Didier Mazel

Didier Mazel

@amazeld.bsky.social

Bacterial geneticist, Prof @ Institut Pasteur.

967 followers256 following46 posts

Didier Mazel reposted

Tominaga K. (tomiken)
@pacyc184.bsky.social

Reverse transcribed ssDNA derepresses translation of a retron antiviral protein: Molecular Cell

cell.comReverse transcribed ssDNA derepresses translation of a retron antiviral proteinRetrons help bacteria defend against phage by initiating a toxic response to restrict viral propagation. Here, Zhang et al. describe the non-canonical mechanism of Retron-Vpa2, which accumulates msDNA in response to phage triggers and regulates its toxic response on a translational level through a highly structured hybrid RNA.
Didier Mazel
@amazeld.bsky.social

A great work by @vincentburrus.bsky.social 's team. Fertility inhibition involves preventing relaxosome assembly by interfering between the relaxase and the mobilization factor! Bravo à tous!

Vincent Burrus 🇨🇦💙💛@vincentburrus.bsky.social

#plasmidbiology #plasmid Just out! 🚀 Thrilled by our discovery: the function of the C-terminal domain of MOBH1 relaxases! We uncovered this thanks to a fertility inhibitor encoded by a parasitic mobile genetic element. Congrats to Florence on a great piece of work! 👏 academic.oup.com/nar/article/...

academic.oup.comConjugative transfer inhibition of IncA and IncC plasmids by SGI1-like elements via relaxosome assembly interferenceAbstract. Broad-host-range IncA and IncC (A/C) conjugative plasmids propagate multidrug resistance in bacteria and mobilize chromosomal resistance islands,
Didier Mazel
@amazeld.bsky.social

Dear all, I have the pleasure to inform you that the online course "Resistance to Antibacterial Agents", produced by the Institut Pasteur, will start on November 3, 2026. How does ABR emerge and spread? ... 🔗 www.fun-mooc.fr/en/courses/r...

fun-mooc.frResistance to antibacterial agentsThe origin, risks, diagnosis, epidemiology of resistance to antibacterial agents in man and livestock worldwide, as well as preventive and countermeasures, in a « one health » perspective.
Didier Mazel
@amazeld.bsky.social

The last paper from our lab and our friends @mmarbout.bsky.social Ole Skovgaard @rkoszul.bsky.social. A milestone!

Marie-Eve VAL@val-meve.bsky.social

This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out! doi.org/10.1038/s414...

doi.orgLarge extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome - Nature CommunicationsBacterial genomes often include extrachromosomal replicons, ranging from small plasmids to chromosome-scale replicons. Here, Czarnecki et al. analyse more than 40,000 complete bacterial genomes and sh...

Didier Mazel reposted

Marie-Eve VAL
@val-meve.bsky.social

This one means a lot. Our paper, “Large extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome,” is out! doi.org/10.1038/s414...

doi.orgLarge extrachromosomal replicons are widespread across bacterial lineages and show coordinated replication termination and spatial coupling with the chromosome - Nature CommunicationsBacterial genomes often include extrachromosomal replicons, ranging from small plasmids to chromosome-scale replicons. Here, Czarnecki et al. analyse more than 40,000 complete bacterial genomes and sh...

Didier Mazel reposted

The Lambrechts Lab
@lambrechtslab.bsky.social

🚨 We're hiring! A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

research.pasteur.frPostdoctoral position in mosquito population genomics at Institut Pasteur in Paris - ResearchThe Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...
Didier Mazel
@amazeld.bsky.social

a quick reminder!

Institut Pasteur | 130 years of biomedical research@pasteur.fr

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

research.pasteur.frCreation of new junior research groups at the Institut Pasteur - Call for applications 2026 - ResearchThe Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

Didier Mazel reposted

Institut Pasteur | 130 years of biomedical research
@pasteur.fr

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

research.pasteur.frCreation of new junior research groups at the Institut Pasteur - Call for applications 2026 - ResearchThe Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...
Didier Mazel
@amazeld.bsky.social

We've come full circle! I began my postdoctoral career by identifying the peptidyl deformylase gene. Today, we show that half of bacterial species harbor multiple PDF genes (up to 7, for always a single Met-tRNA transformylase), and while the role of these PDFs ... academic.oup.com/mbe/article/...

academic.oup.comUnraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and ResistanceAbstract. Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despit

Didier Mazel reposted

Kevin Debatisse
@kdebatisse.bsky.social

Our new paper is out in @narjournal.bsky.social We show that natural transformation enables bacteria to shuffle integron cassettes, boosting their phenotypic diversity. academic.oup.com/nar/article/... 1/5

academic.oup.comBacterial natural transformation drives cassette shuffling and simplifies recombination in chromosomal integronsAbstract. Integrons act as biobanks of gene cassettes conferring functions crucial for bacterial defense, including protection against phages and antibioti
Didier Mazel
@amazeld.bsky.social

A fresh view on phage specificity, which challenges the traditional view of a narrow host spectrum of phages by unveiling that multihost associations are common across ecosystems kudos at @mmarbout.bsky.social & @rkoszul.bsky.social www.nature.com/articles/s41...

nature.comPhages with a broad host range are common across ecosystems - Nature MicrobiologyProximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
Didier Mazel
@amazeld.bsky.social

I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...

pnas.orgMutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNASCircadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to d...
Didier Mazel
@amazeld.bsky.social

Striking and frightening 😒 "They found multiple instances of insecticide-resistance variants in this malaria vector, although most of these weren’t shared with museum specimens collected as recently as 1967, suggesting rapid emergence" www.science.org/doi/10.1126/...

science.orgGenomic diversity of the African malaria vector Anopheles funestusAnopheles funestus s.s. is a major human malaria vector across Africa. To study its evolution, especially under vector control pressure, we sequenced 656 modern specimens (collected 2014 to 2018) and ...

Didier Mazel reposted

Marie-Eve VAL
@val-meve.bsky.social

Replying to @amazeld.bsky.social

Congratulations to PhD students Jasmin Ostermayer and Noa Guzzi (co–first authors 🎉), together with Jakub Czarnecki and Alfonso Soler-Bistué, for compressing the diverse, lineage-wide literature on large extrachromosomal replicons into <5000 words and 80 references 😅

Didier Mazel
@amazeld.bsky.social

A great step for archaea : connection between chromosome organization to genome segregation in Archaea www.nature.com/articles/s41... congrats to @danielabarilla.bsky.social

nature.comCoupling chromosome organization to genome segregation in Archaea - Nature CommunicationsProteins SegA and SegB are important for chromosome segregation and organization in archaea of the order Sulfolobales, but mechanisms are unclear. Here, Kabli et al. uncover patterns and mechanisms th...

Didier Mazel reposted

Morgan Lamberioux
@morgan-lamberioux.bsky.social

Thrilled to share my first PhD paper, out of the Mazel lab! @amazeld.bsky.social We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies doi.org/10.1101/2025...

doi.orgUnraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistancePeptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despite their conserved function, many bacteria encode multip...

Didier Mazel reposted

Jose A Escudero
@jaescudero.bsky.social

Replying to @jaescudero.bsky.social

Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...

science.orgSedentary chromosomal integrons as biobanks of bacterial antiphage defense systemsIntegrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
Didier Mazel
@amazeld.bsky.social

Next Tuesday Clement Gilbert and myself will discuss impact and extent of HGT in both prokaryotes and eukaryotes! It will be broadcasted on France Culture (in French)

Noémie Naguet de Saint Vulfran@nnaguet.bsky.social

Mardi 11 février, le @sciencecqfd.bsky.social de 16h portera sur le concept de transmission horizontale (TH) de matériel génétique. Ce sera sur @franceculture.fr ! Vous savez de quoi il s'agit ? 👇

Didier Mazel
@amazeld.bsky.social

A spectacular discovery! Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus | Science www.science.org/doi/10.1126/...

science.orgSequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleusIn eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...

Didier Mazel reposted

Nicolas Berrod
@nicolasberrod.bsky.social

La directrice de l'Institut Pasteur prévient que "les maladies infectieuses ont toujours représenté un risque, mais elles sont aussi l’une des principales menaces de santé publique à l’avenir." Longue interview, morceaux choisis ⤵️ @leparisien.fr 1/12 www.leparisien.fr/so...

leparisien.fr« Désespérant » : face au « chaos écologique », la patronne de l’Institut Pasteur tire la sonnette d’alarme - Le ParisienEXCLUSIF. Maladies infectieuses, vaccinations, origine des pathologies, sous-investissement dans la recherche… La directrice de l’Institut P

Didier Mazel reposted

Marie-Eve VAL
@val-meve.bsky.social

Replying to @val-meve.bsky.social

8/ 🌍 Broader implications This study not only highlights the elegant coordination of replication between Chr1 and Chr2 in Vibrio but the mechanism described here may reflect a broader strategy used by bacteria to integrate and stabilize secondary replicons derived from ancestral plasmids.

Didier Mazel reposted

Grainger Lab
@graingerlab.bsky.social

PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or antibiotic resistance. Deadlines in January... www.findaphd.com/phds/?Keywor...

findaphd.comgrainger birmingham PhD Projects, Programmes & ScholarshipsFindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
Didier Mazel
@amazeld.bsky.social

Amazing story! kudos @GenevauxPierre and colleagues! the precise mechanism of MenT3 toxicity in M tb. www.nature.com/articles/s41...

nature.comNucleotidyltransferase toxin MenT extends aminoacyl acceptor ends of serine tRNAs to control Mycobacterium tuberculosis growth - Nature CommunicationsIn this work, author demonstrate that the Mycobacterium tuberculosis MenT toxin is capable of specifically depleting its pool of serine tRNA available for protein synthesis.