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newsnetwork.mayoclinic.orgnewsnetwork.mayoclinic.org

The story of scale up of streptomycin for treating TB is an epic one, involving George Merck and his pharmaceutical company--just making enough to do the clinical trial was a challenge newsnetwork.mayoclinic.org/discussion/d...

journals.asm.orgSelman A. Waksman, Winner of the 1952 Nobel Prize for Physiology or Medicine | Applied and Environmental MicrobiologyABSTRACT The history of the discovery and development of streptomycin is reviewed here from the personal standpoint of a member of Dr. Selman Waksman's antibiotic screening research team. The team app...

Thank you, so interesting! I was reading earlier about how it was discovered by Waksman and then-PhD student Albert Schatz. It seems Schatz was drafted into WWII while working on the project. He returned to the lab a few months later after an injury, and then discovered streptomycin.

Strange to imagine what it might have been like if he hadn't returned - maybe someone else in Waksman's lab would have discovered it, but a while later? I hadn't read about the problems with scaling it up for trials though, really interesting

Jake Matthews

@jakemat91.bsky.social

medicurious.substack.comNo 77 - The Art and Science of UK GP: A Historical TimelineA poster that we are presenting at SAPC SW

This is brilliant. I wish I had seen that before a colleague and I made this: medicurious.substack.com/p/no-77-the-... #MedEd #MedSky #TeamGP

Christian Bartels

@chriba.bsky.social

Need gives speed. If there is no urgent need, apparent progress will be slow. Being slow now may enable rapid progress when it is needed.

Rosewind

@rosewind.bsky.social

I was recently part of a community event in a local cemetery where the first man treated with penicillin is buried:

Matt Hall

@cispt2.bsky.social

bbc.comFamily to tell first penicillin patient's story at conference - BBC NewsPC Albert Alexander received the newly-discovered antibiotic after being injured in 1941.

Thank you for sharing this - and here’s a photo of him. www.bbc.com/news/uk-engl...

That's so interesting. Was this in Oxford?

Rosewind

@rosewind.bsky.social

fnrcnewbury.org.ukFriends of Newtown Road Cemetery: Biography

It’s in Newbury, the Newtown Road Cemetery: www.fnrcnewbury.org.uk/biography.as...

ourworldindata.orgWhat was the Golden Age of Antibiotics, and how can we spark a new one?Many antibiotics were developed during the “Golden Age of Antibiotics”. How did it happen, why has antibiotic development slowed down since then, and what can we do to reignite it?

Saloni@scientificdiscovery.dev

The data comes from this very interesting paper on antibiotic development: doi.org/10.1016/j.mi... And is part of a new article I wrote on the Golden Age of Antibiotics and how we can spark a new one!

github.comnotebooks/SaloniDattani/Antibiotic-drugs at main · owid/notebooksOur World In Data jupyter notebooks. Contribute to owid/notebooks development by creating an account on GitHub.

You can find the data and scripts to recreate this timeline on GitHub:

rodbuchanan.bsky.social

@rodbuchanan.bsky.social

pmc.ncbi.nlm.nih.govThe Discovery of Penicillin—New Insights After More Than 75 Years of Clinical UseAfter just over 75 years of penicillin’s clinical use, the world can see that its impact was immediate and profound. In 1928, a chance event in Alexander Fleming’s London laboratory changed the course...

Not sure about p scale up as relatively slow. Florey etal worked fast. US scale up of p was coextensive with a scale up of the whole industry. The Fleming ‘discovery’ thing is misleading – came about partly because neither Florey nor his team talked to the press. pmc.ncbi.nlm.nih.gov/articles/PMC...