Anna Olina

First in-depth evaluation of bacteriophages in wastewater on a global scale www.sciencedirect.com/science/arti...

New from the @multidefence.bsky.social consortium: a deep dive into MANTIS defence. Thanks to @ukri.org for funding. www.biorxiv.org/content/10.6...

Dual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence system https://www.biorxiv.org/content/10.64898/2026.09.23.753747v1

Excited to share this part of my research as a part of @multidefence.bsky.social: meet viPAO1 - the very best Pseudomonas strain for phage research😉 Also check out our temperate phage collection featuring PAnicatthedisco, PAthetic and some other new fun names🎉 www.biorxiv.org/content/10.6...

New preprint from PhD student Yu Sun. TSR1 is a TIR effector specialised for CRISPR defence. It is an obligate dimer activated by cA3 and degrades its own activator using a ring nuclease domain. Perhaps the first confirmed dimeric TIR effector? www.biorxiv.org/content/10.6...

Virus deploys a ‘loose cannon’ enzyme to overpower bacterial defences @nature.com @embl.org www.nature.com/articles/d41... www.nature.com/articles/s41...

Hey friends of microbial evolution and science education! I posted the talk about EvolvingSTEM for anyone unable to attend #ISME20 in New Zealand. youtu.be/xzHI05eH104

Excited to be talking about my #phage #bioinformatics tool #Phables to study #viral #ecology in #IBD-associated #metagenomes. Come check out my talk in session AS13 at 2.30pm on Tuesday 18th Aug in room 303-305. #ISME20 GitHub: github.com/Vini2/phables Publication: academic.oup.com/bioinformati...

@alekseiagapov.bsky.social and I are both presenting posters today at #ISME20 - come talk to us about phages and defences 🧬 PS2.14.246 and PS2.14.248 😉 @multidefence.bsky.social

🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️ Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

#microsky #phagesky #phage #synbio www.nature.com/articles/s41...

Multiplexed CRISPR base editing enables pulse-activated irreversible biocontainment of engineered bacteria academic.oup.com/nar/article/... #microsky

Want to find #prophage in your #bacteria genomes? We built PhiSpy a long time ago, and now we've created a new web page for it: linsalrob.github.io/PhiSpyWeb/ Best of all, the data never leaves your computer! #phage #phagesky

Very happy to share our recent preprint: “An Lsr2-like xenogeneic silencer confers immunity against AT-rich bacteriophage infection” www.researchsquare.com/article/rs-9... @fz-juelich.de; @hhu.de; @spp2330.bsky.social

TIR-like NADases act in bacterial immunity and the RNA vault https://www.biorxiv.org/content/10.64898/2026.05.01.722283v1

Final version of our last paper is out! www.nature.com/articles/s41...

New #AMR pre-print Combining antibiotics with genotoxins can efficiently suppress bacterial in high throughput experimental models. www.biorxiv.org/content/10.6... Fun collaboration with Nassos Typas lab led by @mulkern.bsky.social

What if quorum sensing doesn’t promote biofilms - but restrains it? 🤔 New work from @harisantypas.bsky.social shows that the Fsr QS system in Enterococcus faecalis acts as a brake on biofilm formation and pathogenesis during infective endocarditis (IE). www.nature.com/articles/s41...

Check out largest scale analysis of bacterial DNA polymerases! Diversity and distribution of bacterial DNA polymerases url: academic.oup.com/nar/article/...

Out now in @plosbiology.org : our big joint effort on the role of #CRISPR in plasmid competition. Read on for a really fun (I’m biased ok) analysis of how a defence system has new selective pressures when it’s mobile journals.plos.org/plosbiology/... 1/6

Nature research paper: Nucleotide signals coordinate activation and inhibition of bacterial immunity go.nature.com/4kMuzHu

#microsky #phagesky #phage #MGE Prophages found in conjugative megaplasmids from gut Bacillota www.biorxiv.org/content/10.6...

#microsky #phagesky #phage defence www.nature.com/articles/s41...

Last year, we proposed a model of plasmid evolution via fusion and fragmentation (via mge mediated recombination) generating mosaics, by studying historical isolates. Excited to see a MASSIVE paper from @jrpenades.bsky.social , @epcrocha.bsky.social expanding on this www.biorxiv.org/content/10.6...

Great work by Jamie Gorzynski and Josh-Harling-Lee from the group providing insights into the evolutionary origins of bacterial lineages. A collaboration with @jrpenades.bsky.social @wfigueroac3.bsky.social. #Staph Cell Reports www.cell.com/cell-reports...

Yet another awesome single-phage paper from Ido Golding's lab #phagesky www.biorxiv.org/content/10.6...

1/5 Happy by a recent biorxiv pre-print about DARNA (PD-T7-3) anti-phage defense system. This system is activated by binding to ssDNA, presented by phage SSB, to cleave tRNA in the anti-codon loop. www.biorxiv.org/content/10.6...

From sweets and mulled wine to quizzes and ice skating trips, many laboratories develop traditions to show appreciation to colleagues go.nature.com/4it9ZuK

The host range of generalist and specialist phages in capsule-diverse Klebsiella hosts is driven by the evolvability of receptor-binding proteins @plosbiology.org from @pilardomingoc.bsky.social journals.plos.org/plosbiology/...

@alekseiagapov.bsky.social presenting our data at #MicroEvo25! Always good to see a few new phage defences discovered😉

Long read Metagenomics, #phage and #prophage in the gut by Ami Bhatt's group. Beautiful data showing changes in phages over two years #phagesky www.nature.com/articles/s41...

WE ARE RECRUITING PHD STUDENTS!!! We have three(!) funded PhD studentships advertising presently. If any of these are of interest, please reach out! Thread below with links to more information on each project. #Drosophila #Evolution #Immunity #SelfishGene #Aphids Thread with links below 🧵 1/4

@jpjhall.bsky.social starts the #MicroEvo25 strong! Looks like it's gonna be fun🧬🧫🧪

The hinge bypass gate paper is finally out! doi.org/10.1038/s414... We show how loop-extruding SMC complexes can maintain DNA entrapment while bypassing obstacles on DNA — including transcription machinery & potentially other SMCs. A lucky convergence of 3 projects lead to the initial discovery!

Phage toxin variants are linked to protection specificity in a defensive symbiont https://www.biorxiv.org/content/10.1101/2025.11.21.689672v1

Bacteriophage density influences the rate of resistance evolution. DOI: 10.1101/2025.10.05.680490 https://pubmed.ncbi.nlm.nih.gov/41256655/

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...

KlebPhaCol paper is now out! Go check it out and see all that we offer. And when ready, visit our website for more: www.klebphacol.org

🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8

The ecological roles of bacterial #immune systems are poorly understood. Rafael Custodio @ellinoralseth.bsky.social @brockhurstlab.bsky.social @brownlab.bsky.social & Edze Westra explore how mobile genetic elements and bacterial defenses shape #microbiome structure and function 🧪

⭐ NAR Breakthrough! ⭐ 🔬 New study reveals how the Retron-Eco7 system helps bacteria sense and fight phage attacks, identifying a clever immune-sensing mechanism in the bacteria–phage arms race. 🧬 Read more: doi.org/10.1093/nar/... #NARBreakthrough #Microbiology #PhageBiology #BacterialDefense

Harnessing droplet microfluidics and morphology-based deep learning for the label-free study of polymicrobial-phage interactions. DOI: 10.1038/s42003-025-08925-9 https://pubmed.ncbi.nlm.nih.gov/41225150/

New pre-print: Plasmid dependent phage effectively eliminate AMR bacteria and block plasmid transmission in the chicken gut microbiome Fun collaboration with Tao He lab (JAAS) and @brockhurstlab.bsky.social lab (Manchester) #phagesky#microsky www.biorxiv.org/content/10.1...

😍 #phage #phagesky www.pnas.org/doi/full/10....

@prczhaoyansong.bsky.social’s deep dive into the dark matter of compost communities is now out 🎉 Genomic islands hijack jumbo phages—whose capsids enable transfer of large tracts of DNA—shedding new light on the scale & scope of phage-mediated gene flow 😎 www.pnas.org/doi/10.1073/...

Three new kids on the block. ARMADA, BRIGADE, and TALON. Impressive how multiple labs all come together to contribute to discovery. Great collaboration with Simon, Chase, and Eugene. From the very talented Ryan Bell, together with Thomas Gaudin and our own Yi Wu. www.biorxiv.org/content/10.1...