Sagar Bashyal

Sagar Bashyal

@sagarbashyal.bsky.social

PhD candidate Salk Institute | University of California SanDiego AM symbiosis and anything related MPMI✌️ Mueller Lab🍀 https://mueller.salk.edu/people/

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Sagar Bashyal
@sagarbashyal.bsky.social

Absolutely thrilled to share our story—please take a moment to check it out! Huge thanks to all the contributors and my amazing supervisor @lmueller.bsky.social . This was truly a team effort! #peptides #mycorrhiza www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
Lena Maria Müller@lmueller.bsky.social

Proud to present the first data paper from the lab, published today in @pnas.org. We describe a new mechanism for CLE peptides as local symbiosis-amplifying signals, promoting plant interactions with beneficial arbuscular mycorrhizal fungi. Congratulations @sagarbashyal.bsky.social et al.!

Sagar Bashyal reposted

Plant Physiology
@plantphys.bsky.social

Poplar CLE peptides promoting ectomycorrhizal symbiosis identified through genome-wide analysis of responsive small secreted peptides (Clémence Bonnot , Emmanuelle Morin , et al) doi.org/10.1093/plph... #PlantScience @aspbofficial

doi.orgPoplar CLE peptides promoting ectomycorrhizal symbiosis identified through genome-wide analysis of responsive small secreted peptidesTrees use CLAVATA3/EMBRYO SURROUNDING REGION-related (CLE) peptides to promote ectomycorrhizal symbiosis, revealing an additional regulatory layer in tree–
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Sagar Bashyal
@sagarbashyal.bsky.social

Meloidgyne incognita was selected for further experimental analysis. In situ hybridization assay shows that MiPSK transcripts are expressed in the esophageal glands of nematodes

Sagar Bashyal reposted

Plant Editors
@planteditors.bsky.social

🍅 Happy #TomatoTuesday from @nature.com Nature Genetics! #PlantScience 🍅

Abiotic Stress in Plants@abioticstress.bsky.social

A tomato #telomere-to-telomere #super-pangenome empowers stress #resilience #breeding www.nature.com/articles/s41... #PlantScience #StressBiology #Genomics @natgenet.nature.com @tomatotri.bsky.social @pangenomics.bsky.social @plecevo.bsky.social @plantgenomics.bsky.social @pgrp2026.bsky.social

nature.comA tomato telomere-to-telomere super-pangenome empowers stress resilience breeding - Nature GeneticsA genus-wide super-pangenome across 16 tomato species generated by integrating 20 telomere-to-telomere genome assemblies and 27 published genomes identifies structural variants associated with salinit...

Sagar Bashyal reposted

Penelope Lindsay
@penlindsay.bsky.social

it was great to collaborate with @lmueller.bsky.social to help characterize the Medicago crn mutant!

Journal of Experimental Botany@jxbotany.bsky.social

🌱 EDITOR'S CHOICE 🌱 Plant interactions with beneficial AM fungi are regulated by complex signaling pathways. The pseudokinase CORYNE negatively regulates the symbiosis by integrating plant responses to multiple abiotic and biotic cues - Orosz et al. 🔗 doi.org/10.1093/jxb/... #PlantScience 🧪

Sagar Bashyal
@sagarbashyal.bsky.social

Thank you @aribidopsis.bsky.social for this invitation and was a good open discussion. I really enjoyed it and hope to join more in future.

Arif Ashraf@aribidopsis.bsky.social

S4E2 of #No_Time_To_Read_podcast 🎙️ In this episode, I had a wonderful discussion with a very talented graduate student @sagarbashyal.bsky.social Sagar about his recent PNAS paper. Podcast: tinyurl.com/yc63xmdz Article: www.pnas.org/doi/10.1073/...

Sagar Bashyal reposted

Francis M. Martin
@fmartin54.bsky.social

SALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advance www.science.org/doi/10.1126/...

science.orgSALICYLIC ACID SENSOR1 reveals the propagation of an SA hormone surge during plant pathogen advanceSalicylic acid (SA) is a key phytohormone that orchestrates immune responses against pathogens, including Pseudomonas syringae bacteria. The timing and extent of SA accumulation are tightly controlled...

Sagar Bashyal reposted

Lucia Strader
@luciastrader.bsky.social

The lab is moving to the Salk Institute! We are thrilled to join an inspiring community where we will continue to explore plant growth and development. Deep gratitude for the years of support and collaboration at Duke/NCSU/UNC. www.salk.edu/news-release...

salk.eduPlant biologist Lucia Strader joins Salk faculty to study plant growth signaling - Salk Institute for Biological StudiesLA JOLLA—The Salk Institute will welcome plant biologist Lucia Strader as a new professor and holder of the Howard H. and Maryam R. Newman Chair in Plant Biology in October 2025. Strader is an interna...

Sagar Bashyal reposted

Natalia Guayazán Palacios
@nataliagupa.bsky.social

I am thrilled to share the 2nd chapter of my PhD with @adsteinbrenner.bsky.social In collaboration with @tiszapatrick we demonstrated that the LRR-RLP INR is the missing molecular link between caterpillar recognition and predatory wasp recruitment in the field. A thread 1/6

bioRxiv Plant Bio@biorxiv-plants.bsky.social

A plant immune receptor mediates tritrophic interactions by linking caterpillar detection to predator recruitment https://www.biorxiv.org/content/10.1101/2025.07.29.667524v1

Sagar Bashyal reposted

Gitta Coaker
@gittacoaker.bsky.social

Excited this paper is finally published! We focused on the inner concave surface of LRR RKs to expand bacterial flagellin perception in plants. Selection indicates expanded perception is more common than previously thought. Experiments led by @jerrytli.bsky.social www.nature.com/articles/s41...

nature.comUnlocking expanded flagellin perception through rational receptor engineering - Nature PlantsReceptor kinase FLS2 detects the flg22 epitope of bacterial flagellin. Here the authors identify key residues on FLS2’s concave surface that enable expanded perception of flg22 variants, allowing the ...

Sagar Bashyal reposted

Tatsuya Nobori
@tatsuyanobori.bsky.social

Excited to share my new Tansley Review @newphyt.bsky.social on emerging single-cell and spatial omics technologies, many of which are just beginning to be applied in plant biology! Big opportunities lie ahead for the field. [1/n]  nph.onlinelibrary.wiley.com/doi/10.1111/...

nph.onlinelibrary.wiley.comExploring the untapped potential of single‐cell and spatial omics in plant biologyAdvances in single-cell and spatial omics technologies have revolutionised biology by revealing the diverse molecular states of individual cells and their spatial organization within tissues. The fie...
Sagar Bashyal
@sagarbashyal.bsky.social

Congratulations Michael and the entire team!👏Cool work from the @carogutj.bsky.social lab and a testament to all the long hard work behind it @pnas.org . Grateful to have contributed to this story✌️. Checkout the mechanisms by which the RAM1 functions. www.pnas.org/doi/full/10....

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Sagar Bashyal reposted

Jean-Michel Ané
@jeanmichelane.bsky.social

Great review from @lmueller.bsky.social -> Signaling peptides control beneficial and pathogenic plant-microbe interactions | Journal of Experimental Botany | Oxford Academic

academic.oup.comSignaling peptides control beneficial and pathogenic plant-microbe interactionsInteractions between organisms, such as those between plants and microbes, require extensive signaling between and within each organism to detect and recognize the partner and elicit an appropriate response. Multiple families of small signaling peptides regulate plant interactions with beneficial or pathogenic microbes, and sometimes both. Some of these signaling peptides transmit information between different cells or organs of the host and allow plants to orchestrate a coordinated response towards microbial mutualists or pathogens. However, not only plants produce signaling peptides required for the interactions. Microbes themselves also secrete peptide signals, which are detected by host receptors and required for infection. Among these are microbial peptides mimicking those of plants, allowing mutualistic or pathogenic microbes to hijack endogenous plant signaling pathways and evade the host immune system. In this review, we provide a comprehensive summary of current knowledge on host- and microbe-derived signaling peptides and their cognate receptors regulating mutualistic and parasitic plant-microbe interactions. Furthermore, we describe how microbes hijack endogenous host signaling pathways, and discuss possible crosstalk between the plant signaling pathways controlling mutualism with those modulating immune responses to pathogens.

Sagar Bashyal reposted

Gözde Merve Türksoy
@gozdemerveturksoy.bsky.social

Finally, I am thrilled to share our long-term volatile project is out in Plant Communications! 🥳 Bacterial community-emitted volatiles regulate Arabidopsis growth and root architecture in a distinct manner from those from individual strains: Plant Communications www.cell.com/plant-commun...

cell.comBacterial community-emitted volatiles regulate Arabidopsis growth and root architecture in a distinct manner from those from individual strainsShort summary: This study reveals that the effects of bacterial community-produced volatiles on Arabidopsis growth and root architecture are an emergent property beyond the sum of effects by individua...

Sagar Bashyal reposted

Hiro Nakagami
@grandpahiro.bsky.social

The final version of our study on SERK-BIR module in Marchantia is out. Congratulations Cate and many thanks to collaborators! www.sciencedirect.com/science/arti...

sciencedirect.comConserved role of the SERK-BIR module in development and immunity across land plantsSOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASES (SERKs), which are subfamily II of leucine-rich repeat receptor-like kinases (LRR-RLKs), play diverse role…
Marc Somssich@somssich.bsky.social

New work from @grandpahiro.bsky.social's lab here at the MPIPZ in Cologne: "Conserved role of the SERK-BIR module in development and immunity across land plants" They looked at the evolution of the SERK co-receptors. www.biorxiv.org/content/10.1... #PlantScience #PlantEvoMPMI #PlantEvoDevo

biorxiv.orgConserved role of the SERK–BIR module in development and immunity across land plantsbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

Sagar Bashyal reposted

Jean-Michel Ané
@jeanmichelane.bsky.social

Great paper on CLE peptides in AM symbiosis from @sagarbashyal.bsky.social, @lmueller.bsky.social and colleagues -> A plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN-mediated ROS suppression

pnas.orgA plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN-mediated ROS suppressionCLAVATA3/EMBRYO SURROUNDING REGION-related (CLE) peptides have emerged as key regulators of plant–microbe interactions, including arbuscular mycorrhizal (AM) symbiosis. Here, we identify Medicago truncatula CLE16 as a positive regulator of AM symbiosis. MtCLE16 is expressed in root cells colonized by AM fungi (AMF) and its overexpression within colonized tissues increases arbuscule abundance by finetuning their growth and lifespan. Functional and transcriptomic analyses reveal that MtCLE16 acts via the M. truncatula pseudokinase CORYNE (MtCRN) and suppresses the accumulation of reactive oxygen species (ROS) in roots, thereby attenuating immune responses and promoting root colonization by mutualistic AM fungi. Notably, AMF also express MtCLE16-like peptides. We show that the Rhizophagus irregularis MtCLE16-like peptide, RiCLE1, also attenuates ROS and promotes AMF colonization via MtCRN. This finding suggests that RiCLE1 can interfere with the MtCLE16-MtCRN signaling module of host roots to benefit the fungus. Our research uncovers a functional mechanism underpinning cross-kingdom signaling and molecular mimicry in mutualistic plant–microbe interactions.

Sagar Bashyal reposted

Marc Somssich
@somssich.bsky.social

📜 A plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN- mediated ROS suppression 🧑‍🔬 @sagarbashyal.bsky.social, @lmueller.bsky.social, et al. 📔 @pnas.org 🔗 pnas.org/doi/10.1073/... #️⃣ #PlantScience #PlantSymbiosis #PlantDevelopment #PlantMycorrhiza

pnas.orgA plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN-mediated ROS suppression | PNASCLAVATA3/EMBRYO SURROUNDING REGION-related (CLE) peptides have emerged as key regulators of plant–microbe interactions, including arbuscular mycorr...

Sagar Bashyal reposted

Michael Prigge
@mjprigge.bsky.social

I am very happy to see this story published! This was a wonderful collaboration between the @mestelle.bsky.social lab (@ucsandiego.bsky.social) on the moss side, Annis Richardson’s lab on the maize side, and @luciastrader.bsky.social lab’s help throughout. #plantscience #auxin

Nature Plants@natplants.nature.com

Some auxin-related reading for the week-end: ARFs are degraded, too. - "Comparative mutant analyses reveal a novel mechanism of ARF regulation in land plants" rdcu.be/ehnOT - "ARF degradation defines a deeply conserved step in auxin response" rdcu.be/ehnPa #PlantScience

Sagar Bashyal reposted

Gitta Coaker
@gittacoaker.bsky.social

I'm very excited our most recent work on plant tandem kinases (TKPs) has finally been published! TKPs are a fascinating protein family conferring disease resistance to fungi. Originally in bioRxiv. Many thanks to @yichangsung.bsky.social for leading this work. 🧵 www.nature.com/articles/s41...

nature.comWheat tandem kinase RWT4 directly binds a fungal effector to activate defense - Nature GeneticsThis study shows that RWT4, a wheat tandem kinase, confers resistance to the fungal pathogen Magnaporthe oryzae by directly binding to the pathogen effector AvrPWT4 and activating host defense.

Sagar Bashyal reposted

Sebastian Eves-van den Akker
@sebastianevda.bsky.social

Paper Alert! @pnas.org We think nematodes break open plant cells, sense small molecule signals (termed effectostimulins), which switch on a master regulator SUGR1, which switches on effectors, which break cells. Looks like a feed-forward loop driving infection. www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Sagar Bashyal reposted

Kevin Cox Jr
@kcox-bioguy.bsky.social

Some of my postdoc work has been "exposed" today in @theplantjournal.bsky.social! 😁🎉🔬 We developed ExPOSE - a method to perform expansion microscopy in plant protoplast systems. Here's a quick🧵of the details: @meter76.bsky.social @lily-oconnor.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.comExPOSE: a comprehensive toolkit to perform expansion microscopy in plant protoplast systemsThis method provides a robust approach for performing expansion microscopy in plant protoplasts for imaging single-cell and subcellular compartments at greatly enhanced resolution.

Sagar Bashyal reposted

Tatsuya Nobori
@tatsuyanobori.bsky.social

🚨 We’re hiring–please spread the word! 🚨 Our lab at @thesainsburylab.bsky.social is looking for a pre-doc intern to join our research on plant immunity. If you’re a current undergrad/master’s or recent graduate interested in gaining research experience, please apply! tatsuyanobori.com

The Sainsbury Laboratory@thesainsburylab.bsky.social

VACANCY: Predoc Internship Nobori Lab, UK Plant immunity research at single-cell & spatial resolution Interested in pursuing a PhD or developing your research skills in plant & microbial science? Apply online, position may fill after 24/03 ➡️ www.tsl.ac.uk/working-at-t... @tatsuyanobori.bsky.social