Scott Soderling

Postdoc position available to study mechanisms of protein phosphorylation and dynamic plasticity at the Axon Initial Segment! Join us in curiosity-driven cellular neuroscience research that bridges basic signaling mechanisms and neuromodulation in brain disorders! www.nature.com/naturecareer...

By targeting thrombin in two ways at once, Duke researchers created a synthetic anticoagulant that matched heparin's potency in preclinical studies and paired it with a rapid antidote. https://medschool.duke.edu/news/duke-researchers-create-new-powerful-synthetic-blood-thinner-and-reversal-agent

We're hiring a postdoc (Scientist I) at the Allen Institute in Seattle! We'll be developing and scaling new approaches to study synaptic proteomes in the context of neuronal connectivity. Please share! @alleninstitute.org alleninstitute.org/careers/jobs...

📢 To everyone on the job market who has a vision for neuroscience applied to biomedical applications & technological innovation: The Duke Department of Biomedical Engineering announces a tenure-track faculty job search in neural engineering, broadly defined! academicjobsonline.org/ajo/jobs/32784

getting close to recreating Jane Richardson's style 😎

**Four** positions in AI/ML for biology at @dukemedschool.bsky.social, including in Neurobiology. @scottsoderling.bsky.social and David Page are leading a tremendous initiative in Discovery AI. Wonderful colleagues, wonderful place.

Funny quote of the day. “No major life decisions within 30 days of: A meditation retreat A psychedelic experience Your first encounter with the latest Claude model” 😂

Deeply honored to be named a 2026 Beckman Young Investigator #BYI!🧬 This recognition reflects the creativity and hard work of my incredible lab, and we are so grateful and excited for the Foundation's support as we tackle the next generation of continuous evolution.

Researchers have identified MESH1, an enzyme that helps explain why many people with cancer lose muscle during treatment. https://medschool.duke.edu/news/hidden-enzyme-may-explain-muscle-loss-tied-cancer-treatment-and-aging #AcademicSky #MedSky

It’s brutal in academia right now. A lot is out of our control, but it doesn’t cost anything to remember that there are humans behind papers and grants…reviewers, program officials and funders can be more empathetic in the face of unprecedented chaos in the US scientific enterprise.

My lab was lucky to be able to help test Proteina-Complexa binders experimentally. We were blown away by the results. Congrats to our colleagues at NVIDIA!

Find out more: flip.protein.properties

You can use the model right now to freely generate families for single sequence inputs (i.e., diversification conditioned by intrinsic representations of evolution), or to engineer proteins based on family promts (diversification by conditioning on particular evoluationary trajectories).

@rohitsingh8080.bsky.social USHER: Guiding Foundation Model Representations through Distribution Shifts Aditya Pratapa, Purushothama Rao Tata, Rohit Singh bioRxiv 2025.11.20.689462; doi: doi.org/10.1101/2025...

The existence of specialized phosphatases in regulating the AIS was unclear. In this initial report, we show that a PP2A subunit is enriched at the AIS and contributes to its local phosphoregulation. Fun collaboration with Dr. Matthew Rasband's lab, and thanks to all authors for their contribution!

There is nothing sweeter than the first paper from your former postdoc’s own lab. Huge congratulations to Yudong and his lab! www.nature.com/articles/s41...

Sounds very exciting

The published version of our study on the early-life transition from isolation USVs to adult-like USVs in juvenile mice is out in Animal Behaviour! authors.elsevier.com/a/1m1YDmjMA4GP bsky.app/profile/kati...

Deadline for applications- November 1st!

We are hiring!

Please repost!!: We are searching for new AI-Bio faculty at Duke to be part of a new Discovery AI center. Looking for faculty who focus on pushing boundaries in ML model development in a highly interactive environment. DEADLINE for applications- Nov 1st!! www.nature.com/naturecareer...

I am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...

Cool new work- DynamicsPLM adds prot conformational dynamics to LMs: fuses seq with per-residue structure-token distributions from an ensemble (no averaging) → state-aware embeddings. Gains: +4% HumanPPI, +11% on multi-state proteins. Firing this up in the lab soon! www.biorxiv.org/content/10.1...

Duke Cell Biology is hiring in AI/ML! @scottsoderling.bsky.social, @rohitsingh8080.bsky.social, and others are building a very active community around ML for discovery science, and Duke is a great place to be. academicjobsonline.org/ajo/jobs/30509

Duke is recruiting a tenure-track Assistant Professor in AI/ML for Biology—joint Discovery AI Initiative × Cell Biology Search. Building models for protein design, single-cell/spatial omics, imaging, proteomics, genomics? Apply: academicjobsonline.org/ajo/jobs/30509 #hiring #AIforBio #CompBio

Building a spine is no joke, but thankfully zebrafish have their own clocks to keep the pace. Excited to share our preprint on the role of biological oscillators in coordinating notochord development! (www.biorxiv.org/content/10.1...) Additional thread below

Priyom's preprint is out on biorxiv. See below for a detailed thread. In a nutshell, she has discovered and characterized the oscillator that times notochord and spine segmentation in zebrafish. Turns out that there are uniform Erk oscillations across the entire tissue that act as timekeepers!

Duke researchers have uncovered a promising path to potentially treat a family of rare neurodegenerative disease called neurodegeneration with brain iron accumulation (NBIA). 🔗: https://mgm.duke.edu/news/fundamental-cell-molecule-could-help-fight-rare-brain-disorders #AcademicSky #MedSky

Another milestone for the amazing Munjal lab!

The order is the latest move by the Trump administration to assert control over US science go.nature.com/3H6IxVr

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

Great work from Huanghe Yang’s lab in Duke Biochemistry.

Congrats James! Loved hearing about this at an earlier CZI meeting!

I like o3 pro even better.

Steve Jobs was a vibe coder, he just prompted Steve Wozniak

Researchers are making ever more sophisticated mini organs in the lab — and now they can grow their own blood vessels go.nature.com/4nNF3ri

The new Center of Excellence for Multiscale Immune Systems Modeling (MISM), launching soon by Duke University School of Medicine researchers, will transform how we understand and treat infectious and immune-related diseases. #AcademicSky #MedSky

Lab backpacking trip recently along the AT in NC. It's so nice to get away from it all, together.

In this essay in Hopkins Magazine, I talk about how NIH budget cuts will delay or stop the translation of basic science to the clinic and impact kids with intellectual disability, autism, and epilepsy. hub.jhu.edu/magazine/202...

corporate.dukehealth.org/news/duke-un...

AI research in collaboration with cell biologists is transforming research at Duke. More discoveries coming soon!!

The AI tool Raygun (named as an homage to “Honey, I Shrunk the Kids”) is just one of several tools that a team led by Duke's Rohit Singh, PhD, has built to help scientists work both faster and smarter. 🔗 Read more: medschool.duke.edu/stories/hone... #DukeB&B #DukeCellBiology #AcademicSky #MedSky

Congrats to HHMI Freeman Hrabowski Scholars @channyskye.bsky.social , Josefina del Mármol (@delmarmollab.bsky.social), @yvetteefisher.bsky.social and Theanne Griffith (@doctheagrif.bsky.social), named 2025 McKnight Scholars for their demonstrated commitment to neuroscience & mentoring others! 🌟

Excited to be joining a fantastic community of neuroscientists!

Shuo Han, PhD, a Duke biochemist, is leading research to decode the gut microbiome’s chemical language. Her lab has released a free protocol that helps researchers detect over 800 gut-derived metabolites. 🔗 Read more: www.biochem.duke.edu/news/secret-... #DukeBiochemistry #AcademicSky #MedSky

Looking forward to reading this.

Excited to share our Science paper on HaloDA1.0-the first genetically encoded far-red dopamine sensor! 🥳It enables powerful multiplex imaging in neurons, brain slices, and live animals.🧠🔬 #GRABsensors #Dopamine www.science.org/doi/10.1126/...

Aurora alert! It’s possible the aurora boralis may be visible tonight as far south as Alabama. Start looking tonight after dark around 10 pm (I’ve attached both the NOAA and University of Alaska maps, the former is always very conservative with view lines) www.swpc.noaa.gov/communities/...

Postdoc opportunity in the heart of Europe! Check out the flyer below. Join our team on an international project with Anthony Holtmaat exploring synaptic plasticity and specificity in cortical and thalamocortical circuits.

The unintended consequence of….. www.nytimes.com/2025/05/30/o...