Andy Posbe

Andy Posbe

@adnroide.bsky.social

PhD student at @TheSainsburyLab.bsky.social working on NLR bioengineering and computational prediction of immune receptor activities w/ @KamounLab.bsky.social . πŸ‡¦πŸ‡·πŸ³οΈβ€πŸŒˆ (he/him)

162 followers149 following21 posts

Andy Posbe
@adnroide.bsky.social

No one remembers authorising this firmware update

Andy Posbe@adnroide.bsky.social

Excited to share Fold on Tight! πŸŽ‰ We distil recent advances in plant immunity into 10 lessons for using AI structure prediction critically and effectively, in plants and beyond. πŸ“ zenodo.org/records/2210...

Andy Posbe reposted

Alex McClelland
@alexjmcclelland.bsky.social

Very pleased to have contributed to this concise, digestible overview of AI structure prediction! I think this is a great resource for newbies and experienced AlphaFold users alike. Happy Folding!

Andy Posbe@adnroide.bsky.social

Excited to share Fold on Tight! πŸŽ‰ We distil recent advances in plant immunity into 10 lessons for using AI structure prediction critically and effectively, in plants and beyond. πŸ“ zenodo.org/records/2210...

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Andy Posbe
@adnroide.bsky.social

On tοοls and metrics 🧰 Aside from the lessons, we put together a table of what's currently available and what each tool and metric is actually for. Reproduced below. Links in the reply.

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Andy Posbe
@adnroide.bsky.social

Finally, we apologise to colleagues whose excellent work we could not include because of space limitations. Thank you to the community whose discoveries made these ten lessons possible! πŸ™

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Andy Posbe
@adnroide.bsky.social

Lesson 8 β€” When Predictions Deviate from Canonical Models What if the model is telling us something unexpected? Unusual assemblies or repeated failures can hint at different biology. Interpret outliers using existing evidence, then test them. πŸ”

Andy Posbe
@adnroide.bsky.social

Lesson 9 - Structural Modeling Can Guide Protein Engineering From prediction to design! πŸ› οΈ Interfaces can guide changes that transfer recognition, restore function or create new connections. Combined with binder design, they can help build new immune receptor specificities.

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Andy Posbe
@adnroide.bsky.social

Lesson 6 - AI Can Reveal Novel Protein–Protein Interactions From screening entire proteomes to identifying short binding motifs, modelling can uncover new partners and explain how they interact, generating testable hypotheses and guiding experimental discovery.

Andy Posbe
@adnroide.bsky.social

Lesson 7 - Capture Touch-and-Go Complexes Brief encounters can have big consequences! AI models can help probe contacts that evade biochemical detection, suggesting how partners meet and which residues to test in the lab. πŸ§ͺ

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Andy Posbe
@adnroide.bsky.social

Lesson 4 β€” Structural Similarity Can Reveal Hidden Relationships Proteins with no detectable sequence similarity can share a fold. Comparing predicted structures across families or proteomes can uncover connections that sequence searches miss. πŸ”

Andy Posbe
@adnroide.bsky.social

Lesson 5 - You Can Never Benchmark Enough! A convincing model is a start. How does it compare with what we know? Include known interactors, non-interactors and solved structures as controls. Revisit these controls as tools change. πŸ§ͺ

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Andy Posbe
@adnroide.bsky.social

On tοοls and metrics 🧰 Aside from the lessons, we put together a table of what's currently available and what each tool and metric is actually for. Reproduced below. Links in the reply.

Andy Posbe
@adnroide.bsky.social

Lesson 3 β€” Model Your Proteins with Other Molecules Proteins have company! Lipids, nucleic acids, ions and ligands shape their biology. Including relevant partners can reveal interfaces and improve regions that are poorly modelled in isolation.

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Andy Posbe
@adnroide.bsky.social

Lesson 1 β€” Don’t Ignore Confidence Metrics πŸ” A model can be uncertain overall yet reliable at the interface that matters. Read local and interface scores alongside global confidence to judge which parts support your biological hypothesis.

Andy Posbe
@adnroide.bsky.social

Lesson 2 β€” Sample Multiple Seeds 🎲 How much depends on the seed? Repeat predictions to see which features hold and which vary. Consistency strengthens a hypothesis. Record seeds, model version, weights release and database version so others can reproduce the analysis.

Andy Posbe reposted

Jiorgos Kourelis
@jiorgoskourelis.bsky.social

πŸ“’ 2 PhD Positions Available in Plant Immune Receptor Bioengineering at Imperial College London 🌱 Start: Oct 2026 πŸ“… Deadline: 10 Feb 2026 πŸ‡¬πŸ‡§ UK/settled status only πŸ’° Fully funded (48 months) ℹ️ Info: shorturl.at/po61I #PlantImmunity #PlantPathology #SyntheticBiology πŸ™ Share with interested candidates!

imperial.ac.ukPhD Opportunities | Faculty of Natural Sciences | Imperial College London

Andy Posbe reposted

Sainsbury Laboratory Cambridge University (SLCU)
@slcuplants.bsky.social

πŸŽƒβœ¨ Pumpkin perfection! We were seriously impressed by the beautifully carved and brilliantly lit pumpkins from @thesainsburylab.bsky.socialπŸ•―οΈ We also got spiritedly competitive with our annual team pumpkin carving competition πŸ˜„πŸŽƒ Who knew plant scientists were such talented artists? πŸͺšπŸŽƒπŸŒΏ

Andy Posbe@adnroide.bsky.social

Spooky season has arrived! πŸ‘» We held our annual Pumpkin Carving Competition at @thesainsburylab.bsky.social β€”vote for your favourite carve! πŸŽƒπŸ•―οΈ

Andy Posbe reposted

ClΓ©mence Marchal
@clemmar.bsky.social

Super excited and honoured to have been awarded an ERC Starting Grant for CooPAIRation! How do plant immune receptors work together to trigger an immune response? Can we modulate immune responses for disease resistance? We will tackle these questions in CooPAIRation Positions to be announced soon!

European Research Council (ERC)@erc.europa.eu

πŸ“£ The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➑️ buff.ly/IsafuFh #FrontierResearch πŸ‡ͺπŸ‡Ί#EUfunded #HorizonEurope

Andy Posbe reposted

Josh Bennett
@joshwbennett.bsky.social

Excited to attend my 1st ISMPMI conference, and present our work on a paired wheat CNL/MLKL receptor mechanism! 🌾 Come chat to me at my poster on Tuesday, P-050! πŸ“œ If you miss my poster session, I will be talking in: Crop resistance genetics and genomics on Wednesday - 16:25-16:35!

Andy Posbe reposted

Morgan Carter
@morgancarterphd.bsky.social

Incredibly inspiring talk about the discovery of the more than 200 immune systems in bacteria by Rotem Sorek. From computational discovery in 2018 through functional and structural analyses, even linking bacterial immune systems to that of eukaryotes. #2025ISMPMI

Andy Posbe
@adnroide.bsky.social

Pikobodies vs. Potato Blight πŸ₯ŠπŸ₯” NLR–Nanobody Fusions Take on P. infestans πŸ’₯ 🎀 Talk: Thurs July 17th, 16:35 🧾 Poster P-64: Tues 15th, Session 2 Poster’s up on Zenodo if you’re into spoilers πŸ‘€πŸ“Ž zenodo.org/records/1584... #2025ISMPMI #OpenMPMI🌿

zenodo.orgPikobodies: NLR immune receptor-nanobody fusions can confer resistance to the potato blight pathogen Phythophthora infestansPlant pathogens continuously evolve to evade immunity, driving the need for innovative resistance strategies to safeguard global food security. In proof-of-concept work, we engineered the rice nucleot...

Andy Posbe reposted

Marc Somssich
@somssich.bsky.social

πŸ“œ Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome πŸ§‘β€πŸ”¬ Muniyandi Selvaraj, @kamounlab.bsky.social, @nlrpapi.bsky.social, et al. πŸ“” @biorxiv-plants.bsky.social πŸ”— www.biorxiv.org/content/10.1... #️⃣ (Feeds) #PlantScience #PlantImmunity #PlantEffectors

biorxiv.orgActivation of plant immunity through conversion of a helper NLR homodimer into a resistosomebioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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