Teresa M. Coque

Teresa M. Coque

@tmcoque.bsky.social

Mother, Microbiologist. Crazy about eco-evolutionary aspects of bacteria. #IRYCIS

355 followers267 following35 posts

Teresa M. Coque reposted

Will Matlock
@wtmatlock.bsky.social

🚨 New preprint with @annadewar.bsky.social 🚨 Do plasmids “ameliorate” towards their hosts? Maybe… We show that the classic plasmid-host GC correlation is confounded by population structure, and argue that plasmid mobility shapes the opportunity for host-associated compositional evolution.

doi.orgMobility shapes plasmid GC content evolutionPlasmids are frequently AT-rich relative to their bacterial hosts. Despite this tendency towards lower GC content, plasmid and host chromosome GC content are positively correlated across diverse collections of plasmid-host pairs. However, the evolutionary processes underlying this pattern remain unclear. The classic model of amelioration predicts that horizontally acquired DNA gradually converges on host nucleotide composition. However, because plasmids can repeatedly transfer between bacterial hosts, the opportunity for such host-associated evolution may depend on their transmission dynamics. Using 50,936 plasmid-host pairs from a public sequence database, we found that the apparent global correlation between plasmid and host chromosome GC content was largely driven by differences between bacterial species rather than within species. We therefore accounted for plasmid and host population structure when testing how plasmid mobility shaped host-associated compositional evolution. We compared two contrasting regimes: a population of 3,682 Enterobacterales plasmids distributed across diverse host backgrounds, and six long-term host-associated plasmids from a Rhizobium leguminosarum lineage with INSeq-determined gene essentiality data. In the Enterobacterales population, GC content variation was overwhelmingly explained by plasmid lineage rather than host phylogeny, and conjugative plasmids showed greater similarity to their host chromosomes than mobilisable or non-mobilisable plasmids. In the Rhizobium leguminosarum plasmids, synonymous-site composition was more similar to the host chromosome among genes required across multiple host life stages. Together, these results support a model in which plasmid mobility influences the opportunity for host-associated evolutionary processes to alter nucleotide composition. ### Competing Interest Statement The authors have declared no competing interest. Wellcome Trust, 319534/Z/24/Z St. John's College, University of Oxford, UK

Teresa M. Coque reposted

Moisés Jauregui-Sanchez
@moisesjauregui.bsky.social

¿Un ventilador y luz violeta contra los mosquitos del verano? Sí. Esta trampa casera une biología y física: la luz UV atrae a los insectos al simular su entorno de desove y, al acercarse, el flujo del ventilador vence sus alas. El embudo los absorbe hacia la red, donde mueren por deshidratación.

Teresa M. Coque reposted

Pablo Laborda
@pablolaborda.bsky.social

Our latest work is out in @natcomms.nature.com! Clinical adaptation of #PseudomonasAeruginosa can drive pyruvate secretion, where it scavenges ROS, dampens immune activation and promotes persistence, highlighting bacterial metabolism as an active player in infection🦠 www.nature.com/articles/s41...

nature.comImmune protection and persistence in Pseudomonas aeruginosa infections by pyruvate cross-feeding - Nature CommunicationsThe study shows that metabolic mutations in Pseudomonas aeruginosa lead to pyruvate secretion, which reduces oxidative stress, dampens immune responses, promoting bacterial survival and persistence in...

Teresa M. Coque reposted

Fernando Blanco 🦋 🏳️‍🌈 🏳️‍⚧️
@fernandoblancopsy.com

Como os decía el otro día, tenemos artículo nuevo, es sobre el impacto de la IA en las decisiones médicas. ¿Qué pasa cuando la IA falla? ¿Cómo actuará el humano? journals.plos.org/digitalhealt... Os lo cuento en un hilo 🧵

journals.plos.orgDoctors vs. Algorithms: Physicians, too, struggle to learn from evidence that contradicts AI suggestionsAuthor summary Artificial Intelligence (AI) is now widely used in various fields, including clinical practice, where AI systems assist in classifying patients for diagnosis and treatment. However, the...

Teresa M. Coque reposted

EcoInventos
@ecoinventos.bsky.social

Proyecto español desarrolla fachadas fotoluminiscentes que reducen hasta 2 ºC la temperatura y un 10 % la demanda de refrigeración. ecoinventos.com/proyecto-esp...

ecoinventos.comProyecto español desarrolla fachadas fotoluminiscentes que reducen hasta 2 ºC la temperatura y un 10 % la demanda de refrigeraciónInvestigadores españoles desarrollan fachadas “frías” que convierten radiación ultravioleta en luz para reducir el calentamiento de los edificios.

Teresa M. Coque reposted

GISMAU
@gismau.bsky.social

Europa sigue calentándose el doble que el resto del planeta: "Estamos ante una evidencia científica, no ante una creencia" . Entrevista a Cristina Linares de @gismau.bsky.social www.20minutos.es/ciencia/euro... a través de @20m

20minutos.esEuropa sigue calentándose el doble que el resto del planeta: "Estamos ante una evidencia científica, no ante una creencia"Europa se calienta 0,56°C por década desde mediados de 1990. Desde '20minutos' hablamos con dos expertos en climatología, medio ambiente y salud pública sobre los motivos y sus efectos.

Teresa M. Coque reposted

Moisés Jauregui-Sanchez
@moisesjauregui.bsky.social

Maquetas en simuladores sísmicos universitarios demuestran que fallar en entornos controlados es la mejor pedagogía. Siguiendo lecciones ancestrales como los muros incas, la flexibilidad supera a la rigidez. Reducir la masa y disipar energía evita la resonancia: los sistemas flexibles perduran.

Teresa M. Coque reposted

Lorena Fernández Álvarez
@loretahur.bsky.social

#TalDíaComoHoy en 2024 (repito, 2024), la bióloga Ana María Crespo de las Casas se convierte en la primera presidenta de la Real Academia de Ciencias Exactas, Físicas y Naturales de España, desde su fundación en 1847. #WomenInSTEM

Teresa M. Coque reposted

Sara Aagesen
@saraaagesen.bsky.social

El océano cubre más del 70% de la Tierra y produce el 50% de todo el oxígeno. España fue el primer país europeo en ratificar el Tratado Global de los Océanos. Queremos que el 30% de los mares estén protegidos antes de 2030. La salud de los océanos es la salud de todos 🌊 #DíaMundialdelosOcéanos

Teresa M. Coque reposted

Miren Gurutxe 🌹🌹🌹 🇵🇸
@mirentxu255.bsky.social

🔵 Un equipo de científicos del Institut de Química Avançada de Catalunya ha innovado en la lucha contra el cáncer de mama, utilizando luz para activar medicamentos que eliminan células madre tumorales resistentes. Un avance que plantea nuevas esperanzas para la oncología. 👏👏👏👏👏👏

Teresa M. Coque reposted

AEMET
@aemet.es

🧵🌡️Empezamos una serie de hilos en los que explicaremos las bases científicas del cambio climático. En esta primera entrega vamos a aprender a diferenciar cambio climático y calentamiento global. Os mostraremos gráficas que os ayudarán a entender los conceptos #AemetDivulga

Teresa M. Coque reposted

Cerebro Digital
@cerebrodigital.net

Rebecca Young creó a los 12 años una manta térmica con paneles solares para ayudar a personas sin hogar. Su invento portátil genera calor y fue reconocido en Reino Unido por su impacto social.

Teresa M. Coque reposted

Vaughn Cooper
@vscooper.micropopbio.org

Now out in AEM @asm.org! 🎉🧪 *High school student-isolated mutants 👉🏻 novel genetic causes of biofilm-associated adaptations *We learn how diversity arises quickly and is maintained *EvolvingSTEM enables scalable research in classrooms & promotes scientific literacy journals.asm.org/eprint/FBU9M...

journals.asm.orgGenetic diversification of Pseudomonas fluorescens maintained by multi-niche selection within biofilms | Applied and Environmental MicrobiologyBacterial biofilms dominate microbial life; however, their evolutionary genetics remain incompletely understood. Extensive replication of biofilm selection experiments by secondary school students can...
Vaughn Cooper@vscooper.micropopbio.org

Sharing the most significant work from my group, led by the @evolvingstem.bsky.social team. Come for the discoveries of how Pseudomonas adapts in biofilms, stay for the story of how they were discovered by thousands of young scientists in grades 9-12. 🧪🧫🧬🧵 www.biorxiv.org/content/10.1...

biorxiv.orgStudent-led experimental evolution reveals novel biofilm regulatory networks underlying adaptations to multiple nichesWe established a research-education partnership known as EvolvingSTEM that provides secondary school students the opportunity to conduct authentic research experiments centered on microbial evolution....

Teresa M. Coque reposted

EL PAÍS
@elpais.com

Localizados en la bahía de Algeciras 34 pecios de naves naufragadas entre los siglos V antes de Cristo y XX. El Proyecto Herakles identifica 151 sitios arqueológicos de los que “no se tenía documentación previa”

social.elpais.comLocalizados en la bahía de Algeciras 34 pecios de naves naufragadas entre los siglos V antes de Cristo y XXEl Proyecto Herakles identifica 151 sitios arqueológicos de los que “no se tenía documentación previa”

Teresa M. Coque reposted

José R Penadés
@jrpenades.bsky.social

This paper started as an idea @albertomarina.bsky.social had many years ago… which of course means he was right all along 😄. Some of us just needed a few years (and a lot of experiments) to catch up. Grateful (and slightly humbled) to be part of this. Thanks Alberto! www.cell.com/cell/fulltex...

cell.comPhages communicate across species to shape microbial ecosystemsGallego-del-Sol et al. show that arbitrium-coding phages can sense non-cognate peptide signals from other phages to regulate lysis-lysogeny decisions. This crosstalk affects lysis-lysogeny outcomes of...

Teresa M. Coque reposted

EL PAÍS
@elpais.com

Claude escribe código, maneja archivos, rellena Excel... "Puede ayudar a cualquiera que use un ordenador", cuenta el analista de datos Kiko Llaneras, que lo usa para preparar facturas, predecir elecciones, agilizar su trabajo... Así lo utiliza 👇

elpais.comCómo uso Claude: el agente IA del que todos hablan | AnálisisLa inteligencia artificial dio un salto en diciembre. Un agente llamado Claude está en el centro. Me ayuda en todo: a predecir elecciones, instalar una lavadora o editar esta newsletter
Teresa M. Coque
@tmcoque.bsky.social

We are pleased to share our last article rdcu.be/fabhM. It offers the most comprehensive analysis so far of Ab+non-Ab resistance genes in human gut microbiome, using an Indigenous population (low industrialization, chronic Hg exposure from gold mining) 6/6👇

rdcu.beThe antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the “robust-yet-fragile” architecture ...
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Teresa M. Coque
@tmcoque.bsky.social

We are pleased to share our last article rdcu.be/fabhM. It offers the most comprehensive analysis so far of Ab+non-Ab resistance genes in human gut microbiome, using an Indigenous population (low industrialization, chronic Hg exposure from gold mining) 6/6👇

rdcu.beThe antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the “robust-yet-fragile” architecture ...
View full thread
Teresa M. Coque
@tmcoque.bsky.social

3. Comprehensive resistome monitoring is possible using targeted metagenomic tools like ResCap (PMID: 29335005), which simultaneously detect antibiotic, and also metal and biocide resistance genes, often missed in most metagenomic surveys.

Teresa M. Coque
@tmcoque.bsky.social

In summary, Why matters?: • No microbiome is truly “pristine” • Environmental factors (like Hg pollution) are relevant selective pressures • Resistance can spread fast even in low-impact communities • Definition of "backbone" and "baseline" resistomes are key to interpret AMR

Teresa M. Coque
@tmcoque.bsky.social

We are pleased to share our last article rdcu.be/fabhM. It offers the most comprehensive analysis so far of Ab+non-Ab resistance genes in human gut microbiome, using an Indigenous population (low industrialization, chronic Hg exposure from gold mining) 6/6👇

rdcu.beThe antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the “robust-yet-fragile” architecture ...
Teresa M. Coque
@tmcoque.bsky.social

1. Despite limited Ab exposure, the Wayampi gut microbiome harbors a robust "background" resistome of ACQUIRED resistance genes (antibiotic, metal, biocide) shared with Westerns=AMR is an ancient and conserved feature rather than solely a by-product of human activities.

Teresa M. Coque
@tmcoque.bsky.social

2. Differences in gene distributions reflect ecological and taxonomic variation in microbiome structure. Rapid emergence of clinically relevant ARGs after healthcare or Ab exposure highlights the resistome as a “robust-yet-fragile” ecogenetic system, susceptible to disruption

Teresa M. Coque reposted

The New York Times
@nytimes.com

A federal judge on Wednesday ordered federal agents to stop detaining and deporting refugees in Minnesota who were lawfully admitted to the U.S., granting a temporary restraining order, which halts for now the Trump administration’s operation. The administration is likely to appeal the ruling.

nyti.msJudge Orders Release of Minnesota Refugees Targeted in ICE CrackdownA federal judge granted a temporary restraining order, which halts a Trump administration operation that has swept up at least 100 people so far.
Teresa M. Coque
@tmcoque.bsky.social

And what a beautiful @pnas.org cover @paularamiro.bsky.social and @jerorb.bsky.social !!!!!! You should be very proud!

Jerónimo Rodríguez-Beltrán@jerorb.bsky.social

New paper out in @pnas.org, and it made the cover! 👁️ We represent plasmids as circles and mutations as dots, resembling an eye, because in this paper we literally 𝑤𝑎𝑡𝑐ℎ plasmids evolve. ‼️Check Paula’s 🧵 and the paper👇 𝗣𝗹𝗮𝘀𝗺𝗶𝗱 𝗺𝘂𝘁𝗮𝘁𝗶𝗼𝗻 𝗿𝗮𝘁𝗲𝘀 𝘀𝗰𝗮𝗹𝗲 𝘄𝗶𝘁𝗵 𝗰𝗼𝗽𝘆 𝗻𝘂𝗺𝗯𝗲𝗿 www.pnas.org/doi/10.1073/...

Teresa M. Coque
@tmcoque.bsky.social

Congratulations to @paularamiro.bsky.social and the @jerorb.bsky.social ´s group and collaborators! A must reading for understanding plasmid biology, bacterial evolution and evolution more broadly. Bravo! 👏👏👏 👇

Paula Ramiro-Martínez@paularamiro.bsky.social

New paper out in PNAS!!! 🎉 Do more plasmid copies mean faster evolution? 🧵 Dive into the story www.pnas.org/doi/10.1073/...

pnas.orgPlasmid mutation rates scale with copy number | PNASPlasmids are extrachromosomal DNA molecules that spread by horizontal transfer and shape bacterial evolution. Plasmids are typically present at mul...

Teresa M. Coque reposted

Europa Press
@europapress.es

❗ Investigadores españoles logran eliminar por completo tumores de páncreas en ratones utilizando una triple terapia. Este hito alcanzado por primera vez abre la puerta a tratamientos en humanos para uno de los cánceres más mortales

infosalus.comLogran eliminar por completo tumores de páncreas en ratones utilizando una triple terapiaInvestigadores del Centro Nacional de Investigaciones Oncológicas (CNIO) han logrado eliminar por...

Teresa M. Coque reposted

caixaresearch.bsky.social
@caixaresearch.bsky.social

Replying to @caixaresearch.bsky.social

19/ 🔚We have reached the end of the event! Thank you for joining us and for your commitment to the future of health. Congratulations to all the selected projects!🎉👏 Stay tuned, we’ll be sharing more highlights and details from the ceremony soon!👀

Teresa M. Coque
@tmcoque.bsky.social

A pleasure and an honour to have received this prestigious grant with my admired colleagues and friends @sanmillan.bsky.social and @asanchezlab.bsky.social . More about AMR under plasmid lens!. My sincere gratitude to @caixaresearch.bsky.social @microryc.bsky.social @esgem-sg.bsky.social

caixaresearch.bsky.socialcaixaresearch.bsky.social
caixaresearch.bsky.social@caixaresearch.bsky.social

Congratulations to you and your teams, @sanmillan.bsky.social, @asanchezlab.bsky.social and @tmcoque.bsky.social! We are thrilled to support your work and look forward to the impact your project will have. 👏💫

Teresa M. Coque reposted

EL PAÍS
@elpais.com

Asientos de avión cada vez más pequeños, prendas irreconocibles al segundo lavado, máquinas que te atienden por teléfono para cualquier trámite. El cuidado por las cosas bien hechas parece haber dejado de ser un valor que cuenta

elpais.comEl asombroso fenómeno de la calidad menguanteAsientos de avión cada vez más pequeños, prendas irreconocibles al segundo lavado, máquinas que te atienden por teléfono para cualquier trámite. El cuidado por las cosas bien hechas parece haber dejado de ser un valor que cuenta

Teresa M. Coque reposted

Sofya Garushyants
@garushyants.bsky.social

Cool work by Sanasar investigating how bacteria-phage dynamics affect the distribution of antiphage defense systems in the genome www.biorxiv.org/content/10.1...

biorxiv.orgEvolution of antivirus defense in prokaryotes depending on the environmental virus prevalence and virome dynamicsProkaryotes can acquire antivirus immunity via two fundamentally distinct types of processes: direct interaction with the virus as in CRISPR-Cas adaptive immunity systems and horizontal gene transfer ...