Susan Schlimpert

Susan Schlimpert

@s-lab.bsky.social

Microbiologist, Group Leader and Professor at the John Innes Centre, UK. Our lab is interested in bacterial cell biology and development. We are particularly passionate about #Streptomyces. Lab website: www.schlimpertlab.com

1.2K followers1.1K following55 posts

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Two PhD opportunities in our lab: 1. What do bacterial NLR proteins do beyond phage defence? Join us to explore how these proteins regulate viability, multicellular development and antibiotic production in Streptomyces. Apply 👉 shorturl.at/N8Abx #PhD #Microsky #Bioinformatics #Streptomyces

shorturl.atFrom Defence to Antibiotic production: Uncovering New Roles for NLR Signalling in Multicellular Bacteria (SCHLIMPERT_J27DTP) | Doctoral Training PartnershipNucleotide-binding and oligomerisation domain-like receptors (NLRs) are famous for driving immune responses in plants and animals. However, their extensive presence in multicellular…

Susan Schlimpert reposted

Susan Schlimpert reposted

Incredibly excited about our latest work on R-bodies, 5+ years in the making! These coiled protein ribbons extend into ~10 µm needles in a pH-dependent manner & we caught them springing open inside amoebae after P. aeruginosa gets eaten. (animation: Jegg Yoon)🧵1/2 www.biorxiv.org/content/10.6...

Susan Schlimpert reposted

Susan Schlimpert reposted

Replying to @delafuentelab.bsky.social

We want to use machines to better understand biology and turn that knowledge into new treatments for drug-resistant infections. This'll take people working together across disciplines. Thanks to Aarti Krishnan, Hanqun CAO, & James J. Collins for this collaboration. www.science.org/doi/10.1126/...

science.orgFrom code to cure: Harnessing AI for antibiotic discovery and designAI is accelerating antibiotic discovery, but clinical translation requires standardized data, safety optimization, and new regulatory frameworks.

Susan Schlimpert reposted

Two PhD opportunities in our lab: 1. What do bacterial NLR proteins do beyond phage defence? Join us to explore how these proteins regulate viability, multicellular development and antibiotic production in Streptomyces. Apply 👉 shorturl.at/N8Abx #PhD #Microsky #Bioinformatics #Streptomyces

shorturl.atFrom Defence to Antibiotic production: Uncovering New Roles for NLR Signalling in Multicellular Bacteria (SCHLIMPERT_J27DTP) | Doctoral Training PartnershipNucleotide-binding and oligomerisation domain-like receptors (NLRs) are famous for driving immune responses in plants and animals. However, their extensive presence in multicellular…

Check out this really beautiful study by my colleague @hassansalem.bsky.social and his team. Leaf beetles and their symbionts are pretty amazing.

Hassan Salem@hassansalem.bsky.social

Beetles secrete jelly to embed & sustain symbionts with impossibly tiny genomes🪲 But what is this jelly made of? And how does it help maintain a partnership that has lasted over 62 million years? Thrilled to share our latest, out now in @natcomms.nature.com! www.nature.com/articles/s41...

Susan Schlimpert reposted

Susan Schlimpert reposted

VACANCY - We’re looking for a Postdoctoral Researcher to join the @Barrie Wilkinson Group, in collab with the @Matt Hutchings lab, on a project: Global activation of silent and cryptic biosynthetic pathways in Streptomyces species. Deadline - 26 October 2026 Contract - 36 months, full-time

okt.toPostdoctoral Researcher | John Innes CentreAn exciting opportunity has arisen for a Postdoctoral Researcher to join the Wilkinson Group at the John Innes Centre, working in collaboration with the Hutchings lab, on a project titled: Global...

Susan Schlimpert reposted

Susan Schlimpert reposted

It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social ! Deadline: Jan 6, 2027. #Bacdiv27

EMBO@embo.org

Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027. Deadline: 6 January 2027 https://meetings.embo.org/event/27-cell-division #EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪

Susan Schlimpert reposted

The final version of our manuscript on TnSeq in bacteriophages (“HIDEN-SEQ”) is out today – if you have an interesting phage phenotype and want to know the underlying genetic basis, this one is for you! 1/4

Susan Schlimpert reposted

Susan Schlimpert reposted

How do proteins localize in bacteria? Usually by binding to a prelocalized protein-but how does that protein localize? @vanipande.bsky.social found a #Bacillus subtilis protein that localizes via a lipid cue,undecaprenyl phosphate,that guides it to sites of PG synthesis www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

NLRs aren't just for immunity. Inspired by our colleagues working on plant NLRs, postdoc @maxljordan.bsky.social from my lab asked: Do bacterial NLR-type regulators found in antibiotic-producing #Streptomyces share a similar autoactivation switch? Turns out, yes! Read the full story and his 🧵👇

Max Jordan@maxljordan.bsky.social

Really excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.social www.biorxiv.org/content/10.6...

I had a wonderful time at the 2026 SSM meeting in Montreux, and it was great to meet the Swiss microbiology community. Great science in a beautiful location! Many thanks to the organisers and in particular to @aharms485.bsky.social

Alexander Harms@aharms485.bsky.social

The 2026 Swiss Society for Microbiology meeting in Montreux was fantastic! Highlights beyond the sessions: special talk by Lena Flörl @lenafloerl.bsky.social on microbial terroir in wine and full house for “My career in molecular microbiology”. Great community, great location, great science! 🌊🧬🎤

Susan Schlimpert reposted

Brilliant choice, one of the great microbiologists.

The Royal Society@royalsociety.org

Professor Bonnie Bassler is awarded the Copley Medal for her discovery of the universality of chemical communication in bacteria and for her idea that interfering with this communication could form the basis of novel anti-bacterials. #RSMedals https://royalsociety.org/medals-and-prizes/copley-medal/

Susan Schlimpert reposted

Happy to see this work preprinted! Only our second foray into the mycobacterial T7SS

bioRxiv Microbiology@biorxiv-microbiol.bsky.social

Characterizing the interaction of a type VII-secreted antimycobacterial toxin with its small helical partner proteins https://www.biorxiv.org/content/10.64898/2026.08.24.746431v1

It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social ! Deadline: Jan 6, 2027. #Bacdiv27

EMBO@embo.org

Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027. Deadline: 6 January 2027 https://meetings.embo.org/event/27-cell-division #EMBObacDiv27 #genetics #biochemistry #StructuralBiology #EMBOevents 🧪

Susan Schlimpert reposted

Susan Schlimpert reposted

Susan Schlimpert reposted

Susan Schlimpert reposted

Now published in JBac. Absolutely great publishing experience!!! Thank you to editors and reviewers.https://journals.asm.org/doi/10.1128/jb.00286-26 Another great one from @tommclean.bsky.social @johninnescentre.bsky.social @hbio-isp.bsky.social

journals.asm.orgTrbA binds and locks a sliding clamp KorB to repress transcription on multi-drug resistance plasmids | Journal of BacteriologyPrecise regulation of gene expression ensures gene products are produced at the right time and in the right amounts. Recent works uncovered a new mechanism of bacterial gene regulation based on a clamp sliding and locking in a multi-drug resistance plasmid, RK2. KorB functions as a CTP-dependent DNA-sliding clamp capable of traveling over a long genomic distance. Sliding KorB is captured and locked in place by a partner protein, KorA, forming a stable complex at target promoters to repress transcription. Here, we show that another RK2 regulator, TrbA, also uses this clamp sliding-locking mechanism, and identify an aromatic interface enabling TrbA-KorB-mediated transcriptional repression. Our findings show how a single sliding clamp integrates multiple partners to build a complex transcriptional regulatory network.
Tung Le@tunglejic.bsky.social

Here, @tommclean.bsky.social shows that another RK2 regulator, TrbA, likely also use this “clamp sliding-locking” mechanism to regulate gene expression. Interesting how a single sliding clamp might integrate multiple partners to potentially build a complex regulatory network... shorturl.at/YQJOI

Susan Schlimpert reposted

Susan Schlimpert reposted

We built a a self-dividing synthetic cell ! Check out this #CDlab preprint on BioRxiv: www.biorxiv.org/content/10.6... Great work by 1st author Charu Sharma who encoded dynaminA in a genome and expressed that in liposomes that then divide into daughter cells! Collaboration with Koenderink lab!

Susan Schlimpert reposted

I just still cannot help myself from looking that these beautiful real-time dynamics videos from @anjbadri.bsky.social lab! thanks to all the authors from @joeloparo.bsky.social / @anjbadri.bsky.social and TJ Ha labs.

Miloš Tišma@tismaa.bsky.social

I'm happy to share the first paper from my postdoc work: www.biorxiv.org/content/10.6... How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one? We find that DNA topology is the gatekeeper !! 1/10

Susan Schlimpert reposted

Susan Schlimpert reposted

A family of lanthipeptides with anti-phage function Discovery of 2,000+ lanthipeptide biosynthetic gene clusters with anti-phage potential. Lanthivirins inhibit phage replication by targeting phage proteins & interfering with phage DNA replication. www.cell.com/cell-host-mi...

cell.comA family of lanthipeptides with anti-phage functionShomar, Guillaume, et al. report the genomics-driven discovery of a family of more than 2,000 lanthipeptide biosynthetic gene clusters with anti-phage potential. They experimentally demonstrate anti-p...

Susan Schlimpert reposted

Susan Schlimpert reposted

Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions. Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵