Sidhant Chopra

🧠 New work showing prominent and widespread 𝘪𝘯 𝘷𝘪𝘷𝘰 pre-synaptic terminal reductions in people with schizophrenia.🧠 nature.com/articles/s41... Strongest effects in left hemisphere, but synaptic loss didn't track with MRI grey matter alterations, but did align with..👇1/4

Spatial organization of AQP4 water channel expression in the human brain | doi.org/10.1126/scia... Aquaporins are a key component of the glymphatic system. How are they distributed + how do they relate to brain function and dysfunction? ⤵️

In our latest episode of The Biological Psychiatry Podcast, we sit down with Dr. @sidchop.bsky.social from @orygen.org.au and the @unimelb.edu.au to discuss his latest work distinguishing the effects of psychotic illness and antipsychotic medication on the brain.

New paper from former @holmeslab-bhi.bsky.social post-doc @sidchop.bsky.social. In first-episode psychosis, antipsychotic-naive patients on placebo showed widespread cortical thinning over 12mo. However, patients on antipsychotics did not. Thinning appears to be illness- not drug-driven.

RESEARCH | More targeted and effective treatments for psychosis could be one step closer, with a new study led by Orygen researcher Dr @sidchop.bsky.social revealing large and widespread synaptic loss in people diagnosed with schizophrenia. Details: bit.ly/4wITeSq

Our new paper in @natureportfolio.nature.com. Psychedelics don’t simply disorder the brain. We found hidden, context-sensitive organisation beneath the apparent chaos -- strongest in people reporting more positive, profound experiences and a reduced sense of separation from the world. 🧵👇

Our latest out now in @natneuro.nature.com led by @trangcao.bsky.social looking at the reproducibility of MRI morphometry phenotypes in psychiatric disorders. Paper: www.nature.com/articles/s41... Thread: x.com/TrangCao2016...

So excited to share that our study is out now in @natcomms.nature.com! 🧠🚨 www.nature.com/articles/s41... Big shout out to coauthors @sidchop.bsky.social @ashleasegal.bsky.social @loiclabache.bsky.social Rowena Chin Kaley Joss & @avramholmes.bsky.social

Rutgers Health article on @sidchop.bsky.social and @holmeslab-bhi.bsky.social's latest work.

The study, published in Molecular Psychiatry, was led by senior authors Dr. Avram Holmes @avramholmes.bsky.social and Dr. Rajiv Radhakrishnan at Yale University, and first author former Holmes Lab postdoc, Dr. Sidhant Chopra at Orygen & University of Melbourne. www.nature.com/articles/s41...

Happy to share that our work is finally published in @commsbio.nature.com! We identify molecular and cellular signatures of hemispheric specialization, linking language and attention to distinct neurotransmitter, mitochondrial, & cellular organization across the cortex 🧠 doi.org/10.1038/s420...

Synaptic loss in schizophrenia isn't random. New PET imaging work from our group, led by @sidchop.bsky.social, shows it's left-lateralized, follows neurochemical gradients, and may propagate outward from inferior frontal cortex through axonal networks, independent of MRI grey matter changes

Our paper “Multiscale heterogeneity of atypical functional connectivity in autism” is now out in Nature Mental Health www.nature.com/articles/s44... With @alexfornito.bsky.social, Jan Buitelaar, Marianne Oldehinkel

Great new stuff in @apertureohbm.bsky.social here 👇

Just published! 🎉 My new blog post tackles the mighty `apply()` function in R. Demystify `MARGIN` and master operations from matrices to 5D neuroimaging data. Say goodbye to loops! 🧠📊 drmo.site/k40xD5 #RStats #DataScience #Neuroimaging

Thrilled to share a new paper in @jamapsychiatry.com on path asymmetry in complex dynamic systems of psychopathology! jamanetwork.com/journals/jam... With amazing collaborators @tfblanken.bsky.social, Han van der Maas, & Denny Borsboom 🥳

Unattended working memory items are coded by persistent activity in human medial temporal lobe neurons | Nature Human Behaviour www.nature.com/articles/s41...

Michael X Cohen on why he left academia/neuroscience. mikexcohen.substack.com/p/why-i-left...

When @laurapritschet.bsky.social & Pavel Shapturenka set out to build the 28&Me + 28&He datasets, I don't think any of us could've predicted the spectacularly creative ways the datasets would be used years later. That's the power of open science. 👇🏼

(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025... Funded by National Institute of Mental Health (NIMH)

Congratulations to these Orygen early career researchers, whose innovative work has been recognised with new grants 👏 More details: bit.ly/46BpOdj @sidchop.bsky.social @stephmiles.bsky.social

Hej, Melbourne #rstats folks! Please join me for my in-person workshop on C++ Programming for Faster Statistical Modelling in R on Monday, Sep 29! Lot's of goodies for econometricians and statisticians here! Register at: wombat2025.numbat.space #rstats #rcpp

Neuromorphic hierarchical modular reservoirs | doi.org/10.1101/2025... How does hierarchical modularity shape computational function? ⤵️

Network spreading and local biological vulnerability in amyotrophic lateral sclerosis | doi.org/10.1038/s420... How do brain network structure and local biological features shape the spatial patterning of atrophy in ALS? @asafarahani.bsky.social investigates ⤵️

in preparation for next week's NACS speaker, today's target article

The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n

The BRIDGE Lab has officially been launched! 🔗 bridgelab.ucsd.edu 👉 we Bridge Research in Imaging, Development, Genetics and Emerging mental health 🧠 🧬 🚸 🌉 please don't be shy to reach out if you are interested in learning more about our lab's research!

Our latest work is now out in @natmentalhealth.nature.com! We examined the role of the basal forebrain and its influence on intrinsic brain networks in depressive and anxiety disorders. 🔗 www.nature.com/articles/s44... @psychunimelb.bsky.social, @mbciu.bsky.social, #UnimelbMDHS

🔍 OHBM's SIGs and Committees spotlight research reflecting the topics and challenges that matter to their communities. Explore their selections here: apertureneuro.org/pages/906-fe... @ohbmenvironment.bsky.social @ohbm-com.com @ohbmossig.bsky.social @ohbmofficial.bsky.social

🔥ATTENTION!🔥 Registration for the 2026 Noosa Brain Workshop is now open! Join us for some amazing science, sun, and surf in one of Australia's most beautiful beach towns. Details: tinyurl.com/arbc5pp6 Check out or incredible list of confirmed speakers. More to come...

The @cahbir.bsky.social and @rutgersbhi.bsky.social are hiring! Multiple open area and open rank faculty jobs, wonderful colleagues, amazing resources, and one of the largest communities of brain science research groups on the planet. Please apply and share widely. jobs.rutgers.edu/postings/209...

🧠 We're hiring a computational postdoc! 3+ years with me & @mitulamehta.bsky.social on @wellcometrust.bsky.social funded social cognition/paranoia research at the IoPPN. Lead & develop computational work, collaborate with experimentalists on psychosis/THC data. DM for details! lnkd.in/eCMy9Jf5

Adaptive learning is coordinated across behaviour, time and neurobiology (from synapses and dendrites, to astrocytes and the systems level). If you’ve ever wondered how noradrenaline helps shape these multiscale learning processes, you might like this: www.cell.com/trends/cogni...

NIMH Data Archive is now also imposing NIST/ISO requirements (like NBDC). Not sure how many labs actually have the resources to meet these requirements. Is the golden era of open brain imaging data basically over?

Early bird registration for #WOMBAT2025 ends this week! WOMBAT is a data analytics workshop in Melbourne featuring the latest open source software. 📅 29-30 September (day 1 is tutorials, day 2 is the main event) 📍 In-person | Melbourne CBD, Australia wombat2025.numbat.space

Great write up of the @nature.com study on MRI economics by @bttyeo.bsky.social's research group! With @avramholmes.bsky.social @sidchop.bsky.social @carrisacocuzza.bsky.social

Resting-state fMRI data predicts what people are thinking and how they're thinking it ⬇️

As federal support vanishes for research addressing the root causes of health disparities in the United States, we are left with a dangerous void and an urgent need to rethink science funding, says Vani Pariyadath go.nature.com/4mlvEGo

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see videos, read paper, follow thread doi.org/10.31234/osf...

🎉 WOMBAT is a fantastic event and I'm proud to be co-organising it this year. It's a great opportunity for us to share the latest open-source software and techniques among data analysts from academic, industry, and government.

Interested in cortical wave dynamics? Check out our new preprint led by J Cruddas with @jchrispang.bsky.social where review the physics and physiology of cortical waves and their implications for psychological function: osf.io/preprints/ps... @nsb-lab.bsky.social

My brilliant labmate, Keith Dodd, created this non-aggressive denoising pipeline for fMRI data for his dissertation! It has been super useful on some of our high-motion datasets, and I highly suggest folks check it out for their own studies 🧠📈🪲: direct.mit.edu/imag/article...

1 To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised! 🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

just out in Molecular Psychiatry 😍: spinal & cortical alterations in processing of self-produced sensations in psychosis including: touch, interoception, fMRI, SEP, HEP, behavior🧠🫀 #neuroskyence #PsychSciSky @paulasalamone.bsky.social @adamenmalm.bsky.social @rkaldewaij.bsky.social rdcu.be/exN0e