How do epigenetic modifications contribute to human #neocortex#development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.
@crtd-tud.bsky.social@cp-neuron.bsky.socialwww.sciencedirect.com/science/arti...
A thread below š
Prof. Albert @mareikealbert.bsky.social is part of MICRO-NEST, a new international consortium. Backed by ā¬6 million Horizon Europe grant šŖšŗ, it combines multidisciplinary expertise to study early markers of autism spectrum disorders.
Read more ā”ļø tud.link/319gn4#CMCBnews@tudresden.bsky.social
š£ Deadline extension for #EMBOBrainEpi!
Good news for anyone who did not submit an abstract for the EMBO Workshop 'Brain (epi)genome': the abstract deadline is now 26 January š s.embl.org/brg26-01-bl
Join us to explore how genome and epigenome shape brain cell diversity, function, and disease š§
š„ We have a new PhD!!! Congratulations to Theresa Schütze for an excellent PhD defence! š„³ The result of hard work, dedication and curiosity. Very well deserved! Thank you to the committee members. Stay tuned for the manuscript!!! š§ š§« š¦ š§¬
@crtd-tud.bsky.social#DIGS-ILS#CNV alumnus
New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This ābasal fluidizationā, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
1/
doi.org/10.1101/2025...
š„³ Congratulations to our postdoc, Dr. Anna Czarkwiani @aniaczark.bsky.social, on receiving the ERC Starting Grant @erc.europa.eu!
With ā¬2 million in funding, Anna will explore the biology of gravisensation and uncover insights into related disorders. š§
#CMCBnews@tudresden.bsky.social#ERCStG
The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
Workshop Single Cell Genomics on 13 & 14 Oct in @www.helmholtz-munich.de , right before the @gscnoffice.bsky.social 13th Conference. Register and be part!
#stemcells#singlecell#genomics#data#stammzellen#organoids
1
To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, youāll be surprised!
š§µThread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...
Overall, this study comprehensively characterizes the epigenetic state of specific neural cell types and highlights a novel role for H3K27me3 in regulating the ECM composition in the human developing neocortex. (10/11)
š£ Proud of this fantastic work by two amazing PhD students Nora Ditzer and Ezgi Senoglu from @crtd-tud.bsky.social. š„³ š Huge thanks to all co-authors! Enjoy the read. (11/11)
Our findings are especially interesting considering previous results from the Hippenmeyer lab, where PRC2 knockout in individual cells of the mouse cortex suggested a non-cell autonomous mechanism for the regulation of NPC fate decisions by PRC2. (8/11)
www.science.org/doi/epdf/10....
Intriguingly, pharmacological PRC2 inhibition in human cortical organoids induces increased production of the ECM components Syndecan 1 and Laminin alpha 1. (9/11)
Whereas a recent study from the Treutlein lab and @epign.bsky.social revealed a role of PRC2 in regulating the exit from pluripotency, we now dissect the role of PRC2 within the neural lineage after the initial cell fate commitment. (6/11)
www.nature.com/articles/s41...
Our cell type-specific profiling of the genome-wide H3K27me3 profile not only identified neuronal differentiation, but also extra-cellular matrix (ECM) genes as targets of PRC2. (7/11)
Here, we performed pharmacological inhibition of PRC2 in human cortical organoids from week 3 to 8, leading to a near complete loss of H3K27me3, and studied NPC behaviour. (4/11)
We found that loss of H3K27me3 in human cortical organoids induces a shift of neural progenitor cell proliferation towards differentiation that results in reduced organoid size. (5/11)
We apply an innovative, highly multiplexed approach, Epi-CyTOF, to study > 30 epigenetic modifications at single-cell level in the human developing neocortex. We identify H3K27me3, deposited by PRC2, as the modification with the strongest cell type-specific enrichment. (2/11)
These results beautifully align with a recent study from the Studer lab where PRC2 was shown to contribute to an epigenetic barrier that mediates the protracted maturation of human neurons compared to other species. (3/11)
www.nature.com/articles/s41...
How important is #epigenetics for human brain?
Researchers led by @mareikealbert.bsky.social used brain organoids š§ š§« and Epi-CyTOF to show that histone methylation controls how brain cells multiply and how big the organoid grows.
Read more ā”ļø tud.link/4ywe3g#neuroscience#CMCBnews
Rund 150 (!) aktuell und ehemalig Gefƶrderte waren beim diesjƤhrigen #EmmyNoether-Jahrestreffen - und es war wieder einmal lustig, produktiv, sonnig, kollaborativ, synergetisch, kommunikativ und noch viel mehr. š
Kurzer Bericht, mehr Impressionen & die PrƤsentationen zu den Talks:
fcld.ly/ent2025
Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.
mpi-muenster.mpg.de/career
We are looking for a #Postdoc with a great interest in biological robustness to lead a project investigating the self-correction capabilities of the developing nervous system. Join us at the @rocha-lab.bsky.social Rocha lab @mpi-muenster.bsky.social!
jobs.mpi-muenster.mpg.de/jobposting/0...
#Prospects PhDs & postdocs of all disciplines note: Would you like to lead an independent junior research group? In our online talk you will get first-hand information about the aims and requirements of the DFG Emmy Noether Programme and more. Link to the meeting will be published here: fcld.ly/enp
Award-winning mentors share best practice to keep your team going amid political upheavals, economic downturns and other events
https://go.nature.com/4eErOVx
Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...
For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
We have several open postdoc positions! We do computational biology š§¬š„ļø and deep learning to understand the genomics of genome instability and (somatic) genome evolution in ageing and cancer. Interested? šš» more details: tu-dresden.de/cmcb/biotec/...
Here's a job at my institute that just opened up: Max Planck Director in Biological AI. This is an amazing opportunity -
www.mpi-cbg.de/news-outreac...
Excited to share our latest work out in @pnas.org! We show that the #SARSCoV2 nucleocapsid protein directly prevents DNA recognition of the immune sensor #cGAS by competing for DNA, which may delay early innate immune responses during infection. www.pnas.org/doi/epub/10....#innateimmunity
I gave in! After students asking for it, I now made a simple figure design checklist.
To help all scientists w/o graphic skills create clear, accessible, and truthful charts!
-> Out in @nature Cell Biology: rdcu.be/erwl4#DataVisualization#PhD#SciComm
Thx for review @bethcimini.bsky.social + 2
Congratulations to newly minted Dr. Shuting Xu šćļø
As Shuting is the first PhD graduate from our Dresden lab, I was probably more nervous than she was. But Shuting delivered an outstanding, stimulating presentation and handled the Q&A with confidence. Very well done! 1/2
June 2025 issue of Trends in Neurosciences:
www.cell.com/issue/S0166-...
Cover article: 'Epigenetic and metabolic regulation of developmental timing in neocortex evolution', by Matilde Aquilino, Nora Ditzer, @takashi-namba.bsky.social & @mareikealbert.bsky.socialwww.cell.com/trends/neuro...
Planning to apply for #research#funding from the ERC?
From the next application rounds, expect changes to the:
⢠proposal structure
⢠evaluation process
⢠extra funding you can request
⢠eligibility for Starting & Consolidator #Grants (from 2027)
More š europa.eu/!RPHWvv
Outstanding success: š #TUDresden shines with 5 Clusters of Excellence. @dfg.de & @wissenschaftsrat.de announced that decision today. TUD has impressively proven its claim to be a top university for the 21st century.
ā¹ļø tu-dresden.de/tu-dresden/n...
Three amazing days of the #neurogen2025 conference at @humantechnopole.bsky.social in Milan. Many thanks to all the participants, speakers and fellow co-organizers. We heard fantastic talks in #neurodevelopment#brainevolution#cancerneuroscience#neuroimmunology#neurodegeneration#neurodiversity
Monday is the big day! Very much looking forward to welcoming all participants and speakers of the Neurogenomics Conference to @humantechnopole.bsky.social in Milan. It promises to be an exciting few days filled with amazing science.
Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...
Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...