James Olzmann

Sooo happy to share our new paper in @nature.com “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” A terrific collaboration with @arrudalab.bsky.social, led by co–first authors Alyssa Mathiowetz and Emily Maymand. www.nature.com/articles/s41...

The first one was amazing and its highly recommended!

Save the date! 🔥 The 2027 FASEB Science Research Conference on Ferroptosis: From Mechanism to Medicine is coming to Denver, July 12–15! We are excited to bring the ferroptosis community together again. Experts and newcomers welcome! Please help spread the word! More info soon!

Metabolite buffering of labile iron governs ferroptosis @cellcellpress.bsky.social Preview @olzmannlab.bsky.social www.cell.com/cell/fulltex... on www.cell.com/cell/fulltex...

California Bill Would Create A $23 Billion Fund For University Research

Happy to share the final version of the study where we describe a central role for vitaminB2 in regulating membrane redox state - some new cool experiments were added since the preprint was posted - pls check this out thttps://www.nature.com/articles/s41556-025-01856-x

#Vitamin B2 is converted into molecules which protect cells from oxidative damage. The downside: It also protects #cancer cells. Scientists at the Rudolf Virchow Centre at #JMU discovered that. 📸 Natalie Fahmer ➡️ www.uni-wuerzburg.de/en/news-and-...

New online: FAD-dependent stabilization of FSP1 promotes ferroptosis resistance

Awesome paper and super useful resource of CRISPR-based screens to identify regulators of #LipidDroplet biology under different metabolic conditions: crisprlipid.org

Cool paper alert 🚨! Congrats @olzmannlab.bsky.social! Proud to have made a small contribution to this. One of the prettiest membrane-protein structures I have simulated ☺️

A little late on here but happy to share my 3rd first author paper from grad school finally out in Science Advances!! In collaboration with James Olzmann's group, we find that Tregs utilize FSP1/Aifm2 for preventing lipid peroxide accumulation and preserve their suppressive function in tumor models.

Thrilled to have contributed to this work led by @jgcastillo.bsky.social during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. www.science.org/doi/10.1126/...

Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪

15. And second, also from @olzmannlab.bsky.social, an ER chloride channel pushes LD formation toward the cytosol vs. nucleoplasm and affects nuclear pore complex assembly in @biorxiv-cellbio.bsky.social www.biorxiv.org/content/10.1...

14. Two studies that reshape thinking about lipid droplets biology. First, lipid peroxidation can occur to neutral lipids inside the core of LDs, with protective mechanisms revealed, from @mikelangelipid.bsky.social and @olzmannlab.bsky.social in @natcellbio.nature.com www.nature.com/articles/s41...

Proximity labeling users: check out this study by @zhixingchen2.bsky.social and Peng Zou, which establishes how much contact-dependence vs. diffusion is responsible for biotinylation — tl;dr TurboID has a much smaller effective radius! www.nature.com/articles/s41... 1/2

Two weeks left to apply! If you study any area of metabolism or metabolic disease (broadly defined), we encourage you to apply. The dept is excited about biological and molecular mechanisms, metabolic flux, therapeutics, and physiology related to disease. aprecruit.berkeley.edu/JPF04710

Happy to see our News & Views is out! We highlight two landmark papers demonstrating the potential for therapeutic targeting of FSP1 and #ferroptosis in in vivo cancer models. Beautiful work from @ubellackerlab.bsky.social, Thales Papagiannakopoulos, and colleagues. 🥳 www.nature.com/articles/s41...

Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published: journals.biologists.com/jcs/article/... The result of a fantastic Iwasa-Drubin lab collaboration. @margotriggi.bsky.social @jiwasa.bsky.social movie.biologists.com/video/10.124...

New preprint out! We show that PROTAC-induced ubiquitination can bypass canonical ERAD to degrade ER membrane proteins. Wonderful collaboration w/ @dannomura.bsky.social and huge credit to grad student superstar Sydney Tomlinson! www.biorxiv.org/content/10.1...

We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...

#NatMetabPicks | In @natcellbio.nature.com led by @olzmannlab.bsky.social ( @ucberkeleyofficial.bsky.social ) FSP1, localized to lipid droplets, protects stored lipids from oxidative damage and prevents ferroptosis. www.nature.com/articles/s41...

Curious how proteins find their way to #LipidDroplets? Our bipartite review traces their journey from ER insertion to LD partitioning: 👉 Navigating lipid droplet proteins - part II: Molecular mechanisms of ER-to-LD protein partitioning #Organelles #EndoplasmicReticulum #ER_Literature

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control! shorturl.at/B5XYD

Excited to share our study out in @natcellbio.nature.com! Led by @mikelangelipid.bsky.social, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. www.nature.com/articles/s41...

Great Endoplasmic Reticulum meeting in Paris organized by the amazing Eric Chevet @ericchevet.bsky.social! It was wonderful to also hang out with James Olzmann @olzmannlab.bsky.social and Rachid Thiam @abdourachidthiam.bsky.social.

A giant in molecular biology and virology has passed. RIP David Baltimore. www.nytimes.com/2025/09/07/s...

Join us in celebrating the #ASBMB26 Award Winners! • @abu-remaileh.bsky.social • Suzanne Barbour • @bradylabupenn.bsky.social • George Carman • Joseph Cotruvo • Roger Davis • @rolanddunbrack.bsky.social • Pamela Mertz • @olzmannlab.bsky.social • Kim Orth • Margaret Phillips ow.ly/x05f50WSbax

Congrats to MCB's James Olzmann @olzmannlab.bsky.social on receiving the ASBMB 2026 Avanti Award in Lipids @asbmb.bsky.social! 👍🎉

Humbled and honored to receive the 2026 Avanti Award in Lipids from ASBMB! Grateful to my exceptional lab, mentors, and collaborators for their support and inspiration. Excited to keep pushing the boundaries of lipid biology and therapeutics! www.asbmb.org/asbmb-today/...

First day of class @UCBerkeley! Kicked off the day peeking in on the Therapeutic Discovery and Development class taught by @dannomura.bsky.social @robzonculab.bsky.social @urnov.bsky.social!! 🤩🔥!!

First day of class @UCBerkeley! Kicked off the day peeking in on the Therapeutic Discovery and Development class taught by @dannomura.bsky.social @robzonculab.bsky.social @urnov.bsky.social!! 🤩🔥!!

Tenure track position alert! Assistant Professor of Molecular Therapeutics in MCB @UCBerkeley. Apply and come be our colleague! 🎉 aprecruit.berkeley.edu/JPF05098

Happy to start at Bluesky with a post on our recent manuscript at @nature.com: www.nature.com/articles/s41... Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Hot off the presses! Was an honor to team up with Scott Dixon @stanforduniversity.bsky.social on this Nature Cancer review. We reflect on hurdles that have slowed translation of ferroptosis-directed therapies and share ideas on what it will take to bring these therapies to the clinic. rdcu.be/eBbqV

Jessalyn Ubellacker @ubellackerlab.bsky.social was honored with a FASEB Journal Early Career Researcher Award at the first FASEB Ferroptosis, Oxidative Stress, and Lipid Metabolism meeting, co-organized by James Olzmann @olzmannlab.bsky.social and Scott Dixon, to support early career researchers.

Congrats to MCB's Jennifer Doudna @jenniferdoudna.bsky.social on receiving the 2026 ACS Priestley Medal from the @acs.org! 👏🏅 www.acs.org/pressroom/ne...

ICYMI: New Online! Lysosomal membrane homeostasis and its importance in physiology and disease

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

I am honored to be named a 2025 ASCB Fellow! It is a privilege to be part of the ASCB community. ASCB was the first conference I attended as a grad student, and it has always been a welcoming, supportive home. Thank you for this kind recognition! ☺️ www.ascb.org/society-news...

Riboflavin metabolism shapes FSP1-driven ferroptosis resistance https://www.biorxiv.org/content/10.1101/2025.08.05.668651v1

Vitamin B2 metabolism promotes FSP1 stability to prevent ferroptosis https://www.biorxiv.org/content/10.1101/2025.08.05.668752v1

🚨Preprint alert 🚨 We identify riboflavin (vitamin B₂) as a key modulator of ferroptosis sensitivity via stabilizing FSP1 & recycling lipid-soluble antioxidants. www.biorxiv.org/content/10.1.... pls check @olzmannlab.bsky.social www.biorxiv.org/content/10.1... #ferroptosis #FSP1 #antioxidants