.com 🔥! Jasnauskaite et al. reveal how the minimal bacterial retron Eco2 defends against #phage 🛡️. Phage nucleases trigger Eco2, which cuts RNA, shuts down protein production and stops phage replication 🦠🚫. #phagesky #immunity #microbiology #cryo-em rdcu.be/e4AyH

rdcu.beStructure and mechanism of antiphage retron Eco2Nature Structural & Molecular Biology - This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein...

Andrew Ellisdon reposted

Charles Bayly-Jones
@charlesbj.bsky.social

I’ve officially started my lab at Monash University! 🎉 We’re diving into #cellgrowth and #lysosome biology, through the lens of molecular #structure and mechanism. I’m thrilled to say that PhD student scholarships are available—so please share widely and get in touch if you’re interested. 🤩

Andrew Ellisdon reposted

Brett Collins
@brettcollins.bsky.social

The IMB at the University of Queensland is looking for a new Mass Spectrometry Facility Manager. See details below. Closing date 13th of February. uq.wd3.myworkdayjobs.com/en-GB/uqcare...

uq.wd3.myworkdayjobs.comMass Spectrometry Platform ManagerInstitute for Molecular Bioscience Full-time (100%), permanent position Base salary will be in the range $117,958.12 - $132,247.57+ 17% Superannuation (HEW Level 8) Based at our St Lucia Campus About ...

Andrew Ellisdon reposted

Martin Steinegger 🇺🇦
@martinsteinegger.bsky.social

FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...

science.orgMultiple protein structure alignment at scale with FoldMasonProtein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Andrew Ellisdon reposted

Brett Collins
@brettcollins.bsky.social

Do you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.

biorxiv.orgThe GTPase activating protein Gyp6 binds Retromer and inactivates Rab7/Ypt7 to coordinate the formation of endosomal carriersThe Retromer coat is conserved in all eukaryotes and is crucial for the correct intracellular sorting of many transmembrane receptors and lysosomal hydrolases. Retromer is an effector of the late endosomal small GTPase RAB7 and is also implicated in its inactivation required for proper endosomal maturation. Here, we explore the role of controlled GTP hydrolysis by the RAB7 ortholog Ypt7 in the formation of Retromer-coated membrane carriers in yeast. Proximity labelling and genetic ablation identify the GTPase Activating Protein (GAP) Gyp6 as a critical regulator of Ypt7 activity in the context or Retromer. Structural studies show that Retromer recruits Gyp6 through its Vps29 subunit, which recognises a specific PL motif and a secondary binding site in the C-terminal domain of Gyp6. This interaction does not occur with other yeast GAPs. Ablation of the Gyp6-Retromer interface or the catalytic activity of Gyp6 leads to the accumulation of tubular structures on endo-lysosomal compartments and to increased association of Ypt7 with Retromer and its cargo Vps10. These results support a model in which Gyp6 controls the switch from Ypt7-dependent Retromer coat assembly and cargo collection to the departure of the carrier through membrane fission and uncoating. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, APP2016410 Swiss National Science Foundation, https://ror.org/00yjd3n13, 31003A_179306, 310030_204713, 10.006.083

Andrew Ellisdon reposted

ARC Tracker
@arc-tracker.bsky.social

⁉️The ARC has delayed outcomes of ALL grants 1–4 months & increased scheduled outcome windows from 2 weeks to 3 months! This reverses 4 years of progress in providing greater certainty & ability to plan for researchers, their families & unis. Their excuse? Security checks under new ARC legislation👇

Andrew Ellisdon reposted

Christian Frezza
@frezzalab.bsky.social

Good Sunday, all. Here is a great summary of last week's papers in #cancermetabolism and #mitochondrialbiology. Don't miss it! Find it here: biomed.news/bims-camemi/... Biomed News #keepreading "Life isn't a dress rehearsal; this is it. It's your job to show up for this moment" Oliver Burkeman

Andrew Ellisdon reposted

Ben Engel
@cellarchlab.com

The #ChlamyDataset is on the cover of @cp-molcell.bsky.social 🖼️🥰! Read @lifeonthewedge.bsky.social's great thread🧵 for the inside scoop🍨 on all the #TeamTomo developments already made possible since these 1829 tomos hit EMPIAR 🧪 🧶🧬 For more, here's the old preprint thread: bsky.app/profile/cell...

Ricardo D. Righetto@lifeonthewedge.bsky.social

This one was quite the journey! The paper describing the #ChlamyDataset is finally out and on the cover of Mol Cell! This beautiful rendering made by co-author @jessheebner.bsky.social and Holly Peterson shows an instance of mitochondrial fission found in the dataset 😍 [Maybe long thread ahead]

cell.comToward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtiiUsing the latest advances in instrumentation and computational workflows, Kelley et al. present a large-scale annotated cryo-electron tomography dataset of the model green alga, Chlamydomonas reinhard...
Andrew Ellisdon
@drellisdon.bsky.social

An incredibly challenging single particle cryo-EM structure. Capturing both the N and C termini was difficult enough, but the project required a major effort to resolve the full length protein structure to capture the overall architecture of the KICSTOR-GATOR1 complex. Well worth it in the end!

Andrew Ellisdon reposted

Cell - a Cell Press journal
@cp-cell.bsky.social

Now online! Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex

dlvr.itStructure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplexThis study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation.

Andrew Ellisdon reposted

Lamming Lab
@lamminglab.bsky.social

Replying to @lamminglab.bsky.social

This long-awaited article demonstrates that depletion of individual essential amino acids induces profound changes in the liver epigenome, with AA-specific molecular changes at the level of histone PTMs, the transcriptome, and metabolome www.jbc.org/article/S002...

jbc.orgDepletion of individual dietary amino acids induce distinct metabolic and chromatin statesReducing dietary levels of protein or specific essential amino acids (EAAs) promotes favorable metabolic reprogramming, including improved glucose tolerance, increased insulin sensitivity and reduced ...

Andrew Ellisdon reposted

Yamuna Krishnan
@krishnanyamuna.bsky.social

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

Andrew Ellisdon reposted

Journal of Cell Biology
@jcb.org

Jacqmin, Boonen et al. report that the loss of maspardin, which is deficient in spastic paraplegia 21, results in RAB7 hyperactivation due to mislocalization. This abnormal RAB7 localization leads to defects in #lysosome #trafficking & disruption of the mTOR–TFEB pathway. rupress.org/jcb/article/...

Andrew Ellisdon reposted

Brett Collins
@brettcollins.bsky.social

Congratulations to the Landsberg lab for a fantastic paper in Nat Comms on the structure of the YenTC toxin. Led by Yu Shang Low and Solace Roche. @dr-berger.bsky.social @sarahjpiper.bsky.social

nature.comComplete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins - Nature CommunicationsABC toxins are bacterial insecticides with biotechnological potential. Here, Low et al. have deciphered soluble and membrane-inserted structures of YenTc that highlight structural and mechanistic dive...

Andrew Ellisdon reposted

Eugene Valkov
@eugenevalkov.bsky.social

Happy to share the latest work on a bacterial protein that inhibits human mRNA decay machinery, in collaboration with @smlea.bsky.social #RNAsky www.nature.com/articles/s41... Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay | Nature Communications

nature.comIntracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay - Nature CommunicationsIntracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...