Gerrich

Gerrich

@gerrich.bsky.social

Non-conventional microbes, metabolic engineering and microbial genetics. Bacteria go brrr Finally, finished with my thesis, now off to new frontiers! https://orcid.org/0009-0004-1949-532X

1.2K followers1K following520 posts

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Publication alert 🚨 A new Golden Gate MoClo toolbox for Rhodobacter sphaeroides is out and it's built on Zymo-Parts! @matick.bsky.social & Antoine took our framework and added many new genetic tools and a new automation angle. This adaptation is a dream come true for me. 1/10 🧪🧵

pubs.acs.orgRhodo-Box: A Synthetic Biology Toolbox to Facilitate Metabolic Engineering of Rhodobacter sphaeroidesRhodobacter sphaeroides is a purple nonsulfur alphaproteobacterium with a highly versatile metabolism. This microorganism holds promise as a chassis for sustainable biomanufacturing of numerous chemicals. Yet, its potential is constrained by a lack of standardized, well-characterized genetic elements to tune gene expression such as transcriptional promoters and ribosome binding sites (RBSs). In this study, we present Rhodo-Box, a comprehensive toolkit for R. sphaeroides created by adapting and extending the Zymo-Parts modular cloning framework. Using Rhodo-Box we built and characterized: (a) three broad-host origins of replication (pBBR1, RK2 and RSF1010), (b) a set of 13 promoters, (c) four inducible expression systems (NahR-PsalTTC, LacI-PlacT7A1_O3O4, VanR-PvanCC, and XylS-Pm), (d) 11 RBSs, and (e) four transcriptional terminators. Furthermore, we present a semiautomated, user-friendly cloning approach which enables rapid construction of R. sphaeroides strains. The Rhodo-Box toolkit equips R. sphaeroides with a standardized, automation-compatible collection of parts and workflows essential for efficient design–build–test–learn cycles and advanced metabolic engineering.

Gerrich reposted

The art section on every color page got better! Switch to palettes: each picture becomes the colors extracted from it... Plus: hide the title, let the rows drift, filter by art, pop culture or wiki, and copy any picture's colors with their names. names.color.pizza/color/berry-...

Gerrich reposted

The more parsimoneous explanation is that infants express a preference for the Type G British/Irish electrical plug socket, which is objectively the best type of plug socket. This is evidence for innate rationality in newly born infants.

Dr Nick@nmwilkinson.eurosky.social

New paper! Accepted at Perspectives on Psychological Science. A textbook finding in infant psychology is that newborns - within ~1 hour of birth - visually track a simplified 'three blob' facelike stimulus further than its inverted control (see picture). This suggested inborn knowledge of faces!

Gerrich reposted

Huge congratulations to all three Nobel Laureates, and especially Peter Hegemann! 👏 His seminal work on the green alga Chlamydomonas 🦠 laid the foundation for optogenetics. Thank you for putting Chlamy in the spotlight! ✨ Proof that groundbreaking discoveries don't always come from animal models! 🔬

Nobel Prize@nobelprize.org

BREAKING NEWS The 2026 Nobel Prize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”

Gerrich reposted

Most cells require carbonic anhydrase and/or bicarbonate import to sustain pools of soluble inorganic carbon (SIC=CO2+HCO3-). Here, we identify proteins required for SIC homeostasis in Bacillus subtilis and identify a mutation that bypasses their requirement. www.biorxiv.org/content/10.6...

biorxiv.orgPhysiological Roles of Carbonic Anhydrases and an MpsAB-like Bicarbonate Transporter in Bacillus subtilisCarbonic anhydrase (E.C. 4.2.1.1) is an enzyme that catalyzes the reversible hydration of CO2 to carbonic acid (H2CO3), which dissociates to bicarbonate (HCO3-) at intracellular pH. Copious amounts of...

Gerrich reposted

All the plastic humanity has ever produced is ~10 billion tonnes. Humans emitted ~10 billion tonnes of CO₂ into the atmosphere in the first three months of 2026. When we appreciate orders of magnitude, we see how intractable the CO₂ problem becomes once we dump it into the atmosphere.

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Gerrich reposted

If we keep on advocating the benefits of Eng Microbes for Env Release with the same arguments that we had for 50 yr, no wonder we will also get the same social backlash. A new narrative is badly needed focused on partnership & stewardship—not just containment & control dx.doi.org/10.1111/1751...

dx.doi.orgEnvironmental Release of Genetically Intervened Microorganisms: Towards a New NarrativeFrom control to partnership: Rethinking the environmental release of laboratory-trained microorganisms for bioremediation.

Gerrich reposted

📣 Please share! We’re recruiting to build predictive models of gene regulation in plants. We’d love to hear from anyone with strong foundations in regulatory genomics or ML and fluency with coding agents. Any career stage; no plant background needed. noborilab.org 1/5

noborilab.orgNobori Lab | The Sainsbury LaboratoryDecoding the molecular and cellular basis of plant-microbe interactions. Single-cell and spatial omics of plant immunity. Led by Tatsuya Nobori at TSL, Norwich, UK.
Tatsuya Nobori@tatsuyanobori.bsky.social

Excited to launch our ERC project ImmuneCellState 🚀 We’ll investigate how individual plant cells respond to pathogens and explore new dimensions of plant immunity research by integrating single-cell/spatial omics, deep learning and genome editing. @thesainsburylab.bsky.social @erc.europa.eu

Gerrich reposted

Clonal does not mean uniform. #MicroSky Our new review explores how genetically identical bacteria adopt different cell states, and how that diversity shapes survival, cooperation, antibiotic responses and gene transfer. 🧵 doi.org/10.1146/annu...

doi.orgDecoding Bistability and Drivers of Phenotypic Variation in BacteriaIn a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise i...

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Gerrich reposted

Strange question: has anyone tried to get a winogradsky column through customs? US customs in particular but experience anywhere is welcomed

Germany is under a dry spell the likes of I haven't seen yet. I took some photos today (of the and near the Elbe by Magdeburg), trying to recreate the same viewing point I chose just two years ago.

I am on a flat hike and found this water canister and some young trees (Salix alba?). It's a great idea to allow for community watering in these dry times!

Gerrich reposted

Bottom-up reconstruction of synthetic pyrenoids provides insights into the mechanisms and evolution of carbon concentration by EPYC1 proteins Cool paper! Title says 'carbon concentrating' but I would emphasise 'CO2' or 'inorganic carbon' concentrating. The abstract seems ambivalent but I say 'CO2'.

nature.comBottom-up reconstruction of synthetic pyrenoids provides insights into the mechanisms and evolution of carbon concentration by EPYC1 proteins - Nature PlantsThis study shows that the structural protein essential pyrenoid component 1 (EPYC1) and the enzyme Rubisco are sufficient to assemble into pyrenoid-like structures that are functionally active and sho...

Gerrich reposted

RESULTS ARE COOL!!! Piscinibacter gummiphilus seems the major species but less confident in read quality. If anyone wants to have a peek at what species are growing in my duckweed tank, here are the results as a zip file straight from @plasmidsaurus. Enjoyyyy! drive.google.com/drive/folder...

Sebastian S. Cocioba@atinygreencell.bsky.social

Sample of whatever tf is growing in my duckweed containers has been collected and pickled in Zymo Research's Zymo Shield. Ready to ship to @plasmidsaurus.bsky.social for microbiome analysis tomorrow morning. $45 for seq and $15 for extraction. $75 with shipping and everything. Exciting!

Gerrich reposted

I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481

aprecruit.berkeley.eduAssistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell BiologyUniversity of California, Berkeley is hiring. Apply now!

Gerrich reposted

Replying to @alexdemendoza.bsky.social

By sequencing the genome and through comparative genomics, we found that it doesn't have significant gene family expansions in developmental / information processing genes (e.g. Transcription Factors, signalling pathways). However its large genome (>3Gb) is ~75% transposons. 3/

Man, this stuff is amazing! Check out DABEST2.0 for multi-group comparisons. I was just struggling with how to best account for the block-type set up of my microplate growth experiments and here it is! Sorry, for the censored data. #microsky 🧪