Enya Weidner

Enya Weidner

@eweidner1.bsky.social

PhD || neuroscience of emotions in Bielefeld || artist in Dortmund || birds

153 followers256 following41 posts

Pinned

Happy to report that this work is now available at Psychophysiology! Thanks a lot to the reviewers and editors!! onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com<em>Psychophysiology</em> | SPR Journal | Wiley Online LibraryOur electroencephalography (EEG) study provides evidence for distinct, hemisphere-specific contributions of magno- and parvocellular pathways during early visual attention towards fear-conditioned fa....
Enya Weidner@eweidner1.bsky.social

Happy to share our newest preprint! I always wondered whether the (alleged) subcortical route of fear perception responds to newly acquired threat associations. Our research suggests that it does indeed, how cool! www.biorxiv.org/content/10.6...

biorxiv.orgDistinct visual pathways of threat retrieval in fear-conditioned facesNumerous studies have demonstrated rapid (< 100 ms) visuo-cortical differentiation of threat-associated faces. This may be due to low-spatial frequency (LSF) visual information originating from magnocellular pathways. Yet it remains unclear whether potentially magnocellular fear signals extend beyond evolutionarily prepared emotional faces and whether they are subject to short-term neuroplasticity. If so, spatial frequency characteristics should modulate processing of faces with newly acquired threat-relevance. Furthermore, it is unknown whether sub-bands of the visual spectrum are associated with autonomic arousal. Using a differential fear-conditioning paradigm, this study tested whether early visual attentional capture, indicated by the P1 event-related potential component, prioritizes LSF information of threat-associated faces with neutral expressions. Additionally, it was tested whether such effects would be paralleled by threat signals in the skin conductance response (SCR). For contingency aware participants, stimulus ratings confirmed successful fear conditioning and participants showed a selective left-hemispheric enhancement of the P1 in response to LSF threat-faces. By contrast, CS differentiation in the SCR was not modulated by spatial frequencies but by stimulus duration, with longer CS presentations resulting in larger SCR to threat compared to neutral faces. For contingency unaware participants, trial-by-trial amplitudes of P1 and SCR were positively correlated. Data support the notion that magnocellular-cortical pathways adapt quickly to novel threat-associations and facilitate rapid threat retrieval even for perceptually neutral faces. However, at least in the short term, these signals do not necessarily associate with anticipatory arousal in SCR. ### Competing Interest Statement The authors have declared no competing interest.

Enya Weidner reposted

Replying to @abeba.blacksky.app

"everything that was once alive has been skinned and stuffed, and regards you unblinkingly, with a meaningful glint in its bright, spurious eyes. It’s like looking at someone & wondering if it’s really who you think it is. Or looking in mirror &seeing your likeness, but knowing it isn’t really you"

Enya Weidner reposted

Enya Weidner reposted

I've always found the AI obsession with "general intelligence" frustratingly incoherent and uncomfortable...I'm realizing that a large part of that stems from a eugenics fueled human obsession with "general intelligence" that is equally incoherent and uncomfortable...

angela zhou@angelamczhou.bsky.social

Man I got so much stuff to do I dont have the time to write a "Eugenics is bad. Factor analysis is useful sometimes. We shouldn't write papers that celebrate eugenics in the second paragraph, even if the rest of the paper is about something else"

My self portrait has been featured in Süddeutsche Magazin (WHAT??? This is so cool???) accompanying Kerstin Greiner's exploration of the German Stare 👁👁👁👁👁

Happy to share our newest preprint! I always wondered whether the (alleged) subcortical route of fear perception responds to newly acquired threat associations. Our research suggests that it does indeed, how cool! www.biorxiv.org/content/10.6...

biorxiv.orgDistinct visual pathways of threat retrieval in fear-conditioned facesNumerous studies have demonstrated rapid (< 100 ms) visuo-cortical differentiation of threat-associated faces. This may be due to low-spatial frequency (LSF) visual information originating from magnocellular pathways. Yet it remains unclear whether potentially magnocellular fear signals extend beyond evolutionarily prepared emotional faces and whether they are subject to short-term neuroplasticity. If so, spatial frequency characteristics should modulate processing of faces with newly acquired threat-relevance. Furthermore, it is unknown whether sub-bands of the visual spectrum are associated with autonomic arousal. Using a differential fear-conditioning paradigm, this study tested whether early visual attentional capture, indicated by the P1 event-related potential component, prioritizes LSF information of threat-associated faces with neutral expressions. Additionally, it was tested whether such effects would be paralleled by threat signals in the skin conductance response (SCR). For contingency aware participants, stimulus ratings confirmed successful fear conditioning and participants showed a selective left-hemispheric enhancement of the P1 in response to LSF threat-faces. By contrast, CS differentiation in the SCR was not modulated by spatial frequencies but by stimulus duration, with longer CS presentations resulting in larger SCR to threat compared to neutral faces. For contingency unaware participants, trial-by-trial amplitudes of P1 and SCR were positively correlated. Data support the notion that magnocellular-cortical pathways adapt quickly to novel threat-associations and facilitate rapid threat retrieval even for perceptually neutral faces. However, at least in the short term, these signals do not necessarily associate with anticipatory arousal in SCR. ### Competing Interest Statement The authors have declared no competing interest.

Enya Weidner reposted

New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses. www.science.org/doi/10.1126/...

science.orgA network of basolateral amygdala projection neurons contributes to stress-induced activation of the hypothalamic-pituitary-adrenal axisA network of basolateral amygdala neurons, but not singular projections, contributes to the neuroendocrine response to stress.

Today, I also learned the scary spooky hard way that when you are alone at night at a lake in pitch black darkness, you will hear a sudden, VERY LOUD bang on the water because the local beaver is protecting their territory

Enya Weidner reposted

How does human amygdala circuitry develop through adolescence to support affective and cognitive control processes? Excited to share recent work from my dissertation, now out in Cell Reports, that uses longitudinal, multimodal neuroimaging at 7 Tesla to answer this question! A 🧵 tinyurl.com/5aaf9fpv

cell.comHuman amygdala nuclei show distinct developmental trajectories from adolescence to adulthood in functional integration with prefrontal circuitryOjha et al. use longitudinal 7 T neuroimaging to characterize distinct developmental trajectories of fronto-amygdala connectivity across nuclei through adolescence. They identify how age-related conne...

Enya Weidner reposted

Enya Weidner reposted

This took a WHILE but here it is!! The last part of my PhD work is now published @commsbio.nature.com 🕊 We uncovered the temporal and spatial context that define the mTL's role in fear processing. Huge thank you to my co-authors, reviewers, editors, and participants 💖 rdcu.be/exQKb

rdcu.beFear perception as a function of hemisphere- and time-specific dynamics in the medial temporal lobesCommunications Biology - Electrophysiology from resection patients reveals lateralized, temporally specific functions of the medial temporal lobes in fear perception: the right enhances early fear...

Enya Weidner reposted

"Der Wettbewerb ist spannender denn je" - ich habe mir Wissenschaft ja irgendwie anders vorgestellt als ich damals angefangen habe zu studieren.

Wissenschaftsrat@wissenschaftsrat.de

‼️Ebenso wissen wir jetzt, dass sich 15 Unis Hoffnung machen dürfen, im Neuantragsverfahren als Exzellenzuniversität ausgewählt zu werden. Der Wettbewerb um Spitzenforschung und internationale Sichtbarkeit ist spannender denn je! Alles zum Neuantragsverfahren: www.wissenschaftsrat.de/DE/Aufgabenf...

Enya Weidner reposted

In a recent podcast @dyamins.bsky.social argues: "We want to be able to use the model of the digital brain as a neurobiomedical discovery and diagnostic design platform." neuroscience.stanford.edu/news/buildin... - That view is popular and I believe that there is a fundamental logical error. Thread

neuroscience.stanford.eduBuilding AI simulations of the human brainIn which Wu Tsai Neuro faculty scholar Dan Yamins explores how foundation models of the human brain could