Andres Bendesky

Andres Bendesky

@bendeskylab.com

Neuroscience – behavior – genetics – evolution Columbia University

1.2K followers464 following137 posts

Andres Bendesky reposted

At least this field of very squishy science is talking about being more rigorous. Notable omission -- if you have a phenotype that looks inherited, sequence the genome for a mediating genetic variant. DNA is a really good way of transmitting information between generations.

Cell Press@cellpress.bsky.social

Online now! Rethinking evidence for epigenetic inheritance in human research http://dlvr.it/TW1Qc5 @lohammer.bsky.social & colleagues @cp-trendsgenetics.bsky.social #ASHG26

Andres Bendesky reposted

Andres Bendesky reposted

@joethorntonlab.bsky.social and I are thrilled to co-organize the 2027 Molecular Mechanisms in Evolution GRC, June 13–18, in beautiful Portland, Maine! See our ⭐stellar⭐ lineup of speakers ⬇️ spanning evolutionary biochemistry, cell biology, development, behavior... www.grc.org/molecular-me... 1/n

grc.org2027 Molecular Mechanisms in Evolution Conference GRCThe 2027 Gordon Research Conference on Molecular Mechanisms in Evolution will be held in Portland, Maine. Apply today to reserve your spot.

Andres Bendesky reposted

Northern Saw-whet owl feathers contain porphyrins, which fluoresce under UV but break down over time. Older feathers thus glow less intensely than newly-molted feathers. Here you can see three generations of feathers, making this an after second year bird. 🧠

Andres Bendesky reposted

🩸🩸🩸TODAY WE SHARE TWO MAJOR DISCOVERIES🩸🩸🩸 1. We peered into genomes and brains of the rare mosquitoes that QUIT feeding on blood and found what biting is built from 2. Humans got rid of isoleucine in their blood, malaria suffers from it, and mosquito proteomes budget for it THREADS>

Andres Bendesky reposted

Excited to see our fMRI paper is out, led by Itamar Kahn’s lab. Our grad students, Amir Lawen and Bella Succi, in collab with Darcy Peterka, built a setup for simultaneous fMRI and dopamine fiber photometry in awake behaving mice. We learned some new biology too. www.science.org/doi/10.1126/...

science.orgDopamine release-associated striatal blood oxygenation and whole-brain dynamics during associative learningDopaminergic signaling in the nucleus accumbens (NAc) is central to reward-based learning, but its relationship to brain-wide hemodynamics remains unclear. Using concurrent fMRI and dopamine photometr...

Andres Bendesky reposted

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

Andres Bendesky reposted

Replying to @scottjuntti.bsky.social

This matters because visual input must be transformed into coordinated motor output, moment by moment. Comparing cichlids and zebrafish reveals that similar behavioral goals can be achieved through different movement strategies—linking evolutionary diversity to the organization of behavior.

Andres Bendesky reposted

Andres Bendesky reposted

Andres Bendesky reposted

Replying to @jeremiahycohen.bsky.social

First off, these cells are gigantic. This one, for example, has >72 cm of axon! To our knowledge, it’s the longest neuron ever fully reconstructed. I leave it to the reader as an exercise to estimate the length of a human LC neuron. 5

Andres Bendesky reposted

Happy to share the version of record of our locus coeruleus paper here: www.nature.com/articles/s41... Prior thread on some of our discoveries in this study: bsky.app/profile/jere...

nature.comTopographic structure and function of locus coeruleus noradrenaline neurons - NatureDorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...
Jeremiah Cohen@jeremiahycohen.bsky.social

Delighted to share our discoveries about one of the brain's neurotransmitter systems: www.biorxiv.org/content/10.6... Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

Andres Bendesky reposted

🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇

science.orgNoncoding transcription controls the developmental dynamics of long-range gene regulationThe genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

Andres Bendesky reposted

A 36-year-old man presented to the ophthalmology emergency department with a 1-week history of asymptomatic anisocoria. Video 1A shows the pupillary reaction to light, and Video 1B shows segmental vermiform movements. Read the full case details: https://nej.md/46e2h2c

Andres Bendesky reposted

Can dietary interventions change how fast genomes accumulate mutations with age? We studied how caloric restriction (CR)—one of the most robust lifespan-extending interventions—affects somatic mutations across the genome in different tissues and cell types in mice.

Andres Bendesky reposted

I’m looking to hire an NIH funded postdoc to join our lab here at Davis (please RT). Ongoing areas of interest include: 1) polygenic signals of selection from time series, ARGs, GWAS, etc 2) The interpretation of GWAS, polygenic scores, & sources of confounding

Andres Bendesky reposted

Calling all 2nd- & 3rd-year PhD students in the biological/biomedical sciences: #GilliamFellows applications are NOW OPEN! Robust research support, an incredible scientific community, & professional development for you & your mentor. But don’t just take *our* word for it: bit.ly/gilliam26. 🧪

Andres Bendesky reposted

Andres Bendesky reposted