Shengjun Tan

Shengjun Tan

@clamp131.bsky.social

Associate professor at the Institute of Zoology, Chinese Academy of Sciences

13 followers19 following35 posts

Shengjun Tan reposted

Nature Reviews Genetics
@natrevgenet.nature.com

New online! Decoupling cis and trans transcriptional influences

dlvr.itDecoupling cis and trans transcriptional influencesNature Reviews Genetics, Published online: 27 October 2026; doi:10.1038/s41576-026-01031-4In this Journal Club article, Selin Jessa discusses a 2008 paper by Wilson et al. that used a transchromosomic mouse model to show that species-specific gene expression is determined by variation in cis sequence rather than in trans-acting factors.

Shengjun Tan reposted

Genetics Society of America
@genetics-gsa.bsky.social

New resource for researchers studying speciation and sex chromosome evolution 🪰📊 In #G3journal, read about the newly generated population genomics resource for #Drosophila pseudoobscura, consisting of newly sequenced genomes of samples collected across North America. 🔗 buff.ly/h3yb8ba

Shengjun Tan reposted

Nature Reviews Genetics
@natrevgenet.nature.com

ICYMI: New online! Small variant calling in the era of long-read sequencing

dlvr.itSmall variant calling in the era of long-read sequencingNature Reviews Genetics, Published online: 20 October 2026; doi:10.1038/s41576-026-01020-7Long-read sequencing is expanding the scope of small-variant detection, enabling analysis of genomic regions that were previously difficult to interrogate. In this Review, the authors examine approaches for long-read small-variant calling across sequencing platforms and applications, highlighting advances in deep learning, assembly-based and pangenome-based methods, benchmarking strategies and future challenges.

Shengjun Tan reposted

Cell - a Cell Press journal
@cp-cell.bsky.social

Now online! Deep sequencing of 3,367 maize genomes uncovers substantial contribution of rare variants to agronomic traits

dlvr.itDeep sequencing of 3,367 maize genomes uncovers substantial contribution of rare variants to agronomic traitsDeep coverage sequencing of 3,367 maize genomes reveals substantial contributions of rare variants to trait heritability and provides insights into how selection reshapes their contribution to complex traits.

Shengjun Tan reposted

Nature Biotechnology
@natbiotech.nature.com

An analysis of the CRISPR–Cas patent landscape is essential for understanding applications in depth and overcoming challenges strategically, thereby supporting a safer integration of CRISPR–Cas into clinical practice www.nature.com/articles/s41... rdcu.be/QhJVkdcUu7Ja

nature.comThe global patent landscape of CRISPR–Cas applications in medicine - Nature BiotechnologyAn analysis of the CRISPR–Cas patent landscape is essential for understanding applications in depth and overcoming challenges strategically, thereby supporting a safer integration of CRISPR–Cas into c...

Shengjun Tan reposted

Nature Reviews Genetics
@natrevgenet.nature.com

FYI: New online! Is genome-wide epigenetic reprogramming a eutherian innovation?

dlvr.itIs genome-wide epigenetic reprogramming a eutherian innovation?Nature Reviews Genetics, Published online: 05 October 2026; doi:10.1038/s41576-026-01021-6New methylome data from marsupials indicate that genome-wide DNA methylation erasure is restricted to extraembryonic tissues. Ozren Bogdanovic discusses the implications of these findings for understanding the evolution and developmental functions of epigenetic reprogramming in mammals.

Shengjun Tan reposted

Genetics Society of America
@genetics-gsa.bsky.social

🪰 Latest in #G3journal: A study in #Drosophila simulans suggests that paternal #mitochondrial DNA leakage is genetically controlled, offering new insight into its evolutionary significance and potential role in mitochondrial genome maintenance. 🔗 buff.ly/GNm5EW0

Shengjun Tan reposted

Molecular Cell
@cp-molcell.bsky.social

Online Now: The 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancer Online now:

dlvr.itThe 9-1-1 complex protects ssDNA gaps in BRCA2-deficient cancerGrimsley et al. demonstrate that the 9-1-1 complex safeguards BRCA2-deficient cells from lethal ssDNA gap accumulation by suppressing PRIMPOL-dependent gap formation, restraining EXO1 degradation, and promoting POLζ-mediated filling. This identifies an ATR-independent 9-1-1 role in post-replicative repair and establishes gap length as a key determinant of repair pathway choice.

Shengjun Tan reposted

Cell - a Cell Press journal
@cp-cell.bsky.social

Now online! In vivo genome-editing therapy for Duchenne muscular dystrophy: Preclinical studies and first-in-human trial

dlvr.itIn vivo genome-editing therapy for Duchenne muscular dystrophy: Preclinical studies and first-in-human trialA single-dose AAV-CRISPR therapy restores dystrophin in humanized DMD mice and achieves durable editing with manageable safety in non-human primates. In a first-in-human DMD trial, the therapy yields molecular evidence of muscle editing but reveals a fatal dose-dependent immune complication, highlighting the urgent need to expand the safety margin of systemic AAV-CRISPR treatments.

Shengjun Tan reposted

Molecular Cell
@cp-molcell.bsky.social

Online Now: Amyloid-mediated RNA uptake by sperm for embryonic delivery Online now:

dlvr.itAmyloid-mediated RNA uptake by sperm for embryonic deliverySemen carries extracellular RNA that shapes early embryonic development, but how it reaches sperm is unclear. Mallen et al. show that amyloid fibrils in seminal fluid bind RNA, enter sperm, and deliver their cargo to the zygote at fertilization, where chaperones release it for translation.

Shengjun Tan reposted

Dr. Tyler A. Elliott
@transposableman.bsky.social

#TEsky EDTA-Audit: a taxonomy-aware post-processing framework for quality control of EDTA-based transposable element annotation doi.org/10.1186/s130...

doi.orgEDTA-Audit: a taxonomy-aware post-processing framework for quality control of EDTA-based transposable element annotation - Plant MethodsSummary Batch processing of multiple genome assemblies with EDTA produces numerous result directories that require inspection before downstream analysis. Checking expected output files, reported TE co...

Shengjun Tan reposted

eLife
@elife.bsky.social

Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition

buff.lyNucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transitionEpigenomics and quantitative imaging are used to investigate the re-establishment of histone modifications associated with the Polycomb group of epigenetic regulators during the Drosophila maternal-to-zygotic...

Shengjun Tan reposted

Gladstone Institutes
@gladstoneinst.bsky.social

Led by Alex Marson, researchers from Gladstone and Stanford Medicine used a technique known as perturb-seq to shed new light on how gene regulatory networks operate in human immune cells. @marsonlab.bsky.social @stanford.edu

med.stanford.eduMassive dataset provides blueprint to decode mysteries of the human immune systemBy dialing down more than 12,000 genes in a type of immune cell, scientists shed light on ‘gene regulatory networks’ that govern health and disease.

Shengjun Tan reposted

Molecular Cell
@cp-molcell.bsky.social

Online Now: PARP1 directly disassembles nucleosomes to regulate DNA repair Online now:

dlvr.itPARP1 directly disassembles nucleosomes to regulate DNA repairVerma, Zhu, et al. show that PARP1 promotes NAD+-dependent eviction of H2A-H2B dimers, generating oriented hexasomes with increased DNA accessibility. The H2A C-terminal tail supports this remodeling activity, linking PARP1-dependent nucleosome disassembly to cellular responses to DNA damage.

Shengjun Tan reposted

GPBees
@gpbees.bsky.social

1/5: New in GPB! How does DNA methylation drive sexual size dimorphism (SSD)? Wang et al. reveal the spatiotemporal methylome of Chinese tongue sole, showing how methylation regulates growth and evolution. Read: doi.org/10.1093/gpbj... #DNAMethylation #Genomics #Evolution

doi.orgDNA Methylation in Sex Chromosomes and Genes under Selection Underpins Sexual Size DimorphismAbstract. Sexual size dimorphism (SSD) refers to the differences in body size between males and females. Epigenetic mechanisms, such as DNA methylation, ca

Shengjun Tan reposted

GPBees
@gpbees.bsky.social

1/5: New in GPB! How to decode long-range gene regulation at single-cell resolution? Wen et al. introduce scReGAT, a deep learning framework integrating prior knowledge to reconstruct cell-specific networks. Read: doi.org/10.1093/gpbj... #scRNAseq #DeepLearning

doi.orgscReGAT: Leveraging Knowledge of Regulatory Interactions to Predict Long-range Gene Regulation at Single-cell ResolutionAbstract. Understanding gene regulation at single-cell resolution is crucial for unraveling development, disease, and cellular identity. We introduce singl

Shengjun Tan reposted

GPBees
@gpbees.bsky.social

1/5: New in GPB! How to efficiently build the tree of life for prokaryotes? Zuo introduces WebCVTree4, an alignment-free web server for whole-genome phylogeny and taxonomy, integrating 220k+ genomes. Read: doi.org/10.1093/gpbj... #Phylogeny #Bioinformatics