Peter Ly

🧬 Excited to share our new paper, out today in Nature Cell Biology! 📄 www.nature.com/articles/s41... This work started with a very simple and intriguing question: how can microtubules apply sufficient force in the nucleus to promote chromatin mobility, in particular DNA double stand breaks? 🤔 🧵

Excited to share that our latest work on post-mitotic DNA synthesis (post-MiDAS) at repetitive and difficult-to-replicate DNA sequences such as telomeres and centromeres has been published: www.nature.com/articles/s41....

A guide to distinguishing 'mitotic-phase DNA synthesis' and 'MiDAS' from Chris Chan @gdsc-sussex.bsky.social link.springer.com/article/10.1...

Pleased to share the pre-print of my PhD & post-doc work! Along with co-author @audreylumeau.bsky.social we used single-cell whole genome sequencing to highlight cancer genomes are constantly changing as a result of chromosomal instability. You can find this on BioRxix: doi.org/10.64898/202...

Our work out today in @nature.com! We identified a previously unknown function for WEE1 in cell cycle control that could explain some of the inhibitor side-effects. We found WEE1 inhibits APC/C(Cdh1) to promote S-phase and cell cycle entry. Inhibit Wee1 , block or impair cell cycle entry.

We're hiring! The Department of Biological Chemistry at UCI is seeking a tenure-track Assistant Professor! This is a broad search across biomedical sciences, including genome stability. Join a dynamic department with excellent research resources, great faculty benefits, and year-round sunshine!

Excited to share our next steps in pursuing ALC1 as a safe therapeutic target. We show that ALC1 loss expands PARP inhibitor sensitivity in homologous recombination-proficient, Cyclin E1-high cancers with minimal impact on non-cancer fallopian tube cells. link.springer.com/article/10.1...

Out today in @jcb.org! Work from the Mogessie, Fachinetti & Redemann labs reveals how CENP-A/B/C cooperate to maintain kinetochore function in oocytes and how declining centromere strength predisposes aging eggs to aneuploidy. doi.org/10.1083/jcb.... @health.pew.org @valleefoundation.bsky.social

Excited to share a review on mitotic and meiotic midbody remnants! Karen Schindler and I wrote this piece! Enjoy! Mitotic and meiotic midbody remnants: Divergent architectures with distinct clinical applications: Cell Genomics www.cell.com/cell-genomic...

Very happy to see our work highlighted by @natcellbio.nature.com. A great team effort and a fascinating example of how a simple physical principle can connect mitosis across eukaryotes! @lgudlin.bsky.social, @krunovuk.bsky.social, @kopslab.bsky.social

Have you ever wondered how cells in developing embryos manage to squeeze through tiny spaces? And how do they cope with mechanical stresses imposed by surrounding tissues? Check out our paper, now out @natcellbio.nature.com : www.nature.com/articles/s41...

Very excited to share Waldo: a genetic single-cell barcode that can be read out in both live-cell imaging and single-cell sequencing, so both measurements can be made for the same cells. ⬇️

Did you ever want to sequence that one interesting cell you observed in your microscopy experiment? We have a new pre-print out today that describes a genetic barcoding method, Waldo, to perform live-cell imaging and single-cell sequencing on the same single cells. www.biorxiv.org/content/10.6...

That’s a wrap for FASEB Aneuploidy 2026! Thanks to all the attendees for making it a special meeting. The science was so out-of-this-world that NASA even launched a spaceship for us. 🚀 See you again in 2029!

🔬TWO MORE WEEKS remain to apply for any of our three open faculty positions at cri.utsw.edu/careers #relentlessdiscovery 🧪

Happy to see our review out! 🧬 How does ssDNA arise during DNA replication, and how can complementary approaches help us distinguish its different molecular origins and potential outcomes? www.sciencedirect.com/science/arti... So, mind the…replication-associated ssDNA (one for the UK commuters).

Working with a great team to organize @keystoneSymposia.bsky.social DNA Replication: Pathway Crosstalk Shaping Physiology and Disease, this April! Join us to explore emerging research in London! keysym.us/KSDNA27 #KSDNA27

We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @cri-utsw.bsky.social is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!

🚨Preprint news!!🚨 Using specifically purified mitotic chromosomes, we show that chromosome mechanics vary based on identity and cell type. Chromosomes from differentiated cells are more compact and stiffer, likely due to increased non-covalent crosslinks within them www.biorxiv.org/content/10.6...

Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)

A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.

Thrilled to share a new important study from the lab, published today in @nature.com, showing how cohesin mediates efficient replication fork plasticity and stress response, using its loop extrusion activity to promote 3D contacts on replicating DNA: www.nature.com/articles/s41...

We are recruiting a postdoctoral fellow to study DNA damage repair via the homologous recombination pathway using quantitative cell biology approaches. The position will be initially supported for two years by the MSU Research Foundation Postdoctoral Scholars program. Please share! 1/5

How are mitotic chromosomes built? Our Review @cp-trendsgenetics.bsky.social revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes: authors.elsevier.com/a/1nmwrcQbJI...

My lab at the Center for Gene Expression (CGEN), University of Copenhagen is looking for a motivated Postdoc interested in cohesin biology, 3D chromatin, and super-resolution microscopy. 📩 Please email your CV and letter of intent to fena.ochs(at)sund.ku.dk.

Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)

A long time in the making, now finally out.💥 Our new study shows that division stays on time when kinetochore–microtubule attachments form efficiently. When the process drags, that delay is remembered, limiting future cell proliferation. www.nature.com/articles/s41... #mitosis #biology #microscopy

Fresh preprint from the lab: CIP2A tetramerization is required for mitotic DNA repair. A fantastic collaboration with @marcelvanvugt.bsky.social. By @laurendehaan.bsky.social, @rebeccaschneeweiss.bsky.social, and colleagues from Groningen, Vienna, Leiden, and Amsterdam 🙌 doi.org/10.64898/202...

Structure and sequence fill evolutionary gaps for essential centromeric proteins. Work by @jeremyahollis.bsky.social, @irinakitop.bsky.social, & Jason Stonick. Article by Kelsey Woodruff. www.fredhutch.org/content/www/... Paper: www.science.org/doi/10.1126/...

1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...

How long does DNA damage last? @aaronquinlan.bsky.social and I found evidence that lesions are transmitted from parent (P0) to offspring (F1) in C. elegans. If they segregate unrepaired for multiple cell divisions, lesions generate multi-allelism in the F1 germline. www.biorxiv.org/content/10.6...

Big paper alert! This project has been years in the making. A comprehensive description of somatic mutation rates and signatures across 53 tissues or cell types using NanoSeq. A large collective effort led by Mimy Pham, Mike Stratton and @r-rahbari.bsky.social. www.biorxiv.org/content/10.6...

What is the sequence of events at the kinetochore? Our Spotlight article highlighting a beautiful study by Conway et al. is out now in Trends in Cell Biology! Click here for download: sl1nk.com/euzlpiq A temporal framework for error-free mitosis: Trends in Cell Biology www.cell.com/trends/cell-...

Very happy to see our Nature Reviews Molecular Cell Biology Roadmap out! A fantastic collective effort, led by Carsten Janke and Zdenek Lansky, together with an amazing group of colleagues, and sparked by inspiring discussions at the Fondation des Treilles. www.nature.com/articles/s41...

Latest w/ Bonny Brewer and Raghu. We evolved different DNA repair mutants to investigate the mechanism of a gene amplification we've been working on for many years. We got all sorts of interesting alternate outcomes, including these cool subtelomeric repeats in Ku mutants dx.plos.org/10.1371/jour...

New Online! Towards a systems-level view of the microtubule cytoskeleton and its functions in physiology and disease

Interested in nuclear mechanobiology and want to know what some of the big open questions are in the field? Read our recent editorial with input from >15 leading experts in the field, along with a list of review articles on nuclear mechanobiology: www.tandfonline.com/doi/full/10....

New work from the lab! We report that DDIAS is a downstream effector of CIP2A-TOPBP1 in mitosis that suppresses ssDNA to preserve genome integrity. From the great @yiboxue.bsky.social and many collaborators! Free link: authors.elsevier.com/a/1nfiF3vVUP... Pay link: www.cell.com/molecular-ce...

Our latest work describing DDIAS as a new component of the TOPBP1-CIP2A pathway in mitosis and its requirement for brain development is now published. Fantastic collaboration with @fenaochs.bsky.social, @profstewartlab.bsky.social, Lars Allan Larsen, @tcr-miller.bsky.social, Zafar Iqbal & others

Happy to share our new paper out today @cp-cell.bsky.social. Great collaboration between @andrewblackford.bsky.social and my lab. Congratulations all!

Very pleased to share this new study: In a truly collaborative effort with the lab of Pim Huis in 't Veld @huis.bsky.social, we combined biochemistry with cell biological and genomic approaches to uncover how CIP2A works in mitotic DNA repair. www.biorxiv.org/content/10.6...

Excited to share this review that @needhibhalla.bsky.social and I wrote on meiotic checkpoints! www.annualreviews.org/content/jour...

Supremely excited to share our new paper in @natcellbio.nature.com With an updated genetic cGAMP reporter, we reveal that cGAS activation by DNA damage is a rare event, and that cGAS enrichment on intracellular structures cannot be taken as evidence of activation. www.nature.com/articles/s41...

Our paper is out in The EMBO Journal @embojournal.org! 🎉 We show how replicated chromosomes can maintain sister chromatid cohesion while still allowing dynamic loop folding within nested hierarchy of TADs. Check it out below 👇 1/2

Delighted to share our latest publication, a collaborative work with @hanasedlackova.bsky.social and @puckknipscheer.bsky.social. Grateful to everyone who contributed to this project. www.cell.com/cell-reports...

We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @cri-utsw.bsky.social is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!

The Baylor College of Medicine Conference on Structural Variants and DNA Repeats is back, and this year it has a new home! Join us in person in Houston November 19th–20th. Or join online. Virtual registration is FREE! ErwinLab.org/svar-conference

Excited to share our newest work! We asked whether RNA molecules need to be in a specific place in the cell to do their job. We found that a single RNA must reach the midbody, the structure that pinches two dividing cells apart, for cell division to finish efficiently. 🧵⬇️