John Rubinstein

New preprint! Karin Schumacher's postdoc Nadja used our SidK approach to purify Arabidopsis V-ATPase & Mariia Khamina determined its structure. The structure shows unique plant V-ATPase features and that TLDc proteins (here OXR5) bind V-ATPase in all eukaryotes. 🌱 tinyurl.com/mw9xaszk

We have done so much for cancer outcomes and prevention over the last couple of decades. Some cancers are even being completely eradicated. Because, SCIENCE!

Congratulations to Dr. Fred Possmayer on becoming a member of the Canadian Medical Hall of fame. His research led to the development of bovine lung surfactant (BLES) as a treatment for preterm babies. He stipulated that BLES be available at the lowest possible cost so that it remains accessible

There's new hope for reversing widespread coral decline go.nature.com/4hQid1j

Fantastic article on Canuck memory legend Karim Nader by Samia Madwar. Karim’s 2000 reconsolidation paper was a game changer, reorienting neuroscientific studies towards a more reconstructivist view of memory. thewalrus.ca/karim-nader/

Heh. Chrystia Freeland's book blurbs

Happy to share my PhD work on the regulatory mechanism of E3 ligase RNF213! RNF213 is not a monomer, but a dimer that switches between inhibited and activated states in an ATP-dependent manner. We tracked the activation mechanism and showed how disease mutations can destabilize the inhibited state.

I hear so much about the growing power of predictive biology, especially in drug discovery and "co-folding". I want to see people put their GPU budget where their mouth is!

THERE IS NOTHING WRONG WITH THE PROJECT GRANT PROGRAM EXCEPT IT IS UNDERFUNDED. Breaking it, redesigning it, etc, cannot fix this.

29(!) years ago I visited Richard Henderson at LMB to ask about doing a PhD. Richard asked Sarah, a senior student, to take me for a (truly terrible, this was England in the 90s) coffee at Addenbrooks hospital to talk about grad student life at LMB. Amazing what Sarah has accomplished since then!

New preprint from our lab! Generating Structural Ensembles of Disordered Proteins with Diffusion Models Preprint: doi.org/10.64898/202... Code: github.com/rauscher-lab... #MachineLearning #MolecularDynamics #ComputationalBiophysics #IntrinsicallyDisorderedProteins

Margaret Hamilton, who led the 100-person team that wrote the onboard software for the Apollo missions, has died.

Daniel Drucker, the Canadian scientist behind Ozempic, on why he never gave up. Big Pharma scoffed, but he persevered, by Dan Bilefsky www.begiant.ca/stories/peop... via @be-giant.bsky.social @sinaihealthtoronto.bsky.social

We're in turbulent times in health research with unprecedented advances coupled with funding challenges. CIHR is at the cross-roads of this and is looking for a special advisor to the President (2 days a week, secondment). Be part of the solution. cihr-irsc.gc.ca/e/54823.html

Yet another opportunity @dunnschool.bsky.social! We are looking for an Associate Professor If you have exciting research plans, @dunnschool.bsky.social is a great place: excellent science (and lovely people, obvs) www.path.ox.ac.uk/vacancy/asso...

Molecular & Cellular Biology at the University of Guelph is recruiting an Assistant Professor in Molecular & Cellular Biotechnology through the Canada Impact+ Emerging Leaders program. Please share widely! careers.uoguelph.ca/job/Guelph-A...

This should be the new Tourism Canada advert. Just perfect.

🇨🇦 Today we kicked off our hands-on workshop, “Beyond Consensus Refinements: Advanced Cryo-EM Data Processing with CryoSPARC,” in collaboration with The Hospital for Sick Children @sickkidsto.bsky.social! Excited for two days of diving deeper into advanced #cryoEM data processing with #CryoSPARC. 🔬

The @structurabio.bsky.social @sickkidsto.bsky.social CryoSPARC workshop is underway!

🔎 A classic #cryoEM particle curation conundrum: 2D or 3D classification? "Decoy Classification" using Heterogeneous Refinement in #CryoSPARC curates particles directly in 3D, helping remove junk particles while preserving valuable views. Read more in the CryoSPARC Blog 👉 bit.ly/3SXfwS0

www.sickkids.ca/en/news/arch...

We are looking for a postdoctoral fellow to join the team @ubcmicroimmuno.bsky.social @science.ubc.ca to study TB pathogenesis and host-directed therapy! Please help disseminate amongst your network. ubc.wd10.myworkdayjobs.com/ubcfacultyjo...

This is seismic news for fisheries scientists. Northern cod is *the* iconic symbol of total fisheries collapse due to overfishing (and other factors) *and* the iconic symbol of a complete failure to recover for decades afterwards. This is like announcing the complete recovery of bison on land.

The number of cases of cervical cancer reported in Scotland among women given the HPV vaccine at 12-13 years of age is now zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. Zero. www.bbc.com/news/article...

Professor Bonnie Bassler is awarded the Copley Medal for her discovery of the universality of chemical communication in bacteria and for her idea that interfering with this communication could form the basis of novel anti-bacterials. #RSMedals https://royalsociety.org/medals-and-prizes/copley-medal/

Professor Dame Janet M Thornton DBE FMedSci FRS is awarded the Croonian Medal and Lecture 2027 for her pioneering work in protein structural and functional bioinformatics. #RSMedals https://royalsociety.org/medals-and-prizes/croonian-lecture/

The Francis Crick Medal and Lecture 2027 is awarded to Dr Thi Hoang Duong (Kelly) Nguyen for her ground-breaking discoveries into the molecular mechanisms of telomere maintenance. #RSMedals https://royalsociety.org/medals-and-prizes/francis-crick-lecture/

Professor Lewis E Kay FRS is awarded the Royal Medal (Biological) 2026 for his remarkable contribution to understand and quantify protein dynamics and their relevance to protein function. #RSMedals https://royalsociety.org/medals-and-prizes/royal-medals/

📣📣📣 The University of Gothenburg (Sweden) is recruiting 25 (yes, 25!) Assistant Professors in a wide range of disciplines (from arts to education to geology to maths), two of these at our Faculty. Happy to talk to anyone interested in knowing more about Sweden, Gothenburg or GU!

I met Ada when I was a new PI before her Nobel Prize. She spotted a copy of F.A. Cotton's "Chemical Applications of Group Theory" on my shelf and proceeded to tell me some of the most interesting stories about science and scientists I've ever heard. She was one of a kind. Rest in Peace.

Today 🇨🇦 announced the 64 scholars recruited from top US universities for the Canada Global Impact+ Chairs. They sounds like great scientists. But the enormous level of funding funnelled to this program is jaw-dropping when compared to the pitiful success rates at CIHR.

Such an honor to receive the Francis Crick Medal from the Royal Society. As I always say, I am just very lucky to have worked with amazing people. Big shoutout to all past and present lab members, mentors, colleagues and collaborators for continuing inspiring me!

In April this year at a medical conference (ASCO 2026), results of a drug improving overall survival in patients with #PancreaticCancer received a standing ovation - almost unheard of. Exciting to see the RAS inhibitor #daraxonrasib now approved by the FDA for metastatic pancreatic adenocarcinoma. 🧪

So many important contributions. The story of the development of abberation-corrected electron microscopy, in which Prof. Rose player a central role, is one of the most remarkable in science. Arguably should have been awarded a Nobel Prize.

Harald Rose, the giant of electron microscopy theory, passed away this summer aged 91. Thankful to his contributions to our field! Ruhe in Frieden, Prof. Rose. en.wikipedia.org/wiki/Harald_...

BREAKING: The U.S. is imposing 50% tariffs on $20 billion worth of Canadian products after last-ditch negotiations failed. Canada promises to match the tax.

Exciting news for personalized mRNA cancer vaccines, especially if the phase 3 effect size matches the phase 2 trial (49% reduced death or recurrence), although we have to wait for the official numbers arstechnica.com/health/2026/...

Out now in @natmicrobiol.nature.com: Bacillus subtilis builds protein filaments that act as a pseudomembrane, pulling quinone out of the bilayer and carrying it into the cytosol for reduction by NADH dehydrogenase, well away from the membrane itself. doi.org/10.1038/s415... 1/5

🚀 Preprint alert: cFAR and Relative Signal: Diagnosing Preferred Orientation in Single-Particle #CryoEM Explore how cFAR, tFAR, and Relative Signal provide complementary diagnostics for preferred orientation, tested across 14 #EMPIAR datasets and compared with established metrics 👉 bit.ly/4wBY1Ev

cFAR and Relative Signal: Diagnosing Preferred Orientation in Single-Particle Cryo-EM www.biorxiv.org/content/10.64898/2026.08.11.744264v1 #cryoEM

Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Introducing CsMT: A new CryoSPARC workflow for high-resolution microtubule reconstruction based on novel PF-pair classification! You can reconstruct MTs entirely in CryoSPARC—zero custom scripts needed. Inspired & built through a fantastic collaboration with the Cianfrocco lab! tinyurl.com/kdpm86tw

Wow 🤩 @benoitbruneau.bsky.social Very proud! Big congrats!

Please repost! #microsky🦠 The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x Send CV and cover letter to: glickmanmycolab@gmail.com

Huge congratulations to Professor Jacob Tsimerman of the University of Toronto on receiving the Fields Medal — one of the highest honours in mathematics. Nearly a century after Canadian mathematician J.C. Fields established this award in Toronto, it comes home.

🚀 Can automation solve preferred orientation in your #cryoEM datasets? After automating processing across 21 GPCR datasets in #CryoSPARC, we updated the workflow to be even more robust to preferred orientation, achieving improved map quality over manual processing. Read more 👉 bit.ly/3RyOIGG