SattelyLab

SattelyLab

@sattelylab.bsky.social

Website: https://www.sattelylab.org/ Member-run account of the Elizabeth Sattely Lab at Stanford University Plant natural products | Plant-microbe interactions | Plant chemistry | Pathway discovery | Plant health | Plant-human interactions

175 followers41 following19 posts

SattelyLab
@sattelylab.bsky.social

Great work by Yaereen and Kevin from the lab! Have a look at the unusual biosynthesis of anti-cancer agent homoharringtonine #plants #biosynthesis #anti-cancer #natchembio

Ryo Yokoyama@yokoyama-ryo.bsky.social

Cephalotaxinone enzymes reveal a whole plant model for homoharringtonine biosynthesis www.nature.com/articles/s41... @natchembio.nature.com

nature.comCephalotaxinone enzymes reveal a whole plant model for homoharringtonine biosynthesis - Nature Chemical BiologyHomoharringtonine (HHT) is a plant-derived anticancer drug approved by the US Food and Drug Administration. Here, the authors elucidate a root-tip-specific biosynthetic pathway to its alkaloid core, i...

SattelyLab reposted

Plant Science Spotlight
@plant-sci.bsky.social

🌿🧬 Taxol pathway mapped with new method mpXsn. Seventeen genes known, eight newly discovered. Baccatin III produced in tobacco at natural levels. Breakthrough for anti-cancer drug production. #plantscience @cmcclune.bsky.social @sattelylab.bsky.social @nature.com www.nature.com/articles/s41...

nature.comDiscovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - NatureAn approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

SattelyLab reposted

Nature Biotechnology
@natbiotech.nature.com

Replying to @natbiotech.nature.com

Research Briefing: A PIVOT towards single-cell functional genetic screening in plants www.nature.com/articles/s41...

nature.comA PIVOT towards single-cell functional genetic screening in plants - Nature BiotechnologyWe developed PIVOT, a single-cell screening platform for functional characterization of plant genes. PIVOT enables delivery of gene libraries to tobacco leaves with single multiplicity of infection an...

SattelyLab reposted

Conor McClune
@cmcclune.bsky.social

Lovely C&EN @cenmag.bsky.social story on the history and personal impact of the cancer drug Taxol. After spending recent years deciphering how yew trees, our source for Taxol, synthesize this lifesaving drug, it’s so nice to see it in the larger context #secmet #medsky Plants are amazing chemists.

cen.acs.orgPaclitaxel saved my life. New discoveries could boost supplyAfter decades, scientists have finally pieced together the 23-step biosynthetic pathway to produce this cancer drug
SattelyLab
@sattelylab.bsky.social

Beautiful work by Yaereen and former lab member Kevin! Learn more about the anti-cancer compound homoharringtonine and its'biosynthesis in plants here 🌿https://www.biorxiv.org/content/10.1101/2025.08.26.672243v1

biorxiv.orgDiscovery of homoharringtonine pathway enzymes reveals a whole plant model for coordinated biosynthesisPlants have evolved to produce diverse molecules that inhibit protein translation. A lead example is homoharringtonine (HHT), both a key tool for ribosomal profiling and an FDA-approved treatment for ...
SattelyLab
@sattelylab.bsky.social

Couldn't have said it better! Great job @taralowensohn.bsky.social, Will, and Chun! Special thanks to the Gao lab at @stanford.edu #singlecell #plantbiology

Conor McClune@cmcclune.bsky.social

A truly enabling new approach by @taralowensohn.bsky.social Will Cody and @sattelylab.bsky.social to probe plant genetics at scale. Single-gene-per-cell delivery coupled to an effective transcriptional selection system www.biorxiv.org/content/10.1...

SattelyLab
@sattelylab.bsky.social

@cmcclune.bsky.social will be at the GRC for Single-Cell Approaches in Plant Biology! Be on the lookout for his talk on Wednesday (8/13) at 9.10 am. Talk will be about some new approaches and discoveries recently published in Nature! www.nature.com/articles/s41... #grc #singlecell #plantbiology

nature.comDiscovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - NatureAn approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
SattelyLab
@sattelylab.bsky.social

Congrats!

FrankeLab@frankelab.bsky.social

Extremely happy to see our withanolide biosynthesis paper out in @natcomms.nature.com‬ rdcu.be/evHOF Fantastic team effort with the Pucker group @bpucker.bsky.social‬ @puckerlab.bsky.social‬ at @unibonn.bsky.social and Heretsch, Herde and Witte groups at @unihannover.bsky.social. Funded by @dfg.de

rdcu.bePhylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesisNature Communications - Withanolides are plant steroids with potent bioactivities found in many medicinal plants including Withania somnifera, but their biosynthetic pathway is largely unknown....

SattelyLab reposted

Conor McClune
@cmcclune.bsky.social

Pithy coverage by @plantaeofficial.bsky.social of our recent Taxol work #chemsky #medsky

Plantae.org@plantaeofficial.bsky.social

Plant Science Research Weekly -- Elucidation and recreation of the biosynthetic pathway for taxol (Nature) @cmcclune.bsky.social‬ (Summary by Mary Williams @PlantTeaching.bsky.social) buff.ly/miccEK3 #PlantaePSRW

buff.lyElucidation and recreation of the biosynthetic pathway for taxol | PlantaePaclitaxel (sold as Taxol) is taxane diterpene natural product of yew trees (Taxus spp.) and a potent stabilizer of microtubules that is effective in treatment of cancers. However…
SattelyLab
@sattelylab.bsky.social

Fresh off the press! Check out the newest paper from the Sattely lab and @pollyfordyce.bsky.social lab! Spearheaded by @cmcclune.bsky.social #plants #plantbiology #anticancer #drug #taxol

Conor McClune@cmcclune.bsky.social

Today in Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III & deBz-deoxy-Taxol #SingleCell #secmet 🧬🧪🌾

nature.comDiscovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - NatureAn approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...
SattelyLab
@sattelylab.bsky.social

Preprint for the exciting, upcoming Nature paper! @cmcclune.bsky.social, Jack, Chloe, and Ricardo from the Sattely lab (in collaboration with @pollyfordyce.bsky.social) discovered genes for the anti-cancer drug Taxol pathway - plus a gene boosting the production of a bottleneck intermediate!

Conor McClune@cmcclune.bsky.social

Our Taxol pathway preprint! We developed a systematic strategy to activate and identify gene sets in plants. Used it to identify 8 genes in the Taxol pathway, enabling a 20-gene biosynthesis of a Taxol precursor. Biggest surprise: a new protein that helps our oxidases produce the correct product

biorxiv.orgMultiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursorsPlants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use in the clinic. A prominent example is the anti-c...

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