Stephen Graham's Lab

Now published in Science Advances @science.org Herpes simplex virus has a single protein that completely silences neuronal activity by removing ion channels from the cell surface 🧠🤫⚡ www.science.org/doi/10.1126/... Bluetorial of the preprint 👇

Where in the world is @atomicvirology.bsky.social ?

Excited to be on my way to the mini herpesvirus workshop in Hannover tomorrow. Almost there... 🚅 4/4...no ✈️!

Funded PhD in Cambridge: "Mathematical and computational methods to discover and characterise critical genetic features in RNA viruses, with application to Rift Valley Fever Virus" Group: skittrallgroup.org Ad: bbsrcdtp.lifesci.cam.ac.uk/project-refe... Info: bbsrcdtp.lifesci.cam.ac.uk/how-apply

Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳 www.sciencedirect.com/science/arti... 1/8

Come join us in beautiful Cambridge to uncover the fascinating biology of eukaryotic parasites! #Postdoc #Cambridge #cryoEM #parasitology #cilia #Trypanosoma #Leishmania

Excited to share our now published paper @cp-cell.bsky.social highlighting advances in modeling the evolution of protein-protein interactions with MSA Pairformer. Big thanks to Zhidian Zhang, Olivia Tang, @eunbelivable.bsky.social @milot.bsky.social @martinsteinegger.bsky.social and @sokrypton.org!

💯 - up until now making MD data accessible has been a real pain, kudos to @wheelerlab.org and colleagues.

"Our findings likewise suggest that scientific impact does not translate into happiness. This gap reflects a deeper misalignment: the external recognition conferred by citations may not satisfy researchers’ intrinsic psychological needs" doi.org/10.1093/rese...

Well done to Shrestha, who had a tough slot as second talk of #bunya2026 (straight after the keynote) but did a great job presenting her work on computational affinity maturation of nanobodies against emerging #Oropouche virus variants 💪

The Cambridge crew after a good dinner in a local bar last night, ready for #bunya2026 to kick off!

Where in the world is @atomicvirology.bsky.social ...

Tell a tragic tale in two images...

I know a lot of people on the fence about frontiers… hopefully this is all you need to come down

What do you think, should I go and try to reclaim some of my gold from abcam?

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)

Is this the future of peer review? New from @biologyopen.bsky.social: expanded Fast & Fair trial paying reviewers £220 per paper The result: rapid peer review with no drop in quality or change in acceptance rate Paying referees makes peer review faster & fairer www.biorxiv.org/content/10.6...

Postdoc openings on experimental data integration integration into BioEmu-next, focusing on cryo-EM and binding affinities. Join us at @msftresearch.bsky.social Cambridge or Berlin. #AI #MachineLearning #Protein #Biology apply.careers.microsoft.com/careers/job/...

The Cambridge Protein Screening Facility has launched their new website! This facility, aims to enable the development of novel antibody binders for research, diagnostics and therapeutics using phage and yeast display. See our news post here: www.phar.cam.ac.uk/news/announc...

This is an interesting analysis of AlphaFold3. I don't claim to understand all of the technicalities, but the conclusion matches our own anecdotal experience that evolutionary depth is important for the most confident AlphaFold predictions. www.biorxiv.org/content/10.6...

Thermo Fisher has responded to research integrity activists who spotted apparent manipulation in its antibody catalog: "In ... preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes." More: cen.acs.org/research-int...

This is shocking (but also not terribly surprising)! Blatant manipulation of antibody validation data on the Thermo website... As Mulder said, trust no-one 👽

TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...

📢 Funded #PhD studentship (UK Home students) for a multidisciplinary project on the disinfection of wastewater using novel technologies. Collaboration with environmental engineering firm Hazen & Sawyer, covering microbiology, virology, chemistry. Apply here: tinyurl.com/28he6ztp @dmu.ac.uk

Where in the world is @atomicvirology.bsky.social? (And what in the world is going on 👨‍🚒🚒?!)

Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.

We just had our second -80 freezer failure in four years... On a Friday evening of course. All samples transferred safely, thanks to the amazing dedication of my team. Eppendorf CryoCube is disappointing in every possible way - it's neither a cube, nor does it stay cold.

Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, related Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology

A virus doesn’t become a pandemic simply because it’s deadly.

Still time to apply for one of three joint virology PhDs @cvrinfo.bsky.social and @pirbrightinst.bsky.social, including one with myself and the fantastic @peacockflu.bsky.social! Informal enquiries welcome by e-mail (including re the primary location of ours, which is negotiable), deadline 8th May

Congratulations to @danielacl.bsky.social for winning a poster prize at the @isaricar.bsky.social international conference on antiviral research #ICAR2026 🎉🥳🏅👩‍🔬

Where in the world is @atomicvirology.bsky.social? #ICAR2026

My colleague @socialinfluenza.bsky.social has written an absolutely excellent explainer for @theconversation.com about our recent paper with @dalan-bailey.bsky.social identifying a new human surface receptor for alphacoronaviruses: theconversation.com/scientists-h...

Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells www.nature.com/articles/s41...

Some bat alphacoronaviruses can exploit an entirely different receptor to enter human cells. This could lead to crossover events could be the first step in future epidemics, though we are not there yet and there would be many more barriers to overcome also. www.nature.com/articles/s41...

Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.