International Society of Developmental Biology

Hello my lovely developmental biologists, The International Society for Developmental Biology is here with y'all in this #BlueSky. If you follow us on Twitter (we refuse to call it X), please drop us a follow here! Let's connect! #DevelopmentalBiology #cellbiology

"We were not pretending to convert established scientists to developmental biology, we were thinking of the new generations." An inspiring interview with Professor Roberto Mayor on his effort to bring #devbio education to Latin America. 👏👏 www.sdbonline.org/resource?Res... @socdevbio.bsky.social

A very inspiring interview with our Editor-in-Chief Professor Roberto Mayor @mayorlab.bsky.social. His passion for teaching #devbio has reached well beyond Latin America too!

"We were not pretending to convert established scientists to developmental biology, we were thinking of the new generations." An inspiring interview with Professor Roberto Mayor on his effort to bring #devbio education to Latin America. 👏👏 www.sdbonline.org/resource?Res... @socdevbio.bsky.social

Our review on the interplay between metabolism and tissue mechanics is now published in @dev-journal.bsky.social Development!

Metabolism is traditionally studied at the individual cell level, yet its role during development is very much under-appreciated. @mongeralab.bsky.social, @matyasbl.bsky.social and Olivier Pourquié lab discuss this interesting interplay between metabolism and morphogenesis: doi.org/10.1242/dev....

To build complex tissues, cells need to produce energy to grow, generate forces and modulate mechanical properties. The role of metabolism and tissue mechanics in development is experiencing a renewed interest. Yet, we know very little about how these systems interact to drive morphogenesis...

Metabolism is traditionally studied at the individual cell level, yet its role during development is very much under-appreciated. @mongeralab.bsky.social, @matyasbl.bsky.social and Olivier Pourquié lab discuss this interesting interplay between metabolism and morphogenesis: doi.org/10.1242/dev....

Publication alert!‼️ In collaboration with Jennifer Hocking’s lab (U. Alberta), we carefully analyzed the sub retinal space in fish and mouse. We show that Muller glia and RPE cells extend apical processes contacting each other around cone outer segments. onlinelibrary.wiley.com/doi/10.1002/...

A new paper from the Gareth I. Owen lab describes a robust in vitro framework for vasculogenic mimicry - the ability to form vascular-like structure by non-endothelial cells. Many cancer lines can form VM, and lumen formation defines bona fide VM. @cellpress.bsky.social www.cell.com/cell-reports...

You've probably heard of Twist1, but what about Twist2 and Twist3? Tressa Jacob and colleagues showed that these two genes are expressed during scale development. Messing up Twist2 affects scale morphology and organisation. How interesting? Check it out👇👇 www.sciencedirect.com/science/arti...

A new paper from the Gareth I. Owen lab describes a robust in vitro framework for vasculogenic mimicry - the ability to form vascular-like structure by non-endothelial cells. Many cancer lines can form VM, and lumen formation defines bona fide VM. @cellpress.bsky.social www.cell.com/cell-reports...

Calling all #ECRs: If you have a new paper/preprint in #devbio, #compbio, #cellbio, #mechanobiology, let us know. We want to help promote your work to a wider community, and facilitate new collaboration and networking opportunities. If you want to promote a workshop/conference, let us know too! 🤩

A new paper by @yuritakahashi.bsky.social from @bensteventon.bsky.social lab @geneticscam.bsky.social describes a feedback loop 🔁 between EMT initiation and SNAI2-induced SMAD1 signalling in 🐤 explants. Migration -> ⬆️SMAD1 -> ⬆️BMP signalling -> ⬆️migration. #devbio link.springer.com/article/10.1...

Calling all #ECRs: If you have a new paper/preprint in #devbio, #compbio, #cellbio, #mechanobiology, let us know. We want to help promote your work to a wider community, and facilitate new collaboration and networking opportunities. If you want to promote a workshop/conference, let us know too! 🤩

An old friend asked if I had any videos of cilia laying around for her class to see. I dug up this one from about 10 years ago and it could maybe win a prize for 'most similar to a wacky waving inflatable tube man'.

From MBoC: What helps cells stay connected as they move together to shape tissues? A Drosophila study identified 22 genes involved in testis morphogenesis and uncovered new roles for Par-1 and RN-tre in cell migration and tissue organization. https://www.molbiolcell.org/doi/10.1091/mbc.E26-05-0234

New preprint! Universities increasingly expect academics to practise open science. But is it rewarded when hiring? We analysed 1,356 academic job ads from Norwegian institutions and found that <5% of ads mentioned open science as a required or desired qualification osf.io/preprints/ps...

Scientists have mapped one of the most mysterious parts of the human brain in unprecedented detail go.nature.com/4A6HcDV

Our Dept. of Genetics and Developmental Biology at the Institut Curie in the heart of Paris is hiring a new junior PI. It has a nice start up package and excellent I. Curie facilities. Please spread the word: Deadline Dec. 18th! jpi-recruitment-curie-umr3215-u934.curie.fr

A new paper by @yuritakahashi.bsky.social from @bensteventon.bsky.social lab @geneticscam.bsky.social describes a feedback loop 🔁 between EMT initiation and SNAI2-induced SMAD1 signalling in 🐤 explants. Migration -> ⬆️SMAD1 -> ⬆️BMP signalling -> ⬆️migration. #devbio link.springer.com/article/10.1...

Xenopus oocytes contribute to the 2026 Nobel Prize in Medicine or Physiology. Drs. Nagel and Hegemann expressed channelrhodopsin-2 from single-celled algae in Xenopus oocytes. Light induces membrane channels to open. www.xenbase.org/xenbase/doNe... #science #devbio #cellbio #xenopus #frogs

A new study from the @squeezycellslab.bsky.social lab shows that the same cell population can experience completely different physical challenges within an embryo. Unlike the cranial counterpart, the trunk NCCs adapt as their nuclei are deformed during migration 👏 #ECR www.nature.com/articles/s41...

Laith Bahlouli, Marc Edwards and colleagues identify atypical PI3Ks as specialised regulators of signal attenuation, cAMP relay organization and membrane uptake in Dictyostelium. journals.biologists.com/jcs/article/...

Epithelial wound healing has mainly been analyzed at the apical plane of the epithelium – @yanlanmao.bsky.social and colleagues now reveal a contractile system that connects the apical and basal cell surfaces at the wound edge for efficient wound closure link.springer.com/article/10.1...

🧬 New Research Spotlight 📢 Congratulations to @davidversluis.bsky.social on the latest publication in PLOS Computational Biology! 📖 Read the paper here: journals.plos.org/ploscompbiol... @ucllifesciences.bsky.social

For #amphibians impacted by a widespread fungal pathogen, temperature is an important link between the host and the fungus. Zoo breeding programs provide opportunities to alter environments prior to release. This #RSOS paper investigated this on endangered #frogs: doi.org/10.1098/rsos...

Congratulations to Peter Hegemann winner of the Nobel Prize in Physiology or Medicine 2026 for discoveries concerning light-gated ion channels and optogenetics. Take a look at his 1992 #PhilTransB article on the photoreceptor current of the green alga Chlamydomonas: doi.org/10.1098/rstb...

Our latest paper is now out in @dev-journal.bsky.social. We investigated how Notch signalling, implicated in Hirschsprung disease (HSCR) regulates human enteric nervous system (ENS) development (1/n): journals.biologists.com/dev/article/...

New commentary from the lab - can we identify principles of transcriptional regulation & cis-regulatory element (CRE) control of gene expression? With @jcornwallscoones.bsky.social & @joadelas.bsky.social in @cp-molcell.bsky.social A thread 🧵 doi.org/10.1016/j.mo...

🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

A new study from the @squeezycellslab.bsky.social lab shows that the same cell population can experience completely different physical challenges within an embryo. Unlike the cranial counterpart, the trunk NCCs adapt as their nuclei are deformed during migration 👏 #ECR www.nature.com/articles/s41...

An interesting and important study from the Montecino lab analysing the transcriptional differences between Schizophrenic iPSC neurons versus healthy control showing neuronal enrichment in SZ-cultures and astrocyte enrichment in CT. Check it out: www.sciencedirect.com/science/arti... #mentalhealth

An aptly titled paper shows, for the first time, the significance of heterogeneities of gene expression in the construction of complex systems : fate decisions are group decisions. Previously @biorxivpreprint cell.com/cell/fulltex... #MustRead #Gastruloids @Jshendure lab

1/ Our paper, “Enhancer binding kinetics explain transcription factor hub formation,” is now published! Here we set out to understand why transcription factors form bright clusters or “hubs” in the nucleus, and whether those hubs actually control gene activity. tinyurl.com/38uf8348

Happy #FluorescenceFriday. This video shows a group of neural crest cells (🟣) remodelling a mesh of fibronectin matrix (🔵). This is part of a biorxiv paper showing the reciprocal relationship between NC and neural tube morphogenesis. 📹: Kai Weißenbruch, UCL 👇👇👇 www.biorxiv.org/content/10.6...

#Macrophages are mechanosensitive cells. They respond to mechanical signalling from the surrounding tissue, such as during fibrosis. In this review, the authors discuss the significance of the macrophage-fibroblast communication in a profibrotic niche. #immune 👇 www.sciencedirect.com/science/arti...

Happy #FluorescenceFriday. This video shows a group of neural crest cells (🟣) remodelling a mesh of fibronectin matrix (🔵). This is part of a biorxiv paper showing the reciprocal relationship between NC and neural tube morphogenesis. 📹: Kai Weißenbruch, UCL 👇👇👇 www.biorxiv.org/content/10.6...

How do long-lived multipotent stem cells cope with mechanical stress in vivo? We found that neural crest cells are protected from mechanical stress during migration in confined tissue environment. www.nature.com/articles/s41...

#optogenetics is getting attention!! Welcome aboard the Opto-train 🚄🚂

#optogenetics is getting attention!! Welcome aboard the Opto-train 🚄🚂

❤️ that the #NobelPrize brought the spotlight to #optogenetics. We use the same technique to study how cells move during development, like in this beautiful study by the Solnica-Krezel lab where they show mesoderm can influence endoderm convergent extension in 🐟! www.sciencedirect.com/science/arti...

Woah, such an invaluable resource! You can use this for your lectures too and can make a good resource for students! 🙌

An interdisciplinary #embryology book is out as #OER: @ecampusontario.bsky.social ecampusontario.pressbooks.pub/principlesof... A teamwork turned raw lecture recordings into a colloquial writeup. Please pass any feedback & critiques! @isdb.bsky.social @swedbo.bsky.social @socdevbio.bsky.social 🧪🔬

Are #cilia still hot or ... 👀? Maybe it's time to learn how they are formed! This review by the Pereira lab discusses the structural composition of the distal appendages, how they form the cilia, and how they are regulated in cell cycle and in diseases! www.sciencedirect.com/science/arti...

Great new study from @knoblich-lab.bsky.social, led by @saku-wong.bsky.social, showing that human cerebral organoids cultured for over six months can recapitulate postnatal interneuron migration 🧪🧬🧫🧠 www.biorxiv.org/content/10.6...

CLOK: Truly beautiful new #zebrafish tool for birthdating neurons from the Koyama and Del Bene labs doi.org/10.1038/s415...

Epigenetics News - Old hearts age backwards: transplanted organs adjust to host's biological age www.nature.com/articles/d41... #Epigenetics #News #Aging #Transplant --- Cancer, immunology, and aging; epigenometech.com

☕Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human #meninges and perform comparative studies with #meningioma data. www.nature.com/articles/s41...

#DBfeature #LatestResearch 🐠👁️ Regenerated fish retinas are similar to undamaged retinas, but display local patterning errors in comparison with undamaged retinas; new models could test their functionality recovery. By Deborah L. Stenkamp doi.org/10.1016/j.ydbio.2026.07.009