Claudia Keller Valsecchi

📢 We are excited to announce our latest work on oocyte meiotic checkpoint signalling @crick.ac.uk Led by George Sioutas, the work allowed us to delineate the early steps of the checkpoint signalling program of pre- and postnatal oocytes 🐭🧬https://www.biorxiv.org/content/10.64898/2026.10.13.758765v2

#EMBOXChromosomeEvolution has started and been kickstarted by the first round of amazing talks including @dandergassen.bsky.social

🧬 Mark your calendars! Our EMBO Workshop "Chromatin evolution from molecules to genomes" is coming to St Feliu de Guíxols (Spain), 4–7 Oct 2027 🌊 Amazing programme! #EMBOchromatinEvo meetings.embo.org/event/27-chromatin-evo Register early!

It's live! The next @embo.org #EvoChromo meeting will take place next year October in St Feliu de Guíxols (Spain), check it out here: meetings.embo.org/event/27-chr.... It's been great to co-organise with @dodonova-sveta.bsky.social @kellervalsecchi.bsky.social @cedricfeschotte.bsky.social & Nick I.

ICYMI: New online: Single-molecule chromatin tracing reveals a diversity of megabase heterochromatin domains

Nuclear speckles are “hot”, but how do they actually sequester mRNPs? We find that stalled mRNPs are retained in nuclear speckles by a combinatorial RNA-binding protein network. www.biorxiv.org/content/10.6...

1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...

In one inbred strain of laboratory mice, late-life treatment with a GLP-1 drug extends lifespan. This effect might be more than just a consequence of calorie restriction. go.nature.com/4zOiI2I

Congratulations to Yuping Li on being awarded a prestigious ERC Starting Grant. In her project, she will investigate how bacteria detect and defend themselves against giant viruses known as jumbophages.🧪 @yuping-li.bsky.social @unibas.ch @erc.europa.eu #ERCStartingGrant #research #lifesciences

Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!

What regulates the urge to sleep? William Joo and colleagues identified brain regions that reflect how long mice have been awake. Strikingly, inhibiting one of these regions reduces sleep by 70%, without the major behavioral deficits associated with sleep deprivation. www.nature.com/articles/s41...

Just published in @plosbiology.org: researchers in @labgrosshans.bsky.social reveal how LIN28 keeps development on schedule in C. elegans through just two key targets. www.fmi.ch/news-events/...

⬇️ Check out this preprint from our floor friends @mariahondele.bsky.social , with a small (but mighty) fruit fly 🪰 contribution from our team / Drosophila whisperer Martin @biozentrum.unibas.ch

Job posting: Associate Professor in behavioral ecology and cultural evolution within the Department of Ecology and Evolution (DEE) at the University of Lausanne. Deadline for applications is 30.09.2026: wwwfbm.unil.ch/releve/appli... (there is a button to switch to English at the top right)

New preprint 📢 Thrilled to share our long-awaited work on the role of RSX in marsupial X-inactivation. This was a huge team effort over the years, led by @aureliencourtois.bsky.social @sermenchero.bsky.social Sugako Ogushi and Waz Varsally, that allowed us to set up genome editing in opossum embryos

A MUST READ! Congrats @a-radzisheuskaya.bsky.social and team!

Excited to be able to advertise 1x postdoc and 2x technician positions to join my group in Cambridge working on an exciting ARIA funded project to help bring a plant artificial chromosome into existence! Reposts very welcome please 🙏 (1/2)

I had a fantastic time @imbavienna.bsky.social @viennabiocenter.bsky.social @impvienna.bsky.social Thanks for the invite @pauligroup.bsky.social 🙂 and see you next time!

We are looking for a colleague 👇👇👇

There is more to transcriptional readthrough than meets the eye, and it could even provide a therapeutic opportunity in cancer. Check out our new perspective, inspired by recent work from Neugebauer and Grzechnik labs! #RNABiology #RNASky #Epigenetics

What if an embryo made immune cells before it finished building the tissue they usually come from? In our new preprint, we show that annual killifish embryos specify neutrophils before germ layers are fully resolved. www.biorxiv.org/content/10.6... Huge thanks to my PI, @ohnolog.bsky.social ! 🧵

My first PhD paper is out in Nucleic Acids Research! We describe "Ab-trapping" - an antibody artifact that distorts assays relying on antibody diffusion (microscopy, CUT&Tag, CUT&RUN). The revisions made the story much stronger. Check it out! doi.org/10.1093/nar/...

Congratulations to Prof. Sebastian Hiller and all newly elected EMBO members! This lifelong membership recognizes outstanding scientific achievements. 🧪 #EMBOMembers2026 @hillerlab.bsky.social @unibas.ch @embo.org www.biozentrum.unibas.ch/news/detail/...

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

A big preprint from my group! Muller Elements are considered to be conserved in flies. We tested it by reconstructing the ancestral dipteran karyotype using 340 chromosomal genomes and suprise suprise, they're not... Led by @juliagries.bsky.social and Sam Ebdon. www.biorxiv.org/content/10.6... 🧵👇

Happy to share our preprint! Using massively parallel reporter assays, single-molecule imaging, deep learning and cryo-EM, we decode the sequence requirements for translation initiation and describe the “extended translation initiation sequence” (eTIS) that modulates start codon recognition. 🧵👇

For 40 years the 8-nt ‘Kozak Sequence’ was thought to mark sites of translation initiation. In a new study, we revise this model by identifying an ~80-nt sequence—the extended Translation Initiation Sequence (eTIS)— that guides ribosomes to correct start sites. 🧵 www.biorxiv.org/content/10.6...

Two new papers 📖 from our lab 1️⃣ What is epigenetics (and why X inactivation is?) rdcu.be/fhzSz and 2️⃣ A Baculovirus-based tool to express any gene of interest with high efficiency in Anopheles cells rdcu.be/fhzTy

Female mice grow testes after this single DNA tweak www.nature.com/articles/d41...

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Cool paper, turning evolutionary theory on its head - gene conversion overcomes the cost of asexual reproduction… Gene conversion empowers natural selection in a clonal fish species www.nature.com/articles/s41...

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

Our Lab is searching a postdoc for an exciting ERC-funded project that will start this summer. Apply if you’re passionate about multi-omics, cutting-edge computational approaches, and exploring biological questions across the animal 🪼 🪱 🐞 🦎 🦋 🕷️ tree of life www.biozentrum.unibas.ch/open-positio...

Salinity tunes mode of multicellularity in a tidepool choanoflagellate www.nature.com/articles/s41... - paper in @nature.com

Congratulations Dr. Fritz Garcia! You can be proud of all what you achieved!

For once an article about the "how to get to Rome" and not "Rome" itself. Collaboration with my "partner-in-crime" @felibas.bsky.social has been a key ingredient of my research over the years. Sara Miller at Molecular Cell spoke with us of how we got there and what we think about collaborations.

Stunning lecture („Antrittsvorlesung“) by @hilgerslab.bsky.social - friend, mentor and scientific inspiration at the very same time 😀 Happy that our paths join again in #Basel

When you work in #Switzerland and Conference Organizers choose the most stunning place #engadin @nccr-rna-disease.bsky.social

New year - New paper! Congratulations to @miyapan.bsky.social @hugodarras.bsky.social and team! Conservation of a transcribed lncRNA (?) without sequence similarity 😉

Thanks to our amazing collaborators: the Colgan @hibernogruppe.bsky.social 🐝, Keller Valsecchi @kellervalsecchi.bsky.social and Darrouzet labs