Emilia Dimitrova

Latest from the Klose lab: we discover a new role for the PNUTS-PP1 phosphatase complex in regulation of PolII pause release. www.cell.com/molecular-ce...

(1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @andersshansen.bsky.social! We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions: www.biorxiv.org/content/10.6...

Great to see this work @mileshuseyin.bsky.social out. Enjoyed seeing some of the data when he visited our lab, looking forward to digging in the details

Very proud of this study! Two fundamental processes in gene expression turn out less tightly connected than thought. And their relationship may help explain some surprising vulnerabilities of cancer cells. A big thank you to Agata and Deepshika for years of hard work, and kudos to all collaborators!

Dr. Amanda Fisher from the University of Oxford will be presenting groundbreaking research for this year’s P01 Symposium! Save your spot today: nyulangone.zoom.us/webinar/regi... #chromatin2026

We are all looking forward to Adele joining us! Stayed tuned, more exciting announcements soon!

Great session next week! Not to be missed! @paul-villain.bsky.social from our neighbouring lab has a fantastic story

On of my favourite meetings! Great opportunity to learn about UK-based science! Lovely to see @oxfordbiochemistry.bsky.social being well represented this year. Also - 3 Klose lab alumni! Gutted that I don't think I can make it to York this time!

I really enjoyed chatting with Stefan at the recent EMBO transcription and chromatin meeting about some of my thoughts on CpG island biology!

Deadline fast approaching for the Transcription and Chromatin UK meeting - 18-20 November 2026. Submit your abstract for this exciting meeting by tomorrow for a chance to present. Hope to see you in York! 🧬

Beautiful! Congratulations @joyjoychoi.bsky.social

Excited to share our new preprint on in situ chromatin structure of the inactive X chromosome in differentiated female mouse embryonic stem cells. www.biorxiv.org/content/10.6... 🧵1/8

📣 Interested in non-coding disease-causing variants? Check out our review "Mechanisms underlying disease-causing variants in promoters and enhancers". Interesting mechanisms, challenges and future perspectives. Great to work with @wbickmor.bsky.social, Kun and Ryan! www.nature.com/articles/s41...

🎤 #FragileNucleosome is back next Wednesday! Hope you enjoyed the summer!Join us next 📅Wednesday to hear about 🧬fascinating research from @mpalamin.bsky.social from Krebs lab and @robertovn.bsky.social from Vos lab. To register if you haven't before: us06web.zoom.us/webinar/regi...

Delighted to finally share the preprint on this crazy project! Deleting all the major NAPs of E. coli is viable. The strain, while fragile, grows surprisingly well. But, what happens with transcription, genome compaction, genome organisation...? Find out here: www.biorxiv.org/content/10.6...

Crazy stuff! Love the idea of Frankencoli! 😂 well done @paul-villain.bsky.social and @tobiaswarnecke.bsky.social

@mileshuseyin.bsky.social and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region-Capture Micro-C in @natprot.nature.com : www.nature.com/articles/s41... See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/M...

Amazing new method for live-cell imaging of RNA molecules developed by Adam in the Brockdorff lab! Worth having a look at!

Does every enhancer work with every promoter? With @jengreitz.bsky.social and Will Greenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field. A tour 🧵👇 www.biorxiv.org/content/10.6...

"the first validated, large-scale framework for judging the quality of life science papers independently of venue, identity, and prestige...Blinded domain-expert professors sided with score three times more often than with journal rank" the-one-percent.qedscience.com 1/n

Gloves are off! TODAY WE RELEASE THE 1% A list of the year’s very best papers 👇 (see thread)

We looked at 57,455 preprints. No names. No institutions. No reputations. Just the science❕ In 48 hours, we reveal The 1%. #The1Percent #QEDScience #Preprints

This study led by @flavia-con.bsky.social from the Brockdorff lab is finally published at Nature Communications! www.nature.com/articles/s41... Using live-cell and single-molecule imaging, this work dissects how the epigenetic regulator #SMCHD1 interacts with chromatin during X-inactivation.

Yaay! Well done @bluebuleta.bsky.social and team! Great to see this work finally out! Read the paper to see how SETDB1 and HUSH regulate Xist transcription

Unacceptable! Have people started asking for refunds? We don't use Thermo antibodies much but have a couple in the freezer (one I have to admit is good!)

Help please! We need to do some large(ish) cell culture inhibiting E-cadherin with a monoclonal antibody. Does anyone have the DECMA-1 hybridoma cell line so we could purify our own antibody? or a similar monoclonal that would do the job. Any help greatly appreciated, just DM me. Please repost!

Congratulations @robklose.bsky.social for being elected as a Fellow of the Royal Society! royalsociety.org/news/2026/05... great news to have two outstanding scientists, Rob and Colin, from @oxfordbiochemistry.bsky.social joining the Royal society today!

Today we celebrate our colleagues Colin Kleanthous and Rob Klose as they join the Fellowship of the Royal Society, one of the highest honours in the scientific world, in recognition of their impactful contributions to knowledge. Congratulations! 👏 👏 👏 Read more ⬇️

Happy 100th birthday, Sir David Attenborough! 🎂 A legendary broadcaster, natural historian and Clare College alumnus whose voice has inspired generations worldwide for decades. Thank you for a century of curiosity, wonder and unwavering dedication to life on earth.

Very importantly, one of the co-organisers @xrnchew.bsky.social is cycling to the meeting to raise awareness and funds for 'All things small and green' . Please join him or sponsor him! gofund.me/f4068dc3c

Only 1 week left to register for the RNA 3' ends processing meeting, come one, get a wiggle on!! meetings.embo.org/event/26-rna3

Looking forward to hosting Iva Tchasovnikarova @oxfordbiochemistry.bsky.social today for a seminar today! Come along to hear about Fluorogenetic interrogation of epigenetic repression 1 pm Dorothy Crowfoot Hodgkin Building - Seminar Room 2 Department of Biochemistry Oxford

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

I wrote an essay. It’s about gain-of-function mutations. And penguins. Also ion channels, chihuahuas, the film Alien, recycled cardboard, and the Apollonian mind. Oh, and muffins. Thanks to the editors of #GENETICS @genetics-gsa.bsky.social for letting me take some stylistic liberties. 1/2

Just a quick reminder that the first of these Associate Professorships have a closing date for applications of April the 8th. Get your application in now! Please repost

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

We are looking for a Postdoc to join our lab at @oxfordbiochemistry.bsky.social. This is a dry-lab focused post on the computational analysis of long read single-cell sequencing data to understand the role of transposable elements (TEs) in early development. my.corehr.com/pls/uoxrecru... #TEsky

Another fantastic evening celebrating truly inspirational women at the Suffrage Science Awards in Life Sciences 2026. Read about the awardees and what the nominators - previous recipients - had to say about why they nominated these exceptional women: bit.ly/LifeSciences2026

daylight savings in the USA skipped us forward 1 hour, so we might be starting 1 hour earlier for some. Check your time against 9:00 PDT / 12:00 EDT (instead of PST/EST) to ensure you've got the correct start time for tomorrow!

⏰ Calling all chromatin aficionados! We we will be joined by @adelmanlab.bsky.social from @harvardmed.bsky.social for our March 27th webinar 📅 Karen will be sharing her groups work on 'Transcription & RNA Quality Control in Health & Disease' 😷🧬 Register here: us06web.zoom.us/webinar/regi...

meetings.embo.org/event/26-rna3 To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!

Happy to share our new preprint! 📊 We benchmarked methods for locus-level transposable element quantification in short-read scRNA-seq, using both real datasets and simulations with read-level ground truth. Huge thanks to @catavallejos.bsky.social and @antonio-scialdone.bsky.social! #TEsky

Help needed: I know this has been discussed before - what are people doing now that phase lock tubes have disappeared from the market? Is everyone making their own and that's why companies are not selling them anymore? If so, what is the best vaccum grease you would recommend? 🤷‍♀️

Very nice review by @mileshuseyin.bsky.social and colleagues!

Excited to share @suminkim.bsky.social and @mileshuseyin.bsky.social 's new Current Opinion review on how Polycomb complexes mediate 3D genome interactions including mechanistic models and potential roles in gene regulation: www.sciencedirect.com/science/arti...

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

In less than an hour. Will be great!

Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social

Come to hear Alan's great new story on SET1/MLL proteins and transcription next Wednesday. @fnucleosome.bsky.social