Nicki Lygo

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

Although the precise level of risk in endurance runners does remain uncertain, the physiological mechanisms and potential severity of these complications make NSAID use during prolonged endurance exercise, a risk worth avoiding 17/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

Prostaglandins and inflammatory signalling are involved in the body's response to exercise and the adaptations that follow. NSAIDs can alter some of these processes, although the extent to which this translates into impaired long-term endurance performance isn't entirely clear 15/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

The effects are minimal in healthy kidneys & normal activity. But, added to physiological insults imposed by ultrarunning, NSAIDs can be the final straw By compromising renal blood flow, they may tip the balance from kidneys that cope, into an AKI severe enough to require hospital or dialysis 13/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

Despite fluid intake, managing losses via medication such as loperamide & electrolytes, and ensuring effort is not excessive, the variables of fluid depletion & muscle damage are likely to be present to an extent in the long-distance runner, although it will vary from person to person 11/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

The second mechanism is through exertional muscle activity, which can cause muscle cell damage. Myoglobin, released from damaged muscle cells, can, in turn, contribute to kidney injury, particularly when combined with reduced renal blood flow, dehydration and other physiological stresses 9/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

Now to the kidneys. Running in its own right already potentially hits the kidneys in two ways: The first mechanism is through dehydration, either owing to inadequate fluid intake for excessive fluid losses, which include (but are not limited to) sweating, diarrhoea and vomiting 7/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

That means reduced blood supply for days. This can contribute to gut inflammation and dysfunction, which, alongside other factors, can slow gastric emptying, potentially leading to sloshing, reduced food and fluid intake, nausea and vomiting and pain. 5/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

However, during long-distance running it can be potentially harmful. NSAIDs are known to cause irritation and damage to the gut lining. It is also well established that, during endurance running, the gut can suffer from a reduced oxygen supply as blood is shunted towards muscles and the skin 3/18

I've been asked to put together a thread on the dangers of ibuprofen and other NSAIDs in ultra running by @matt-amato.bsky.social It's rather mammoth, but a topic that's hard to condense whilst maintaining enough accuracy. Please share if you find it useful! 1/18 😬

Caramelised baked pears with cinnamon. Fresh from the garden. Some for dinner and some to go with oats and yoghurt for breakfast Who else wants some? #Homegrown

Face painting with a twist. Draw from a pot to see who will be painting you, then from a second pot to see what they will be painting. Then collect the relevant guide photo from the designs wall Did we all nail it? 😂