Khaled_Selim Lab

Khaled_Selim Lab

@selimlab.bsky.social

Microbial BioChem | Structural Biology | Cell Signaling | Institute of Phototrophic Microbiology @hhu.de https://www.phototrophic-microbiology.hhu.de/en/ Transporters & Metabolism Coordination by #PII & #cdiAMP & #cdiGMP & #Ca2+ signaling #Cyanobacteria

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Khaled_Selim Lab
@selimlab.bsky.social

🧵 #Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org A great collab. w/ @weiss-lab.bsky.social #TeamTomo @hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social link.springer.com/article/10.1...

link.springer.comThe calcium-binding protein CSE links Ca2+ signaling with cell-cell communication in cyanobacteria - The EMBO JournalMulticellular cyanobacteria have evolved sophisticated cell–cell communication machinery to exchange, synchronize, and coordinate the efforts of individual cells. Analogous to gap junctions that have ...
Khaled_Selim Lab
@selimlab.bsky.social

Interesting 🤔 Why DNA uses thymine instead of uracil remains unresolved, since thymine is more susceptible to ultraviolet UV? www.pnas.org/doi/10.1073/... Although thymine is more photoreactive, it preferentially channels UV damage into reversible lesions amenable to nonenzymatic self-repair

pnas.orgUV photodamage pathways and the evolutionary selection of thymine over uracil in early genetic systems | PNASThe evolutionary selection of thymine over uracil in DNA presents a paradox from a photostability perspective, since thymine is found to be more su...
Khaled_Selim Lab
@selimlab.bsky.social

Come and join our cluster @ceplas.bsky.social @hhu.de We are looking for new colleague W2-Professorship in Root-Microbiome Interactions

CEPLAS - Cluster of Excellence on Plant Sciences@ceplas.bsky.social

📣Please RT: IPK Gatersleben and Heinrich Heine University Düsseldorf jointly call for applications for a W2-Professorship in Root-Microbiome Interactions to be filled as soon as possible. Further info ▶️https://berufungsportal.hhu.de/ @leibnizipk.bsky.social @hhu.de @plantsciencedbg.bsky.social

Khaled_Selim Lab reposted

Ben Engel
@cellarchlab.com

Cool #TeamTomo tool from the @becklab.bsky.social for quantifying the thickness of native membranes. And a great use of two community resources: 1) The #ChlamyDataset: bsky.app/profile/life... 2) #MemBrain: bsky.app/profile/lore... Thanks for this great tool. This is how #OpenScience works! 🔬🧪

Journal of Cell Biology@jcb.org

Systematic membrane thickness variation across cellular #organelles revealed by #cryoET. New computational workflow developed by @deglushk.bsky.social, Stefanie Böhm, and @becklab.bsky.social: rupress.org/jcb/article/... 📕 Part of our #Tools collection: rupress.org/jcb/collecti...

Khaled_Selim Lab reposted

Şuayb Üstün
@suaybuestuen.bsky.social

65 years of Turkish immigration to Germany. 🇹🇷🇩🇪 From a child with Turkish roots born to a working class family to becoming a professor, I wonder how much has really changed. The road to success is still harder for some of us. And no matter how far you come,you're still made to feel like a foreigner.

tagesschau.deVom Neuanfang zur Heimat in Deutschland: 65 Jahre Anwerbeabkommen mit der TürkeiVom Neuanfang zur Heimat in Deutschland: 65 Jahre Anwerbeabkommen mit der Türkei

Khaled_Selim Lab reposted

erzbergerlab.bsky.social
@erzbergerlab.bsky.social

Methyltransferase RsmB chaperones E. coli ribosome assembly by orchestrating the recruitment of ribosomal proteins | Science Advances www.science.org/doi/10.1126/...

science.orgMethyltransferase RsmB chaperones E. coli ribosome assembly by orchestrating the recruitment of ribosomal proteinsRibosomal RNA modification enzymes increase cellular fitness, but it’s little known whether this benefit arises from rRNA modification or a chaperone function of the modification enzyme. Here, we show...

Khaled_Selim Lab reposted

Simone Mattei
@simonemattei.bsky.social

Struggling to choose a pixel size for your cryo-ET acquisition? Worry not: super-resolution processing can take in situ subtomogram averaging beyond physical Nyquist! We reached 2.8 A loc-res of a ribosome dataset with 4.78 A physical Nyquist limit! Our new preprint 👇: doi.org/10.64898/202...

Khaled_Selim Lab
@selimlab.bsky.social

A cool study could be interesting for @mibinet.bsky.social @faltegoer.bsky.social @usadellab.bsky.social @vivienrosenthal.bsky.social

PLOS Biology@plosbiology.org

Symbiotic #rhizobia form nitrogen-fixing partnerships with #plant roots. This study by @albinteulet.bsky.social & @dromius.bsky.social uses structural modelling to predict how secreted proteins may mimic plant factors in a strategy shared with pathogens. 🧪 #AcademicSky #symbiosis plos.io/4j6bWj0

Khaled_Selim Lab reposted

Arnaud Kengmo Tchoupa
@kengmo.bsky.social

What if bacteria were using wax esters to shape skin microbiomes? Staphylococcal lipases convert skin antimicrobial fatty acids into harmless wax esters. This publication is the very first first-author paper for my first PhD student, my first time acting as last author, and our first ISME paper.

track.smtpsendmail.comExtracellular wax ester biosynthesis by staphylococcal lipases detoxifies skin fatty acids and shapes interspecies competitionAbstract. To maintain its barrier function, human skin requires lipids, including cholesterol, ceramides, free fatty acids, and wax esters. In contrast to

Khaled_Selim Lab reposted

Matt Hutchings
@matthutchings.bsky.social

Fully funded PhD with me and @barriewilks.bsky.social - starting Oct 27. We identified a Streptomyces spore phase regulator, when we over express this it activates loads of silent antibiotic biosynthesis pathways. Come help us understand how! biodtp.norwichresearchpark.ac.uk/projects/ant...

biodtp.norwichresearchpark.ac.ukAntibiotic discovery in Streptomyces bacteria (HUTCHINGS_J27DTP) | Doctoral Training PartnershipAntimicrobial resistance in disease-causing bacteria represents a significant threat to global health. To address this, we urgently need to replenish the antibiotic discovery pipeline with new…

Khaled_Selim Lab reposted

Susan Schlimpert
@s-lab.bsky.social

Two PhD opportunities in our lab: 1. What do bacterial NLR proteins do beyond phage defence? Join us to explore how these proteins regulate viability, multicellular development and antibiotic production in Streptomyces. Apply 👉 shorturl.at/N8Abx #PhD #Microsky #Bioinformatics #Streptomyces

shorturl.atFrom Defence to Antibiotic production: Uncovering New Roles for NLR Signalling in Multicellular Bacteria (SCHLIMPERT_J27DTP) | Doctoral Training PartnershipNucleotide-binding and oligomerisation domain-like receptors (NLRs) are famous for driving immune responses in plants and animals. However, their extensive presence in multicellular…

Khaled_Selim Lab reposted

Evgenii Protasov
@evgenii-protasov.bsky.social

The archaeon Sukunaarchaeum mirabile, associated with dinoflagellates, has a genome of only 238 kbp🧬🤯 #archaea #symbiosis #eukaryotes #protists #MicroSky @currentbiology.bsky.social www.cell.com/current-biol...

cell.comA hidden archaeal lineage with an ultra-reduced genome retaining only its replicative coreHarada et al. describe an archaeon, recovered from a single marine plankton cell, whose 238-kb genome is the smallest known for the domain. It has lost nearly all metabolism but keeps the machinery to...
Khaled_Selim Lab
@selimlab.bsky.social

A good read do @spp2389.bsky.social members

Will Ratcliff@wcratcliff.bsky.social

Out today in @nature.com: our review on how single cells evolve into multicellular organisms. With Ozan Bozdag, @kaitong25.bsky.social, Peter Yunker, and @matthewherron.bsky.social. rdcu.be/9ZuiKow9twKa For an overview, check out the video below.

Khaled_Selim Lab reposted

Tung Le
@tunglejic.bsky.social

🚨PhD opportunity alert!!! Come work with us on this new cool NERC DTP PhD project Investigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments. Retweet = nice. Thank you!!! aries-dtp.ac.uk/studentships...

aries-dtp.ac.ukInvestigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments? | AriesProfessor Tung Le, John Innes Centre – contact me Professor Jonathan Todd, Quadram Institute & UEA Dr Ngat Tran, John Innes Centre Horizontal gene transfer (HGT) is a major driver of bacterial…

Khaled_Selim Lab reposted

Andreas P.M. Weber 🌾🌱🧬
@apmweber.bsky.social

Asgard archaea can actively crawl, using protrusions that are filled with an actin-based "cytoskeleton". Speed in the range of µm / s. www.nature.com/articles/s41...

nature.comDynamic protrusions mediate crawling motility in Asgard archaea - NatureAnoxic live-cell imaging shows actin-dependent crawling motility and dynamic protrusions in Asgard archaea, providing insights into cellular innovations that may have contributed to eukaryotic evoluti...

Khaled_Selim Lab reposted

Diorge Souza
@diorgeps.bsky.social

Finally out! Our work uncovers evolutionary links between bacterial and archaeal ribosome hibernation and eukaryotic energy sensing, through the archaeal hibernation factor AHA link.springer.com/article/10.1...

link.springer.comA conserved archaeal protein with evolutionary links to bacterial ribosome hibernation and eukaryotic energy sensing - The EMBO JournalRibosome hibernation helps cells survive stress by reversibly silencing translation and preserving ribosomal complexes. Although well characterized in bacteria and eukaryotes, archaeal hibernation rem...
Khaled_Selim Lab
@selimlab.bsky.social

@floravincent.bsky.social presented @mibinet.bsky.social conference Where N comes from?

Ákos T Kovács@evolvedbiofilm.bsky.social

@floravincent.bsky.social on symbiosis in marine unicellular eukaryotes - online presentation at #MibiNet first on diatom cell structure, see their @currentbiology.bsky.social www.cell.com/current-biol...

cell.comDiatom ultrastructural diversity across controlled and natural environmentsFlori et al. establish high-resolution and generalizable immunofluorescence in cultured and environmental diatoms, thanks to 4-fold cryo-expansion microscopy. This represents a step-change for compara...

Khaled_Selim Lab reposted

Susan Schlimpert
@s-lab.bsky.social

It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social ! Deadline: Jan 6, 2027. #Bacdiv27

EMBO@embo.org

Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027. Deadline: 6 January 2027 https://meetings.embo.org/event/27-cell-division #EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪

Khaled_Selim Lab reposted

Dina Grohmann
@curiousdina.bsky.social

🌙 Bringing Archaea to moon! Our latest study with the Orsi lab shows that M. okinawensis can survive, perform methanogenesis, and grow under simulated Enceladus conditions. Yet another reminder of how astonishingly adaptable Archaea are. www.science.org/doi/10.1126/...

science.orgEnceladus-like geochemistry fuels methanogenesis under extreme CO2 limitationSaturn’s icy moon Enceladus features chemical signatures consistent with an alkaline soda ocean with H2 production via hydrothermal water-rock reactions. Chemolithoautotrophic methanogenesis is thermo...

Khaled_Selim Lab reposted

Alexander Harms
@aharms485.bsky.social

The final version of our manuscript on TnSeq in bacteriophages (“HIDEN-SEQ”) is out today – if you have an interesting phage phenotype and want to know the underlying genetic basis, this one is for you! 1/4