Microbiologist, Group Leader and Professor at the John Innes Centre, UK. Our lab is interested in bacterial cell biology and development. We are particularly passionate about #Streptomyces. Lab website: www.schlimpertlab.com
Two PhD opportunities in our lab:
1. What do bacterial NLR proteins do beyond phage defence? Join us to explore how these proteins regulate viability, multicellular development and antibiotic production in Streptomyces.
Apply 👉 shorturl.at/N8Abx#PhD#Microsky#Bioinformatics#Streptomyces
How is the replication of RepABC-dependent chromosomes or megaplamids switched on during the cell cycles of Alphaproteobacteria?
--> Find out in our latest article, just published @narjournal.bsky.social
Incredibly excited about our latest work on R-bodies, 5+ years in the making! These coiled protein ribbons extend into ~10 µm needles in a pH-dependent manner & we caught them springing open inside amoebae after P. aeruginosa gets eaten. (animation: Jegg Yoon)🧵1/2 www.biorxiv.org/content/10.6...
My collaborator Netanel Tzarum developed a cool method to express and purify highly toxic bacterial proteins. We helped a bit. Very useful for anyone working with toxin-antitoxin or effector-immunity systems.
Now in Microbial Biotechnology
enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...
We want to use machines to better understand biology and turn that knowledge into new treatments for drug-resistant infections. This'll take people working together across disciplines.
Thanks to Aarti Krishnan, Hanqun CAO, & James J. Collins for this collaboration.
www.science.org/doi/10.1126/...
A DTP PhD opportunity in our group:
Breaking Code: Deciphering the Biology of the Selfless Virus-like Gene Transfer Agents.
Come help us figuring out!!! retweet = nice. Thank you!!!
Apply 👉 shorturl.at/1v9ms#PhD#Microsky#phages#GTA#Caulobacter
Two PhD opportunities in our lab:
1. What do bacterial NLR proteins do beyond phage defence? Join us to explore how these proteins regulate viability, multicellular development and antibiotic production in Streptomyces.
Apply 👉 shorturl.at/N8Abx#PhD#Microsky#Bioinformatics#Streptomyces
2. Joint-PhD project with @andrewbeekman.bsky.social: Join us to design, synthesise and test peptides that block a key cell-division protein interaction in Mycobacteria to combat antibiotic-resistant pathogens?
Apply 👉 shorturl.at/R24e2#PhD#AntibioticResistance#ChemicalBiology#Microsky
Beetles secrete jelly to embed & sustain symbionts with impossibly tiny genomes🪲
But what is this jelly made of? And how does it help maintain a partnership that has lasted over 62 million years?
Thrilled to share our latest, out now in @natcomms.nature.com!
www.nature.com/articles/s41...
Fully funded PhD with me and @barriewilks.bsky.social - starting Oct 27. We identified a Streptomyces spore phase regulator, when we over express this it activates loads of silent antibiotic biosynthesis pathways. Come help us understand how!
biodtp.norwichresearchpark.ac.uk/projects/ant...
VACANCY - We’re looking for a Postdoctoral Researcher to join the @Barrie Wilkinson Group, in collab with the @Matt Hutchings lab, on a project: Global activation of silent and cryptic biosynthetic pathways in Streptomyces species.
Deadline - 26 October 2026
Contract - 36 months, full-time
Dear colleagues, I am delighted to announce that the team’s website is now live santinlab.weebly.com 🥳🥳
I would also like to take this opportunity to let you know that, I am recruiting a junior postdoc to start on 1 January 2027. For further information, please feel free to contact me.
🚨PhD opportunity alert!!! Come work with us on this new cool NERC DTP PhD project
Investigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments.
Retweet = nice. Thank you!!!
aries-dtp.ac.uk/studentships...
really cool work from @lore-fermar.bsky.social et al
Differential restructuring of a complex compost microbiome by metabolically distinct #Streptomyces through community-dependent microbial interactions eprints.gla.ac.uk/396050/1/396...
It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social !
Deadline: Jan 6, 2027. #Bacdiv27
Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027.
Deadline: 6 January 2027
https://meetings.embo.org/event/27-cell-division#EMBObacDiv27#genetics#biochemistry#StructuralBiology#EMBOevents 🧪
The final version of our manuscript on TnSeq in bacteriophages (“HIDEN-SEQ”) is out today – if you have an interesting phage phenotype and want to know the underlying genetic basis, this one is for you! 1/4
Interested in #archaea, #methane, #cell-envelopes?
New paper out @nature.com !
We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description
www.nature.com/articles/s41...#MicroSky 🧵👇
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11!
GRS will be on June 5-6, 2027
We’ll likely be oversubscribed, so please apply early!
EMBO Workshop on Bacterial Networks: Our microbiology editor Ieva Gailite presenting the @embojournal.org poster prize to Morgane Wuckelt from the @mathieucoureuil.bsky.social lab - congratulations!
How do proteins localize in bacteria? Usually by binding to a prelocalized protein-but how does that protein localize? @vanipande.bsky.social found a #Bacillus subtilis protein that localizes via a lipid cue,undecaprenyl phosphate,that guides it to sites of PG synthesis
www.pnas.org/doi/10.1073/...
Susan Schlimpert @s-lab.bsky.social on a conserved cell division factor organises Z-ring formation in Actinobacteria
#EMBOBacNet
Teaser on Streptomyces compartmentalisation and division, their recent Curr Opin Micro review: www.sciencedirect.com/science/arti...
Max Jordan @maxljordan.bsky.social (from @s-lab.bsky.social lab) on autoactivation of an NLR-related transcriptional regulator enables characterisation of downstream signalling that activates Streptomyces antibiotic production
#EMBOBacNet
NLRs aren't just for immunity. Inspired by our colleagues working on plant NLRs, postdoc @maxljordan.bsky.social from my lab asked: Do bacterial NLR-type regulators found in antibiotic-producing #Streptomyces share a similar autoactivation switch? Turns out, yes!
Read the full story and his 🧵👇
Really excited to share our new manuscript on how the #NLR protein #AfsR regulates #Streptomyces antibiotic production - and how we can use its similarity to plant NLR immune receptors to enhance this production! 📄🧵 (1/17) @johninnescentre.bsky.socialwww.biorxiv.org/content/10.6...
I had a wonderful time at the 2026 SSM meeting in Montreux, and it was great to meet the Swiss microbiology community. Great science in a beautiful location! Many thanks to the organisers and in particular to @aharms485.bsky.social
The 2026 Swiss Society for Microbiology meeting in Montreux was fantastic! Highlights beyond the sessions: special talk by Lena Flörl @lenafloerl.bsky.social on microbial terroir in wine and full house for “My career in molecular microbiology”. Great community, great location, great science! 🌊🧬🎤
Professor Bonnie Bassler is awarded the Copley Medal for her discovery of the universality of chemical communication in bacteria and for her idea that interfering with this communication could form the basis of novel anti-bacterials. #RSMedalshttps://royalsociety.org/medals-and-prizes/copley-medal/
Characterizing the interaction of a type VII-secreted antimycobacterial toxin with its small helical partner proteins https://www.biorxiv.org/content/10.64898/2026.08.24.746431v1
It is happening, and registration is open for the EMBO Workshop: Bacterial and archaeal cell division: diverse mechanisms and models. 20–23 April 2027 | Barga, Italy. Come and join us @awehenkel.bsky.social, @seamusholden.bsky.social, @s-lab.bsky.social !
Deadline: Jan 6, 2027. #Bacdiv27
Sign up now for the EMBO Workshop "Bacterial and archaeal #CellDivision: Diverse mechanisms and models" in Barga (Lucca), Italy, 20–23 April 2027.
Deadline: 6 January 2027
https://meetings.embo.org/event/27-cell-division#EMBObacDiv27#genetics#biochemistry#StructuralBiology#EMBOevents 🧪
@felixrl.bsky.social told us previously *how* #Staph aureus does orthogonal cell division. In his latest paper he tells us *why*: to arrange cell surface proteins required to form staphylococcal abscess colonies. (Videos S1-S2 are amazing!). 🤯
www.cell.com/cell-reports...
VACANCY - Group Leader in Fundamental Biology of Legumes
We’re hiring for a tenure track Group Leader in fundamental plant biology relevant to legumes or other rotation crops.
https://okt.to/saqLz6
Here, @tommclean.bsky.social shows that another RK2 regulator, TrbA, likely also use this “clamp sliding-locking” mechanism to regulate gene expression. Interesting how a single sliding clamp might integrate multiple partners to potentially build a complex regulatory network...
shorturl.at/YQJOI
We are looking for a PhD student interested in AMR development in pathogenic corynebacteria.
Link: jobs.uni-kiel.de/jobposting/e...
The advert is bilingual (scroll down for English). Applications need to be submitted online via the indicated link. We are looking forward to you applications!
We built a a self-dividing synthetic cell !
Check out this #CDlab preprint on BioRxiv: www.biorxiv.org/content/10.6...
Great work by 1st author Charu Sharma who encoded dynaminA in a genome and expressed that in liposomes that then divide into daughter cells!
Collaboration with Koenderink lab!
Our new preprint is out! We investigate chromosome organization in obligate mammalian symbionts and show that these bacteria maintain stable chromosome orientations while displaying conserved lifestyle-associated chromosome architectures across species.
www.biorxiv.org/cgi/content/...
I'm happy to share the first paper from my postdoc work:
www.biorxiv.org/content/10.6...
How does RecA find one homologous sequence in an entire chromosome -and what turns that encounter into a repair-competent one?
We find that DNA topology is the gatekeeper !!
1/10
A family of lanthipeptides with anti-phage function
Discovery of 2,000+ lanthipeptide biosynthetic gene clusters with anti-phage potential. Lanthivirins inhibit phage replication by targeting phage proteins & interfering with phage DNA replication.
www.cell.com/cell-host-mi...
Systematic identification of cell division proteins in haloarchaea and the discovery of a membrane anchor for the Z ring.
www.biorxiv.org/content/10.6...
Some bacteria do not live as individuals. They build multicellular filaments and connect neighboring cells through tiny cell-cell junctions.
Cyanobacteria are among the most beautiful examples 😍 In our new paper, we reveal first molecuar insights on the cyanobacterial septal junction architecture 🧵