Baptiste Castel

Baptiste Castel

@baptistebio.bsky.social

🌿 Plant biologist 👨‍🔬 Researcher in the Leptosphaeria team (BIOGER, INRAE, campus AgroParisTech, Paris-Saclay University) 🛡️🧬 Interested in the plant immune system

248 followers212 following39 posts

Baptiste Castel reposted

Did you know that Selaginella kraussiana lycophytes have explosive spore dispersal? Neither did we, until we noticed the spores getting everywhere when we were trying to image them! New blog post from our former summer student Mo Inall: biology.ed.ac.uk/plant-scienc...

biology.ed.ac.ukBlog - Exploding spore dispersal | Molecular Plant Sciences | BiologyA rare chance at seeing how some spikemosses launch the next generation into new heights.

Baptiste Castel reposted

The last talk of the meeting! We’re a little sad that #MAdLand2026 is coming to an end, but very happy to welcome our guest speaker, @pierremarcdelaux.bsky.social from Toulouse. He will talk about the evolution of plant–microbe interactions at the water-to-land transition. 🌱 #plantsci

Baptiste Castel reposted

Still one week to apply!

Mariana Schuster@marischuster.bsky.social

I'm excited to share that my newly funded #ERCStG FRONTERA is recruiting two postdoctoral researchers at @ipbhalle.bsky.social 🌱🔬 If you are passionate about plant immunity, proteolysis, membrane proteins, or proteomics, I'd love to hear from you. 🧵 Please RT/share!

Baptiste Castel reposted

Benthamiana rhapsody 🎶 🌱 How benthi is the go-to system for cracking the activation mechanism of an Arabidopsis TIR-NLR immune receptor— that’s the rhapsody. Congrats He Zhao and Selvaraj for this wonderful collaboration 👇🏼 doi.org/10.64898/202...

Baptiste Castel reposted

Congratulations Sylvain and @nemopeeters.bsky.social !

Nemo Peeters@nemopeeters.bsky.social

🆕 version work @sylvain-vicente.bsky.social and collaborators #BIOSP #MathNum @inrae-dpt-spe.bsky.social. Re-evaluation of STAMP modelling, introducing time-resolution. Works also on Animal-bacterial infection models. #infection #Ralstonia #Pseudomonas #Klebsiella www.biorxiv.org/content/10.1...

Baptiste Castel reposted

Baptiste Castel reposted

I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life. www.biorxiv.org/content/10.6...

biorxiv.orgSystematic discovery of TIR-based immune signaling systems in bacteriaToll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...

Baptiste Castel reposted

New preprint from our group led by @metalichen.bsky.social on the discovery of a Starship giant transposable element in the genome of a lichen-forming fungus.

Gulnara Tagirdzhanova@metalichen.bsky.social

New preprint: 🚀🧬 Starship in the genome of the lichen fungus Xanthoria. Discovery of giant transposons Starships challenged what we thought we knew about fungal genomes. But what about Starships in #lichen fungi? Let us present Tangerine! 🖥️ 🧪 🦠 🧫 #SymbioSky doi.org/10.1101/2025...

Baptiste Castel reposted

Baptiste Castel reposted

🛑Exciting update from our work with @pierremarcdelaux.bsky.social team on the ericoid mycorrhizal symbiosis❗❗ 🔥New results support a conserved three-gene module and master regulator for nutrient-responsive intracellular accommodation of fungal symbionts🤯 Check the nice thread below👇🏼 #plantscience

Katharina Melkonian@katharinamel1.bsky.social

1/ It is my pleasure to share the latest preprint of the team: "Symbiotic diversification relies on an ancestral gene network in plants" doi.org/10.1101/2025... Here, we identified and functionally validated a novel master regulator of intracellular symbioses! A thread ... #PlantScience

Baptiste Castel reposted

Sooo happy to see this preprint out 🍄☘️! Congratulations @leocastanedo.bsky.social @katharinamel1.bsky.social et al. ! It has been a long journey, from developing ericoid-mycorrhizae in the lab (Leo) to the genetics in Marchantia (Katharina), and many other details (#teamwork)

Katharina Melkonian@katharinamel1.bsky.social

1/ It is my pleasure to share the latest preprint of the team: "Symbiotic diversification relies on an ancestral gene network in plants" doi.org/10.1101/2025... Here, we identified and functionally validated a novel master regulator of intracellular symbioses! A thread ... #PlantScience

Congratulations!

Katharina Melkonian@katharinamel1.bsky.social

1/ It is my pleasure to share the latest preprint of the team: "Symbiotic diversification relies on an ancestral gene network in plants" doi.org/10.1101/2025... Here, we identified and functionally validated a novel master regulator of intracellular symbioses! A thread ... #PlantScience

bmcbiol.biomedcentral.comExploring fern pathosystems and immune receptors to bridge gaps in plant immunity - BMC BiologyLand plants include angiosperms, gymnosperms, bryophytes, lycophytes, and ferns, each of which may deploy distinct strategies to resist pathogens. Here, we investigate fern-pathogen interactions by characterizing novel pathosystems and analyzing the diversity of fern immune receptors. A collection of fern species was inoculated with a diverse set of filamentous microbes, and disease symptoms were assessed. We further leveraged published genome mining tools to analyse the diversity of receptor-like kinases, receptor-like proteins (RLKs/RLPs) and nucleotide-binding and leucine-rich repeats (NLRs), along with key immune signalling components, in ferns. Our results reveal that ferns exhibit a range of responses to pathogens, including putative non-host resistance and more specific resistance mechanisms. Among ten ferns tested, Pteris vittata displays the broadest spectrum of pathogen compatibility. Genome mining indicates that ferns encode a diverse repertoire of putative immune receptors, antimicrobial peptides, and mediators of systemic acquired resistance. Ferns possess numerous RLKs/RLPs, resembling those required for cell-surface immunity in angiosperms. They also encode diverse NLRs, including sub-families lost in flowering plants. These findings provide insights into disease resistance evolution and open promising perspectives for crop protection strategies.
View full thread

3\ Ferns reproduce via alternance of gametophytes (💚 algae-looking tiny plants) and sporophyte (🌿dominant phase, the form we are most familiar with). For some pathogens, gametophytes are more resistant than their sporophyte. 3/4

4\ We found a class of immune receptors enriched in ferns. According to the features you are looking at, they could be CC-NLRs, or potentially a new class of intracellular immune receptors. They remain to be characterized … (drop us a message if you are interested in doing that with us ⬇️) 4/4

bmcbiol.biomedcentral.comExploring fern pathosystems and immune receptors to bridge gaps in plant immunity - BMC BiologyLand plants include angiosperms, gymnosperms, bryophytes, lycophytes, and ferns, each of which may deploy distinct strategies to resist pathogens. Here, we investigate fern-pathogen interactions by characterizing novel pathosystems and analyzing the diversity of fern immune receptors. A collection of fern species was inoculated with a diverse set of filamentous microbes, and disease symptoms were assessed. We further leveraged published genome mining tools to analyse the diversity of receptor-like kinases, receptor-like proteins (RLKs/RLPs) and nucleotide-binding and leucine-rich repeats (NLRs), along with key immune signalling components, in ferns. Our results reveal that ferns exhibit a range of responses to pathogens, including putative non-host resistance and more specific resistance mechanisms. Among ten ferns tested, Pteris vittata displays the broadest spectrum of pathogen compatibility. Genome mining indicates that ferns encode a diverse repertoire of putative immune receptors, antimicrobial peptides, and mediators of systemic acquired resistance. Ferns possess numerous RLKs/RLPs, resembling those required for cell-surface immunity in angiosperms. They also encode diverse NLRs, including sub-families lost in flowering plants. These findings provide insights into disease resistance evolution and open promising perspectives for crop protection strategies.

Baptiste Castel reposted

A first dive in fern x pathogen interaction! More to come! Congratulations @baptistebio.bsky.social @jacquet-chris.bsky.social et al.!

Jacquet-chris@jacquet-chris.bsky.social

Want to see ferns under attack and how they respond to pathogens? Check out our latest paper! doi.org/10.1186/s129... Congrats on this huge team effort to @baptistebio.bsky.social @madeleinebaker.bsky.social @kellerjeanphd.bsky.social @maximebonhomme.bsky.social @pierremarcdelaux.bsky.social

Baptiste Castel reposted

~12 years after we coined it EPP1 with @oswaldovaldesl.bsky.social one afternoon when we were postdoc with @jeanmichelane.bsky.social! Congrats @melaniekrich.bsky.social @tatiana-vernie.bsky.social et al. for the hard work! EPP1 is the fourth member of the Common Symbiosis Pathway 🍄🌱!

Mélanie Rich 🌱🍄@melaniekrich.bsky.social

So happy to see the latest preprint of the team out! www.biorxiv.org/content/10.1... The continuation of a long standing project started by @oswaldovaldesl.bsky.social in @jeanmichelane.bsky.social‘s lab. 1/7 🧵

Baptiste Castel reposted

VACANCY - Independent research fellowships leading to tenured positions We’re inviting applications from outstanding researchers who either hold, or wish to apply for, Independent Research Fellowships. APPLICATION DEADLINE: 10 November 2025 Click here to apply: jic.link/Fellows

Baptiste Castel reposted

Baptiste Castel reposted

Baptiste Castel reposted

Super excited to share our new preprint! 🎉 This project has been an incredible learning experience, thanks to the amazing lab and wonderful people I get to work with. Huge thanks to my supervisor! @plantevolution.bsky.social

PlantEvolution 🌱🌾@plantevolution.bsky.social

1/3 New preprint led by Shanshan Wang, in collaboration with the Timmermans lab. Several groups have presented sc/snRNA-seq analyses of Arabidopsis leaves after bacterial infection before. Is there anything left to discover? Turns out: Yes. #plantscience www.biorxiv.org/content/10.1...

Baptiste Castel reposted

Baptiste Castel reposted

Baptiste Castel reposted

#2025ISMPMI 📣 In silico screening of PRR-epitope interactions is now possible! Here, we developed mamp-ml to predict their immunogenic outcomes without structural context. Let's accelerate engineering plant receptors for robust resistance! 🚀🌱 Small 🧵 www.biorxiv.org/content/10.1...

biorxiv.orgmamp-ml: A deep learning approach to epitope immunogenicity in plantsEukaryotes detect biomolecules through surface-localized receptors, key signaling components. A subset of receptors survey for pathogens, induce immunity, and restrict pathogen growth. Comparative gen...