Daniel Hurdiss

Excited to share that our norovirus NS3 study is now online in Nature Communications! 🎉 These enzymes, found across an entire order of RNA viruses, have long been molecular motors in search of a function. We think we’ve uncovered their role. (🧵) www.nature.com/articles/s41... #virology #cryoEM

Structural basis for protocadherin-1 recognition by New World hantaviruses | @nature.com www.nature.com/articles/s41...

Meet the giant Sissivirus (and its #virophage)! With 4 Mbp genome, Sissivirus is the champion of all known viruses (by genome size). Check the preprint to learn how it got so big. The study led by Julien Andreani, Frederik Schulz @fmschu.bsky.social & Bernard La Scola www.biorxiv.org/content/10.6...

I’m very excited to share the first big project from my PhD (my first proper-first, yay!) where we use cryoET and a fun new flavour of CLEM to study the re-organisation of photosynthetic machinery of cyanobacteria growing beyond the red limit of light. doi.org/10.64898/202...

Very happy to share that I've been awarded an NWO Vidi grant! Excited for the opportunity to expand our lab and continue investigating the molecular arms race between bacteria and their viruses! 🔬❄️ www.nwo.nl/nieuws/109-v... Congratulations to all the other awardees!

Thrilled to announce that I have received the Vidi grant from the Dutch Research Council (NWO). This will enable my young lab to grow! For a period of five year, we will investigate how actin filaments interact with proteins at the membrane to drive cell adhesion. www.nwo.nl/en/news/109-...

In new study, we show that SARS-CoV-2 has evolved decreased inherent antigenicity in humans, as quantified by a ~3-fold decrease in the number of naïve human B cells that can bind the spike RBD. doi.org/10.64898/202...

Struggling to choose a pixel size for your cryo-ET acquisition? Worry not: super-resolution processing can take in situ subtomogram averaging beyond physical Nyquist! We reached 2.8 A loc-res of a ribosome dataset with 4.78 A physical Nyquist limit! Our new preprint 👇: doi.org/10.64898/202...

Programmable gold nanoparticle conjugates enable precise AMPA receptor localization at brain synapses by cryo-ET pubmed.ncbi.nlm.nih.gov/42892767/ #cryoEM

We have a medium-term PDRA position open in the York Bioenergetics Lab. The post will continue our fundamental work on mycobacterial bioenergetics and how bioenergetics is affected by some of the game-changing antibiotics being developed against TB. Please repost!

💥 Post-doc opportunity! 💥 Come join our team (www.thelowlab.org) at Imperial, London, working on the cryo-EM structure and mechanism of bacterial secretion systems. 48 months. Please RT. For more details and to apply: www.imperial.ac.uk/jobs/search-...

Exciting times for cryo-EM in NL 🇳🇱! As part of EMPower, two new Titan Krios G5 microscopes have been installed at NeCEN in Leiden and Utrecht. First benchmarks with ApoF reached 1.12 Å resolution 🤯. Looking forward to seeing all the exciting science these microscopes will enable! 🔬

Really cool work from my previous colleagues Edo and Jenia developing tools to combine cryo-volume EM and cryo-ET!

Enterovirus 2C Protein Drug Design, Assay Development, and Drug Resistance Studies pubs.acs.org/achre4/artic...

LoL-align is out in @natmethods.nature.com! It aligns protein structures without superposition. More sensitive than TM-align and DALI, producing better alignments 5–20× faster. Now available in Foldseek! 📄 www.nature.com/articles/s41... 💾 github.com/steineggerlab/foldseek 🌐 search.foldseek.com

1/5 Telomerase has long been linked to chromosome maintenance in eukaryotes. Now, we show that telomerase-like activity is also present in bacteria, shedding new light on its ancient origins. Excited to share that our work on DRT10 is now out in @nature.com! www.nature.com/articles/s41...

Assembly and activation of the AAA+ motor of the multi-subunit cobaltochelatase www.biorxiv.org/content/10.64898/2026.10.09.757910v1 #cryoEM

🎥 Recordings from the recent Wellcome-MRC In Situ Cryo-ET Course 2026 are now available on YouTube! From sample preparation and cryo-FIB milling to data collection, image processing and STA, check it out here: www.youtube.com/playlist?lis... #CryoET #CryoEM #StructuralBiology #eBIC #Microscopy

Towards broader-spectrum direct-acting antivirals against RNA viruses www.nature.com/articles/s41...

We have 2 new preprints on @biorxivpreprint.bsky.social that describe reconstitution of #Alzheimers paired helical filaments in experimental model systems: one in human brain organoids and one in murine primary cultures. www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6...

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Mechanism of spike opening in a mammalian gammacoronavirus www.biorxiv.org/content/10.6...

Systematic exploration of predicted quaternary structures within pandemic-relevant viral proteomes www.biorxiv.org/content/10.6...

Fantastic evening at ARTIS cheering on Miguel for his @heinekenprizes.bsky.social Young Scientist award. Here with @danielhurdiss.bsky.social and @fmattiroli.bsky.social 😁

Those who had a careful look at the methods section of our work on the #cryoEM structure of the CDK11-cyclin L-SAP30BP complex will have noticed that we added a short peptide to our sample before freezing. If you wonder why...

1/7 Excited to share GuideFlip! We use guided discrete flow matching to co-design protein sequences and structures for flexible interactions, with experimental validation across three systems: α-synuclein, RBX1 and active-state GPCR nanobodies.

SARS-CoV-2 phenotypic trajectory and the Omicron Paradox. Discussion of the following pre-print and the complex intertwined pathways that have dictated phenotypic outcomes for SARS-CoV-2. This can be otherwise termed the pandemic to endemic trajectory: www.biorxiv.org/content/10.6...

In-cell structures visualize human pre-ribosome assembly in the nucleolus pubmed.ncbi.nlm.nih.gov/42784657/ #cryoEM

🎉 Out today in Cell: the paper I've been looking forward to sharing for a long time 🎉 We used cryo-ET to find a molecular machine nobody knew existed on the surface of a minimal bacterium, and worked out what it does. 🧵(1/7) #TeamTomo #cryoET

Dave's contribution to Instruct continues, in the audience there is one of the Instruct-ERIC interns Tino Hoeksma from @danielhurdiss.bsky.social lab visiting Dave's lab at the @ox.ac.uk also part of Instruct-UK. The call for internships is now open! instruct-eric.org/submit-call/...

Amazing tool to keep track of all your big datasets!! Great to see @simon-alkema.bsky.social is continuing his tomo journey

Check out the latest influenza work from the group of @xdh.bsky.social! 🦠 Katherine Marougka et al explore how changes in the HA–NA–receptor balance may have helped the 2009 pandemic H1N1 virus cross the species barrier from swine to humans. www.pnas.org/doi/10.1073/... #Influenza #H1N1 #Virology

Very happy to share the first paper from our lab, out now in Nature Communications!🎉🥳 Structural basis of step II Spliced Leader RNA trans-splicing in trypanosomatid parasites 🧬🔬 🔗 www.nature.com/articles/s41... @natcomms.nature.com @universitedeliege.bsky.social @rockefeller.edu #cryoEM #cryo-EM

🔎 A classic #cryoEM particle curation conundrum: 2D or 3D classification? "Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views. Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0

A clever new tool for building full icosahedral capsids from AlphaFold models — from the talented team behind ViperDB. FoldaVirus, a knowledge-based icosahedral capsid prediction tool using AlphaFold www.pnas.org/doi/10.1073/...

A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.

Co-authors @merylhaas.bsky.social, @danielhurdiss.bsky.social from @utrechtvirology.bsky.social and others show that the norovirus  NS3 protein forms an RNA-engaging molecular motor that may transport viral RNA during infection. #Virology #CryoEM http://dlvr.it/TVbP01

ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use. We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition. github.com/PacesaLab/Bi...