Simon Cleary

Read about how research into lymphatic function is changing our understanding of immune regulation in the lungs in our review: doi.org/10.1016/j.co... Congratulations to co-authors Amy Rivers and Camila Migues Ramirez!

An old friend asked if I had any videos of cilia laying around for her class to see. I dug up this one from about 10 years ago and it could maybe win a prize for 'most similar to a wacky waving inflatable tube man'.

Very excited about this preprint! We present a new method to flexibly align your 2P imaging plane with curved biological structures. Great work of PhD student Shinjini Ghosh, with Fritjof Helmchen, @nvladimus.bsky.social, and many others! www.biorxiv.org/content/10.6...

Looking for a change? Is this your Time-of-flight? @babrahaminst.bsky.social are seeking an ambitious and scientifically accomplished proteomics specialist to lead our Mass Spectrometry Facility during an exciting period of growth. Come and join us! babraham.current-vacancies.com/Jobs/Advert/...

Check out our Comment in @natureportfolio.nature.com where we write about: i) The decline in physician-scientist numbers worldwide ii) Why this might be, based on our data and others’ iii) Steps to reverse the decline www.nature.com/articles/d41... @bealelab.bsky.social @mhaniffa.bsky.social

AI image generators are being used to make movies that, at 1st glance, look like real microscopy but on closer inspection are misleading slop. Ok to use these images for public engagement, competitions, decoration, research? Join live discussion later today: events.bitesizebio.com/nikon-small-...

Sign up for this excellent - and timely - webinar (Weds 14 Oct 5pm BST) addressing questions surrounding AI in scientific imaging 🙂👇 events.bitesizebio.com/nikon-small-... @bioimaginguk.bsky.social @rmsearlycareer.bsky.social

1. CRISPR came from basic research on bacteria. 2. Optogenetics started with a discovery in algae. 3. The GFP protein comes from jellyfish. The biggest breakthroughs all trace to scientists following their curiosity, and this is one huge reason why we must keep funding basic research!

Interested in cancer-associated thrombosis? We are proposing a PACE postdoctoral fellowship to study it in a joint effort between the Crick and UCL. If this sounds interesting, apply here: A dangerous NETwork: neutrophils and cancer-associated thrombosis @TheCrick www.crick.ac.uk/careers-stud...

Nikon have made the right choice and an important discussion has been started on acceptable use of AI in microscopy. Look at this weird little guy (now 5th place, a sea slug captured by Igor Adameyko)!!

Join >300 scientists, clinicians, patients and charity workers by signing this letter demanding a transparent & positive resolution after an AI-generated movie claiming to represent an airway of a child with PCD was awarded 1st place in Nikon's video-microscopy contest:

It is wrong that a largely AI-generated movie has been awarded 1st prize in the Nikon Small World in Motion competition. If you agree and want microscopy competitions and research to stay rooted in reality, please co-sign this letter:

Since this year #NobelPrize is for #optogenetics, here is one of my favorite systems, the optoRas. Originally designed for neutrophils, I adapted this to my embryonic myeloid cells! I use it to induce a new protrusion and drives this EM cell to go backward. #MicroscopyMonday

lnkd.in/p/eTV6xSxk pretty poor placeholder #NikonSmallWorldInMotion on a Saturday evening over two weeks since this all kicked off… #ReleaseTheRawData #MicroscopyMatters #CiliaGate

Having seen the news: www.bbc.co.uk/news/article... thought I'd share a cilia movie captured at UCL GOS ICH with Eriomina Shahaj & Vanesa Papastavrou using simple DIC on a Nikon Ti2 with DIC at 60x1.4. 500 fps here slowed down 20 times. Processed with Nikon's denoiseAI and an unsharp mask in Fiji.

Applications are open for our new fellowship programme with @lifearc.bsky.social 🚀 The scheme supports clinician scientists to build the skills, networks and experience needed to turn innovations in rare diseases into real-world impact. See eligibility and apply: bit.ly/4z1bUNQ

Hey! Submit your papers, and spread the word, this will be great! Thanks for inviting us @jcellsci.bsky.social and great to work with @pihanson.bsky.social on this issue!

There is a clear distinction between processing images to remove noise + spillover to better see real things (fine) and generating fake structures and time points (not fair!)

#FluorescenceFriday: Given the recently grown interest in ciliary beating, here is a movie of beating cilia in a human airway model that I captured last week with lattice light-sheet microscopy. No AI „processing“, this is the raw data! Frame rate is ca. 170fps, displayed here at 25fps.

Update on the "AI-based triage" which is getting lots of (negative) attention

I would prefer a lottery system to a potentially biased AI-triage. Would also have lower costs for the funder.

Even if it were ok to add AI-generated details in the lower half of the movie, what we are now told is a section of one ciliated cell is way too wide to be based on real images of one cell.

Out now @nature.com! We report a new means of cell communication: receptor-free signal transduction. TLRs engage MyD88 for minutes, yet myddosomes signal for hours. TRAM releases myddosomes from TLRs, letting them mature and sustain signaling in the cytosol. rdcu.be/jGdKxErXyAsa Details below:

What in the world am I looking at here? @Nikon? www.nikonsmallworld.com/galleries/20...

Neutrophil NADPH oxidase breaks the inflammatory IL-1β/IL-17A circuit to enhance pathogen clearance during respiratory virus infections @natcomms.nature.com @kingscollegelondon.bsky.social www.nature.com/articles/s41...

Check out Annika Warnatsch's work identifying neutrophil Nox2 as an inflammation-limiting mediator in viral pneumonia! A potential mechanism underlying the failure of antioxidant treatments in ARDS trials: www.nature.com/articles/s41...

$3.7 billion spent on APCs in 2025. That's ~1000X more than it costs to run bioRxiv/medRxiv. Worth thinking about as we consider how to fund infrastructure... arxiv.org/pdf/2608.16322

Hope you enjoy this short piece, which came out yesterday. Some thoughts I’ve been musing on for a while about why adaptive immunity evolved. Read it for free at rdcu.be/fAO5P

The AJP-Lung editorial fellowship is inviting applications for a new round: ow.ly/rUAN50Zq10K I really enjoyed and benefitted from participating - more info in this article from previous fellows: doi.org/10.1152/ajplung.00251.2026

A query for the immunologists: Are there any PAMPs left to discover?

Are tapes a good option for long-term cold storage of microscopy data? I'm looking at storing ~200 TB with no recurring fee (no cloud) and with as little esoteric server/command line fuss as possible www.ibm.com/fr-fr/produc...

We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

UK-based cell biologist? Interested in membrane trafficking? Want to find a conference? Looking for a job (PI, postdoc...)? Do link to www.ukmembranetraffic.com, where @jezcarlton.bsky.social and Chris Stefan (not here?) do sterling work