Spirochrome

Spirochrome probes: the Standard for live-cell imaging. 📊 1700+ publications cite SiR-actin, 📊 1300+ cite SiR-tubulin, 📊 1200+ cite SiR-DNA Trusted by thousands of labs worldwide. Join the community → spirochrome.com/products/ #LiveCellImaging #Microscopy #Fluorescence 🧪

Spirochrome probes: the Standard for live-cell imaging. 📊 1700+ publications cite SiR-actin, 📊 1300+ cite SiR-tubulin, 📊 1200+ cite SiR-DNA Trusted by thousands of labs worldwide. Join the community → spirochrome.com/products/ #LiveCellImaging #Microscopy #Fluorescence 🧪

1/3 A few snapshots from the past intense days at the University of Helsinki for our FLIM and FCS course! We combined lectures, hands-on microscopy and analysis with plenty of questions and discussion. A fantastic group of researchers to learn with. 🔬 #FLIM #FCS #Microscopy

Spoiler: lots of 😍 SPY555-FastAct live cell movies in there.

An amazing new tool to explore "non-models" is just about to open a new world of imagining possibilities....

Casually posting this one for no particular reason! #MayTheFourth

Overly proud that Katie Holden's image won Evident Microscopy's 6th Annual Image of the Year "Global Winner" award🏆 The image shows Live iPSC-derived neurospheres. DNA (magenta) & MT (blue) were stained with our probes SiR-tubulin & SPY555-DNA probes. evidentscientific.com/en/landing/i...

What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

Mesmerizing light sheet imaging of neutrophils swarming at a yeast target! The neutrophils were labeled with SPY650-DNA (yellow) and a calcium dye (blue). This movie is part of the recent manuscript by @strickland-evelyn.bsky.social that we highly recommend reading! www.biorxiv.org/content/10.6...

What a probe! Congratulations @cepourroy.bsky.social! We're happy to share that we re working hard on making CenSpark probes available to the centriole aficionados in the coming weeks!

Organoids stained with Spirochrome probes for actin and DNA! 😍

See how PKMito dyes promote mitochondrial research😀 @spirochrome.com

📢 Staining #Peroxisomes in live & fixed cells with Peroxi_SPY probes has never been so easy! There is now a very detailed #JOVE video that explains it all step by step. Video link: dx.doi.org/10.3791/6940... Peroxi_SPY link: spirochrome.com/products/?_c... 🧪

📢 Staining #Peroxisomes in live & fixed cells with Peroxi_SPY probes has never been so easy! There is now a very detailed #JOVE video that explains it all step by step. Video link: dx.doi.org/10.3791/6940... Peroxi_SPY link: spirochrome.com/products/?_c... 🧪

🤩 Another amazing example of U-ExM actin staining with HAK-actin by @dudinlab.bsky.social et. al.

An amazing example of actin imaging with our expansion microscopy probe for actin HAK-actin™. These are U-ExM expanded platelets stained with HAK-Actin (magenta bottom), (anti-integrin αIIb magenta top), and fibrin (fibrinogen-A488, green). Movie from preprint www.biorxiv.org/content/10.6... 🧪

🧵 1/5 A new BioRxiv preprint reveals that membrane tension acts as a mechanical gate for lung cell fate during development! 🫁 Our Flipper-TR probe was key to assess live Cell Membrane Tension (CMT) Here’s how Flipper-TR unlocked a hidden layer of lung development & fibrosis. 👇 #Mechanobiology

🟢FastAct™ goes green! 🟢🔬 We launch SPY488-FastAct™ a green channel live cell actin probe SPY488-FastAct allows imaging F-actin in live and fixed cells Compatible with SPY555 and SPY650 for easy 3 color imaging. spirochrome.com/product/spy4... available at our distributors in a couple of days. 🧪

🟢FastAct™ goes green! 🟢🔬 We launch SPY488-FastAct™ a green channel live cell actin probe SPY488-FastAct allows imaging F-actin in live and fixed cells Compatible with SPY555 and SPY650 for easy 3 color imaging. spirochrome.com/product/spy4... available at our distributors in a couple of days. 🧪

1/New preprint just dropped! 🔥🔥 We investigate how the genome is destroyed in apoptotic cells in a way that prevents DNA fragments from spreading beyond the dying cell 🧬⚰ Done here at @imbavienna.bsky.social & in the super @rcollepardo.bsky.social & Rosen labs: www.biorxiv.org/content/10.6...

Mesmerizing actin fireworks 💥 with our actin probe SPY650-FastAct_X for #FluorescenceFriday Easy to use: just dilute the probe in cell culture medium and image 30 min later! 🔗 spirochrome.com/product/spy6... 🙏 Big thanks to @lazaresaladin.bsky.social for the images. 🧪

Mesmerizing actin fireworks 💥 with our actin probe SPY650-FastAct_X for #FluorescenceFriday Easy to use: just dilute the probe in cell culture medium and image 30 min later! 🔗 spirochrome.com/product/spy6... 🙏 Big thanks to @lazaresaladin.bsky.social for the images. 🧪

An amazing preprint by @gerlichlab.bsky.social on the fate of DNA during apoptosis. Definitely to add on your reading list! Our SPY650-DNA probe was heavily used to visualize DNA throughout the manuscript. Congratulations to the team!

SPY555-Tubulin and SPY650-FastActX wound up looking good together for 11hrs. Thanks for the helpful info!

Another fiery 💥 probes combination by @j-today.bsky.social, this time with SPY555-Tubulin and SPY650-FastAct_X. 🤩

ICYMI SPY555-FastAct_X and SiR-tubulin in action here! 🤯 16h imaging of neurons 💥 Thank you @j-today.bsky.social for posting this gem!

Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells. Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!

📐 Visual communication for @spirochrome.com Design for the launch of HAK-actin™, a new fluorescent probe for Expansion Microscopy. Project included a clear usage schematic, flyer, and folded leaflet, with a minimalist, efficient style aligned with Spirochrome’s visual identity.

Peroxi_SPY probes were designed for peroxisome live cell imaging. Turns out they work with fixed cells as well! Peroxi_SPY can thus be combined with immunofluorescence labeling. A new article provides a detailed protocol: app.jove.com/t/69405/pero... Products link: spirochrome.com/products/?_c...

Peroxi_SPY probes were designed for peroxisome live cell imaging. Turns out they work with fixed cells as well! Peroxi_SPY can thus be combined with immunofluorescence labeling. A new article provides a detailed protocol: app.jove.com/t/69405/pero... Products link: spirochrome.com/products/?_c...