Matt Hall

Matt Hall

@cispt2.bsky.social

🇦🇺 SD at NCATS, all about treatments for rare diseases, drug discovery and technologies. Views my own. Etc.

1K followers107 following136 posts

Matt Hall reposted

Thiago Carvalho
@cyrilpedia.bsky.social

'If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yes— but not always. I present five examples where failed control experiments triggered entirely new fields of research.' link.springer.com/article/10.1...

link.springer.comThe controls that got out of control - EMBO ReportsEMBO Reports - When experimental controls go wrong, it does not necessarily mean your experiment is flawed. It might well be the first sign of something unexpected.

Matt Hall reposted

Ian M. Mackay, PhD (he/him) 🦠🤧🧬📑🦟🧀
@mackayim.bsky.social

"He urged the public and healthcare workers not to dismiss early symptoms such as vomiting and headaches, warning that misinformation leads many people to believe they have been poisoned rather than seeking hospital care." www.abc.net.au/news/2026-06...

abc.net.auBrazil authorities investigate two possible Ebola cases as outbreak growsThe true reach of the Ebola outbreak in central Africa could be much wider than the official figures published by central African authorities, the World Health Organization is warning.
Matt Hall
@cispt2.bsky.social

Love this from Samuel Johnson: “In lexicographers, as in many other arts, naked science is too delicate for the purposes of life”

Matt Hall
@cispt2.bsky.social

Today we are hosting Dr Barbara Slusher from John’s Hopkins speaking about her drug discovery research programs - amazing scientist and a full house for her seminar !

Matt Hall reposted

Cell Chemical Biology
@cp-cellchembiol.bsky.social

Online now! Discovery of a tau-aggregate clearing compound that covalently targets P4HB #chembiol

dlvr.itDiscovery of a tau-aggregate clearing compound that covalently targets P4HBConway et al. integrate phenotypic screening with chemoproteomics to discover an aminoindole that potently clears tau aggregates across multiple tauopathy models via covalently targeting of the ER enzyme P4HB, revealing potential therapeutic strategies for neurodegenerative disease.

Matt Hall reposted

C&EN (Chemical & Engineering News)
@cenmag.bsky.social

Ice freshly ejected from Enceladus contains complex organics Reanalyzing data from Cassini's 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon. cen.acs.org/physical-che... #chemsky 🧪

cen.acs.orgIce freshly ejected from Enceladus contains complex organicsReanalyzing data from <i>Cassini</i>'s 2008 flyby reveals new, complex organic molecules in the spray from Saturn’s icy moon

Matt Hall reposted

Matt Hall
@cispt2.bsky.social

As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!

Matt Hall
@cispt2.bsky.social

As a little boy, my grandparents gave me this book. This story of Pasteur is the one that made me want to be a scientist. And it doesn’t even mention optical activity!!

Matt Hall reposted

Matt Hall
@cispt2.bsky.social

I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes

Matt Hall reposted

The Society for Functional Precision Medicine
@thesfpm.bsky.social

We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵 www.nih.gov/news-events/...

nih.govSecretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer InstituteDr. Letai will serve as NCI’s 18th director.
Matt Hall
@cispt2.bsky.social

It reminds me of this banger: "Revised Estimates for the Number of Human and Bacteria Cells in the Body" - We estimate the total # of bacteria in the 70 kg "reference man" to be 3.8X10^13. - # of bacteria in the body is actually of the same order as the # of human cells, & total mass is ~0.2 kg.

Matt Hall
@cispt2.bsky.social

I rarely post about work, but in writing this email today asking how to be reimbursed for the cost of hosting a scientific visitor I wrote this explainer. This is not a complaint - but shows how we have to use our own salaries to enrich our environment and the commitment that takes

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Matt Hall
@cispt2.bsky.social

One of the posters from my group was on a drug discovery strategy for inhibitors of biliverdin reductase - a target relevant for several rare diseases. Our postbac Christa did an amazing job presenting her work - it’s a collab with scientists at Einstein.

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Matt Hall reposted

Matt Hall
@cispt2.bsky.social

Replying to @cispt2.bsky.social

But the poster sessions are buzzing - so much amazing NIH science on show! I got in trouble for standing on a ledge to take this photo….. you’re welcome

Matt Hall reposted

Nature Reviews Cancer
@natrevcancer.nature.com

#ResearchHighlight 🚨 In a recent study, the Nussenzweig lab investigated the mechanisms underlying #cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of #gemcitabine. 📖⬇️

nature.comSame same but different - Nature Reviews CancerIn a recent study published in Nature, Liu, Wang, et al. investigate the mechanisms underlying cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of other nucleoside analogues, such as gemcitabine.